Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K., & Yamashita, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19081 · Cited by 1,503

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho

Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Baum, M. G., Schiavi, S. C., Hu, M. C., Moe, O. W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500457200 · Cited by 1,381

Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease

Jahn, D., Rau, M., Hermanns, H. M., & Geier, A. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.016 · Cited by 65

Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation

Xu, J., Bussiere, J. L., Yie, J., Sickmier, E. A., An, P., Belouski, E., Stanislaus, S., & Walker, K. W. (2013) · Bioconjugate Chemistry · doi:10.1021/bc300603k · Cited by 61

Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application

Struik, D., Dommerholt, M. B., & Jonker, J. W. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000599 · Cited by 61

Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease—a comprehensive review from the ERA CKD-MBD working group

Kanbay, M., Copur, S., Özbek, L., Mutlu, A., Cejka, D., Ciceri, P., Cozzolino, M. G., & Haarhaus, M. L. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad276 · Cited by 60

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

Smith, R. J., Duguay, A. N., Bakker, A., Li, P., Weiszmann, J., Thomas, M. R., Alba, B. M., Wu, X., Gupte, J., Li, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061432 · Cited by 59

FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes

Chen, M. Z., Chang, J. C., Zavala-Solorio, J., Kates, L., Thai, M., Ogasawara, A., Bai, X., Flanagan, S., Nunez, V., Phamluong, K., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.09.003 · Cited by 58

Sex Differences in Nonalcoholic Fatty Liver Disease: Estrogen Influence on the Liver–Adipose Tissue Crosstalk

Morán-Costoya, A., Proenza, A. M., Gianotti, M., Lladó, I., & Valle, A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0044 · Cited by 58

Dynamic Change of Serum FGF21 Levels in Response to Glucose Challenge in Human

Lin, Z., Gong, Q., Wu, C., Yu, J., Lü, T., Pan, X., Lin, S., & Li, X. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1132 · Cited by 58

The Protective Effect of FGF21 on Diabetes-Induced Male Germ Cell Apoptosis Is Associated With Up-Regulated Testicular AKT and AMPK/Sirt1/PGC-1α Signaling

Jiang, X. M., Chen, J., Zhang, C., Zhang, Z., Tan, Y., Feng, W., Skibba, M. E., Xin, Y., & Cai, L. (2015) · Endocrinology · doi:10.1210/en.2014-1619 · Cited by 58

FGF23 beyond Phosphotropic Hormone

Takashi, Y., & Fukumoto, S. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.08.006 · Cited by 58

Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis

Langlet, F. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00286 · Cited by 61

Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21

Muise, E. S., Souza, S., Chi, A., Tan, Y., Zhao, X., Liu, F., Dallas-yang, Q., Wu, M., Sarr, T., Zhu, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073011 · Cited by 57

Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue

Kobayashi, M., Deguchi, Y., Nozaki, Y., & Higami, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116025 · Cited by 63

Increased Placental Expression of Fibroblast Growth Factor 21 in Gestational Diabetes Mellitus

Nitert, M. D., Barrett, H. L., Kubala, M. H., Scholz‐Romero, K., Denny, K. J., Woodruff, T. M., McIntyre, D. H., & Callaway, L. K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2581 · Cited by 57

Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver

Cui, G., Martin, R. C. G., Jin, H., Liu, X., Pandit, H., Zhao, H., Cai, L., Zhang, P., Li, W., & Li, Y. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0781-8 · Cited by 56

Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways

Lee, K. J., Jang, Y. O., Cha, S., Kim, M. Y., Park, K., Eom, Y. W., & Baik, S. K. (2018) · Gut and Liver · doi:10.5009/gnl17443 · Cited by 56

Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway

Lei, Y., Li, N., He, Z., Zeng, X., Yan, N., Chen, J., Miao, P., Ying, Y., Lin, W. Y., Zhao, X., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1893-6 · Cited by 55

Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD

Inagaki, T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00147 · Cited by 55

Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage

Luo, Y., Ye, S., Chen, X., Gong, F., Lu, W., & Li, X. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.08.001 · Cited by 56

Role of exercise-induced hepatokines in metabolic disorders

Ennequin, G., Sirvent, P., & Whitham, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2018 · Cited by 54

The Prevention of Diabetic Cardiomyopathy by Non-Mitogenic Acidic Fibroblast Growth Factor Is Probably Mediated by the Suppression of Oxidative Stress and Damage

Zhang, C., Zhang, L., Chen, S., Feng, B., Lu, X., Bai, Y., Liang, G., Tan, Y., Shao, M., Skibba, M. E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082287 · Cited by 54

Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting

Fougerat, A., Bruse, J., Polizzi, A., Montagner, A., Guillou, H., & Wahli, W. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101303 · Cited by 56

Fibroblast Growth Factor 21 Attenuates Vascular Calcification by Alleviating Endoplasmic Reticulum Stress Mediated Apoptosis in Rats

Shi, Y., Wang, S., Peng, H., Lv, Y., Li, W., Cheng, S., & Liu, J. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.28873 · Cited by 53

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism

Ozaki, Y., Saito, K., Nakazawa, K., Konishi, M., Itoh, N., Hakuno, F., Takahashi, S.-I., Kato, H., & Takenaka, A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002846 · Cited by 51

Fibroblast growth factor 15/19 expression, regulation, and function: An overview

Guthrie, G. J., Vonderohe, C. E., & Burrin, D. G. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111617 · Cited by 57

Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice

Grefhorst, A., van den Beukel, J. C., van Houten, E. L. A. F., Steenbergen, J., Visser, J. A., & Themmen, A. P. N. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0025-y · Cited by 54

Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk

Jin, L., Lin, Z., & Xu, A. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.1.22 · Cited by 52

Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice

Martin, A., Ecklu-Mensah, G., Ha, C. W. Y., Hendrick, G., Layman, D. K., Gilbert, J. A., & Devkota, S. (2021) · Nature Communications · doi:10.1038/s41467-021-24074-z · Cited by 52

FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system

Choi, M., Schneeberger, M., Fan, W., Bugde, A., Gautron, L., Vale, K., Hammer, R. E., Zhang, Y., Friedman, J. M., Mangelsdorf, D. J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.005 · Cited by 51

Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice

Wu, X., Qi, Y., Chang, J.-R., Lu, W., Zhang, J., Wang, S., Cheng, S., Zhang, M., Fan, Q., Lv, Y., et al. (2014) · Heart and Vessels · doi:10.1007/s00380-014-0557-9 · Cited by 51

Fibroblast growth factor signaling in the developing neuroendocrine hypothalamus

Tsai, P., Brooks, L. R., Rochester, J. R., Kavanaugh, S. I., & Chung, W. C. J. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.11.002 · Cited by 52

The regulation of FGF21 gene expression by metabolic factors and nutrients

Erickson, A., & Moreau, R. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0016 · Cited by 53

HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection

Zhang, J., Xu, Z., Gu, J., Jiang, S., Liu, Q., Zheng, Y., Freedman, J. H., Sun, J., & Cai, L. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00465.2017 · Cited by 50

Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice

Bozadjieva-Kramer, N., Shin, J. H., Shao, Y., Gutiérrez‐Aguilar, R., Li, Z., Heppner, K. M., Chiang, S., Vargo, S. G., Granger, K., Sandoval, D. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24914-y · Cited by 49

Multi-organ FGF21-FGFR1 signaling in metabolic health and disease

Kaur, N., Gare, S. R., Shen, J., Raja, R., Fonseka, O., & Liu, W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.962561 · Cited by 49

Fibroblast Growth Factor Receptor Like-1 (FGFRL1) Interacts with SHP-1 Phosphatase at Insulin Secretory Granules and Induces Beta-cell ERK1/2 Protein Activation*

Silva, P. N., Altamentova, S., Kilkenny, D., & Rocheleau, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.440677 · Cited by 56

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

Hernandez, G., Luo, T. F., Javed, T. A., Wen, L., Kalwat, M. A., Vale, K., Ammouri, F., Husain, S. Z., Kliewer, S. A., & Mangelsdorf, D. J. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay5186 · Cited by 49

Myogenic-specific ablation of Fgfr1 impairs FGF2-mediated proliferation of satellite cells at the myofiber niche but does not abolish the capacity for muscle regeneration

Yablonka‐Reuveni, Z., Danoviz, M. E., Phelps, M., & Stuelsatz, P. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00085 · Cited by 50

Role of fibroblast growth factor 19 in the control of glucose homeostasis

Schaap, F. G. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283547171 · Cited by 48

FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance

Bernardo, B. L., Lu, M. M., Bandyopadhyay, G. K., Li, P., Zhou, Y., Huang, J. S., Levin, N., Tomás, E., Calle, R. A., Erion, D. M., et al. (2015) · Scientific Reports · doi:10.1038/srep11382 · Cited by 49

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

Kim, T. H., Hong, D.-G., & Yang, Y. M. (2021) · Biomedicines · doi:10.3390/biomedicines9121903 · Cited by 57

Dark and bright side of targeting fibroblast growth factor receptor 4 in the liver

Gadaleta, R. M., & Moschetta, A. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.07.029 · Cited by 47

Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress

Yang, C., Wang, C., Ye, M., Jin, C., He, W., Wang, F., McKeehan, W. L., & Luo, Y. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-94 · Cited by 48

Organokines in disease

(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46

Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets

Le, T. D. V., Fathi, P. A., Watters, A. B., Ellis, B. J., Besing, G.-L. K., Bozadjieva-Kramer, N., Perez, M. B., Sullivan, A. I., Rose, J. P., Baggio, L. L., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101718 · Cited by 49

Metabolic roles of endocrine fibroblast growth factors

Fernandes-Freitas, I., & Owen, B. M. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.014 · Cited by 46

Extrarenal effects of FGF23

Haffner, D., & Leifheit‐Nestler, M. (2016) · Pediatric Nephrology · doi:10.1007/s00467-016-3505-3 · Cited by 46

Secretomics to Discover Regulators in Diseases

Song, P., Kwon, Y., Joo, J., Kim, D.-G., & Yoon, J. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163893 · Cited by 48

Role of hepatokines in non-alcoholic fatty liver disease

Ke, Y., Xu, C., Lin, J., & Li, Y. (2019) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2019-0029 · Cited by 46

Pemafibrate Protects Against Retinal Dysfunction in a Murine Model of Diabetic Retinopathy

Tomita, Y., Lee, D., Miwa, Y., Jiang, X., Ohta, M., Tsubota, K., & Kurihara, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176243 · Cited by 46

FGF, Mechanism of Action, Role in Parkinson’s Disease, and Therapeutics

Liu, Y., Deng, J., Liu, Y., Li, W., & Nie, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.675725 · Cited by 46

Targeted inhibition of the FGF 19‐ FGFR 4 pathway in hepatocellular carcinoma; translational safety considerations

Mellor, H. R. (2014) · Liver International · doi:10.1111/liv.12462 · Cited by 45

Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children

Kunert, S. K., Hartmann, H., Haffner, D., & Leifheit‐Nestler, M. (2016) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-016-0746-y · Cited by 45

Metabolic actions of fibroblast growth factor 21

Ramos, D. C., Aguilar-Salinas, C. A., & Gomez-Perez, F. J. (2012) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283557d22 · Cited by 46

Linking liver metabolic and vascular disease via bile acid signaling

Fiorucci, S., & Distrutti, E. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.10.005 · Cited by 48

Short Term Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome Via B-hydroxybutyrate and Fibroblast Growth Factor 21

Kim, E. R., Kim, S. R., Cho, W., Lee, S., Kim, S. H., Kim, J. H., Choi, E., Kim, J., Yu, J., Lee, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843520 · Cited by 44

Central FGF21 production regulates memory but not peripheral metabolism

Zhou, B., Claflin, K. E., Flippo, K. H., Sullivan, A. I., Asghari, A., Tadinada, S. M., Jensen-Cody, S. O., Abel, T. G., & Potthoff, M. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111239 · Cited by 43

Fibroblast growth factor 21 in heart failure

Tucker, W., Tucker, B., Rye, K., & Ong, K. L. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10268-0 · Cited by 44

Eye on the horizon: The metabolic landscape of the RPE in aging and disease

Hansman, D., Du, J., Casson, R. J., & Peet, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101306 · Cited by 50

Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases

Yi, H. (2019) · Endocrinology and Metabolism · doi:10.3803/enm.2019.34.1.39 · Cited by 43

FGF8-FGFR1 Signaling Acts as a Niche Factor for Maintaining Undifferentiated Spermatogonia in the Mouse1

Hasegawa, K., & Saga, Y. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.121012 · Cited by 41

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Li, D., Jing, D., Liu, Z., Chen, Y., Huang, F., & Behnisch, T. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00133 · Cited by 43

YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity

Wang, L., Mazagova, M., Pan, C., Yang, S. T., Brandl, K., Liu, J., Reilly, S. M., Wang, Y., Miao, Z., Loomba, R. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904360116 · Cited by 43

Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer

Ewendt, F., Feger, M., & Föller, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.601006 · Cited by 43

Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)

Cheng, X., Vispute, S. G., Liu, J., Cheng, C., Kharitonenkov, A., & Klaassen, C. D. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.04.013 · Cited by 42

Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes

Donate‐Correa, J., Martín‐Núñez, E., Pérez‐Delgado, N., de Fuentes, M. M., Ortíz, A., Fernández, C. M., & Navarro‐González, J. F. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.12.003 · Cited by 44

The Roles of Fibroblast Growth Factors in the Testicular Development and Tumor

Jiang, X. M., Skibba, M. E., Zhang, C., Tan, Y., Xin, Y., & Qu, Y. (2013) · Journal of Diabetes Research · doi:10.1155/2013/489095 · Cited by 42

The roles of FGF21 in atherosclerosis pathogenesis

Shanehbandpour-Tabari, F., Karimian, A., Parsian, H., Rameshknia, V., Mahmoodpoor, A., Majidinia, M., Maniati, M., & Yousefi, B. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09488-x · Cited by 41

Role of the fibroblast growth factor 19 in the skeletal system

Chen, H., Li, J., Zhang, D., Zhou, X., & Xie, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118804 · Cited by 41

β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130

Geng, L., Liao, B., Jin, L., Yu, J., Zhao, X., Zhao, Y., Zhong, L., Wang, B., Li, J., Liu, J., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00572-2 · Cited by 41

New insights into the role of Klotho in inflammation and fibrosis: molecular and cellular mechanisms

Zhao, X., Han, D., Zhao, C., Yang, F., Wang, Z., Gao, Y., Jin, M., & Tao, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1454142 · Cited by 48

A Contemporary Atlas of the Mouse Diaphragm

Stuelsatz, P., Keire, P. A., Almuly, R., & Yablonka‐Reuveni, Z. (2012) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155412452417 · Cited by 40

Escalated Oxycodone Self-Administration Causes Differential Striatal mRNA Expression of FGFs and IEGs Following Abstinence-Associated Incubation of Oxycodone Craving

Blackwood, C. A., Leary, M., Salisbury, A. J., McCoy, M. T., & Cadet, J. L. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.030 · Cited by 40

Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease

Su, X., Kong, Y., & Peng, D. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.08.005 · Cited by 40

The regulation of healthspan and lifespan by dietary amino acids

Babygirija, R., & Lamming, D. W. (2021) · Translational Medicine of Aging · doi:10.1016/j.tma.2021.05.001 · Cited by 43

Aerobic exercise regulates FGF21 and NLRP3 inflammasome-mediated pyroptosis and inhibits atherosclerosis in mice

Li, X.-H., Liu, L., Chen, L., Pan, Q., Ouyang, Z., Fan, D., Pan, X., Lu, S.-Y., Luo, Q.-H., Tao, P., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273527 · Cited by 40

Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice

Bartesaghi, S., Wallenius, K., Hovdal, D., Liljeblad, M., Wallin, S., Dekker, N., Barlind, L., Davies, N. M., Seeliger, F., Winzell, M. S., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.04.010 · Cited by 40

Fibroblast Growth Factor 15/19 in Hepatocarcinogenesis

Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Urtasun, R., Bárcena‐Varela, M., Elizalde, M., Jiménez, M., Rodríguez‐Ortigosa, C. M., Corrales, F. J., Fernández‐Barrena, M. G., et al. (2017) · Digestive Diseases · doi:10.1159/000450905 · Cited by 39

FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation

Huang, J.-Y., Miskus, M. L., & Lu, H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1174-17.2017 · Cited by 38

Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta1–42-Induced Toxicity in SH-SY5Y Cells

Amiri, M., Braidy, N., & Aminzadeh, M. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9914-2 · Cited by 38

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions

Min, X., Weiszmann, J., Johnstone, S., Wang, W., Yu, X., Romanow, W. G., Thibault, S. A., Li, Y., & Wang, Z. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004343 · Cited by 37

Fibroblast Growth Factor 23 Expression Is Increased in Multiple Organs in Mice With Folic Acid-Induced Acute Kidney Injury

Egli-Spichtig, D., Zhang, M. Y. H., & Perwad, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01494 · Cited by 39

Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies

Hua, S., Liu, Q., Li, J., Fan, M., Yan, K., & Ye, D. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09661-1 · Cited by 39

Liver Brain Interactions: Focus on FGF21 a Systematic Review

Prida, E., Álvarez-Delgado, S., Pérez-Lois, R., Soto-Tielas, M., Estany‐Gestal, A., Fernø, J., Seoane, L. M., Quiñones, M., & Al–Massadi, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113318 · Cited by 40

Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes

Lee, D. V., Li, D., Yan, Q., Zhu, Y., Goodwin, B. J., Calle, R. A., Brenner, M. B., & Talukdar, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111767 · Cited by 38

FGF21 (Fibroblast Growth Factor 21) Defines a Potential Cardiohepatic Signaling Circuit in End-Stage Heart Failure

Sommakia, S., Almaw, N. H., Lee, S. H., Ramadurai, D. K. A., Taleb, I., Kyriakopoulos, C. P., Stubben, C., Jing, L., Campbell, R. A., Alharethi, R. A., et al. (2021) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.008910 · Cited by 38

Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles

Kanodia, J., Chai, D. H., Vollmer, J., Kim, J., Raue, A., Finn, G., & Schoeberl, B. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-34 · Cited by 39

Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

Luo, Y., Yang, C., Ye, M., Jin, C., Abbruzzese, J. L., Lee, M., Yeung, S. J., & McKeehan, W. L. (2013) · Cancer & Metabolism · doi:10.1186/2049-3002-1-21 · Cited by 36

Novel Mediators of Adipose Tissue and Muscle Crosstalk

Indrakusuma, I., Sell, H., & Eckel, J. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0174-7 · Cited by 38

Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases

Agha, E. E., Seeger, W., & Bellusci, S. (2016) · Developmental Dynamics · doi:10.1002/dvdy.24468 · Cited by 39

The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes

Izaguirre, M., Gil, M. J., Monreal, I., Montecucco, F., Frühbeck, G., & Catalán, V. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0866-3 · Cited by 41

Study of the association of DHEAS, testosterone and cortisol with S-Klotho plasma levels in healthy sedentary middle-aged adults

Dote‐Montero, M., Amaro‐Gahete, F. J., De‐la‐O, A., Jurado‐Fasoli, L., Gutiérrez, Á., & Castillo, M. J. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.03.010 · Cited by 37

FXR agonist GW4064 improves liver and intestinal pathology and alters bile acid metabolism in rats undergoing small intestinal resection

Cao, Y. L., Xiao, Y., Zhou, K., Yan, J., Wang, P., Yan, W., & Cai, W. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00356.2017 · Cited by 38

Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?

Ritchie, M. M., Hanouneh, I. A., Noureddin, M., Rolph, T., & Alkhouri, N. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1718104 · Cited by 37

Antibody-Mediated Inhibition of the FGFR1c Isoform Induces a Catabolic Lean State in Siberian Hamsters

Samms, R. J., Lewis, J. E., Lory, A., Fowler, M. J., Cooper, S., Warner, A., Emmerson, P. J., Adams, A. C., Luckett, J., Perkins, A. C., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.10.010 · Cited by 37

Insights From Genetic Disorders of Phosphate Homeostasis

Christov, M., & Jüppner, H. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.12.015 · Cited by 37

Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target

Liu, W., Xie, D.-M., Zhu, G., Huang, G., Lin, Y.-Q., Wang, L., Shi, K., Hu, B., Braddock, M., Chen, Y., et al. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.997711 · Cited by 38

Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis

Shenoy, V. K., Beaver, K. M., Fisher, F. M., Singhal, G., Dushay, J. R., Maratos–Flier, E., & Flier, S. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164351 · Cited by 36

Hair Follicle Development and Cashmere Traits in Albas Goat Kids

Diao, X., Yao, L., Wang, X., Li, S., Qin, J., Yang, L., He, L., & Zhang, W. (2023) · Animals · doi:10.3390/ani13040617 · Cited by 35

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling

Jager, J., Wang, F., Fang, B., Lim, H., Peed, L. C., Steger, D. J., Won, K., Kharitonenkov, A., Adams, A. C., & Lazar, M. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719120 · Cited by 35

Differential Expression of the Fibroblast Growth Factor Receptor (FGFR) Multigene Family in Normal Human Adult Tissues

Hughes, S. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704500710 · Cited by 283

Characterization of FGF21 Sites of Production and Signaling in Mice

Sullivan, A. I., Jensen-Cody, S. O., Claflin, K. E., Vorhies, K., Flippo, K. H., & Potthoff, M. J. (2024) · Endocrinology · doi:10.1210/endocr/bqae120 · Cited by 11

The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform

Hultman, K., Scarlett, J. M., Baquero, A. F., Cornea, A. M., Zhang, Y., Salinas, C. B. G., Brown, J. M., Morton, G. J., Whalen, E. J., Grove, K. L., et al. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24668 · Cited by 65

High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice

Lin, Q., Hui, X., Gu, C., Min, K., Xiong, L., Zhou, W., Xu, J. J., Watson, S. E., Wintergerst, K. A., Cai, L., et al. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf096 · Cited by 2

187 EXPRESSION AND REGULATION OF THE FIBROBLAST GROWTH FACTOR GENE FAMILY DURING MOUSE FOLLICULAR DEVELOPMENT

Furukawa, S., Naito, K., & Sugiura, K. (2012) · Reproduction Fertility and Development · doi:10.1071/rdv25n1ab187