Cited by 140Estrogen and related hormone effectsAdrenal Hormones and DisordersStress Responses and Cortisol

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Minireview: Glucocorticoids in Autoimmunity: Unexpected Targets and Mechanisms

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Flammer, Jamie R., Rogatsky, Inez·2011·Molecular Endocrinology

DOI 10.1210/me.2011-0068PMC PMC5417249

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Abstract

For decades, natural and synthetic glucocorticoids (GC) have been among the most commonly prescribed classes of immunomodulatory drugs. Their unsurpassed immunosuppressive and antiinflammatory activity along with cost-effectiveness makes these compounds a treatment of choice for the majority of autoimmune and inflammatory diseases, despite serious side effects that frequently accompany GC therapy. The activated GC receptor (GR) that conveys the signaling information of these steroid ligands to the transcriptional machinery engages a number of pathways to ultimately suppress autoimmune responses. Of those, GR-mediated apoptosis of numerous cell types of hematopoietic origin and suppression of proinflammatory cytokine gene expression have been described as the primary mechanisms responsible for the antiinflammatory actions of GC. However, along with the ever-increasing appreciation of the complex functions of the immune system in health and disease, we are beginning to recognize new facets of GR actions in immune cells. Here, we give a brief overview of the extensive literature on the antiinflammatory activities of GC and discuss in greater detail the unexpected pathways, factors, and mechanisms that have recently begun to emerge as novel targets for GC-mediated immunosuppression.

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Baechler, E. C., Batliwalla, F., Karypis, G., Gaffney, P. M., Ortmann, W. A., Espe, K. J., Shark, K. B., Grande, W. J., Hughes, K. M. H., Kapur, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337679100 · Cited by 2,246
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,210
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Bennett, L. B., Palucka, K., Arce, E., Cantrell, V., Borvák, J., Banchereau, J., & Pascual, V. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021553 · Cited by 1,988
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,888
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Kotenko, S. V., Gallagher, G. E., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., Langer, J. A., Sheikh, F. G., Dickensheets, H. L., & Donnelly, R. P. (2002) · Nature Immunology · doi:10.1038/ni875 · Cited by 1,867
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,685
Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,676
Systemic Lupus Erythematosus
Rahman, A., & Isenberg, D. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmra071297 · Cited by 1,663
IL-28, IL-29 and their class II cytokine receptor IL-28R
Sheppard, P. O., Kindsvogel, W., Xu, W., Henderson, K., Schlutsmeyer, S., Whitmore, T. E., Kuestner, R. E., Garrigues, U., Birks, C., Roraback, J., et al. (2002) · Nature Immunology · doi:10.1038/ni873 · Cited by 1,563
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553
Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
Jonat, C., Rahmsdorf, H. J., Park, K.-K., Cato, A. C. B., Gebel, S., Ponta, H., & Herrlich, P. (1990) · Cell · doi:10.1016/0092-8674(90)90395-u · Cited by 1,544
Regulation of JAK–STAT signalling in the immune system
Shuai, K., & Liu, B. (2003) · Nature reviews. Immunology · doi:10.1038/nri1226 · Cited by 1,410
A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage
Steinman, L. (2007) · Nature Medicine · doi:10.1038/nm1551 · Cited by 1,391
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Manel, N., Unutmaz, D., & Littman, D. R. (2008) · Nature Immunology · doi:10.1038/ni.1610 · Cited by 1,328
Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis
Tzartos, J. S., Friese, M. A., Craner, M. J., Palace, J. A., Newcombe, J., Esiri, M. M., & Fugger, L. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070690 · Cited by 1,225
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.
Ray, A., & Prefontaine, K. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.752 · Cited by 1,064
Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7
Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049
Systemic Lupus Erythematosus
Rahman, M. U. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-4007-1.50153-x · Cited by 1,018
Immune Interferon in the Circulation of Patients with Autoimmune Disease
Hooks, J. J., Moutsopoulos, H. Μ., Geis, S. A., Stahl, N. I., Decker, J. L., & Notkins, A. L. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907053010102 · Cited by 921
Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys
Crispín, J. C., Oukka, M., Bayliss, G. P., Cohen, R. A., van Beek, C., Stillman, I. E., Kyttaris, V. C., Juang, Y., & Tsokos, G. C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8761 · Cited by 800
Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
Matusevičius, D., Kivisäkk, P., He, B., Kostulas, N., Özenci, V., Fredrikson, S., & Link, H. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500206 · Cited by 751
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C., & Caspi, R. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071258 · Cited by 732
Ambulatory Medical Care Utilization Estimates for 2006
Schappert, S. M., & Rechtsteiner, E. A. (2008) · PsycEXTRA Dataset · doi:10.1037/e587152010-001 · Cited by 699
Functional interactions between Stat5 and the glucocorticoid receptor
Stöcklin, E., Wissler, M., Gouilleux, F., & Groner, B. (1996) · Nature · doi:10.1038/383726a0 · Cited by 675
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
Graham, R., Kozyrev, S. V., Baechler, E. C., Reddy, M., Plenge, R. M., Bauer, J. W., Ortmann, W. A., Koeuth, T., Escribano, M. F. G., Groups, T. A. A. S. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1782 · Cited by 672
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647
Glucocorticoids and the Th1/Th2 Balance
Elenkov, I. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.010 · Cited by 618
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Sigurðsson, S., Nordmark, G., Göring, H. H. H., Lindroos, K. M., Wiman, A.-C., Sturfelt, G. K., Jönsen, A., Rantapää‐Dahlqvist, S., Möller, B., Kere, J., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/428480 · Cited by 608
The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection
Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., & Akira, S. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040520 · Cited by 576
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
Chen, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25308 · Cited by 560
The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
Nissen, R. M., & Yamamoto, K. R. (2000) · Genes & Development · doi:10.1101/gad.827900 · Cited by 559
Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity
Wong, C. K., Lit, L. C. W., Tam, L., Li, E. K. M., Wong, P. T. Y., & Lam, C. W. K. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.01.019 · Cited by 535
An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.
James, J. A., Kaufman, K. M., Farris, A. D., Taylor‐Albert, E., Lehman, T. J. A., & Harley, J. B. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119856 · Cited by 521
Review of the in Vivo Functions of the p160 Steroid Receptor Coactivator Family
Xu, J., & Li, Q. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0116 · Cited by 493
Allosteric effects of DNA on transcriptional regulators
Lefstin, J. A., & Yamamoto, K. R. (1998) · Nature · doi:10.1038/31860 · Cited by 489
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP‐1
Kassel, O., Sancono, A., Krätzschmar, J., Kreft, B., Stassen, M., & Cato, A. C. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7108 · Cited by 487
Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro
Ramírez, F., Fowell, D. J., Puklavec, M. J., Simmonds, S. J., & Mason, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2406 · Cited by 483
Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
Bengtsson, A. A., Sturfelt, G. K., Truedsson, L., Blomberg, J., Alm, G. V., Vallin, H., & Rönnblom, L. (2000) · Lupus · doi:10.1191/096120300674499064 · Cited by 465
Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon
Preble, O. T., Black, R. J., Friedman, R. M., Klippel, J. H., & Vilček, J. (1982) · Science · doi:10.1126/science.6176024 · Cited by 458
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
Picard, F., Géhin, M., Annicotte, J., Rocchi, S., Champy, M., O’Malley, B. W., Chambon, P., & Auwerx, J. H. (2002) · Cell · doi:10.1016/s0092-8674(02)01169-8 · Cited by 444
Th1 and Th17 cells
Damsker, J. M., Hansen, A. M., & Caspi, R. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05133.x · Cited by 438
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1
Abraham, S. M., Lawrence, T., Kleiman, A., Warden, P., Medghalchi, M., Tuckermann, J., Saklatvala, J., & Clark, A. R. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060336 · Cited by 430
Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38
Lasa, M., Abraham, S., Boucheron, C., Saklatvala, J., & Clark, A. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.7802-7811.2002 · Cited by 386
Induction of arthritis with monoclonal antibodies to collagen
Terato, K., Hasty, K. A., Reife, R. A., Cremer, M. A., Kang, A. H., & Stuart, J. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2103 · Cited by 383
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
Guiducci, C., Gong, M., Xu, Z., Gill, M. A., Chaussabel, D., Meeker, T., Chan, J. H., Wright, T. B., Punaro, M., Bolland, S. M., et al. (2010) · Nature · doi:10.1038/nature09102 · Cited by 382
Serum interferon levels in patients with systemic lupus erythematosus
Ytterberg, S. R., & Schnitzer, T. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780250407 · Cited by 382
Possible induction of systemic lupus erythematosus by interferon‐α treatment in a patient with a malignant carcinoid tumour
Rönnblom, L., Alm, G. V., & Öberg, K. E. (1990) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1990.tb00144.x · Cited by 362
Glucocorticoid-mediated repression of nuclear factor-κBdependent transcription involves direct interference with transactivation
Bosscher, K. D., Schmitz, M. L., Berghe, W. V., Plaisance, S., Fiers, W. C., & Haegeman, G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13504 · Cited by 360
Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes
Blotta, M. H. S. L., DeKruyff, R. H., & Umetsu, D. T. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.12.5589 · Cited by 346
Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell
Bosscher, K. D., Berghe, W. V., Vermeulen, L., Plaisance, S., Boone, E., & Haegeman, G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.3919 · Cited by 335
Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor κB
Ayroldi, E., Migliorati, G., Bruscoli, S., Marchetti, C., Zollo, O., Cannarile, L., D'Adamio, F., & Riccardi, C. (2001) · Blood · doi:10.1182/blood.v98.3.743 · Cited by 327
Inhibition of AP-1 by the Glucocorticoid-inducible Protein GILZ
Mittelstadt, P. R., & Ashwell, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101522200 · Cited by 301
The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs
Rogge, L., D’Ambrosio, D., Biffi, M., Penna, G., Minetti, L. J., Presky, D. H., Adorini, L., & Sinigaglia, F. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6567 · Cited by 297
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement
Pratt, W. B., Galigniana, M. D., Harrell, J. M., & DeFranco, D. B. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.02.004 · Cited by 285
Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids
De Bosscher, K., & Haegeman, G. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0283 · Cited by 284
Interference between pathway‐specific transcription factors: glucocorticoids antagonize phorbol ester‐induced AP‐1 activity without altering AP‐1 site occupation in vivo.
König, H., Ponta, H., Rahmsdorf, H. J., & Herrlich, P. A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05283.x · Cited by 271
The Function of TIF2/GRIP1 in Mouse Reproduction Is Distinct from Those of SRC-1 and p/CIP
Géhin, M., Mark, M. P., Dennefeld, C., Dierich, A., Gronemeyer, H., & Chambon, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5923-5937.2002 · Cited by 267
Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.
Takahashi, S., Fossati, L., Iwamoto, M., Merino, R., Motta, R., Kobayakawa, T., & Izui, S. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118584 · Cited by 258
Corticosteroids Enhance the Capacity of Macrophages to Induce Th2 Cytokine Synthesis in CD4+ Lymphocytes by Inhibiting IL-12 Production
DeKruyff, R. H., Fang, Y., & Umetsu, D. T. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.5.2231 · Cited by 241
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
Biswas, P. S., Gupta, S. K., Chang, E., Li, S., Stirzaker, R. A., Liao, J. K., Bhagat, G., & Pernis, A. B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42856 · Cited by 234
Glucocorticoids inhibit the production of IL 6 from monocytes, endothelial cells and fibroblasts
Waage, A., Slupphaug, G., & Shalaby, R. (1990) · European Journal of Immunology · doi:10.1002/eji.1830201112 · Cited by 231
Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts
Rogatsky, I., Luecke, H. F., Leitman, D. C., & Yamamoto, K. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262671599 · Cited by 226
Adrenocortical Hormone in Arthritis
Hench, P. S., Kendall, E. C., Slocumb, C. H., & Polley, H. F. (1949) · Annals of the Rheumatic Diseases · doi:10.1136/ard.8.2.97 · Cited by 222
The glucocorticoid receptor blocks P-TEFb recruitment by NFκB to effect promoter-specific transcriptional repressionPreprint
Luecke, H. F., & Yamamoto, K. R. (2005) · Genes & Development · doi:10.1101/gad.1297105 · Cited by 217
A Comprehensive View of Regulation of Gene Expression by Double-stranded RNA-mediated Cell Signaling
Geiss, G. K., Jin, G., Guo, J., Bumgarner, R. E., Katze, M. G., & Sen, G. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100137200 · Cited by 211
Prostaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness
Wu, C. Y., Wang, K., McDyer, J. F., & Seder, R. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.2723 · Cited by 207
Interferon-γ impacts at multiple points during the progression of autoimmune diabetes
Wang, B., André‐Schmutz, I., Gonzalez, A., Katz, J. D., Aguet, M., Benoist, C. O., & Mathis, D. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13844 · Cited by 204
Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis
Brostjan, C., Anrather, J., Csizmadia, V., Stroka, D., Soares, M. P., Bach, F. H., & Winkler, H. J. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19612 · Cited by 197
IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor
Chen, Q., Yang, W., Gupta, S. K., Biswas, P. S., Smith, P., Bhagat, G., & Pernis, A. B. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.011 · Cited by 196
IL-23/IL-17 immunity as a hallmark of Crohnʼs disease
Hölttä, V., Klemetti, P., Sipponen, T. M., Westerholm‐Ormio, M., Kociubinski, G., Salo, H. M., Räsänen, L., Kolho, K., Färkkilä, M. A., Savilahti, E., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20475 · Cited by 196
IFN-λ: Novel Antiviral Cytokines
Ank, N., West, H., & Paludan, S. R. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.373 · Cited by 193
Microarray analysis of gene expression in lupus.
Crow, M. K., & Wohlgemuth, J. G. (2003) · Arthritis Research · doi:10.1186/ar1015 · Cited by 184
Current evidence for the management of rheumatoid arthritis with glucocorticoids: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis
GORTER, S. L., Bijlsma, J. W. J., Cutolo, M., Gómez-Reino, J. J., Kouloumas, M., Smolen, J. S., & Landewé, R. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.127332 · Cited by 181
Glucocorticoids Inhibit Bioactive IL-12p70 Production by In Vitro-Generated Human Dendritic Cells Without Affecting Their T Cell Stimulatory Potential
Vieira, P. L., Kaliński, P., Wierenga, E. A., Kapsenberg, M. L., & de Jong, E. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5245 · Cited by 175
Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase‐3 response element that mediates regulation by phorbol esters and hormones
Rogatsky, I., Zarember, K. A., & Yamamoto, K. R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6071 · Cited by 170
Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids
Bianchi, M., Meng, C. F., & Ivashkiv, L. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160099797 · Cited by 164
Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease
Chopra, A. R., Louet, J., Saha, P., An, J., DeMayo, F. J., Xu, J., York, B., Karpen, S. J., Finegold, M. J., Moore, D. D., et al. (2008) · Science · doi:10.1126/science.1164847 · Cited by 161
Characterization of Stat5a and Stat5b Homodimers and Heterodimers and Their Association with the Glucocortiocoid Receptor in Mammary Cells
Cella, N., Groner, B., & Hynes, N. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.1783 · Cited by 159
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
Reily, M. M., Pantoja, C., Hu, X., Chinenov, Y., & Rogatsky, I. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600919 · Cited by 149
Restraint stress-induced thymic involution and cell apoptosis are dependent on endogenous glucocorticoids
Tarcic, N., Ovadia, H., Weiss, D. W., & Weidenfeld, J. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00186-0 · Cited by 142
Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene
Thanos, D., & Maniatis, T. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.152 · Cited by 140
IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2
Kishore, N. N., Huynh, Q. K., Mathialagan, S., Hall, T., Rouw, S., Creely, D., Lange, G., Caroll, J., Reitz, B. A., Donnelly, A. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110474200 · Cited by 138
Blood‐induced joint damage: A canine in vivo study
Roosendaal, G., TeKoppele, J. M., Vianen, M. E., van den Berg, H. M., Lafeber, F. P. J. G., & Bijlsma, J. W. J. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5 · Cited by 137
The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition
Flammer, J. R., Dobrovolná, J., Kennedy, M. A., Chinenov, Y. V., Glass, C. K., Ivashkiv, L. B., & Rogatsky, I. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00146-10 · Cited by 135
Similar effects of disease‐modifying antirheumatic drugs, glucocorticoids, and biologic agents on radiographic progression in rheumatoid arthritis: Meta‐analysis of 70 randomized placebo‐controlled or drug‐controlled studies, including 112 comparisons
Graudal, N. A., & Jűrgens, G. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27592 · Cited by 135
Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-α-stimulated Transcription Factor ISGF3
Martinez-Moczygemba, M., Gutch, M. J., French, D. L., & Reich, N. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20070 · Cited by 135
RAISED ANTIBODY TITRES TO E.B. VIRUS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Evans, A., Rothfield, N., & Niederman, J. (1971) · The Lancet · doi:10.1016/s0140-6736(71)91937-4 · Cited by 133
Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity
Levy, D. E., Marié, I., & Prakash, A. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00011-0 · Cited by 130
The roles of protein–protein interactions and protein methylation in transcriptional activation by nuclear receptors and their coactivators
Stallcup, M. R., Kim, J. H., Teyssier, C., Lee, Y., Ma, H., & Chen, D. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00222-x · Cited by 121
Promoter-dependent Synergy between Glucocorticoid Receptor and Stat5 in the Activation of β-Casein Gene Transcription
Lechner, J., Welte, T., Tomasi, J. K., Bruno, P., Cairns, C. A., Gustafsson, J.-Α., & Doppler, W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20954 · Cited by 118
STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the α2-macroglobulin genePreprint
Lerner, L. R., Henriksen, M. A., Zhang, X., & Darnell, J. E., Jr. (2003) · Genes & Development · doi:10.1101/gad.1135003 · Cited by 116
Steroid Receptor Coactivator 2 Is Critical for Progesterone-Dependent Uterine Function and Mammary Morphogenesis in the Mouse
Mukherjee, A., Soyal, S. M., Fernandez‐Valdivia, R., Géhin, M., Chambon, P., DeMayo, F. J., Lydon, J. P., & O’Malley, B. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00654-06 · Cited by 115
Glucocorticoid Repression of AP-1 Is Not Mediated by Competition for Nuclear Coactivators
Bosscher, K. D., Berghe, W. V., & Haegeman, G. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.2.0591 · Cited by 94
Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients
Luther, C., Adamopoulou, E., Stoeckle, C., Brucklacher-Waldert, V., Rosenkranz, D., Stoltze, L., Lauer, S., Poeschel, S., Melms, A., & Tolosa, E. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802046 · Cited by 93
Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor
Pérez, P., Page, A., Bravo, A., Río, M. D., Gimenez-Conti, I. B., Budunova, I. V., Slaga, T. J., & Jorcano, J. L. (2001) · The FASEB Journal · doi:10.1096/fj.00-0772fje · Cited by 90
Impaired adrenal stress response in Toll-like receptor 2-deficient mice
Bornstein, S. R., Zacharowski, P., Schumann, R. R., Barthel, A., Tran, N., Papewalis, C., Rettori, V., McCann, S. M., Schulze-Osthoff, K., Scherbaum, W. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407550101 · Cited by 90
IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice
Edgerton, C. C., Crispín, J. C., Moratz, C. M., Bettelli, E., Oukka, M., Simovic, M. O., Zacharia, A., Egan, R., Chen, J., Lucca, J. J. D., et al. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.09.019 · Cited by 89
A gene signature of inhibitory MHC receptors identifies a BDCA3 + subset of IL‐10‐induced dendritic cells with reduced allostimulatory capacity in vitro
Velten, F., Duperrier, K., Bohlender, J., Metharom, P., & Goerdt, S. (2004) · European Journal of Immunology · doi:10.1002/eji.200324732 · Cited by 86
Loss of IRF-4–binding protein leads to the spontaneous development of systemic autoimmunity
Fanzo, J., Yang, W., Jang, S. Y., Gupta, S. K., Chen, Q., Siddiq, A., Greenberg, T., & Pernis, A. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24096 · Cited by 86
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?
Biswas, P. S., Bhagat, G., & Pernis, A. B. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00864.x · Cited by 84
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation
McCoy, C. E., Carpenter, S., Pålsson-McDermott, E. M., Gearing, L. J., & O'Neill, L. A. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709731200 · Cited by 82 · cited 1×
“Indeed, GC were shown to inhibit the activity of TANK-binding kinase (TBK)1 that activates IRF3 and IRF7, key components of the IFN enhanceosome (101, 105).”
Background
Antinuclear antibodies: Diagnostic significance and methods
Friou, G. J. (1967) · Arthritis & Rheumatism · doi:10.1002/art.1780100210 · Cited by 81
Building Transcriptional Regulatory Complexes: Signals and SurfacesPreprint
Yamamoto, K. R., Darimont, B. D., WAGNER, R. L., & Iñiguez-Lluhı́, J. A. (1998) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1998.63.587 · Cited by 73
The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism
Jeong, J., Kwak, I., Lee, K. Y., White, L. D., Wang, X., Brunicardi, F. C., O’Malley, B. W., & DeMayo, F. J. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0407 · Cited by 69
Induction of autoantibodies to the adrenal cortex and pancreatic islet cells by interferon alpha therapy for chronic hepatitis C
Wesche, B., Jaeckel, E., Trautwein, C., Wedemeyer, H., Falorni, A., Frank, H., Mühlen, A. V. Z., Manns, M.-P., & Brabant, G. E. (2001) · Gut · doi:10.1136/gut.48.3.378 · Cited by 69
Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid predendritic cells (pDCs)
Lepelletier, Y., Zollinger, R., Ghirelli, C., Raynaud, F., Hadj-Slimane, R., Cappuccio, A., Hermine, O., Liu, Y.-J., & Soumelis, V. (2010) · Blood · doi:10.1182/blood-2010-05-282913 · Cited by 63
Glucocorticoid Receptor Interacting Protein-1 Restores Glucocorticoid Responsiveness in Steroid-Resistant Airway Structural Cells
Bhandare, R., Damera, G., Banerjee, A., Flammer, J. R., Keslacy, S., Rogatsky, I., Panettieri, R. A., Amrani, Y., & Tliba, O. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0239rc · Cited by 61
Glucocorticoid Inhibition of Interleukin-1-Induced Interleukin-6 Production by Human Lung Fibroblasts: Evidence for Transcriptional and Post-Transcriptional Regulatory Mechanisms
Zitnik, R. J., Whiting, N. L., & Elias, J. A. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.10.6.7516173 · Cited by 59
Discovery of the LE cell and its morphology.
Hargraves, M. M. (1969) · PubMed · Cited by 57
A Microbial Polysaccharide Reduces the Severity of Rheumatoid Arthritis by Influencing Th17 Differentiation and Proinflammatory Cytokines Production
Monari, C., Bevilacqua, S., Piccioni, M., Pericolini, E., Perito, S., Calvitti, M., Bistoni, F., Kozel, T. R., & Vecchiarelli, A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804144 · Cited by 56
MX HOMOLOGOUS PROTEIN IN MONONUCLEAR CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
von Wussow, P., Jakschies, D., Hochkeppel, H. K., Horisberger, M. A., Hartung, K., & Deicher, H. (1989) · Arthritis & Rheumatology · doi:10.1002/j.2326-5205.1989.tb00024.x · Cited by 56
Immunosuppressive agents mediate reduced allostimulatory properties of myeloid-derived dendritic cells despite induction of divergent molecular phenotypes
Duperrier, K., Velten, F., Bohlender, J., Demory, A., Metharom, P., & Goerdt, S. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.01.006 · Cited by 36
The Nuclear Receptor Signaling Atlas: Development of a Functional Atlas of Nuclear Receptors
Margolis, R., Evans, R. M., & O’Malley, B. W. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0461 · Cited by 35
Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent
Fahey, A. J., Robins, R. A., Kindle, K. B., Heery, D. M., & Constantinescu, C. S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605296 · Cited by 33
Synergistic and combinatorial control of T cell activation and differentiation by transcription factors
Sundrud, M. S., & Nolan, M. A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.03.006 · Cited by 30
Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF‐2 deficient mice
Patchev, A. V., Fischer, D., Wolf, S. S., Herkenham, M. A., Götz, F., Géhin, M., Chambon, P., Patchev, V. K., & Almeida, O. F. X. (2006) · The FASEB Journal · doi:10.1096/fj.06-6952com · Cited by 28
Methylprednisolone inhibits interleukin-17 and interferon-gamma expression by both naive and primed T cells
Momčilović, M. B., Miljković, Ž., Popadic, D. M., Marković, M., Savić, E., Ramić, Z., Miljković, D. M., & Mostarica‐Stojković, M. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-47 · Cited by 27
Inhibitory effect of rapamycin and dexamethasone on production of IL-17 and IFN-γ in Vogt–Koyanagi–Harada patients
Yang, K., Wen, J., Liu, X., Kijlstra, A., Chen, L., Chi, W., Zhou, H., Huang, X., & Yang, P. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2008.142489 · Cited by 22
Clinical effects of cortisone administered orally to 100 patients with rheumatoid arthritis.
Ward, E. L., Slocumb, C. H., Polley, H. F., KENDALL, E. C., & Hench, P. S. (1951) · PubMed · Cited by 19
The danger model in deciphering autoimmunity
Tveita, A. A. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq004 · Cited by 16
Organ-specific hematopoietic changes induced by a recombinant human interferon-? in mice
ROSENTHAL, G. (1990) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(90)90292-r · Cited by 13
Thyroid autoantibodies and thyroid dysfunction during treatment with interferon-α for chronic hepatitis C
Kiehne, K., Kloehn, S., Hinrichsen, H. M., Gallwitz, B., & Mönig, H. (1997) · Endocrine · doi:10.1007/bf02820497 · Cited by 12
Recent Advances in Glucocorticoid Receptor Action
(2002) · Springer eBooks · doi:10.1007/978-3-662-04660-9 · Cited by 6

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Authors: Flammer, J. R., & Rogatsky, I.
Affiliations: Hospital for Special Surgery (US)
ORCID: Rogatsky, Inez
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2011-07-01
Volume: 25
Issue: 7
Pages: 1075-1086
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2011-0068
PMC: PMC5417249
OpenAlex: W2021846928
Cited by: 140
References: 131
Citations by year: 2026: 5 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 22 · 2013: 10 · 2012: 15
FWCI: 1.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: glucocorticoids, glucocorticoid receptor, autoimmunity, immunosuppression, anti-inflammatory mechanism, apoptosis, inflammatory cytokines, hematopoietic cells, novel therapeutic targets, glucocorticoid adverse effects
MeSH terms: Animals, Glucocorticoids, T-Lymphocytes, Helper-Inducer, Humans, Interferon Type I, Lymphocyte Activation, Receptors, Glucocorticoid, Signal Transduction, Autoimmunity, STAT Transcription Factors

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Minireview: Glucocorticoids in Autoimmunity: Unexpected Targets and Mechanisms

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