Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., & Saltiel, A. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7686 · Cited by 2,679

Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*

Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y., & Yamamura, K. (1990) · Endocrinology · doi:10.1210/endo-127-1-126 · Cited by 1,267

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185

Expression of ghrelin receptor mRNA in the rat and the mouse brain

Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

Dixit, V. D., Schaffer, E. M., Pyle, R. S., Collins, G. D., Sakthivel, S. K., Palaniappan, R., Lillard, J. W., & Taub, D. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21134 · Cited by 882

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

Baldanzi, G., Filigheddu, N., Cutrupi, S., Catapano, F., Bonissoni, S., Fubini, A., Malan, D., Baj, G., Granata, R., Broglio, F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200207165 · Cited by 724

Ghrelin, a Natural GH Secretagogue Produced by the Stomach, Induces Hyperglycemia and Reduces Insulin Secretion in Humans

Broglio, F., Arvat, E., Benso, A. S., Gottero, C., Muccioli, G., Papotti, M. G., van der Lely, A. J., Deghenghi, R., & Ghigo, E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.8098 · Cited by 720

Mice lacking ghrelin receptors resist the development of diet-induced obesity

Zigman, J. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26002 · Cited by 663

Ghrelin

Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034

Ghrelin, CCK, GLP-1, and PYY(3–36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB

Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

DiGruccio, M. R., Mawla, A. M., Donaldson, C. J., Noguchi, G. M., Vaughan, J., Cowing-Zitron, C., van der Meulen, T., & Huising, M. O. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.007 · Cited by 353

Ghrelin

Pradhan, G., Samson, S. L., & Sun, Y. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328365b9be · Cited by 311

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

Wang, Q., Liu, C., Uchida, A., Chuang, J.-C., Walker, A. K., Liu, T., Osborne-Lawrence, S. L., Mason, B. L., Mosher, C. A., Berglund, E. D., et al. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.001 · Cited by 253

Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes

Rafacho, A., Ortsäter, H., Nadal, A., & Quesada, I. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0373 · Cited by 216

Ghrelin regulation of glucose metabolism

Poher, A.-L., Tschöp, M. H., & Müller, T. D. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.015 · Cited by 186

Inter‐organ communication: a gatekeeper for metabolic health

Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178

Neuroanatomical characterization of a growth hormone secretagogue receptor‐green fluorescent protein reporter mouse

Mani, B. K., Walker, A. K., Soto, E. J. L., Raingo, J., Lee, C. E., Perelló, M., Andrews, Z. B., & Zigman, J. M. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23627 · Cited by 178

The CD36-PPARγ Pathway in Metabolic Disorders

Maréchal, L., Laviolette, M., Rodrigue‐Way, A., Sow, B., Brochu, M., Caron, V., & Tremblay, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051529 · Cited by 173

Mechanisms of the amplifying pathway of insulin secretion in the β cell

Kalwat, M. A., & Cobb, M. H. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.003 · Cited by 151

Ghrelin as a Survival Hormone

Mani, B. K., & Zigman, J. M. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.10.001 · Cited by 140

Physiological Effect of Ghrelin on Body Systems

Akalu, Y., Molla, M. D., Dessie, G., & Ayelign, B. (2020) · International Journal of Endocrinology · doi:10.1155/2020/1385138 · Cited by 129

Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents

Islam, M. N., Mita, Y., Maruyama, K., Tanida, R., Zhang, W., Sakoda, H., & Nakazato, M. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0102 · Cited by 109

Hormone changes and diabetes resolution after biliopancreatic diversion and laparoscopic sleeve gastrectomy: a comparative prospective study

Tsoli, M., Chronaiou, A., Kehagias, I., Kalfarentzos, F. E., & Alexandrides, T. K. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.12.006 · Cited by 101

Effects of ghrelin in energy balance and body weight homeostasis

Mihalache, L., Gherasim, A., Niță, O., Ungureanu, M.-C., Pădureanu, S., Gavril, R. S., & Arhire, L. I. (2016) · HORMONES · doi:10.14310/horm.2002.1672 · Cited by 98

Ghrelin’s Relationship to Blood Glucose

Mani, B. K., Shankar, K., & Zigman, J. M. (2019) · Endocrinology · doi:10.1210/en.2019-00074 · Cited by 101

Estradiol modulates Kiss1 neuronal response to ghrelin

Frazão, R., Lemko, H. M. D., da Silva, R. P., Ratra, D. V., Lee, C. E., Williams, K. W., Zigman, J. M., & Elias, C. F. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00211.2013 · Cited by 96

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells

Sakata, I., Park, W.-M., Walker, A. K., Piper, P. K., Chuang, J.-C., Osborne-Lawrence, S. L., & Zigman, J. M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00041.2012 · Cited by 98

Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release

Park, S., Jiang, H. F., Zhang, H., & Smith, R. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209590109 · Cited by 91

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete, M. D., Pacheco, D. R. F., Villa-Osaba, A., Hormaechea‐Agulla, D., Ibáñez‐Costa, A., Martínez‐Fuentes, A. J., Gracia‐Navarro, F., Castano, J. P., & Luque, R. M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0391 · Cited by 90

Brain accessibility delineates the central effects of circulating ghrelin

Perelló, M., Cabral, A., Cornejo, M. P., Francesco, P. N. D., Fernández, G., & Uriarte, M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12677 · Cited by 83

LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue

Shankar, K., Metzger, N. P., Singh, O., Mani, B. K., Osborne-Lawrence, S. L., Varshney, S., Gupta, D., Ogden, S. B., Takemi, S., Richard, C. P., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101327 · Cited by 79

The Regulation of Peripheral Metabolism by Gut-Derived Hormones

Sun, E. W. L., Martin, A. M., Young, R. L., & Keating, D. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00754 · Cited by 71

Ghrelin Regulation of Glucose Metabolism

Gray, S., Page, L. C., & Tong, J. (2019) · Journal of neuroendocrinology · doi:10.1111/jne.12705 · Cited by 45

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons

Soto, E. J. L., Agosti, F., Cabral, A., Mustafá, E. R., Damonte, V. M., Gandini, M. A., Rodríguez, S., Castrogiovanni, D. C., Felix, R., Perelló, M., et al. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201511383 · Cited by 69

Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation

Hopkins, A. L., Nelson, T. A. S., Guschina, I. A., Parsons, L., Lewis, C. L., Brown, R. C. D., Christian, H., Davies, J. S., & Wells, T. (2017) · Scientific Reports · doi:10.1038/srep45541 · Cited by 70

MECHANISMS IN ENDOCRINOLOGY: Regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions

Heppner, K. M., & Tong, J. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0183 · Cited by 68

Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose

Scott, M. M., Perelló, M., Chuang, J.-C., Sakata, I., Gautron, L., Lee, C. E., Lauzon, D. A., Elmquist, J. K., & Zigman, J. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044089 · Cited by 61

The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

Kurashina, T., Dezaki, K., Yoshida, M., Rita, R. S., Ito, K., Taguchi, M., Miura, R., Tominaga, M., Ishibashi, S., Kakei, M., et al. (2015) · Scientific Reports · doi:10.1038/srep14041 · Cited by 60

Circulating Ghrelin Acts on GABA Neurons of the Area Postrema and Mediates Gastric Emptying in Male Mice

Cabral, A., Cornejo, M. P., Fernández, G., Francesco, P. N. D., Romero, G. G., Uriarte, M., Zigman, J. M., Portiansky, E. L., Reynaldo, M. B., & Perelló, M. (2017) · Endocrinology · doi:10.1210/en.2016-1815 · Cited by 55

Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass

Uchida, A., Zechner, J. F., Mani, B. K., Park, W.-M., Aguirre, V., & Zigman, J. M. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.07.009 · Cited by 52

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals

Mani, B. K., Osborne-Lawrence, S. L., Vijayaraghavan, P., Hepler, C., & Zigman, J. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86270 · Cited by 52

Physiologic Concentrations of Exogenously Infused Ghrelin Reduces Insulin Secretion Without Affecting Insulin Sensitivity in Healthy Humans

Tong, J., Prigeon, R. L., Davis, H. W., Bidlingmaier, M., Tschöp, M. H., & D’Alessio, D. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4162 · Cited by 53

Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors

Engelstoft, M. S., & Schwartz, T. W. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.07.001 · Cited by 53

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

Mani, B. K., Osborne-Lawrence, S. L., Méquinion, M., Lawrence, S., Gautron, L., Andrews, Z. B., & Zigman, J. M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.011 · Cited by 52

“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”

Gupta, D., Ogden, S. B., Shankar, K., Varshney, S., & Zigman, J. M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101128 · Cited by 55

Ghrelin mediates exercise endurance and the feeding response post-exercise

Mani, B. K., Castorena, C. M., Osborne-Lawrence, S. L., Vijayaraghavan, P., Metzger, N. P., Elmquist, J. K., & Zigman, J. M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.006 · Cited by 50

Peptides in the regulation of glucagon secretion

Andersen, D. B., & Holst, J. J. (2021) · Peptides · doi:10.1016/j.peptides.2021.170683 · Cited by 50

Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice

Ma, X., Lin, Y., Lin, L., Qin, G., Pereira, F. A., Haymond, M. W., Butte, N. F., & Sun, Y. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00576.2011 · Cited by 39

Glucagon Stimulates Ghrelin Secretion Through the Activation of MAPK and EPAC and Potentiates the Effect of Norepinephrine

Gagnon, J., & Anini, Y. (2013) · Endocrinology · doi:10.1210/en.2012-1994 · Cited by 40

Capromorelin: a ghrelin receptor agonist and novel therapy for stimulation of appetite in dogs

Rhodes, L., Zollers, B., Wofford, J. A., & Heinen, E. (2017) · Veterinary Medicine and Science · doi:10.1002/vms3.83 · Cited by 41

The Physiological Role of Ghrelin in the Regulation of Energy and Glucose Homeostasis

Sovetkina, A., Nadir, R., Fung, J. N. M., Nadjarpour, A., & Beddoe, B. (2020) · Cureus · doi:10.7759/cureus.7941 · Cited by 47

Ghrelin receptor signaling in health and disease: a biased view

Gross, J., Zhou, Y., Barak, L. S., & Caron, M. G. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.12.001 · Cited by 42

Exogenous and endogenous ghrelin counteracts GLP‐1 action to stimulate cAMP signaling and insulin secretion in islet β‐cells

Boldbaatar, D., Dezaki, K., Kurashina, T., Sone, H., Rita, R. S., Kakei, M., & Yada, T. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.06.034 · Cited by 38

β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress

Gupta, D., Chuang, J.-C., Mani, B. K., Shankar, K., Rodriguez, J. A., Osborne-Lawrence, S. L., Metzger, N. P., & Zigman, J. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0334-7 · Cited by 38

Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade

Mani, B. K., Uchida, A., Lee, Y., Osborne-Lawrence, S. L., Charron, M. J., Unger, R. H., Berglund, E. D., & Zigman, J. M. (2017) · Diabetes · doi:10.2337/db16-1303 · Cited by 34

Interleukin-6 amplifies glucagon secretion: coordinated control via the brain and pancreas

Barnes, T. M., Otero, Y. F., Elliott, A. D., Locke, A. D., Malabanan, C. M., Coldren, A., Briššová, M., Piston, D. W., & McGuinness, O. P. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00343.2014 · Cited by 33

Gene Signature of the Human Pancreatic ε Cell

Gutiérrez, G. D., Kim, J., Lee, A., Tong, J., Niu, J., Gray, S. M., Wei, Y., Ding, Y., Ni, M., Adler, C., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00833 · Cited by 30

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions

Gupta, D., Patterson, A. M., Osborne-Lawrence, S. L., Bookout, A. L., Varshney, S., Shankar, K., Singh, O., Metzger, N. P., Richard, C. P., Wyler, S. C., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101258 · Cited by 32

Acyl Ghrelin Acts in the Brain to Control Liver Function and Peripheral Glucose Homeostasis in Male Mice

Stark, R., Reichenbach, A., Lockie, S. H., Pracht, C., Wu, Q., Tups, A., & Andrews, Z. B. (2014) · Endocrinology · doi:10.1210/en.2014-1733 · Cited by 33

Role of ERβ and GPR30 in the endocrine pancreas: A matter of estrogen dose.

Ropero, A. B., Pang, Y., Alonso-Magdalena, P., Thomas, P., & Nadal, A. (2012) · Steroids · doi:10.1016/j.steroids.2012.01.015 · Cited by 30

A long-acting LEAP2 analog reduces hepatic steatosis and inflammation and causes marked weight loss in mice

Shankar, K., Metzger, N. P., Lawrence, C., Gupta, D., Osborne-Lawrence, S. L., Varshney, S., Singh, O., Richard, C. P., Zaykov, A. N., Rolfts, R., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101950 · Cited by 29

High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets

Gupta, D., Dowsett, G. K. C., Mani, B. K., Shankar, K., Osborne-Lawrence, S. L., Metzger, N. P., Lam, B., Yeo, G. S. H., & Zigman, J. M. (2021) · Endocrinology · doi:10.1210/endocr/bqab148 · Cited by 29

The atypical antipsychotic, olanzapine, potentiates ghrelin-induced receptor signaling: An in vitro study with cells expressing cloned human growth hormone secretagogue receptor

Tagami, K., Kashiwase, Y., Yokoyama, A., Nishimura, H., Miyano, K., Suzuki, M., Shiraishi, S., Matoba, M., Ohe, Y., & Uezono, Y. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.12.010 · Cited by 27

The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation

Moran, G. W., & Thapaliya, G. (2021) · Nutrients · doi:10.3390/nu13030981 · Cited by 32

The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery

Skuratovskaia, D., Vulf, M., Chasovskikh, N. Y., Komar, A., Кириенкова, Е. В., Shunkin, E. O., Затолокин, П. А., & Litvinova, L. S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.612501 · Cited by 26

An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice

Smith, J. T., Reichenbach, A., Lemus, M. B., Mani, B. K., Zigman, J. M., & Andrews, Z. B. (2013) · Peptides · doi:10.1016/j.peptides.2013.06.012 · Cited by 25

Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon

Sekar, R., Singh, K., Arokiaraj, A. W. R., & Chow, B. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.05.002 · Cited by 26

Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model

Rodriguez, J. A., Bruggeman, E. C., Mani, B. K., Osborne-Lawrence, S. L., Lord, C. C., Roseman, H. F., Viroslav, H., Vijayaraghavan, P., Metzger, N. P., Gupta, D., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00801 · Cited by 23

Different ghrelin localisation in adult human and rat endocrine pancreas

Raghay, K., Gallego, R., Scoazec, J., García‐Caballero, T., & Morel, G. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1593-y · Cited by 22

Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling

Zhang, C., Li, L., Zhao, B., Jiao, A., Li, X., Sun, N., & Zhang, J. (2016) · International Journal of Endocrinology · doi:10.1155/2016/4513051 · Cited by 22

Ghrelin’s orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

Barrile, F., Cassano, D., Fernández, G., Francesco, P. N. D., Reynaldo, M. B., Cantel, S., Fehrentz, J., Donato, J., Schiöth, H. B., Zigman, J. M., et al. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106333 · Cited by 21

Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake

Schalla, M. A., Taché, Y., & Stengel, A. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200007 · Cited by 28

β Cell GHS-R Regulates Insulin Secretion and Sensitivity

Pradhan, G., Wu, C., Villarreal, D., Lee, J. H., Han, H. W., Gaharwar, A. K., Tian, Y., Fu, W., Guo, S., Smith, R. G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083950 · Cited by 19

FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling

Cao, T., Yang, D., Zhang, X., Wang, Y., Qiao, Z., Gao, L., Liang, Y., Yu, B., & Zhang, P. (2017) · Cell Biology and Toxicology · doi:10.1007/s10565-017-9387-8 · Cited by 18

Neuroendocrine and metabolic activities of ghrelin gene products

Baragli, A., Lanfranco, F., Allasia, S., Granata, R., & Ghigo, E. (2011) · Peptides · doi:10.1016/j.peptides.2011.10.024 · Cited by 18

“Sibling” battle or harmony: Crosstalk between nesfatin-1 and ghrelin

Chen, X., Dong, J., Jiao, Q., Du, X., Bi, M., & Jiang, H. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04193-6 · Cited by 17

Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons

Gannaban, R. B., NamKoong, C., Ruiz, H. H., Choi, H. J., & Shin, A. C. (2020) · Diabetes · doi:10.2337/db20-0510 · Cited by 17

Stem cell therapy for insulin-dependent diabetes: Are we still on the road?

Yang, L., Hu, Z.-M., Jiang, F., & Wang, W. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i7.503 · Cited by 21

Ghrelin receptor in agouti‐related peptide neurones regulates metabolic adaptation to calorie restriction

Wu, C., Bongmba, O. Y. N., Lee, J. H., Tuchaai, E., Zhou, Y., Li, D., Xue, B., Chen, Z., & Sun, Y. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12763 · Cited by 17

Role of SST, CORT and ghrelin and its receptors at the endocrine pancreas

Chanclón, B., Martínez‐Fuentes, A. J., & Gracia‐Navarro, F. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00114 · Cited by 17

Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?

Mingardi, J., Meanti, R., Paoli, C., Cifani, C., Torsello, A., Popoli, M., & Musazzi, L. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22999240722095039 · Cited by 16

Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling

Ma, C., Fukuda, T., Ochi, H., Sunamura, S., Xu, C., Xu, R., Okawa, A., & Takeda, S. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.01.002 · Cited by 16

Circulating glucagon to ghrelin ratio as a determinant of insulin resistance in hyperthyroidism

Ağbaht, K., Erdoğan, M. F., Emral, R., Başkal, N., & Güllü, S. (2013) · Endocrine · doi:10.1007/s12020-013-9951-9 · Cited by 16

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Shankar, K., Gupta, D., Mani, B. K., Findley, B. G., Osborne-Lawrence, S. L., Metzger, N. P., Liu, C., Berglund, E. D., & Zigman, J. M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00606 · Cited by 16

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Prommer, E. (2017) · Palliative Care Research and Treatment · doi:10.1177/1178224217726336 · Cited by 15

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Gewehr, M. C. F., Silvério, R., Neto, J. C. R., Lira, F. S., Reckziegel, P., & Ferro, E. S. (2020) · Molecules · doi:10.3390/molecules25051093 · Cited by 15

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Chandra, R., & Liddle, R. A. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283567f16 · Cited by 13

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Long, A., Wang, Y., Guo, Y., Hong, J., Ning, G., Meng, Z., Wang, Y., & Wang, Y. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.008 · Cited by 11

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Huang, W. Q., Guo, J. H., Yuan, C., Cui, Y. G., Diao, F., Yu, M., Liu, J. Y., Ruan, Y. C., & Chan, H. C. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00835 · Cited by 11

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Hewawasam, N. V., Sakar, D., Bolton, O., Delishaj, B., Almutairi, M., King, A., Dereli, A. S., Despontin, C., Gilon, P., Reeves, S., et al. (2024) · Journal of Endocrinology · doi:10.1530/joe-24-0135 · Cited by 8

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Conde, K., Kulyk, D., Vanschaik, A., Daisey, S., Rojas, C. M., Wiersielis, K., Yasrebi, A., Degroat, T. J., Sun, Y., & Roepke, T. A. (2022) · Biomolecules · doi:10.3390/biom12101370 · Cited by 8

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Hassouna, R., Fernández, G., Lebrun, N., Fiquet, O., Roelfsema, F., Labarthe, A., Zizzari, P., Tomasetto, C., Epelbaum, J., Viltart, O., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.754522 · Cited by 8

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Morriseau, T. S., Doucette, C. A., & Dolinsky, V. W. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00411.2021 · Cited by 9

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Pradhan, G., Lee, J. H., Wu, C., Wang, H., Lin, L., Donti, T., Graham, B. H., Rajan, A. S., Balasubramanyam, A., Samson, S. L., et al. (2022) · Biomolecules · doi:10.3390/biom12030407 · Cited by 8

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Perret, J., Vriese, C. D., & Delporte, C. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000072 · Cited by 7

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Shabanov, P. D., Vinogradov, P. M., Aa, L., Roik, R. O., & Morozov, V. I. (2017) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf15438-45 · Cited by 7

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Sun, X., Yi, Y., Liang, B., Yu, Y., He, N., Ode, K. L., Uç, A., Wang, K., Gibson-Corley, K. N., Engelhardt, J. F., et al. (2019) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2019.01.010 · Cited by 7

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Saenz, C., Fernández, G., Llovera, R. E., Tolosa, M. J., Cantel, S., Fehrentz, J., Mackie, K., Leggio, L., Zigman, J. M., Francesco, P. N. D., et al. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02876-3 · Cited by 7

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Nakamura, T., Yoshikawa, T., Naganuma, F., Mohsen, A. S., Iida, T., Miura, Y., Sugawara, A., & Yanai, K. (2014) · FEBS Open Bio · doi:10.1016/j.fob.2014.12.001 · Cited by 6

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Date, Y., Nakazato, M., Hashiguchi, S., Dezaki, K., Mondal, M. S., Hosoda, H., Kojima, M., Kangawa, K., Arima, T., Matsuo, H., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.1.124 · Cited by 582

Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach

Katayama, T., Shimamoto, S., Oda, H., Nakahara, K., Kangawa, K., & Murakami, N. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.001 · Cited by 30

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Dezaki, K., Hosoda, H., Kakei, M., Hashiguchi, S., Watanabe, M., Kangawa, K., & Yada, T. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3142 · Cited by 372

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Callaghan, B. P., Hunne, B., Martins, V. M., Brock, J. A., & Furness, J. B. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1114.2

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Salehi, A. A., de la Cour, C. D., Håkanson, R., & Lundquist, I. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2003.12.001 · Cited by 140