The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Insulin and Leptin as Adiposity Signals
Open accessAbstract
There is now considerable consensus that the adipocyte hormone leptin and the pancreatic hormone insulin are important regulators of food intake and energy balance. Leptin and insulin fulfill many of the requirements to be putative adiposity signals to the brain. Plasma leptin and insulin levels are positively correlated with body weight and with adipose mass in particular. Furthermore, both leptin and insulin enter the brain from the plasma. The brain expresses both insulin and leptin receptors in areas important in the control of food intake and energy balance. Consistent with their roles as adiposity signals, exogenous leptin and insulin both reduce food intake when administered locally into the brain in a number of species under different experimental paradigms. Additionally, central administration of insulin antibodies increases food intake and body weight. Recent studies have demonstrated that both insulin and leptin have additive effects when administered simultaneously. Finally, we recently have demonstrated that leptin and insulin share downstream neuropeptide signaling pathways. Hence, insulin and leptin provide important negative feedback signals to the central nervous system, proportional to peripheral energy stores and coupled with catabolic circuits.
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“Thus, leptin insufficiency together with decreased insulin levels may act in conjunction to suppress melanocortin tone and limit weight loss via a reduction in T3 levels and energy expenditure.”
From Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass (2009) · cites this paper as [40]
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Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · cited 1×
“1996; Friedman, 1997; Buchanan et al., 1998; Woods et al., 1998; Schwartz et al., 2000 ).”
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · cited 1×
“They are induced during development and injury and in response to a wide spectrum of physiological stimuli (Lauri et al., 1998; Bernfield et al., 1999; Hsueh and Sheng, 1999 ).”
BackgroundCongenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Functions of Cell Surface Heparan Sulfate Proteoglycans
Bernfield, M. R., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J. M., & Zako, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.729 · Cited by 2,722
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924 · cited 4×
“Bray, 1989; Fan et al., 1997; Seeley et al., 1997; Thiele et al., 1998).”
BackgroundInfluentialAntagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881 · cited 3×
“Niswender and Schwartz (2003) published an excellent recent review of insulin as an adiposity signal.”
BackgroundInfluentialIdentification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499 · cited 3×
“The ARC contains receptors for each in particularly high concentrations (Banks et al., 1996; Schwartz et al., 1996b; Woods et al., 2003) and each signal has important shared mediators in the hypothalamus.”
BackgroundInfluential
Research works printed but not linked: 1
- Matson CA, Wiater MF, Weigle DS 1996 Leptin and the regulation of body adiposity: a critical review. Diabetes Rev 4:488508
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The role of insulin receptor signaling in the brain
Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604
Rosenbaum, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25977 · Cited by 575
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 556
The gut and energy balance: visceral allies in the obesity wars
Badman, M. K., & Flier, J. S. (2005) · Science · doi:10.1126/science.1109951 · Cited by 532
Modulation of appetite by gonadal steroid hormones
Asarian, L., & Geary, N. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1860 · Cited by 529
Metadata
- Authors
- Benoit, S. C.
- Affiliations
- University of Cincinnati Medical Center (US)
- Corresponding author
- Benoit, S. C.
- Venue
- Recent Progress in Hormone Research
- Publisher
- The Endocrine Society
- Published
- 2004-01-01
- Volume
- 59
- Issue
- 1
- Pages
- 267-285
- ISSN
- 0079-9963 (ISSN-L)
- OpenAlex
- W2125667577
- Cited by
- 266
- References
- 111
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 4 · 2017: 12 · 2016: 10 · 2015: 16 · 2014: 22 · 2013: 22 · 2012: 19
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Recent Progress in Hormone Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Cincinnati
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, insulin, adiposity signals, food intake regulation, energy balance, leptin receptor, insulin receptor, brain, negative feedback, neuropeptide signaling, body weight, insulin antibodies
- MeSH terms
- Adipose Tissue, alpha-MSH, Body Composition, Brain, Humans, Hypothalamus, Insulin, Neuropeptide Y, Signal Transduction, Leptin
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