Personality and risk for Alzheimer's disease in adults 72 years of age and older: A 6-year follow-up.

Duberstein, Paul R.; Chapman, Benjamin P.; Tindle, Hilary A.; Sink, Kaycee M.; Bamonti, Patricia; Robbins, John; Jerant, Anthony F.; Franks, Peter

doi:10.1037/a0021377

Cited by 146Dementia and Cognitive Impairment ResearchPersonality Traits and PsychologyAlzheimer's disease research and treatments

Personality and risk for Alzheimer's disease in adults 72 years of age and older: A 6-year follow-up.

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Duberstein, Paul R., Chapman, Benjamin P., Tindle, Hilary A., Sink, Kaycee M., Bamonti, Patricia, Robbins, John, Jerant, Anthony F., Franks, Peter·2011·Psychology and Aging

DOI 10.1037/a0021377PMC PMC3115437

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Abstract

[Correction Notice: An erratum for this article was reported in Vol 26(2) of Psychology and Aging (see record 2011-05802-001). This article contains an error in the Discussion, under the Implications, Caveats, Future Directions heading. The third paragraph includes the sentences that should have been removed. The corrected paragraph appears in the correction.] We conducted secondary analyses to determine the relationship between longstanding personality traits and risk for Alzheimer's disease (AD) among 767 participants 72 years of age or older who were followed for more than 6 years. Personality was assessed with the NEO-FFI. We hypothesized that elevated Neuroticism, lower Openness, and lower Conscientiousness would be independently associated with risk of AD. Hypotheses were supported. The finding that AD risk is associated with elevated Neuroticism and lower Conscientiousness can be added to the accumulating literature documenting the pathogenic effects of these two traits. The link between lower Openness and AD risk is consistent with recent findings on cognitive activity and AD risk. Findings have implications for prevention research and for the conceptualization of the etiology of AD.

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Flagged first, then by citations

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Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine
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Authors: Duberstein, P. R., Chapman, B. P., Tindle, H. A., Sink, K. M., Bamonti, P., Robbins, J., Jerant, A. F., & Franks, P.
Affiliations: University of Rochester Medicine (US)
University of Pittsburgh (US)
Wake Forest University (US)
University of California, Davis (US)
ORCID: Duberstein, Paul R.
Chapman, Benjamin P.
Tindle, Hilary A.
Sink, Kaycee M.
Bamonti, Patricia
Robbins, John
Franks, Peter
Venue: Psychology and Aging
Publisher: American Psychological Association (APA)
Published: 2011
Volume: 26
Issue: 2
Pages: 351-362
ISSN: 0882-7974 (ISSN-L)
1939-1498
DOI: 10.1037/a0021377
PMC: PMC3115437
OpenAlex: W1965795263
Cited by: 146
References: 108
Citations by year: 2026: 2 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 13 · 2018: 11 · 2017: 20 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 15 · 2012: 13
FWCI: 7.42
Type: journal article
Language: en
Update notices: correction (2011-03-21)
Open access: green
www.ncbi.nlm.nih.gov
Locations: Psychology and Aging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (T32 MH073452; K24MH072712)
National Center for Complementary and Alternative Medicine (U01 AT000162)
Office of Dietary Supplements
National Institute on Aging
National Heart, Lung, and Blood Institute
University of Pittsburgh (P50AG05133; K08AG031328)
Roena Kulynych Center for Memory and Cognition Research
National Institute of Neurological Disorders and Stroke
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, personality traits, neuroticism, openness to experience, conscientiousness, older adults, dementia risk, NEO-FFI, cognitive activity, disease prevention
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Follow-Up Studies, Humans, Personality, Personality Inventory, Risk Factors, Proportional Hazards Models

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Personality and risk for Alzheimer's disease in adults 72 years of age and older: A 6-year follow-up.

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