Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity
Open accessAbstract
Aggregation of the amyloid-beta (Abeta) peptide in the extracellular space of the brain is critical in the pathogenesis of Alzheimer's disease. Abeta is produced by neurons and released into the brain interstitial fluid (ISF), a process regulated by synaptic activity. To determine whether behavioral stressors can regulate ISF Abeta levels, we assessed the effects of chronic and acute stress paradigms in amyloid precursor protein transgenic mice. Isolation stress over 3 months increased Abeta levels by 84%. Similarly, acute restraint stress increased Abeta levels over hours. Exogenous corticotropin-releasing factor (CRF) but not corticosterone mimicked the effects of acute restraint stress. Inhibition of endogenous CRF receptors or neuronal activity blocked the effects of acute stress on Abeta. Thus, behavioral stressors can rapidly increase ISF Abeta through neuronal activity in a CRF-dependent manner, and the results suggest a mechanism by which behavioral stress may affect Alzheimer's disease pathogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Extracellular occurrence of oligomers is consistent with the rapid outpouring of Aβ, and perhaps small oligomers, into brain interstitial fluid, measured by microdialysis in mouse models and humans.
“Extracellular occurrence of oligomers is consistent with the rapid outpouring of Aβ, and perhaps small oligomers, into brain interstitial fluid, measured by microdialysis in mouse models and humans (Cirrito et al., 2005; Kang et al., 2007; Kang et al., 2009).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Kang et al., 2007
Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,012 · see citing works
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works
APP Processing and Synaptic Function
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630 · see citing works
Influence of education and occupation on the incidence of Alzheimer's disease
Stern, Y. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370056032 · Cited by 1,434 · see citing works
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works
Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., & Borst, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118214 · Cited by 1,108 · see citing works
Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias
Plassman, B. L., Havlik, R. J., Steffens, D. C., Helms, M. J., Newman, T. N., Drosdick, D., Phillips, C., Gau, B. A., Welsh–Bohmer, K. A., Burke, J. R., et al. (2000) · Neurology · doi:10.1212/wnl.55.8.1158 · Cited by 896 · see citing works
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885 · see citing works
Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases
Selkoe, D. J. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1054 · Cited by 863 · see citing works
Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease
Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 806 · see citing works
Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease
Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., & LaFerla, F. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2797-06.2006 · Cited by 623 · see citing works
Chang, C.-P., Pearse, R. V., O'Connell, S., & Rosenfeld, M. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90230-o · Cited by 537 · see citing works
Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R., & Savonenko, A. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5080-04.2005 · Cited by 517 · see citing works
Potter, E., Sutton, S., Donaldson, C., Chen, R., Perrin, M., Lewis, K., Sawchenko, P. E., & Vale, W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8777 · Cited by 514 · see citing works
Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works
Harper, J. D., Wong, S. S., Lieber, C. M., & Lansbury, P. T. (1999) · Biochemistry · doi:10.1021/bi9904149 · Cited by 454 · see citing works
Proneness to psychological distress is associated with risk of Alzheimer’s disease
Wilson, R. S., Evans, D. A., Bienias, J. L., Mendes de Leon, C. F., Schneider, J. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000096167.56734.59 · Cited by 428 · see citing works
Plasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia
Csernansky, J. G., Dong, H., Fagan, A. M., Wang, L., Xiong, C., Holtzman, D. M., & Morris, J. C. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.12.2164 · Cited by 426 · see citing works
Self-citationPlasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia
Csernansky, J. G., Dong, H., Fagan, A. M., Wang, L., Xiong, C., Holtzman, D. M., & Morris, J. C. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.12.2164 · Cited by 421 · see citing works
Cirrito, J. R., May, P. C., O'Dell, M. A., Taylor, J. W., Parsadanian, M., Cramer, J. W., Audia, J. E., Nissen, J. S., Bales, K. R., Paul, S. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08844.2003 · Cited by 394 · see citing works
Dong, H., Goico, B., Martin, M., Csernansky, C. A., Bertchume, A., & Csernansky, J. G. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.040 · Cited by 342 · see citing works
Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W., & Siggins, G. R. (1983) · Science · doi:10.1126/science.6603658 · Cited by 309 · see citing works
Souza, E. B. D., Whitehouse, P. J., Kuhar, M. J., Price, D. L., & Vale, W. (1986) · Nature · doi:10.1038/319593a0 · Cited by 255 · see citing works
Individual housing induces altered immuno-endocrine responses to psychological stress in male mice
Bartolomucci, A., Palanza, P., Sacerdote, P., Ceresini, G., Chirieleison, A., Panerai, A. E., & Parmigiani, S. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00039-2 · Cited by 241 · see citing works
Ni, Y., Zhao, X., Bao, G., Zou, L., Teng, L., Wang, Z., Song, M., Xiong, J., Bai, Y., & Pei, G. (2006) · Nature Medicine · doi:10.1038/nm1485 · Cited by 237 · see citing works
The Role of Corticotropin‐Releasing Factor in Behavioural Responses to Stress
Koob, G. F., Heinrichs, S. C., Pich, E. M., Menzaghi, F., Baldwin, H. A., Miczek, K. A., & Britton, K. T. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch14 · Cited by 232 · see citing works
Blank, T., Nijholt, I. M., Eckart, K., & Spiess, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03788.2002 · Cited by 210 · see citing works
Baram, T. Z., & Hatalski, C. G. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01275-2 · Cited by 206 · see citing works
Proneness to psychological distress and risk of Alzheimer disease in a biracial community
Wilson, R. S., Barnes, L. L., Bennett, D. A., Li, Y., Bienias, J. L., de Leon, C. F. M., & Evans, D. A. (2005) · Neurology · doi:10.1212/01.wnl.0000149525.53525.e7 · Cited by 201 · see citing works
Watts, A. B. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.09.001 · Cited by 194 · see citing works
Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress
Chen, Y., Brunson, K. L., Adelmann, G., Bender, R. A., Frotscher, M., & Baram, T. Z. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.036 · Cited by 179 · see citing works
Disease modifying therapy for AD?<sup>1</sup>
Golde, T. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04211.x · Cited by 117 · see citing works
Chen, F. M., Bilezikjian, L. M., Perrin, M. H., Rivier, J., & Vale, W. (1986) · Brain Research · doi:10.1016/0006-8993(86)90688-8 · Cited by 116 · see citing works
Haug, T. M., & Storm, J. F. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.2071 · Cited by 110 · see citing works
Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent
Chen, Y., Fenoglio, K. A., Dubé, C. M., Grigoriadis, D. E., & Baram, T. Z. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001863 · Cited by 98 · see citing works
Overexpression of agouti protein and stress responsiveness in mice
Harris, R. B. S., Zhou, J. F., Shi, M., Redmann, S. M., Mynatt, R. L., & Ryan, D. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00508-x · Cited by 41 · see citing works
Brunson, K. L., Schultz, L., & Baram, T. Z. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00130-8 · Cited by 23 · see citing works
Bayraktar (2000) · doi:10.1002/(sici)1096-9861(20000508)420:3
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
Van Pett, K., Viau, V., Bittencourt, J. C., Chan, R. K. W., Li, H.-Y., Arias, C., Prins, G. S., Perrin, M., Vale, W., & Sawchenko, P. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001211)428:2
Flagged first, then by citations
Cited by
Sorted by citations
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works
Histone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680 · see citing works
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
Cirrito, J. R., Kang, J.-E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G., Mennerick, S., & Holtzman, D. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.003 · Cited by 635 · see citing works
Association between circadian rhythms and neurodegenerative diseases
Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 660 · see citing works
Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease
Musiek, E. S., Xiong, D. D., & Holtzman, D. M. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.121 · Cited by 529 · see citing works
Pathways linking late-life depression to persistent cognitive impairment and dementia
Butters, M. A., Young, J. K., López, O. L., Aizenstein, H. J., Mulsant, B. H., Reynolds, C. F., DeKosky, S. T., & Becker, J. T. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.3/mabutters · Cited by 538 · see citing works
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works
Restraint stress in biobehavioral research: Recent developments
Buynitsky, T., & Mostofsky, D. I. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.004 · Cited by 426 · see citing works
Midlife psychological stress and risk of dementia: a 35-year longitudinal population study
Johansson, L. H., Guo, X., Wærn, M., Östling, S., Gustafson, D., Bengtsson, C., & Skoog, I. G. (2010) · Brain · doi:10.1093/brain/awq116 · Cited by 291 · see citing works
Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System
Huang, Y. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.235 · Cited by 281 · see citing works
Sexual dimorphism in predisposition to Alzheimer's disease
Fisher, D. W., Bennett, D. A., & Dong, H. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.04.004 · Cited by 270 · see citing works
Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice
Yan, P., Bero, A. W., Cirrito, J. R., Xiao, Q., Hu, X., Wang, Y., Gonzales, E., Holtzman, D. M., & Lee, J.-M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2637-09.2009 · Cited by 264 · see citing works
The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.
Deussing, J., & Chen, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2017 · Cited by 234 · see citing works
Sotiropoulos, I., Catania, C., Pinto, L., Silva, R., Pollerberg, G. E., Takashima, A., Sousa, N. J., & Almeida, O. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-11.2011 · Cited by 265 · see citing works
Tran, H. T., LaFerla, F. M., Holtzman, D. M., & Brody, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0858-11.2011 · Cited by 255 · see citing works
Amyloid‐β efflux from the central nervous system into the plasma
Roberts, K. F., Elbert, D. L., Kasten, T. P., Patterson, B. W., Sigurdson, W. C., Connors, R., Ovod, V., Munsell, L. Y., Mawuenyega, K. G., Miller‐Thomas, M. M., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24270 · Cited by 250 · see citing works
Yuede, C. M., Zimmerman, S., Dong, H., Kling, M. J., Bero, A. W., Holtzman, D. M., Timson, B. F., & Csernansky, J. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.002 · Cited by 250 · see citing works
Carroll, J. C., Iba, M., Bangasser, D. A., Valentino, R. J., James, M. J., Brunden, K. R., Lee, V. M. ‐., & Trojanowski, J. Q. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3836-11.2011 · Cited by 256 · see citing works
The relationship between stress and Alzheimer's disease
Justice, N. J. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.04.002 · Cited by 237 · see citing works
A lifespan view of anxiety disorders
Lenze, E. J., & Wetherell, J. L. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.4/elenze · Cited by 227 · see citing works
Tong, Z., Zhang, J., Luo, W., Wang, W., Li, F., Li, H., Luo, H., Lu, J. N., Zhou, J., Wan, Y., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.07.013 · Cited by 212 · see citing works
Du, X., & Pang, T. Y. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00032 · Cited by 211 · see citing works
Siemers, E., Friedrich, S. W., Dean, R. A., Gonzales, C., Farlow, M. R., Paul, S. M., & Demattos, R. B. (2010) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181cb577a · Cited by 192 · see citing works
Chronic stress as a risk factor for Alzheimer’s disease
Machado, A., Herrera, A. J., de Pablos, R. M., Espinosa‐Oliva, A. M., Soto, M. S., Ayala, A., Venero, J. L., Santiago, M., Villarán, R. F., Delgado‐Cortés, M. J., et al. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0035 · Cited by 177 · see citing works
Pentkowski, N. S., Rogge-Obando, K., Donaldson, T. N., Bouquin, S. J., & Clark, B. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.005 · Cited by 169 · see citing works
Sculpting the hippocampus from within: stress, spines, and CRH
Maras, P. M., & Baram, T. Z. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.005 · Cited by 174 · see citing works
Exploring the relationship between personality and regional brain volume in healthy aging
Jackson, J., Balota, D. A., & Head, D. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.12.009 · Cited by 174 · see citing works
It's complicated: The relationship between sleep and Alzheimer's disease in humans
Lucey, B. P. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105031 · Cited by 165 · see citing works
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works
Alzheimer's disease amyloid β-protein and synaptic function
Ondrejcak, T., Klyubin, I., Hu, N.-W., Barry, A. E., Cullen, W. K., & Rowan, M. J. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8091-0 · Cited by 146 · see citing works
Lee, K., Kim, J., Seo, J., Kim, T., Im, J., Baek, I., Kim, K., Lee, J., & Han, P. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05769.x · Cited by 145 · see citing works
Wiseman, F. K., Pulford, L. J., Barkus, C., Liao, F., Portelius, E., Webb, R., Chávez-Gutiérrez, L., Cleverley, K., Noy, S., Sheppard, O., et al. (2018) · Brain · doi:10.1093/brain/awy159 · Cited by 133 · see citing works
Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis
Groves, J. A., Lee, A., Yildirir, G., & Zachara, N. E. (2013) · Cell Stress and Chaperones · doi:10.1007/s12192-013-0426-y · Cited by 143 · see citing works
Adding fuel to the fire: the impact of stress on the ageing brain
Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136 · see citing works
Effects of Stress and Stress Hormones on Amyloid-β Protein and Plaque Deposition
Dong, H., & Csernansky, J. G. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1152 · Cited by 124 · see citing works
Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer’s Disease
Minakawa, E. N., Wada, K., & Nagai, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040803 · Cited by 118 · see citing works
Ren, Y. L., Savadlou, A., Park, S., Siska, P., Epp, J. R., & Sargin, D. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101061 · Cited by 130 · see citing works
Srivareerat, M., Tran, T. T., Alzoubi, K. H., & Alkadhi, K. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.021 · Cited by 122 · see citing works
Srivareerat, M., Tran, T. T., Salim, S., Aleisa, A. M., & Alkadhi, K. A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.015 · Cited by 121 · see citing works
Wu, K.-Y., Hsiao, I., Chen, C., Chen, C., Hsieh, C., Wai, Y., Chang, C., Tseng, H., Yen, T.-C., Liu, C.-Y., et al. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-013-2627-0 · Cited by 121 · see citing works
Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?
Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139 · see citing works
Dong, H., Yuede, C. M., Yoo, H.-S., Martin, M. V., Deal, C., Mace, A. G., & Csernansky, J. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.017 · Cited by 112 · see citing works
Stress and glucocorticoid footprints in the brain—The path from depression to Alzheimer's disease
Sotiropoulos, I., Cerqueira, J., Catania, C., Takashima, A., Sousa, N., & Almeida, O. F. X. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.007 · Cited by 101 · see citing works
Johansson, L., Guo, X., Hällström, T., Norton, M. C., Waern, M., Östling, S., Bengtsson, C., & Skoog, I. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003142 · Cited by 101 · see citing works
BACE1 Structure and Function in Health and Alzheimers Disease
Cole, S., & Vassar, R. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954758 · Cited by 96 · see citing works
Rissman, R. A., Staup, M. A., Lee, A. R., Justice, N. J., Rice, K. C., Vale, W., & Sawchenko, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203140109 · Cited by 97 · see citing works
3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress
Rothman, S. M., Herdener, N. D., Camandola, S., Texel, S. J., Mughal, M. R., Cong, W., Martin, B., & Mattson, M. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.005 · Cited by 95 · see citing works
Innes, K. E., Selfe, T. K., Brown, C. J., Rose, K. M., & Thompson-Heisterman, A. A. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/927509 · Cited by 94 · see citing works
Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression
Perna, G., Iannone, G., Alciati, A., & Caldirola, D. (2015) · Neural Plasticity · doi:10.1155/2016/8457612 · Cited by 96 · see citing works
Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐ AD mice
Baglietto‐Vargas, D., Chen, Y., Suh, D., Ager, R. R., Rodríguez‐Ortiz, C. J., Medeiros, R., Myczek, K., Green, K. N., Baram, T. Z., & LaFerla, F. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13195 · Cited by 93 · see citing works
Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer's disease
Pentkowski, N. S., Berkowitz, L. E., Thompson, S. M., Drake, E., Maestas-Olguin, C. R., & Clark, B. J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.024 · Cited by 86 · see citing works
Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid β Protein
Kandimalla, K. K., Scott, O. G., Fulzele, S., Davidson, M. W., & Poduslo, J. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004627 · Cited by 88 · see citing works
Mifflin, M. A., Winslow, W., Surendra, L., Tallino, S., Vural, A. S., & Velázquez, R. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.018 · Cited by 87 · see citing works
New Research on Anxiety Disorders in the Elderly and an Update on Evidence-Based Treatments
Andreescu, C., & Varon, D. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0595-8 · Cited by 85 · see citing works
The gut microbiome and Alzheimer’s disease: Complex and bidirectional interactions
Tarawneh, R. M., & Penhos, E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104814 · Cited by 88 · see citing works
Locus coeruleus, norepinephrine and Aβ peptides in Alzheimer's disease
Ross, J. A., McGonigle, P., & Bockstaele, E. J. V. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.09.002 · Cited by 85 · see citing works
Pistollato, F., Cano, S. S., Elío, I., Vergara, M. M., Giampieri, F., & Battino, M. A. (2016) · Advances in Nutrition · doi:10.3945/an.115.011775 · Cited by 81 · see citing works
Justice, N. J., Huang, L., Tian, J.-B., Cole, A., Pruski, M., Hunt, A. J., Flores, R., Zhu, M. X., Arenkiel, B. R., & Zheng, H. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3333-14.2015 · Cited by 81 · see citing works
Esmaeili, M. H., Bahari, B., & Salari, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.01.001 · Cited by 81 · see citing works
Mouse models of neurodegeneration: Know your question, know your mouse
Fisher, E., & Bannerman, D. M. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaq1818 · Cited by 79 · see citing works
Cui, B., Li, K., Gai, Z., She, X., Zhang, N., Xu, C.-X., Chen, X., An, G., Ma, Q., & Wang, R. (2015) · Scientific Reports · doi:10.1038/srep12943 · Cited by 74 · see citing works
β-Amyloid Dynamics in Human Plasma
Huang, Y., Potter, R. C., Sigurdson, W. C., Kasten, T. P., Connors, R., Morris, J. C., Benzinger, T. L. S., Mintun, M. A., Ashwood, T. J., Ferm, M. T., et al. (2012) · JAMA Neurology · doi:10.1001/archneurol.2012.18107 · Cited by 77 · see citing works
Jiang, X., Jia, L., Li, X., Cheng, X., Xie, J., Ma, Z., Xu, W., Liu, Y., Yao, Y., Du, L., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121837 · Cited by 69 · see citing works
Bangasser, D. A., Dong, H., Carroll, J., Plona, Z., Ding, H., Rodriguez, L., McKennan, C. G., Csernansky, J. G., Seeholzer, S. H., & Valentino, R. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.185 · Cited by 71 · see citing works
Pardon, M., & Rattray, I. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.005 · Cited by 65 · see citing works
Chung, J. K., Initiative, A. D. N., Plitman, E., Nakajima, S., Chow, T. W., Chakravarty, M. M., Caravaggio, F., Gerretsen, P., Brown, E. E., Iwata, Y., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142931 · Cited by 65 · see citing works
George, D. R. (2011) · Quality of Life Research · doi:10.1007/s11136-010-9837-8 · Cited by 65 · see citing works
Cuadrado‐Tejedor, M., Ricobaraza, A., Frechilla, D., Franco, R., Pérez‐Mediavilla, A., & García‐Osta, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110572 · Cited by 62 · see citing works
Longitudinal plasma amyloid beta as a biomarker of Alzheimer’s disease
Rissman, R. A., Trojanowski, J. Q., Shaw, L. M. J., & Aisen, P. S. S. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0772-4 · Cited by 62 · see citing works
Monitoring of β-Amyloid Dynamics after Human Traumatic Brain Injury
Marklund, N., Farrokhnia, N., Hånell, A., Vanmechelen, E., Enblad, P., Zetterberg, H., Blennow, K., & Hillered, L. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2964 · Cited by 61 · see citing works
Hoeijmakers, L., Lesuis, S. L., Krugers, H. J., Lucassen, P. J., & Kőrösi, A. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.02.003 · Cited by 63 · see citing works
Ross, J. A., Gliebus, G. P., & Bockstaele, E. J. V. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.004 · Cited by 62 · see citing works
Dong, H., Murphy, K. M., Meng, L., Montalvo‐Ortiz, J. L., Zeng, Z., Kolber, B. J., Zhang, S., Muglia, L. J., & Csernansky, J. G. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111328 · Cited by 60 · see citing works
Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease
Phan, T., & Malkani, R. G. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.10.001 · Cited by 64 · see citing works
Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice
Minakawa, E. N., Miyazaki, K., Maruo, K., Yagihara, H., Fujita, H., Wada, K., & Nagai, Y. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.05.054 · Cited by 59 · see citing works
Lenze, E. J., & Wetherell, J. L. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2074 · Cited by 57 · see citing works
Targeting psychologic stress signaling pathways in Alzheimer’s disease
Futch, H. S., Croft, C. L., Truong, V., Krause, E. G., & Golde, T. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0190-z · Cited by 60 · see citing works
Gonzales, C., Zaleska, M. M., Riddell, D. R., Atchison, K. P., Robshaw, A., Zhou, H., & Rizzo, S. J. S. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.08.010 · Cited by 56 · see citing works
c-Jun N-terminal kinases in memory and synaptic plasticity
Sherrin, T., Blank, T., & Todorovic, C. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.032 · Cited by 56 · see citing works
Park, H., Ran, Y., Jung, J. I., Holmes, O. W., Price, A. R., Smithson, L. A., Ceballos‐Diaz, C., Han, C. J., Wolfe, M. S., Daaka, Y., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201488795 · Cited by 56 · see citing works
Zhang, C., Kuo, C., Moghadam, S. H., Monte, L., Campbell, S. N., Rice, K. C., Sawchenko, P. E., Masliah, E., & Rissman, R. A. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.09.007 · Cited by 56 · see citing works
Dynamic Contributions of Slow Wave Sleep and REM Sleep to Cognitive Longevity
Scullin, M. K., & Gao, C. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0131-6 · Cited by 56 · see citing works
Emerging role of amyloid beta in stress response: Implication for depression and diabetes
Morgese, M. G., Schiavone, S., & Trabace, L. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.08.031 · Cited by 52 · see citing works
Sex differences in chronic stress responses and Alzheimer's disease
Yan, Y., Dominguez, S., Fisher, D. W., & Dong, H. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.03.002 · Cited by 54 · see citing works
Schwetye, K. E., Cirrito, J. R., Esparza, T. J., Mac Donald, C. L., Holtzman, D. M., & Brody, D. L. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.06.018 · Cited by 51 · see citing works
Seo, J., Lee, K.-W., Kim, T., Baek, I., Im, J., & Han, P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.02.035 · Cited by 50 · see citing works
Environmental factors in the development and progression of late-onset Alzheimer’s disease
Wainaina, M. N., Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1425-9 · Cited by 51 · see citing works
Relationship between Plasma Analytes and SPARE-AD Defined Brain Atrophy Patterns in ADNI
Toledo, J. B., Da, X., Bhatt, P., Wolk, D. A., Arnold, S. E., Shaw, L. M. J., Trojanowski, J. Q., Davatzikos, C. A., & Initiative, A. D. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055531 · Cited by 47 · see citing works
Stress and Alzheimer’s disease: A senescence link?
Lyons, C. E., & Bartolomucci, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.010 · Cited by 47 · see citing works
Blocking beta2-adrenergic receptor attenuates acute stress-induced amyloid beta peptides production.
Yu, N.-N., Wang, X.-X., Yu, J.-T., Wang, N.-D., Lu, R.-C., Miao, D., Tian, Y., & Tan, L. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.087 · Cited by 48 · see citing works
Laske, C., Stransky, E., Fritsche, A., Eschweiler, G. W., & Leyhe, T. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0838-3 · Cited by 47 · see citing works
Roe, A. D., Staup, M. A., Serrats, J., Sawchenko, P. E., & Rissman, R. A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07764.x · Cited by 45 · see citing works
Correia, A. S., Cardoso, A., & Vale, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168525 · Cited by 44 · see citing works
Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease (Erratum)
Chouliaras, L., Sierksma, A. S. R., Kenis, G., Prickaerts, J., Lemmens, M. A. M., Brasnjevic, I., van Donkelaar, E. L., Martínez‐Martínez, P., Losen, M. H., Baets, M. H. D., et al. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/356862 · Cited by 44 · see citing works
Herukka, S.-K., Rummukainen, J., Ihalainen, J., von und zu Fraunberg, M., Koivisto, A. M., Nerg, O., Puli, L. K., Seppälä, T. T., Zetterberg, H., Pyykkö, O. T., et al. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142862 · Cited by 43 · see citing works
Vandael, D., & Gounko, N. V. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0581-8 · Cited by 45 · see citing works
Stress-Induced Tau Phosphorylation: Functional Neuroplasticity or Neuronal Vulnerability?
Rissman, R. A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1153 · Cited by 43 · see citing works
Mice lacking adenylyl cyclase‐5 cope badly with repeated restraint stress
Kim, K., & Han, P. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22119 · Cited by 42 · see citing works
Dong, H., Wang, S. D., Zeng, Z., Li, F., Montalvo‐Ortiz, J. L., Tucker, C., Akhtar, S., Shi, J., Meltzer, H. Y., Rice, K. C., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3629-8 · Cited by 42 · see citing works
Midlife Psychological Distress Associated With Late-Life Brain Atrophy and White Matter Lesions
Johansson, L. H., Skoog, I. G., Gustafson, D., Olesen, P. J., Wærn, M., Bengtsson, C., Björkelund, C., Pantoni, L., Simoni, M., Lissner, L., et al. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318246eb10 · Cited by 42 · see citing works
- Authors
- Kang, J.-E., Cirrito, J. R., Dong, H., Csernansky, J. G., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Departments of *Neurology,
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-06-19
- Volume
- 104
- Issue
- 25
- Pages
- 10673-10678
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1965571
- OpenAlex
- W2031441539
- Cited by
- 219
- References
- 44
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 7 · 2021: 12 · 2020: 9 · 2019: 12 · 2018: 13 · 2017: 11 · 2016: 5 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 10
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association (AG13956)
- Eli Lilly and Company
- Cure Alzheimer's Fund
- National Institutes of Health (AG13956)
- National Institute on Aging (AG 025824, R01AG013956, R01AG025824, R37AG013956, AG13956)
- National Institute on Drug Abuse (DA07261, T32DA007261)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- amyloid-beta, interstitial fluid, acute stress, restraint stress, isolation stress, corticotropin-releasing factor, CRF receptors, neuronal activity, synaptic activity, amyloid precursor protein transgenic mice, Alzheimer's disease, corticosterone
- MeSH terms
- Acute Disease, Animals, Corticotropin-Releasing Hormone, Crosses, Genetic, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Stress, Psychological, Amyloid beta-Peptides, Microdialysis, Extracellular Fluid, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review