Cited by 219Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity

Open access
Kang, Jae-Eun, Cirrito, John R., Dong, Hongxin, Csernansky, John G., Holtzman, David M.·2007·Proceedings of the National Academy of Sciences

Abstract

Aggregation of the amyloid-beta (Abeta) peptide in the extracellular space of the brain is critical in the pathogenesis of Alzheimer's disease. Abeta is produced by neurons and released into the brain interstitial fluid (ISF), a process regulated by synaptic activity. To determine whether behavioral stressors can regulate ISF Abeta levels, we assessed the effects of chronic and acute stress paradigms in amyloid precursor protein transgenic mice. Isolation stress over 3 months increased Abeta levels by 84%. Similarly, acute restraint stress increased Abeta levels over hours. Exogenous corticotropin-releasing factor (CRF) but not corticosterone mimicked the effects of acute restraint stress. Inhibition of endogenous CRF receptors or neuronal activity blocked the effects of acute stress on Abeta. Thus, behavioral stressors can rapidly increase ISF Abeta through neuronal activity in a CRF-dependent manner, and the results suggest a mechanism by which behavioral stress may affect Alzheimer's disease pathogenesis.

Integrity signals

Registry

Crossref · 10.1073/pnas.0700148104

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Extracellular occurrence of oligomers is consistent with the rapid outpouring of Aβ, and perhaps small oligomers, into brain interstitial fluid, measured by microdialysis in mouse models and humans.

    “Extracellular occurrence of oligomers is consistent with the rapid outpouring of Aβ, and perhaps small oligomers, into brain interstitial fluid, measured by microdialysis in mouse models and humans (Cirrito et al., 2005; Kang et al., 2007; Kang et al., 2009).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kang, J.-E., Cirrito, J. R., Dong, H., Csernansky, J. G., & Holtzman, D. M.
Affiliations
  • Washington University in St. Louis (US)
  • Departments of *Neurology,
Venue
Proceedings of the National Academy of Sciences
Published
2007-06-19
Volume
104
Issue
25
Pages
10673-10678
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2031441539
Cited by
219
References
44
Citations by year
2026: 6 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 7 · 2021: 12 · 2020: 9 · 2019: 12 · 2018: 13 · 2017: 11 · 2016: 5 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 10
FWCI
10.24
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Alzheimer's Association (AG13956)
  • Eli Lilly and Company
  • Cure Alzheimer's Fund
  • National Institutes of Health (AG13956)
  • National Institute on Aging (AG 025824, R01AG013956, R01AG025824, R37AG013956, AG13956)
  • National Institute on Drug Abuse (DA07261, T32DA007261)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
amyloid-beta, interstitial fluid, acute stress, restraint stress, isolation stress, corticotropin-releasing factor, CRF receptors, neuronal activity, synaptic activity, amyloid precursor protein transgenic mice, Alzheimer's disease, corticosterone
MeSH terms
Acute Disease, Animals, Corticotropin-Releasing Hormone, Crosses, Genetic, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Stress, Psychological, Amyloid beta-Peptides, Microdialysis, Extracellular Fluid, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review