The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Increased vagal tone accounts for the observed immune paralysis in patients with traumatic brain injury
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“It has been reported that patients with TBI encounter a higher infection rate ranging from 50% to 70%, and are more susceptible to sepsis or pneumonia.”
From Investigating the Safety and Efficacy of Therapeutic Hypothermia in Pediatric Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis (2024) · cites this paper as [47]
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“It also has been noted that hypothermia decreases the leukocyte number in blood circulation, attributed to a higher risk of infection and mortality [46,47,48]”
From Investigating the Safety and Efficacy of Therapeutic Hypothermia in Pediatric Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis (2024) · cites this paper as [47]
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Cites
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Cited by
The vagal innervation of the gut and immune homeostasis
Matteoli, G., & Boeckxstaens, G. E. (2013) · Gut · doi:10.1136/gutjnl-2012-302550 · Cited by 276
Sepsis-associated encephalopathy: A vicious cycle of immunosuppression
Ren, C., Yao, R.-Q., Zhang, H., Feng, Y.-W., & Yao, Y.-M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1701-3 · Cited by 259
Is there a role for vagus nerve stimulation therapy as a treatment of traumatic brain injury?
Kumaria, A., & Tolias, C. M. (2012) · British Journal of Neurosurgery · doi:10.3109/02688697.2012.663517 · Cited by 38
Naseri Alavi, S. A., Habibi, M. A., Majdi, A., Hajikarimloo, B., Rashidi, F., Fathi Tavani, S., Minaee, P., Eazi, S. M., & Kobets, A. J. (2024) · Children · doi:10.3390/children11060701 · Cited by 5
Metadata
- Authors
- Kox, M., Pompe, J. C., Pickkers, P., Hoedemaekers, C. W., van Vugt, A. B., & van der Hoeven, J. G.
- Affiliations
- From the Department of Intensive Care Medicine (M.K., J.C.P., P.P., C.W.H., J.G.v.d.H.) and Department of Surgery, Section Traumatology (J.C.P., A.B.v.V.), Radboud University Nijmegen Medical Centre, The Netherlands.
- Venue
- Neurology
- Published
- 2008-02-05
- Volume
- 70
- Issue
- 6
- Pages
- 480-485
- ISSN
- 0028-3878
- 1526-632X
- Cited by
- 51
- References
- 10
- Language
- en
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- CoChat. (2026). Citation check: Increased vagal tone accounts for the observed immune paralysis in patients with traumatic brain injury. https://app.cochat.ai/papers/10.1212/01.wnl.0000279479.69502.3e
- The paper
- Kox, M., Pompe, J. C., Pickkers, P., Hoedemaekers, C. W., van Vugt, A. B., & van der Hoeven, J. G. (2008). Increased vagal tone accounts for the observed immune paralysis in patients with traumatic brain injury. Neurology. https://doi.org/10.1212/01.wnl.0000279479.69502.3e
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
