The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Physical frailty in older persons is associated with Alzheimer disease pathology
Open accessAbstract
OBJECTIVE: We examined the extent to which physical frailty in older persons is associated with common age-related brain pathology, including cerebral infarcts, Lewy body pathology, and Alzheimer disease (AD) pathology. METHODS: We studied brain autopsies from 165 deceased participants from the Rush Memory and Aging Project, a longitudinal clinical-pathologic study of aging. Physical frailty, based on four components, including grip strength, time to walk 8 feet, body composition, and fatigue, was assessed at annual clinical evaluations. Multiple regression analyses were used to examine the relation of postmortem neuropathologic findings to frailty proximate to death, controlling for age, sex, and education. RESULTS: The mean age at death was 88.1 years (SD = 5.7 years). The level of AD pathology was associated with frailty proximate to death ( = 0.252, SE = 0.077, p = 0.001), accounting for 4% of the variance of physical frailty. Neither cerebral infarcts ( = -0.121, SE = 0.115, p = 0.294) nor Lewy body disease pathology ( = 0.07, SE = 0.156, p = 0.678) was associated with frailty. These associations were unchanged after controlling for the time interval from last clinical evaluation to autopsy. The association of AD pathology with frailty did not differ by the presence of dementia, and this association was unchanged even after considering potential confounders, including physical activity; parkinsonian signs; pulmonary function; or history of chronic diseases, including vascular risk factors, vascular disease burden, falls, joint pain, or use of antipsychotic or antihypertensive medications. CONCLUSION: Physical frailty in old age is associated with Alzheimer disease pathology in older persons with and without dementia.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00745.x · Cited by 1,605
Ferrucci, L., Guralnik, J. M., Studenski, S., Fried, L. P., Cutler, G. B., Walston, J. D., & The Interventions on Frailty Working Group (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52174.x · Cited by 1,027
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
Bennett, D. A., Schneider, J. A., Bienias, J. L., Evans, D. A., & Wilson, R. S. (2005) · Neurology · doi:10.1212/01.wnl.0000152982.47274.9e · Cited by 537
Self-citationFrailty is associated with incident Alzheimer's disease and cognitive decline in the elderly
Buchman, A. S., Boyle, P. A., Wilson, R. S., Tang, Y., & Bennett, D. A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318068de1d · Cited by 420
Self-citationRelation of cognitive activity to risk of developing Alzheimer disease
Wilson, R. S., Scherr, P. A., Schneider, J. A., Tang, Y., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271087.67782.cb · Cited by 400
Self-citationPerformance-based physical function and future dementia in older people
Wang, L., Larson, E. B., Bowen, J. D., & van Belle, G. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1115 · Cited by 329
Cited by
Religious Orders Study and Rush Memory and Aging Project
Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179939 · Cited by 1,260
Self-citationBoyle, P. A., Buchman, A. S., Wilson, R. S., Leurgans, S. E., & Bennett, D. A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02671.x · Cited by 510
Self-citationHaran, J. P., Bhattarai, S. K., Foley, S. E., Dutta, P., Ward, D. V., Bucci, V., & McCormick, B. A. (2019) · mBio · doi:10.1128/mbio.00632-19 · Cited by 412
Rijk, J. M., Roos, P. R., Deckx, L., van den Akker, M., & Buntinx, F. (2016) · Geriatrics & Gerontology International · doi:10.1111/ggi.12508 · Cited by 376
Loss of motor function in preclinical Alzheimer's disease
Buchman, A. S., & Bennett, D. A. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.57 · Cited by 311
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Metadata
- Authors
- Buchman, A. S., Schneider, J. A., Leurgans, S., & Bennett, D. A.
- Venue
- Neurology
- Published
- 2008-08-12
- Volume
- 71
- Issue
- 7
- Pages
- 499-504
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1978210447
- Cited by
- 259
- References
- 8
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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