Physical frailty is associated with incident mild cognitive impairment in community-based older persons
Open accessAbstract
OBJECTIVES: To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI). DESIGN: Prospective, observational cohort study. SETTING: Approximately 40 retirement communities across the Chicago metropolitan area. PARTICIPANTS: More than 750 older persons without cognitive impairment at baseline. MEASUREMENTS: Physical frailty, based on four components (grip strength, timed walk, body composition, and fatigue), was assessed at baseline, and cognitive function was assessed annually. Proportional hazards models adjusted for age, sex, and education were used to examine the association between physical frailty and the risk of incident MCI, and mixed effect models were used to examine the association between frailty and the rate of change in cognition. RESULTS: During up to 12 years of annual follow‐up, 305 of 761 (40%) persons developed MCI. In a proportional hazards model adjusted for age, sex, and education, physical frailty was associated with a high risk of incident MCI, such that each one‐unit increase in physical frailty was associated with a 63% increase in the risk of MCI (hazard ratio=1.63; 95% confidence interval=1.27–2.08). This association persisted in analyses that required MCI to persist for at least 1 year and after controlling for depressive symptoms, disability, vascular risk factors, and vascular diseases. Furthermore, a higher level of physical frailty was associated with a faster rate of decline in global cognition and five cognitive systems (episodic memory, semantic memory, working memory, perceptual speed, and visuospatial abilities). CONCLUSION: Physical frailty is associated with risk of MCI and a rapid rate of cognitive decline in aging.
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A 12-year prospective cohort of 750 cognitively intact older adults found frailty associated with higher risk of incident mild cognitive impairment (HR 1.63, CI 1.27-2.08).
“A prospective cohort study (n=750) of older people without cognitive impairment at baseline reported that frailty was associated with an increased risk of developing mild cognitive impairment over 12 years of follow-up (hazard ratio, HR, 1.63, CI, 1.27-2.08) (30).”
From Frailty in elderly people (2013) · cites this paper as [30]
Greater frailty severity is linked to more rapid cognitive decline.
“Increasing degree of frailty was also associated with a faster rate of cognitive decline.”
From Frailty in elderly people (2013) · cites this paper as [30]
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- Authors
- Boyle, P. A., Buchman, A. S., Wilson, R. S., Leurgans, S. E., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2010-01-27
- Volume
- 58
- Issue
- 2
- Pages
- 248-255
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- PMC
- PMC3150526
- OpenAlex
- W1606270551
- Cited by
- 510
- References
- 50
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 32 · 2023: 32 · 2022: 32 · 2021: 38 · 2020: 53 · 2019: 47 · 2018: 36 · 2017: 33 · 2016: 22 · 2015: 26 · 2014: 29 · 2013: 35 · 2012: 22
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG017917, R01‐AG17917, K23AG023040, R01AG024480, R01AG034374)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- physical frailty, mild cognitive impairment, cognitive decline, older adults, grip strength, timed walk, body composition, fatigue, episodic memory, semantic memory, working memory, perceptual speed, visuospatial ability, retirement communities
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Chicago, Cognition Disorders, Female, Humans, Male, Memory Disorders, Prospective Studies, Risk, Comorbidity, Proportional Hazards Models, Frail Elderly
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