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Physical frailty in older persons is associated with Alzheimer disease pathology
Open accessAbstract
OBJECTIVE: We examined the extent to which physical frailty in older persons is associated with common age-related brain pathology, including cerebral infarcts, Lewy body pathology, and Alzheimer disease (AD) pathology. METHODS: We studied brain autopsies from 165 deceased participants from the Rush Memory and Aging Project, a longitudinal clinical-pathologic study of aging. Physical frailty, based on four components, including grip strength, time to walk 8 feet, body composition, and fatigue, was assessed at annual clinical evaluations. Multiple regression analyses were used to examine the relation of postmortem neuropathologic findings to frailty proximate to death, controlling for age, sex, and education. RESULTS: The mean age at death was 88.1 years (SD = 5.7 years). The level of AD pathology was associated with frailty proximate to death ( = 0.252, SE = 0.077, p = 0.001), accounting for 4% of the variance of physical frailty. Neither cerebral infarcts ( = -0.121, SE = 0.115, p = 0.294) nor Lewy body disease pathology ( = 0.07, SE = 0.156, p = 0.678) was associated with frailty. These associations were unchanged after controlling for the time interval from last clinical evaluation to autopsy. The association of AD pathology with frailty did not differ by the presence of dementia, and this association was unchanged even after considering potential confounders, including physical activity; parkinsonian signs; pulmonary function; or history of chronic diseases, including vascular risk factors, vascular disease burden, falls, joint pain, or use of antipsychotic or antihypertensive medications. CONCLUSION: Physical frailty in old age is associated with Alzheimer disease pathology in older persons with and without dementia.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
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Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
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Self-citationFrailty is associated with incident Alzheimer's disease and cognitive decline in the elderly
Buchman, A. S., Boyle, P. A., Wilson, R. S., Tang, Y., & Bennett, D. A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318068de1d · Cited by 420
Self-citationRelation of cognitive activity to risk of developing Alzheimer disease
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Self-citationPerformance-based physical function and future dementia in older people
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Cited by
Religious Orders Study and Rush Memory and Aging Project
Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179939 · Cited by 1,260
Self-citationBoyle, P. A., Buchman, A. S., Wilson, R. S., Leurgans, S. E., & Bennett, D. A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02671.x · Cited by 510
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Rijk, J. M., Roos, P. R., Deckx, L., van den Akker, M., & Buntinx, F. (2016) · Geriatrics & Gerontology International · doi:10.1111/ggi.12508 · Cited by 376
Loss of motor function in preclinical Alzheimer's disease
Buchman, A. S., & Bennett, D. A. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.57 · Cited by 311
Self-citationWallace, L. M. K., Theou, O., Godin, J., Andrew, M. K., Bennett, D. A., & Rockwood, K. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30371-5 · Cited by 310
Self-citationNontraditional risk factors combine to predict Alzheimer disease and dementia
Song, X., Mitnitski, A., & Rockwood, K. (2011) · Neurology · doi:10.1212/wnl.0b013e318225c6bc · Cited by 220
Neuroinflammation and Cognitive Aging
Ownby, R. L. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-009-0082-1 · Cited by 212
James, B. D., Boyle, P. A., Buchman, A. S., Barnes, L. L., & Bennett, D. A. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318211c219 · Cited by 177
Self-citationPhysical activity, common brain pathologies, and cognition in community-dwelling older adults
Buchman, A. S., Yu, L., Wilson, R. S., Lim, A., Dawe, R. J., Gaiteri, C., Leurgans, S. E., Schneider, J. A., & Bennett, D. A. (2019) · Neurology · doi:10.1212/wnl.0000000000006954 · Cited by 108
Self-citationLatimer, C. S., Shively, C. A., Keene, C. D., Jorgensen, M. J., Andrews, R. N., Register, T. C., Montine, T. J., Wilson, A. M., Neth, B. J., Mintz, A., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.06.3057 · Cited by 98
Neuropathologic burden and the degree of frailty in relation to global cognition and dementia
Wallace, L. M. K., Theou, O., Darvesh, S., Bennett, D. A., Buchman, A. S., Andrew, M. K., Kirkland, S. A., Fisk, J. D., & Rockwood, K. (2020) · Neurology · doi:10.1212/wnl.0000000000010944 · Cited by 79
Self-citationRelationship between frailty and Alzheimer's disease biomarkers: a scoping review
Wallace, L., Theou, O., Rockwood, K., & Andrew, M. K. (2018) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.05.002 · Cited by 72
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Abreu, W., Tolson, D., Jackson, G. A., Staines, H., & Costa, N. (2019) · Health & Social Care in the Community · doi:10.1111/hsc.12678 · Cited by 43
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Self-citationWandering Dementia—A Syndrome with Forensic Implications
Byard, R. W., & Langlois, N. E. I. (2019) · Journal of Forensic Sciences · doi:10.1111/1556-4029.13885 · Cited by 33
Metadata
- Authors
- Buchman, A. S., Schneider, J. A., Leurgans, S., & Bennett, D. A.
- Venue
- Neurology
- Published
- 2008-08-12
- Volume
- 71
- Issue
- 7
- Pages
- 499-504
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1978210447
- Cited by
- 259
- References
- 8
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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