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Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders

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Sato, Douglas Kazutoshi, Callegaro, Dagoberto, Lana-Peixoto, Marco Aurelio, Waters, Patrick J., Jorge, Frederico M. de Haidar, Takahashi, Toshiyuki, Nakashima, Ichiro, Apostolos-Pereira, Samira Luisa, Talim, Natalia, Simm, Renata Faria, Lino, Angelina Maria Martins, Misu, Tatsuro, Leite, Maria Isabel, Aoki, Masashi, Fujihara, Kazuo·2014·Neurology

DOI 10.1212/wnl.0000000000000101PMC PMC3937859

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Abstract

OBJECTIVE: To evaluate clinical features among patients with neuromyelitis optica spectrum disorders (NMOSD) who have myelin oligodendrocyte glycoprotein (MOG) antibodies, aquaporin-4 (AQP4) antibodies, or seronegativity for both antibodies. METHODS: Sera from patients diagnosed with NMOSD in 1 of 3 centers (2 sites in Brazil and 1 site in Japan) were tested for MOG and AQP4 antibodies using cell-based assays with live transfected cells. RESULTS: Among the 215 patients with NMOSD, 7.4% (16/215) were positive for MOG antibodies and 64.7% (139/215) were positive for AQP4 antibodies. No patients were positive for both antibodies. Patients with MOG antibodies represented 21.1% (16/76) of the patients negative for AQP4 antibodies. Compared with patients with AQP4 antibodies or patients who were seronegative, patients with MOG antibodies were more frequently male, had a more restricted phenotype (optic nerve more than spinal cord), more frequently had bilateral simultaneous optic neuritis, more often had a single attack, had spinal cord lesions distributed in the lower portion of the spinal cord, and usually demonstrated better functional recovery after an attack. CONCLUSIONS: Patients with NMOSD with MOG antibodies have distinct clinical features, fewer attacks, and better recovery than patients with AQP4 antibodies or patients seronegative for both antibodies.

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Authors: Sato, D. K., Callegaro, D., Lana-Peixoto, M. A., Waters, P. J., Jorge, F. M. D. H., Takahashi, T., Nakashima, I., Apostolos-Pereira, S. L., Talim, N., Simm, R. F., Lino, A. M. M., Misu, T., Leite, M. I., Aoki, M., & Fujihara, K.
Affiliations: Universidade Federal de Minas Gerais (BR)
From the Departments of Neurology (D.K.S., T.T., I.N., M.A.) and Multiple Sclerosis Therapeutics (T.M., K.F.), Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurology (D.C., F.M.d.H.J., S.L.A.-P., R.F.S., A.M.M.L.), Faculty of Medicine, University of São Paulo, Brazil; CIEM MS Research Center (M.A.L.-P., N.T.), Federal University of Minas Gerais Medical School, Belo Horizonte, Brazil; Neuroimmunology Group (P.J.W., M.I.L.), Nuffield Department of Clinical Neurosciences,...
ORCID: Sato, Douglas Kazutoshi
Callegaro, Dagoberto
Waters, Patrick J.
Takahashi, Toshiyuki
Nakashima, Ichiro
Lino, Angelina Maria Martins
Misu, Tatsuro
Leite, Maria Isabel
Aoki, Masashi
Fujihara, Kazuo
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-02-11
Volume: 82
Issue: 6
Pages: 474-481
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0000000000000101
PMC: PMC3937859
OpenAlex: W2103812851
Cited by: 850
References: 21
Citations by year: 2026: 25 · 2025: 41 · 2024: 45 · 2023: 67 · 2022: 69 · 2021: 94 · 2020: 95 · 2019: 83 · 2018: 76 · 2017: 82 · 2016: 66 · 2015: 66 · 2014: 38
FWCI: 62.41
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
Locations: Neurology (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (22229008)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: neuromyelitis optica spectrum disorder, anti-MOG antibodies, aquaporin-4 antibodies, seronegative NMOSD, clinical features, optic neuritis, spinal cord lesions, disease phenotypes, functional recovery, relapse rate
MeSH terms: Adolescent, Adult, Aged, Autoantibodies, Child, Preschool, Female, Humans, Male, Middle Aged, Neuromyelitis Optica, Phenotype, Sex Factors, Aquaporin 4, Young Adult, Myelin-Oligodendrocyte Glycoprotein

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Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders

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