The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI
Open accessAbstract
OBJECTIVES: In Alzheimer disease (AD), mounting evidence points to a greater role for synaptic loss than neuronal loss. Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates and then atrophy before there is substantial loss of the CA1 pyramidal neurons themselves. In this cross-sectional study, we tested whether tissue loss in the CA1 apical neuropil layer can be observed in vivo in patients with mild AD. METHODS: We performed ultra-high-field 7-T MRI on subjects with mild AD (n = 14) and age-matched normal controls (n = 16). With a 2-dimensional T2*-weighted gradient-recalled echo sequence that was easily tolerated by subjects, we obtained cross-sectional slices of the hippocampus at an in-plane resolution of 195 μm. RESULTS: On images revealing the anatomic landmarks of hippocampal subfields and strata, we observed thinning of the CA1 apical neuropil in subjects with mild AD compared to controls. By contrast, the 2 groups exhibited no difference in the thickness of the CA1 cell body layer or of the entire CA1 subfield. Hippocampal volume, measured on a conventional T1-weighted sequence obtained at 3T, also did not differentiate these patients with mild AD from controls. CONCLUSIONS: CA1 apical neuropil atrophy is apparent in patients with mild AD. With its superior spatial resolution, 7-T MRI permits in vivo analysis of a very focal, early site of AD pathology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Normal volume of the CA1 subfield was reported by Lim et al. [31], who used the same automated segmentation protocol used in the present study, and by Kerchner et al. [32], who inferred volume by measuring the thickness of the CA1 subfield”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [32]
In the citing paper
“both of the aforementioned studies included patients whose disease severity was similar to that of our patients (as indicated by MMSE and CDR scores).”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [32]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
Zhang, Y., Brady, M., & Smith, S. M. (2001) · IEEE Transactions on Medical Imaging · doi:10.1109/42.906424 · Cited by 7,628
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.024 · Cited by 2,350
Self-citationPropagation of Tau Misfolding from the Outside to the Inside of a Cell
Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808759200 · Cited by 1,252
(2006) · doi:10.1093/acprof:oso/9780195100273.001.0001 · Cited by 1,186
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123
Frequent amyloid deposition without significant cognitive impairment among the elderly
Aizenstein, H. J., Nebes, R. D., Saxton, J. A., Price, J. C., Mathis, C. A., Tsopelas, N. D., Ziolko, S. K., James, J. A., Snitz, B. E., Houck, P. R., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1509 · Cited by 1,059
Cited by
Sorted by citations
Iglesias, J. E., Augustinack, J. C., Nguyen, K., Player, C. M., Player, A., Wright, M., Roy, N., Frosch, M. P., McKee, A. C., Wald, L. L., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.042 · Cited by 1,267
Yushkevich, P. A., Pluta, J. B., Wang, H., Xie, L., Ding, S., Gertje, E. C., Mancuso, L., Kliot, D., Das, S. R., & Wolk, D. A. (2014) · Human Brain Mapping · doi:10.1002/hbm.22627 · Cited by 587
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Min, S.-W., Chen, X., Tracy, T. E., Li, Y., Zhou, Y., Wang, C., Shirakawa, K., Minami, S. S., Defensor, E., Mok, S. A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3951 · Cited by 516
Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation
Zhang, Y., Dong, Z., Wang, S., Yu, X., Yao, X., Zhou, Q., Hu, H., Li, M., Jiménez-Mesa, C., Ramı́rez, J., et al. (2020) · Information Fusion · doi:10.1016/j.inffus.2020.07.006 · Cited by 461
Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease
de Florès, R., Joie, R. L., & Chételat, G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.033 · Cited by 387
Metadata
- Authors
- Kerchner, G. A., Hess, C. P., Hammond-Rosenbluth, K. E., Xu, D., Rabinovici, G. D., Kelley, D. A. C., Vigneron, D. B., Nelson, S. J., & Miller, B. L.
- Affiliations
- University of California, San Francisco (US)
- From the Stanford Center for Memory Disorders (G.A.K.), Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford; Memory and Aging Center, Department of Neurology (G.A.K., G.D.R., B.L.M.), and Departments of Radiology and of Bioengineering and Therapeutic Sciences (C.P.H., D.X., D.B.V., S.J.N.), University of California, San Francisco; UCSF/UCB Joint Graduate Group in Bioengineering (K.E.H.-R.), University of California, San Francisco, and University of...
- Venue
- Neurology
- Published
- 2010-10-12
- Volume
- 75
- Issue
- 15
- Pages
- 1381-1387
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3013485
- OpenAlex
- W2036550078
- Cited by
- 193
- References
- 39
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 4 · 2021: 10 · 2020: 18 · 2019: 10 · 2018: 10 · 2017: 15 · 2016: 11 · 2015: 19 · 2014: 22 · 2013: 10 · 2012: 11
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Larry L. Hillblom Foundation
- National Institutes of Health
- National Institute on Aging (K23AG031861, P01AG019724)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- Alzheimer's disease, mild Alzheimer disease, hippocampal CA1, synaptic loss, ultra-high field MRI, 7T MRI, hippocampal subfields, hippocampal volume
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Case-Control Studies, Statistics, Nonparametric, Neuropil, CA1 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
