Cited by 193Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAdvanced MRI Techniques and Applications

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Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI

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Kerchner, G.A., Hess, C.P., Hammond-Rosenbluth, K.E., Xu, D., Rabinovici, G.D., Kelley, D.A.C., Vigneron, D.B., Nelson, S.J., Miller, B.L.·2010·Neurology

DOI 10.1212/wnl.0b013e3181f736a1PMC PMC3013485

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Abstract

OBJECTIVES: In Alzheimer disease (AD), mounting evidence points to a greater role for synaptic loss than neuronal loss. Supporting this notion, multiple postmortem studies have demonstrated that the hippocampal CA1 apical neuropil is one of the earliest sites of pathology, exhibiting tau aggregates and then atrophy before there is substantial loss of the CA1 pyramidal neurons themselves. In this cross-sectional study, we tested whether tissue loss in the CA1 apical neuropil layer can be observed in vivo in patients with mild AD. METHODS: We performed ultra-high-field 7-T MRI on subjects with mild AD (n = 14) and age-matched normal controls (n = 16). With a 2-dimensional T2*-weighted gradient-recalled echo sequence that was easily tolerated by subjects, we obtained cross-sectional slices of the hippocampus at an in-plane resolution of 195 μm. RESULTS: On images revealing the anatomic landmarks of hippocampal subfields and strata, we observed thinning of the CA1 apical neuropil in subjects with mild AD compared to controls. By contrast, the 2 groups exhibited no difference in the thickness of the CA1 cell body layer or of the entire CA1 subfield. Hippocampal volume, measured on a conventional T1-weighted sequence obtained at 3T, also did not differentiate these patients with mild AD from controls. CONCLUSIONS: CA1 apical neuropil atrophy is apparent in patients with mild AD. With its superior spatial resolution, 7-T MRI permits in vivo analysis of a very focal, early site of AD pathology.

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Authors: Kerchner, G. A., Hess, C. P., Hammond-Rosenbluth, K. E., Xu, D., Rabinovici, G. D., Kelley, D. A. C., Vigneron, D. B., Nelson, S. J., & Miller, B. L.
Affiliations: University of California, San Francisco (US)
From the Stanford Center for Memory Disorders (G.A.K.), Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford; Memory and Aging Center, Department of Neurology (G.A.K., G.D.R., B.L.M.), and Departments of Radiology and of Bioengineering and Therapeutic Sciences (C.P.H., D.X., D.B.V., S.J.N.), University of California, San Francisco; UCSF/UCB Joint Graduate Group in Bioengineering (K.E.H.-R.), University of California, San Francisco, and University of...
ORCID: Kerchner, G.A.
Hess, C.P.
Xu, D.
Rabinovici, G.D.
Vigneron, D.B.
Nelson, S.J.
Miller, B.L.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-10-12
Volume: 75
Issue: 15
Pages: 1381-1387
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0b013e3181f736a1
PMC: PMC3013485
OpenAlex: W2036550078
Cited by: 193
References: 39
Citations by year: 2026: 9 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 4 · 2021: 10 · 2020: 18 · 2019: 10 · 2018: 10 · 2017: 15 · 2016: 11 · 2015: 19 · 2014: 22 · 2013: 10 · 2012: 11
FWCI: 8.28
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Larry L. Hillblom Foundation
National Institutes of Health
National Institute on Aging (K23AG031861, P01AG019724)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: Alzheimer's disease, mild Alzheimer disease, hippocampal CA1, synaptic loss, ultra-high field MRI, 7T MRI, hippocampal subfields, hippocampal volume
MeSH terms: Aged, Alzheimer Disease, Atrophy, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Case-Control Studies, Statistics, Nonparametric, Neuropil, CA1 Region, Hippocampal

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Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI

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