β-Amyloid burden in healthy aging: Regional distribution and cognitive consequences
Open accessAbstract
OBJECTIVE: Several lines of evidence suggest that pathologic changes underlying Alzheimer disease (AD) begin years prior to the clinical expression of the disease, underscoring the need for studies of cognitively healthy adults to capture these early changes. The overall goal of the current study was to map the cortical distribution of β-amyloid (Aβ) in a healthy adult lifespan sample (aged 30-89), and to assess the relationship between elevated amyloid and cognitive performance across multiple domains. METHODS: A total of 137 well-screened and cognitively normal adults underwent Aβ PET imaging with radiotracer (18)F-florbetapir. Aβ load was estimated from 8 cortical regions. Participants were genotyped for APOE and tested for processing speed, working memory, fluid reasoning, episodic memory, and verbal ability. RESULTS: Aβ deposition is distributed differentially across the cortex and progresses at varying rates with age across cortical brain regions. A subset of cognitively normal adults aged 60 and over show markedly elevated deposition, and also had a higher rate of APOE ε4 (38%) than nonelevated adults (19%). Aβ burden was linked to poorer cognitive performance on measures of processing speed, working memory, and reasoning. CONCLUSIONS: Even in a highly selected lifespan sample of adults, Aβ deposition is apparent in some adults and is influenced by APOE status. Greater amyloid burden was related to deleterious effects on cognition, suggesting that subtle cognitive changes accrue as amyloid progresses.
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A similar proportion of individuals clinically diagnosed as AD dementia have normal amyloid PET or CSF Aβ42 studies.
“and a similar proportion has normal amyloid PET or CSF Aβ42 studies [53–62].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [62]
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- Authors
- Rodrigue, K. M., Kennedy, K. M., Devous, M. D., Rieck, J. R., Hebrank, A. C., Diaz-Arrastia, R., Mathews, D., & Park, D. C.
- Affiliations
- The University of Texas at Dallas (US)
- Venue
- Neurology
- Published
- 2012-02-07
- Volume
- 78
- Issue
- 6
- Pages
- 387-395
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3280058
- OpenAlex
- W2037403969
- Cited by
- 419
- References
- 6
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 25 · 2023: 22 · 2022: 43 · 2021: 31 · 2020: 30 · 2019: 29 · 2018: 28 · 2017: 32 · 2016: 24 · 2015: 32 · 2014: 28 · 2013: 40 · 2012: 19
- FWCI
- 27.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association (IIRG-09-135087)
- National Institutes of Health (AG12300, AG-036848)
- Avid Radiopharmaceuticals (5R37AG-006265)
- National Institute on Aging (3R37AG-006265-25S1, P30AG012300, P30AG-12300, R00AG036848, AG-036848, R00AG036818, 1K99-AG-036848-1, K99AG036848, R37AG006265, AG 12300)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- amyloid-beta, amyloid PET, 18F-florbetapir, healthy aging, Alzheimer's disease, APOE ε4, cognitive performance, processing speed, working memory, fluid reasoning, episodic memory, verbal ability, preclinical Alzheimer's disease
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Cognition, Cognition Disorders, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Radionuclide Imaging, Amyloid beta-Peptides
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