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Cited by 185Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Autoimmune disease preceding amyotrophic lateral sclerosis: An epidemiologic study

Open access
Turner, Martin R., Goldacre, Raph, Ramagopalan, Sreeram, Talbot, Kevin, Goldacre, Michael J.·2013·Neurology
DOI 10.1212/wnl.0b013e3182a6cc13PMC PMC3795611
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Abstract

OBJECTIVE: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease. METHODS: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease. RESULTS: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis. CONCLUSIONS: Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors.

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Crossref · 10.1212/wnl.0b013e3182a6cc13

Cites

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Misclassification of some type 1 diabetes cases as type 2 would most likely have underestimated the real inverse association between type 2 diabetes and ALS risk.

    “Considering that diabetes mellitus type 1 has been shown to have a positive association with the risk of ALS, we expect that the misclassification of some cases of diabetes mellitus type 1 as type 2 would most likely have underestimated the real inverse association between diabetes type 2 and risk of ALS [38, 41].”

    From Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study (2024) · cites this paper as [41]

    The Results passage (page unavailable) reports an increased ALS rate ratio for people whose first recorded diagnosis of insulin-dependent diabetes was before age 30, but not for those with that diagnosis across all ages. The paper does not assess whether misclassifying type 1 diabetes as type 2 would underestimate an inverse association; that is the citing authors’ inference, not a finding of this source. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Diabetes mellitus type 1 has been shown to have a positive association with the risk of ALS.

    “Considering that diabetes mellitus type 1 has been shown to have a positive association with the risk of ALS, we expect that the misclassification of some cases of diabetes mellitus type 1 as type 2 would most likely have underestimated the real inverse association between diabetes type 2 and risk of ALS [38, 41].”

    From Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study (2024) · cites this paper as [41]

    The Results and table (page not available in our copy) report an increased ALS rate ratio for people whose first recorded diagnosis of insulin-dependent diabetes was before age 30. They report no increase for people with a coded diagnosis of insulin-dependent diabetes across all ages, so the unqualified claim about type 1 diabetes is broader than the finding. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Patients with autoimmune diseases showed a slightly increased frequency of developing ALS.

    “Moreover, patients with autoimmune diseases showed a slightly increased frequency of developing ALS.86”

    From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [86]

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Cites

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Research works printed but not linked: 1

  1. Turner MR, Wotton C, Talbot K, Goldacre MJ. Cardio- vascular fitness as a risk factor for amyotrophic lateral scle- rosis: indirect evidence from record linkage study. J Neurol Neurosurg Psychiatry 2012;83:395-398.

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Authors
Turner, M. R., Goldacre, R., Ramagopalan, S., Talbot, K., & Goldacre, M. J.
Affiliations
John Radcliffe Hospital (GB)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-10
Volume
81
Issue
14
Pages
1222-1225
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0b013e3182a6cc13
PMC
PMC3795611
OpenAlex
W2167295920
Cited by
185
References
28
Citations by year
2026: 2 · 2025: 13 · 2024: 12 · 2023: 13 · 2022: 22 · 2021: 19 · 2020: 19 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 18 · 2015: 20 · 2014: 11 · 2013: 2
FWCI
10.80
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Motor Neurone Disease Association (TURNER/JAN13/944-795)
  • Medical Research Council (MR/K01014X/1)
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
amyotrophic lateral sclerosis, autoimmune disease, asthma, celiac disease, multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren's syndrome, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes, ALS incidence, genetic risk factors, environmental risk factors
MeSH terms
Amyotrophic Lateral Sclerosis, Autoimmune Diseases, England, Female, Hospital Records, Humans, Male, Risk, Cohort Studies, Comorbidity, Incidence

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