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Amitriptyline versus placebo in postherpetic neuralgia
Abstract
To study the effects of amitriptyline in treating postherpetic neuralgia, 24 patients were randomly assigned to either drug or placebo in a double-blind crossover study. We found good to excellent pain relief in 16 of 24 patients (p less than or equal to 0.001). We did not find an antidepressant effect in most patients (p greater than 0.05). The median dose of amitriptyline was 75 mg. The median blood level was 65 ng per milliliter, and of nortriptyline 30 ng per milliliter. Good responses were maintained in 12 of 22 patients. Amitriptyline is useful in treating postherpetic neuralgia and may not act as an antidepressant.
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Cited by
Complex Regional Pain Syndromes: Guidelines for Therapy
Stanton-Hicks, M., Baron, R., Boas, R., Gordh, T., Harden, N., Hendler, N., Koltzenburg, M., Raj, P., & Wilder, R. (1998) · The Clinical Journal of Pain · doi:10.1097/00002508-199806000-00012 · Cited by 378
Amitriptyline for neuropathic pain and fibromyalgia in adults
Moore, R. A., Derry, S., Aldington, D., Cole, P., & Wiffen, P. J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008242.pub2 · Cited by 293
Lim, G., Sung, B., Ji, R.-R., & Mao, J. (2003) · Pain · doi:10.1016/s0304-3959(03)00242-2 · Cited by 195
McCleane, G. (2008) · CNS Drugs · doi:10.2165/00023210-200822020-00005 · Cited by 109
Merskey, H. (1989) · The Canadian Journal of Psychiatry · doi:10.1177/070674378903400413 · Cited by 61
Self-citation
Metadata
- Authors
- Watson, C. P., Evans, R. J., Reed, K., Merskey, H., Goldsmith, L., & Warsh, J.
- Venue
- Neurology
- Published
- 1982-06
- Volume
- 32
- Issue
- 6
- Pages
- 671-671
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2150883260
- Cited by
- 559
- References
- 0
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Watson, C. P., Evans, R. J., Reed, K., Merskey, H., Goldsmith, L., & Warsh, J. (1982). Amitriptyline versus placebo in postherpetic neuralgia. Neurology. https://doi.org/10.1212/wnl.32.6.671
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
