Cited by 279Multiple Sclerosis Research StudiesNeural and Behavioral Psychology StudiesDementia and Cognitive Impairment Research

The DOI matches its Crossref record.

Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis

Arnett, P. A., Rao, S. M., Bernardin, L., Grafman, J., Yetkin, F. Z., Lobeck, L.·1994·Neurology

DOI 10.1212/wnl.44.3_part_1.420

Open this paper in CoChat — free account

Abstract

Conceptual reasoning deficits are common in patients with multiple sclerosis (MS) and are typically associated with focal lesions involving the frontal lobes. In this study, we predicted that MS patients with frontal white matter lesions (MS-F) would be more impaired on a standard conceptual reasoning task (Wisconsin Card Sorting Test; WCST) than patients with minimal frontal lesions (MS-NF), even if the total cerebral lesion area (TLA), measured from MRI, was equivalent across groups. We subdivided 43 definite MS patients into three groups based on MRI findings: seven in the MS-F group (mean TLA = 41.4 cm2) and seven in the MS-NF group (mean TLA = 50.0 cm2); 29 MS patients served as a low lesion burden control group (MS-C; mean TLA = 6.4 cm2). The groups did not differ with regard to demographic and illness characteristics. Although the three subgroups obtained comparable scores on a measure of global cognitive functioning (verbal intelligence), the MS-F group achieved significantly fewer categories and made more total errors on the WCST than did the MS-NF and MS-C groups. The MS-F group made significantly more perseverative responses than the MS-C group and nonsignificantly more than the MS-NF group. These results suggest that the pattern of cognitive decline in MS is a function of the location of demyelinating lesions within the cerebral hemispheric white matter. Finally, we supplement the group study results with a case report of an MS patient who was studied serially with MRI and cognitive testing.

Integrity signals

Registry

Crossref · 10.1212/wnl.44.3_part_1.420

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 279

Cognitive functioning in multiple sclerosis.
Julian, L. (2011) · Neurologic clinics · doi:10.1016/j.ncl.2010.12.003 · Cited by 31
Short-Term Cognitive Training Improves Mental Efficiency and Mood in Patients with Multiple Sclerosis
Brenk, A., Laun, K., & Haase, C. G. (2008) · European Neurology · doi:10.1159/000157885 · Cited by 57
Cognitive and neuropsychiatric disease manifestations in MS.
Feinstein, A., DeLuca, J., Baune, B., Filippi, M., & Lassman, H. (2013) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2012.08.001 · Cited by 68
“Other studies demonstrated an association between lesion location (e.g., the frontal lobes, parieto-occipital lobes) and specific patterns of cognitive decline (Swirsky-Sacchetti et al., 1992; Arnett et al., 1994).”
Background
Patterns of cognitive impairment in relapsing-remitting multiple sclerosis and their relationship to neuropathology on magnetic resonance images.
Ryan, L., Clark, C. M., Klonoff, H., Li, D., & Paty, D. (1996) · Neuropsychology · doi:10.1037/0894-4105.10.2.176 · Cited by 58
Metamemory in multiple sclerosis: exploring affective and executive contributors
Randolph, J. J. (2003) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(03)00026-x · Cited by 53
“X Downloaded from https://academic.oup.com/acn/article-abstract/19/2/259/2388 by guest on 30 July 2018”
MethodResult
Possible Contributions of Myelin and Oligodendrocyte Dysfunction to Schizophrenia
Stewart, D. G., & Davis, K. L. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59015-3 · Cited by 54
Exploration of the relationships between regional grey matter atrophy and cognition in multiple sclerosis
Nocentini, U., Bozzali, M., Spanò, B., Cercignani, M., Serra, L., Basile, B., Mannu, R., Caltagirone, C., & Luca, J. D. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9170-7 · Cited by 52
“One of the working hypotheses in MS research is that cognitive decline is associated with the extent of lesion load, as suggested by some previous studies (Arnett et al. 1994; Camp et al. 1999; Benedict et al. 2002, 2005).”
Result
Cognitive but Not Affective Theory of Mind Deficits in Mild Relapsing-Remitting Multiple Sclerosis
Roca, M., Manes, F., Gleichgerrcht, E. L., Ibáñez, A. M., de Toledo, M. E. G., Marenco, V., Bruno, D., Torralva, T., & Sinay, V. J. (2014) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000017 · Cited by 54
Wisconsin card sorting test synchronizes the prefrontal, temporal and posterior association cortex in different frequency ranges and extensions
González-Hernández, J. A., Pita-Alcorta, C., Cedeño, I., Bosch‐Bayard, J., Galán‐Garcia, L., Scherbaum, W. A., & Figueredo-Rodríguez, P. (2002) · Human Brain Mapping · doi:10.1002/hbm.10051 · Cited by 50
“Many clinical studies suggest that patients with frontal lobe lesions, especially in the DLPFC, show greater impairment on the WCST than patients with lesions in other areas [Arnett et al., 1994].”
Background
Memory dysfunction in multiple sclerosis corresponds to juxtacortical lesion load on fast fluid-attenuated inversion-recovery MR images.
Moriarty, D. M., Blackshaw, A. J., Talbot, P. R., Griffiths, H. L., Snowden, J. S., Hillier, V. F., Capener, S., Laitt, R. D., & Jackson, A. (1999) · PubMed Central · Cited by 51
Multiple sclerosis: Cognition and saccadic eye movements
Fielding, J., Kilpatrick, T. J., Millist, L., & White, O. B. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.10.001 · Cited by 50
“Cognitive deficits in MS have been conventionally attributed to slowed conduction, a result of WM pathology [11–13], although correlations between cognitive status and T2-weighted MRI or microscopic tissue damage have been quite modest [12–16].”
Background
The Effects of SARS-CoV-2 Infection on the Cognitive Functioning of Patients with Pre-Existing Dementia
Dubey, S., Das, S., Ghosh, R., Dubey, M. J., Chakraborty, A. P., Roy, D., Das, G. C., Dutta, A., Santra, A., Sengupta, S., et al. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220090 · Cited by 51
Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis
Welton, T., Kent, D., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2014) · Radiology · doi:10.1148/radiol.14140925 · Cited by 46
Anosognosia and patterns of impaired self-awareness observed in clinical practice
Prigatano, G. P. (2014) · Cortex · doi:10.1016/j.cortex.2014.07.014 · Cited by 59
A multiparametric MRI study of frontal lobe dementia in multiple sclerosis
Comi, G., Rovaris, M., Falautano, M., et al. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00266-x · Cited by 47
Fatigue, emotional functioning, and executive dysfunction in pediatric multiple sclerosis
Holland, A. A., Graves, D. F., Greenberg, B. M., & Harder, L. L. (2012) · Child Neuropsychology · doi:10.1080/09297049.2012.748888 · Cited by 43
“Prior research suggests that greater frontal lobe lesion burden and atrophy are associated with worse executive functioning in adult-onset MS (Arnett et al., 1994; Benedict et al., 2002; Foong et al., 1997, 1999; Holtzer & Foley, 2009).”
Background
Metacognition and self-awareness in Multiple Sclerosis
Mazancieux, A., Souchay, C., Casez, O., & Moulin, C. J. A. (2018) · Cortex · doi:10.1016/j.cortex.2018.11.012 · Cited by 45
Verbal abstraction deficit in multiple sclerosis.
Beatty, W. W., Hames, K. A., Blanco, C. R., Paul, R. H., & Wilbanks, S. L. (1995) · Neuropsychology · doi:10.1037/0894-4105.9.2.198 · Cited by 44
MR imaging quantitation of gray matter involvement in multiple sclerosis and its correlation with disability measures and neurocognitive testing.
Catalaa, I., Fulton, J. C., Zhang, X., Udupa, J. K., Kolson, D. L., Grossman, M., Wei, L., McGowan, J. C., Polansky, M., & Grossman, R. I. (1999) · PubMed Central · Cited by 43
White matter dementia
Filley, C. M. (2012) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285612454323 · Cited by 45
Executive functions in multiple sclerosis: An analysis of temporal ordering, semantic encoding, and planning abilities.
Arnett, P. A., Rao, S. M., Grafman, J. H., Bernardin, L., Luchetta, T., Binder, J. R., & Lobeck, L. J. (1997) · Neuropsychology · doi:10.1037//0894-4105.11.4.535 · Cited by 46
Self-citation
Age-Associated Memory Impairment
Hänninen, T., & Soininen, H. S. (1997) · Drugs & Aging · doi:10.2165/00002512-199711060-00007 · Cited by 42
Neuropsychological assessment of fitness to drive following acquired cognitive impairment
Bliokas, V. V., Taylor, J. E., Leung, J., et al. (2011) · Brain Injury · doi:10.3109/02699052.2011.559609 · Cited by 41
“Several studies using functional PET or SPECT and MRI imaging have supported the sensitivity of the test to frontal lobe functioning [63, 65, 66].”
Background
Cognitive dysfunction evaluation in multiple sclerosis patients treated with interferon beta-1b: an open-label prospective 1 year study.
Flechter, S., Vardi, J., Finkelstein, Y., et al. (2007) · PubMed · Cited by 41
Psychiatric Manifestations of Multiple Sclerosis: A Review
Rodgers, J., & Bland, R. C. (1996) · The Canadian Journal of Psychiatry · doi:10.1177/070674379604100709 · Cited by 41
“Results of an investigation by Arnett and others (24) suggest a relationship between frontal lobe white matter lesions in MS patients and impaired conceptual reasoning skill as measured by the Wisconsin Card Sorting Test.”
Background
Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patterns
Tiemann, L., Penner, I., Haupts, M. R., et al. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509106853 · Cited by 40
Corpus Callosum Microstructural Changes Correlate with Cognitive Dysfunction in Early Stages of Relapsing-Remitting Multiple Sclerosis: Axial and Radial Diffusivities Approach
Rimkus, C. D. M., Junqueira, T. D. F., Lyra, K., Jackowski, M. P., Machado, M. A. R., Miotto, E. C., Callegaro, D., Otaduy, M. C. G., & Leite, C. D. C. (2011) · Multiple Sclerosis International · doi:10.1155/2011/304875 · Cited by 39
Neurobehavioral Effects of Acute Exposure to Inorganic Mercury Vapor
Haut, M. W., Morrow, L. A., Pool, D., Callahan, T. S., Haut, J. S., & Franzen, M. D. (1999) · Applied Neuropsychology · doi:10.1207/s15324826an0604_1 · Cited by 39
Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats
Cowen, S. L., Phelps, C. E., Navratilova, E., McKinzie, D. L., Okun, A., Husain, O., Gleason, S. D., Witkin, J. M., & Porreca, F. (2018) · Pain · doi:10.1097/j.pain.0000000000001226 · Cited by 38
Self-reported executive dysfunction, neuropsychological impairment, and functional outcomes in multiple sclerosis
Basso, M. R., Shields, I., Lowery, N., Ghormley, C. O., Combs, D. R., Arnett, P. A., & Johnson, J. (2008) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390801888733 · Cited by 38
“Indeed, frontal lobe lesions emerge as potent and specific predictors of impaired executive function in MS (Arnett et al., 1994; Swirsky-Sacchetti et al., 1992).”
BackgroundSelf-citation
Cognitive strategies application of multiple sclerosis patients
Birnboim, S., & Miller, A. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms980oa · Cited by 42
Object Working Memory Performance Depends on Microstructure of the Frontal-Occipital Fasciculus
Walsh, M., Montojo, C. A., Sheu, Y.-S., Marchette, S. A., Harrison, D. M., Newsome, S. D., Zhou, F., Shelton, A. L., & Courtney, S. M. (2011) · Brain Connectivity · doi:10.1089/brain.2011.0037 · Cited by 37
“Previous studies of the cognitive effects of frontal lobe lesions, both related and not related to MS, have shown mixed results (Arnett et al., 1994; Bobholz et al., 2006; Dineen et al., 2009; Mesaros et al., 2008; Morgen et al., 2006; Morgen et al., 2007; Owen et al., 1996; Sepulcre et al., 2008).”
Cognitive dysfunction in pediatric multiple sclerosis
Suppiej, A., & Cainelli, E. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s48495 · Cited by 36
Specificity of frontal dysfunctions in relapsing–remitting multiple sclerosis
SANTIAGO, O., GUARDIA, J., Casado, V., Carmona, O., & Arbizu, T. (2007) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2007.04.003 · Cited by 35
Towards patient collaboration in cognitive assessment: Specificity, sensitivity, and incremental validity of self-report
Schwartz, C. E., Kozora, E., & Zeng, Q. (1996) · Annals of Behavioral Medicine · doi:10.1007/bf02883395 · Cited by 36
Epidemiology of disabling neurological disease: how and why does disability occur?
Wade, D. T. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.3.242 · Cited by 36
Neuropsychologic profile of college students with schizotypal traits
Kim, M., Oh, S. H., Hong, M.-H., & Choi, D. B. (2010) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2010.10.010 · Cited by 32
Cortical sources of resting state electroencephalographic rhythms differ in relapsing–remitting and secondary progressive multiple sclerosis
Babiloni, C., Percio, C. D., Capotosto, P., Noce, G., Infarinato, F., Muratori, C., Marcotulli, C., Bellagamba, G., Righi, E., Soricelli, A., et al. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.05.029 · Cited by 31
“On one hand, structural and functional MRI studies showed vascular lesions and abnormal BOLD activity in MS patients compared to healthy control (HC) subjects, as a function of disease onset and cognitive impairment (Swirsky-Sacchetti et al., 1992; Arnett et al., 1994; Morgen et al., 2006; Calabrese et al., 2010).”
Background
MRI and cognition in multiple sclerosis
Filippi, M., & Rocca, M. A. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0367-5 · Cited by 33
MRI correlates of cognitive dysfunction in multiple sclerosis patients.
Rovaris, M., & Filippi, M. (2000) · PubMed · Cited by 33
Induced oscillations and the distributed cortical sources during the Wisconsin card sorting test performance in schizophrenic patients: new clues to neural connectivity
González-Hernández, J. A., Cedeño, I., Pita-Alcorta, C., Galán, L., Aubert, E., & Figueredo-Rodríguez, P. (2003) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(03)00019-9 · Cited by 32
“Many clinical studies suggest that patients with frontal lobe lesions, especially in the DLPFC, show greater impairment on the WCST than patients with lesions in other areas (Arnett et al., 1994).”
Background
Behavioral evidence for working memory of sensory dimension in macaque monkeys
Mansouri, F. A., & Tanaka, K. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00182-1 · Cited by 32
Effects of caffeine on cognitive and autonomic measures in heavy and light caffeine consumers
Lyvers, M., Brooks, J., & Matica, D. (2004) · Australian Journal of Psychology · doi:10.1080/00049530410001688119 · Cited by 30
“Arnett et al. (1994) suggest that such skills include "selective, sustained, or divided attention; working or long-term memory; or speed of information-processing" (p.”
Background
Magnetic Resonance Imaging Predictors of Executive Functioning in Patients with Pediatric-Onset Multiple Sclerosis
Till, C., Ho, C., Dudani, A., García-Lorenzo, D., Collins, D. L., & Banwell, B. (2012) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acs058 · Cited by 29
“…in MS. Studies in adult MS patients show moderate correlations between T2-weighted lesion load in the frontal lobe and executive dysfunction (Arnett et al., 1994; Foong et al., 1997; Foong et al., 1999; Swirsky-Sacchetti et al., 1992), in support of the prefrontal cortex in its role as the…”
Background
Influence of cerebral lesion volume and lesion distribution on event-related brain potentials in multiple sclerosis
Sailer, M., Heinze, H. –., Tendolkar, I., Decker, U., Kreye, O., Rolbicki, U. V., & Münte, T. F. (2001) · Journal of Neurology · doi:10.1007/s004150170024 · Cited by 29
“The slope was significantly different from zero (F [1, 32]=20.”
Interferon Beta 1-B in Verbal Memory Functioning of Patients with Relapsing-Remitting Multiple Sclerosis
Selby, M. J. P., Ling, N. D., Williams, J. M., et al. (1998) · Perceptual and Motor Skills · doi:10.2466/pms.1998.86.3.1099 · Cited by 29
Cognitive dysfunction in primary progressive multiple sclerosis: a neuropsychological and MRI study
Ukkonen, M., Vahvelainen, T., Hämäläinen, P. I., et al. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509106231 · Cited by 28
Whole-brain N-acetylaspartate concentration: correlation with T2-weighted lesion volume and expanded disability status scale score in cases of relapsing-remitting multiple sclerosis.
Bonneville, F., Moriarty, D. M., Li, B. S. Y., et al. (2002) · PubMed · Cited by 28
Multiple Sclerosis Decreases Explicit Counterfactual Processing and Risk Taking in Decision Making
Simioni, S., Schluep, M., Bault, N., Coricelli, G., Kleeberg, J., Pasquier, R. D., Gschwind, M., Vuilleumier, P. O., & Annoni, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050718 · Cited by 30
“Several studies have demonstrated deficits in frontal lobe functions, including impaired working memory [2], diminished verbal fluency [3], increased sensitivity to interference [3] and impaired conceptual reasoning [4].”
Case—Control Studies of Cardiovascular Medications as Risk Factors for Clinically Diagnosed Depressive Disorders in a Hospitalized Population
Patten, S. B., Williams, J. V. A., & Love, E. J. (1996) · The Canadian Journal of Psychiatry · doi:10.1177/070674379604100713 · Cited by 25
Age-Related Differences in the Reliance on Executive Control in Working Memory: Role of Task Demand
Isingrini, M. L., Angel, L., Fay, S., Taconnat, L., Lemaire, P., & Bouazzaoui, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145361 · Cited by 26
“A structural MRI study [34] and a study of patients with frontal lobe lesions [35] demonstrated that the Wisconsin Card Sorting TestModified is associated with prefrontal cortex regions.”
Background
Neuroimaging of Dementia
Bertelson, J. A., & Ajtai, B. (2013) · Neurologic Clinics · doi:10.1016/j.ncl.2013.07.001 · Cited by 22
Does Diet Have a Role in the Treatment of Alzheimer's Disease?
Thelen, M., & Brown‐Borg, H. M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.617071 · Cited by 24
“Executive function requires higher order cognition such as planning, reasoning, and cognitive flexibility and is observed in humans through tests such as the Wisconsin Card Sorting Task (Drewe, 1974; Robinson et al., 1980; Arnett et al., 1994).”
Method
Assessment of the damage of the cerebral hemispheres in MS using neuroimaging techniques
Comi, G., Rovaris, M., Leocani, L., et al. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00282-8 · Cited by 23
Functional lateralization of the prefrontal cortex during traditional frontal lobe tasks
Horn, J. D. V., Berman, K. F., & Weinberger, D. R. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00249-9 · Cited by 23
The Complex Interplay Between Trait Fatigue and Cognition in Multiple Sclerosis
Guillemin, C., Lommers, É., Delrue, G., Gester, E., Maquet, P., & Collette, F. (2022) · Psychologica Belgica · doi:10.5334/pb.1125 · Cited by 23
An Investigation of the Reliability and Self-Regulatory Correlates of Conflict Adaptation
Feldman, J. L., & Freitas, A. L. (2016) · Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) · doi:10.1027/1618-3169/a000328 · Cited by 21
Identification of neuroanatomical substrates of set-shifting ability: evidence from patients with focal brain lesions
Mukhopadhyay, P., Dutt, A., Das, S. K., Basu, A., Hazra, A., Dhibar, T., & Roy, T. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)68008-x · Cited by 22
Right frontal event related EEG coherence (ERCoh) differentiates good from bad performers of the Wisconsin Card Sorting Test (WCST)
Carrillo‐de‐la‐Peña, M. T., & Garcı́a-Larrea, L. (2007) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2007.02.002 · Cited by 22
The relationship between executive functions and fluid intelligence in multiple sclerosis
Goitia, B., Bruno, D., Abrevaya, S., Sedeño, L., Ibáñez, A. M., Manes, F. F., Sigman, M., Sinay, V. J., Torralva, T., Duncan, J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231868 · Cited by 21
Frontal White Matter Damage Impairs Response Inhibition in Children Following Traumatic Brain Injury
Lipszyc, J., Levin, H., Hanten, G., Hunter, J., Dennis, M., & Schachar, R. (2014) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acu004 · Cited by 20
The Face-Symbol Test and the Symbol-Digit Test are not reliable surrogates for the Paced Auditory Serial Addition Test in multiple sclerosis
Williams, J. R., O’Rourke, K., Hutchinson, M., & Tubridy, N. J. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070752 · Cited by 20
“Some correlation has been observed between the extent of abnormalities in the cerebral white matter detected by MRI and the severity of cognitive symptoms [12].”
Background
Cortical deficits in multiple sclerosis on the basis of subcortical lesions
Jeffery, D., Absher, J. R., Pfeiffer, F. E., et al. (2000) · Multiple Sclerosis Journal · doi:10.1177/135245850000600110 · Cited by 20
Functional and structural brain MRI changes associated with cognitive worsening in multiple sclerosis: a 3-year longitudinal study
Azzimonti, M., Preziosa, P., Pagani, E., Valsasina, P., Tedone, N., Vizzino, C., Rocca, M. A., & Filippi, M. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11778-z · Cited by 21
Structural brain indices and executive functioning in multiple sclerosis: A review
Román, C. A. F., & Arnett, P. A. (2016) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2015.1105199 · Cited by 19
“Arnett et al. (1994), for example, examined performance on theWCST between individuals with MS with a high ratio of frontal white matter lesions (MS-F), those with a low ratio of frontal white matter lesions (MS-NF), and an MS control group (MS-C) with minimal lesions overall.”
BackgroundSelf-citation
Cognitive Rehabilitation for Multiple Sclerosis Patients With Executive Dysfunction
Birnboim, S., & Miller, A. (2004) · Cited by 18
Neuropsychological Deficits but Not Coping Strategies Are Related to Physical Disability in Multiple Sclerosis
Haase, C. G., Lienemann, M., & Faustmann, P. M. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0759-6 · Cited by 18
“Those deficits have been attributed to lesions in frontal and temporal lobes of MS-patients [4, 5], supported by the evidence that the right temporal lobe supports visual memory performance whereas the left temporal lobe supports verbal memory performance, preferentially [3–5, 38].”
Result
Relación entre la sustancia blanca y las funciones cognitivas
Ustárroz, J. T., Luna-Lario, P., Goñi, P. H., & Suescun, I. G. (2011) · Revista de Neurología · doi:10.33588/rn.5212.2010554 · Cited by 19
“Arnett et al [157] publicaron la primera demostración incontes table de que problemas particulares de cognición en la esclerosis múltiple se asocian con lesiones de la sustancia blanca en determinadas regiones cerebra les.”
Background
Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis
Woolmore, J. A., Stone, M., Holley, S. L., Jenkinson, P. M., W.A., I. G. A. K. C. A., Jones, P., Fryer, A. A., Strange, R. C., Stephens, R., Langdon, D. W., et al. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458507081343 · Cited by 17
“tracts, which subserve cognitive functions [4,5].”
Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes
Chitnis, T., Vandercappellen, J., King, M., & Brichetto, G. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00368-2 · Cited by 19
“[22-179] [44, 49, 63, 69, 93, 116, 120, 174-176, 180-227] [36, 39, 49, 63, 92, 100, 120, 129, 130, 192, 196-198, 201, 202, 204, 208, 228246] [63, 192, 247-251]”
Flight training changes the brain functional pattern in cadets
Chen, X., Wang, Z., Jiang, H., Yu, M., Wang, H., Li, Y., Xu, K., Yang, J., & Luo, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1120628 · Cited by 16
Deconstructing spatial working memory and attention deficits in multiple sclerosis.
Gmeindl, L., & Courtney, S. M. (2011) · Neuropsychology · doi:10.1037/a0026213 · Cited by 16
“Based on bilateral cortical atrophy and the spread of lesions across white-matter tracts connecting distant cortical regions in both hemispheres (Arnett et al., 1994; Benedict et al., 2002; Morgen et al., 2006, Swirsky-Sacchetti et al., 1992), one would expect that spatial WM, like verbal WM, would be impaired in MS.”
Improvement in word-fluency performance in patients with multiple sclerosis by electromagnetic fields
Sandyk, R. (1994) · International Journal of Neuroscience · doi:10.3109/00207459408986069 · Cited by 16
Updating Information in Verbal Working Memory and Executive Functioning
Doiseau, F., & Isingrini, M. L. (2005) · Psychological Reports · doi:10.2466/pr0.96.1.67-76 · Cited by 16
[Neuropsychological profile of multiple sclerosis].
Arango‐Lasprilla, J. C., DeLuca, J., & Chiaravalloti, N. D. (2007) · PubMed · Cited by 16
Clinical and MRI assessment of brain damage in MS
Comi, G., Rovaris, M., Leocani, L., et al. (2001) · Neurological Sciences · doi:10.1007/s100720100049 · Cited by 15
“Several studies assessed, using conventional T2-weighted scanning, whether specific patterns of cognitive decline were the result of lesion location in specific sites of the hemispheric white matter [14, 15, 17, 18, 21].”
BackgroundResult
Relationship Between Global Cognitive Decline and Depressive Symptoms in Multiple Sclerosis
Barwick, F. H., & Arnett, P. A. (2011) · The Clinical Neuropsychologist · doi:10.1080/13854046.2010.538435 · Cited by 14
Self-citation
Brain Activation of Negative Feedback in Rule Acquisition Revealed in a Segmented Wisconsin Card Sorting Test
Wang, J., Cao, B., Cai, X., Gao, H., & Li, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140731 · Cited by 13
Neurocognitive and emotional status after one-year of mindfulness-based intervention in patients with relapsing-remitting multiple sclerosis
la Torre, G. G. D., Mato, I., Doval, S., Espinosa, R., Moya, M. A., Cantero, R., González, M., Gonzalez, C., Garcia, M. A., Hermans, G., et al. (2020) · Applied Neuropsychology Adult · doi:10.1080/23279095.2020.1732388 · Cited by 14
“The way in which the disease is disseminated gives rise not only to physical symptoms but also to cognitive effects (Arnett et al., 1994).”
BackgroundInfluential
Kognitive Defizite bei Multipler Sklerose
Engel, C., Greim, B., & Zettl, U. K. (2005) · Der Nervenarzt · doi:10.1007/s00115-005-1901-1 · Cited by 14
Denial or unawareness of cognitive deficit associated with multiple sclerosis? A case report
Prigatano, G., Hendin, B., & Heiserman, J. (2014) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2014.890700 · Cited by 13
“The neuropsychological test findings also were suggestive of “executive” dysfunction commonly observed in MS patients with frontal lobe pathology (Arnett et al., 1994; Foong et al., 1997).”
Background
Neuropsychology of the Prefrontal Cortex
Grafman, J. H. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-092668-1.50014-4 · Cited by 16
Self-citation
Treatment with electromagnetic fields improves dual-task performance (Talking while walking) in multiple sclerosis
Sandyk, R. (1997) · International Journal of Neuroscience · doi:10.3109/00207459708986393 · Cited by 13
Subcortical gray matter atrophy is associated with cognitive deficit in multiple sclerosis but not in systemic lupus erythematosus patients
Kalinowska, A., Pawlak, M. A., Pietrzak, A., et al. (2017) · Lupus · doi:10.1177/0961203317735186 · Cited by 13
Multiple Sclerosis
Khoury, S. J., & Weiner, H. L. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.6.565 · Cited by 13
“Moreover, the pattern of cognitive impairment in MS depends on the location of the cerebral lesions, with frontal lobe lesions correlating with impaired conceptual reasoning.(73)”
Background
Normative data for two neuropsychological tests sensitive to frontal dysfunction
Pomati, S., Farina, E., Magni, E., et al. (1996) · Neurological Sciences · doi:10.1007/bf01995684 · Cited by 13
Neuropsychological Correlates of Anger, Hostility, and Relationship-Relevant Distortions in Thinking among Partner Violent Men
Persampiere, J., Poole, G. M., & Murphy, C. M. (2014) · Journal of Family Violence · doi:10.1007/s10896-014-9614-5 · Cited by 12
“Neuro-imaging studies provide further evidence the WCST-128 is sensitive to frontal lobe functioning (e.g., Arnett et al. 1993; Anderson et al. 1995).”
Background
Resolution of Left Hemisphere Cognitive Dysfunction in Multiple Sclerosis with Magnetic Resonance Correlates: A Case Report
Rozewicz, L. (1996) · Cognitive Neuropsychiatry · doi:10.1080/135468096396677 · Cited by 12
Detecting Cognitive Dysfunction in Multiple Sclerosis with a Magnetic Resonance Imaging Rating Scale: A Pilot Study
Chamelian, L., Bocti, C., Gao, F.-Q., Black, S., & Feinstein, A. (2005) · CNS Spectrums · doi:10.1017/s1092852900022768 · Cited by 11
How the Conflict between American Psychiatry and Neurology Delayed the Appreciation of Cognitive Dysfunction in Multiple Sclerosis
Butler, M. A., Corboy, J. R., & Filley, C. M. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9089-y · Cited by 11
“Many studies have reported total lesion burden on MRI predicts cognitive impairment as assessed neuropsychologically (Arnett et al. 1994; Comi et al. 1993; Patti et al. 1995; Richardson et al. 1997; Ryan et al. 1996), and in general, cognitive loss becomes more severe as plaque burden and cerebral atrophy advance (Fil…”
Background
The role of magnetic resonance in the assessment of multiple sclerosis
Rovaris, M., & Filippi, M. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00270-1 · Cited by 11
Disorders Primarily Affecting White Matter
Valk, J., Barkhof, F., & Scheltens, P. (2002) · Springer eBooks · doi:10.1007/978-3-642-56269-3_5 · Cited by 11
Association between regional cerebral blood flow and eye-tracking performance and the Wisconsin Card Sorting Test in schizophrenics: a single photon emission computed tomography study
Yang, Y. K., Chen, C. C., Lee, I. H., et al. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00021-0 · Cited by 11
“It has been well documented that patients with frontal lobe lesions show greater impairment on the WCST than patients with lesions in other areas (Milner, 1963; Arnett et al., 1994).”
Background
Bipedal hopping timed to a metronome to detect impairments in anticipatory motor control in people with mild multiple sclerosis
Kirkland, M. C., Chen, A., Downer, M. B., Holloway, B. J., Wallack, E. M., Lockyer, E. J., Buckle, N. C. M., Abbott, C. L., & Ploughman, M. (2018) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2018.04.009 · Cited by 11
Skeletonized mean diffusivity and neuropsychological performance in relapsing‐remitting multiple sclerosis
Chylińska, M., Karaszewski, B., Komendziński, J., Wyszomirski, A., Sabisz, A., Hałas, M., & Szurowska, E. (2022) · Brain and Behavior · doi:10.1002/brb3.2591 · Cited by 9
“Moreover, focal disruption of crucial functional brain networks due to axonal transection or demyelination could be critical for particular cognitive dysfunction (Arnett et al. 1994; da Silva et al., 2020; Tewarie et al., 2014).”
Background
Recommendations for the detection and therapeutic management of cognitive impairment in multiple sclerosis
Bensa, C., Bodiguel, E., Brassat, D., et al. (2012) · Revue Neurologique · doi:10.1016/j.neurol.2012.02.009 · Cited by 10
Contribution des fonctions exécutives et de la vitesse de traitement au vieillissement de la mémoire épisodique
Clarys, D., Souchay, C., Baudouin, A., Fay, S., Vanneste, S., Taconnat, L., & Isingrini, M. L. (2007) · L’Année psychologique · doi:10.4074/s0003503307001029 · Cited by 10
Executive Control Function in Psychiatric and Medical Illness
Schillerstrom, J. E. (2002) · Journal of Psychiatric Practice · doi:10.1097/00131746-200205000-00005 · Cited by 9
Neuropsychological assessment in multiple sclerosis: methodological issues and concerns
Hutchinson, J., Burke, T., & Hutchinson, M. (1996) · Multiple Sclerosis Journal · doi:10.1177/135245859600200201 · Cited by 10
Cognitive dysfunction in MS: bridging the gap between neurocognitive deficits, neuropsychological batteries and MRI
Grazioli, E., Yeh, E. A., Benedict, R. H. B., Parrish, J. B., & Weinstock‐Guttman, B. (2007) · Future Neurology · doi:10.2217/14796708.3.1.49 · Cited by 8
“(1994) QMRI Frontal white matter lesions Executive functioning (Wisconsin card sorting test) [54]”
BackgroundMethod

Authors: Arnett, P. A., Rao, S. M., Bernardin, L., Grafman, J., Yetkin, F. Z., & Lobeck, L.
Affiliations: National Institutes of Health (US)
ORCID: Arnett, P. A.
Rao, S. M.
Grafman, J.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1994-03
Volume: 44
Issue: 3_part_1
Pages: 420-420
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.44.3_part_1.420
OpenAlex: W2041731350
Cited by: 279
References: 0
Citations by year: 2026: 4 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 13 · 2013: 5 · 2012: 12
FWCI: 8.67
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k04ns001055-03, 5r01ns022128-07)
National Institute of Neurological Disorders and Stroke (K04 NS01055, NINDS R01 NS22128)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: multiple sclerosis, frontal lobe lesions, Wisconsin Card Sorting Test, conceptual reasoning, perseveration, white matter lesions, lesion localization, cognitive decline, demyelinating lesions, frontal lobe
MeSH terms: Adult, Aged, Cognition, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Neuropsychological Tests

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks