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Cited by 20Traumatic Brain Injury ResearchNeural and Behavioral Psychology StudiesTraumatic Brain Injury and Neurovascular Disturbances

Frontal White Matter Damage Impairs Response Inhibition in Children Following Traumatic Brain Injury

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Lipszyc, J., Levin, H., Hanten, G., Hunter, J., Dennis, M., Schachar, R.·2014·Archives of Clinical Neuropsychology
DOI 10.1093/arclin/acu004PMC PMC4000231
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Abstract

Inhibition, the ability to suppress inappropriate cognitions or behaviors, can be measured using computer tasks and questionnaires. Inhibition depends on the frontal cortex, but the role of the underlying white matter (WM) is unclear. We assessed the specific impact of frontal WM damage on inhibition in 29 children with moderate-to-severe traumatic brain injury (15 with and 14 without frontal WM damage), 21 children with orthopedic injury, and 29 population controls. We used the Stop Signal Task to measure response inhibition, the Behavior Rating Inventory of Executive Function to assess everyday inhibition, and T2 fluid-attenuated inversion recovery magnetic resonance imaging to identify lesions. Children with frontal WM damage had impaired response inhibition compared with all other groups and poorer everyday inhibition than the orthopedic injury group. Frontal WM lesions most often affected the superior frontal gyrus. These results provide evidence for the critical role of frontal WM in inhibition.

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  • A previous lesion study of traumatic brain injury observed that response inhibition was correlated with frontal white matter volume.

    “Response inhibition was correlated with frontal white matter volume, consistent with previous observations in a lesion study of traumatic brain injury (Lipszyc et al., 2014).”

    From Brain structure, working memory and response inhibition in childhood leukemia survivors (2017) · cites this paper as Lipszyc et al., 2014

    The Abstract reports that children with frontal white matter lesions had poorer response inhibition, supporting the general connection to a TBI lesion study. But the paper does not report a correlation with frontal white matter volume; the Regression Analysis instead found no significant relationship between response inhibition and total lesion volume. Total lesion volume is not the same measure as frontal white matter volume. (LLM, conf=0.88)

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Cited by

Sorted by citations

  • Brain structure, working memory and response inhibition in childhood leukemia survivors

    van der Plas, E., Schachar, R. J., Hitzler, J., Crosbie, J., Guger, S. L., Spiegler, B. J., Ito, S., & Nieman, B. J. (2017) · Brain and Behavior · doi:10.1002/brb3.621 · Cited by 59 · see citing works

    “Similar processes are known to be disrupted in individuals with traumatic brain injury or stroke (Lipszyc et al., 2014; Ornstein et al., 2013; Sinopoli, Schachar, & Dennis, 2011) and, like individuals with brain injury, childhood cancer survivors need longterm follow- up care to identify and treat late effects (Blaauw…”
    BackgroundResultSelf-citation

Authors
Lipszyc, J., Levin, H., Hanten, G., Hunter, J., Dennis, M., & Schachar, R.
Affiliations
  • University of Toronto (CA)
  • Baylor College of Medicine (US)
  • Texas Children's Hospital (US)
  • Hospital for Sick Children (CA)
Corresponding author
Schachar, R.
ORCID
Venue
Archives of Clinical Neuropsychology
Publisher
Oxford University Press (OUP)
Published
2014-03-11
Volume
29
Issue
3
Pages
289-299
ISSN
  • 0887-6177 (ISSN-L)
  • 1873-5843
DOI
10.1093/arclin/acu004
PMC
PMC4000231
OpenAlex
W2111077259
Cited by
20
References
13
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • Archives of Clinical Neuropsychology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Toronto
  • Hospital for Sick Children
  • National Institutes of Health
  • Canadian Institutes of Health Research (44070, MOP44070, 64277_1, 64277, 74699, 74699_1)
  • National Institute of Neurological Disorders and Stroke (NS21889, R01NS021889)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
response inhibition, traumatic brain injury, children, stop-signal task, executive function, superior frontal gyrus, orthopedic trauma
MeSH terms
Adolescent, Analysis of Variance, Brain Injuries, Child, Cognition Disorders, Female, Frontal Lobe, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Social Class, Leukoencephalopathies

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