Cited by 570Restless Legs Syndrome ResearchNeurological diseases and metabolismAdvanced MRI Techniques and Applications

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MRI measurement of brain iron in patients with restless legs syndrome

Allen, R.P., Barker, P.B., Wehrl, F., Song, H.K., Earley, C.J.·2001·Neurology

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Abstract

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

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Authors: Allen, R. P., Barker, P. B., Wehrl, F., Song, H. K., & Earley, C. J.
Affiliations: Johns Hopkins University (US)
ORCID: Allen, R.P.
Barker, P.B.
Song, H.K.
Earley, C.J.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-01-23
Volume: 56
Issue: 2
Pages: 263-265
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.56.2.263
OpenAlex: W2057995083
Semantic Scholar: 625746e30bd55bfd738f1234deeed324587e6703
Cited by: 570
References: 9
Citations by year: 2026: 4 · 2025: 13 · 2024: 18 · 2023: 13 · 2022: 17 · 2021: 11 · 2020: 23 · 2019: 23 · 2018: 11 · 2017: 20 · 2016: 16 · 2015: 26 · 2014: 29 · 2013: 25 · 2012: 23
FWCI: 16.07
Type: journal article
Language: en
Update notices: correction (2015-01-06)
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: restless legs syndrome, brain iron, iron deficiency, R2* MRI, substantia nigra, putamen, RLS severity
MeSH terms: Aged, Brain, Humans, Iron, Middle Aged, Restless Legs Syndrome

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MRI measurement of brain iron in patients with restless legs syndrome

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