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MRI measurement of brain iron in patients with restless legs syndrome
Abstract
Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.
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“Autopsy and MRI investigations show decreased iron concentrations in the substantia nigra of patients with restless leg syndrome that are associated with disease severity.197,198”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [197]
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Metadata
- Authors
- Allen, R. P., Barker, P. B., Wehrl, F., Song, H. K., & Earley, C. J.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neurology
- Published
- 2001-01-23
- Volume
- 56
- Issue
- 2
- Pages
- 263-265
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2057995083
- Semantic Scholar
- 625746e30bd55bfd738f1234deeed324587e6703
- Cited by
- 570
- References
- 9
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 18 · 2023: 13 · 2022: 17 · 2021: 11 · 2020: 23 · 2019: 23 · 2018: 11 · 2017: 20 · 2016: 16 · 2015: 26 · 2014: 29 · 2013: 25 · 2012: 23
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Update notices
- correction (2015-01-06)
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- restless legs syndrome, brain iron, iron deficiency, R2* MRI, substantia nigra, putamen, RLS severity
- MeSH terms
- Aged, Brain, Humans, Iron, Middle Aged, Restless Legs Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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