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The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementia
Abstract
BACKGROUND: Frontotemporal dementia (FTD) is associated with a variety of cognitive and behavioral dysfunctions. Symptoms may be influenced by the relative involvement of the right versus the left hemisphere, with left-sided FTD manifesting language changes and right-sided FTD presenting with aggressive, antisocial, and other socially undesirable behaviors. OBJECTIVE: To test the hypothesis that right-sided FTD is associated with socially undesirable behavior. METHODS: The authors assessed 41 patients with FTD diagnosed by the new research criteria for FTD(1) including behavioral, neuropsychologic, and neurologic testing as well as SPECT and MRI. Based on visual inspection of SPECT scans, 12 patients were classified as having predominantly right-sided and 19 patients were classified as having predominantly left-sided FTD. A clinician blinded to the imaging data reviewed medical records to tabulate the frequency of the following socially undesirable behaviors: criminal behavior, aggression, loss of job, alienation from family/friends, financial recklessness, sexually deviant behavior, and abnormal response to spousal crisis. RESULTS: Eleven of 12 right-sided and 2 of 19 left-sided FTD patients had socially undesirable behavior as an early presenting symptom (chi = 23.3, p < 0.001). CONCLUSION: The authors conclude that right-sided frontotemporal degeneration is associated with socially undesirable behavior. The early presence of socially undesirable behavior in FTD differentiates right-sided from left-sided degeneration. The results highlight the importance of the right hemisphere, especially frontotemporal regions, in the mediation of social behavior. The potential mechanism for these social losses with right-sided disease is discussed.
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“This becomes particularly important given the pervasive lack of empathy commonly reported by caregivers of patients with semantic dementia (Mychack et al., 2001;Rankin et al., 2006).”
From Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia (2012) · cites this paper as Mychack et al., 2001
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The Enigmatic temporal pole: a review of findings on social and emotional processing
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“…emotional blunting, depression, irritability, apathy), personality (e.g. from extraverted to introverted; sudden acquisition of peculiar new interests and hobbies) and in socially appropriate behaviour (Miller et al., 1995, 1997; Bozeat et al., 2000; Mychack et al., 2001; Thompson et al., 2003).”
BackgroundInfluentialNeuroanatomical correlates of behavioural disorders in dementia
Rosen, H. J., Allison, S. C., Schauer, G. F., Gorno-Tempini, M. L., Weiner, M. W., & Miller, B. L. (2005) · Brain · doi:10.1093/brain/awh628 · Cited by 497
“…disturbances including apathy (Ott et al., 1996; Benoit et al., 2002), delusions (Staff et al., 1999; Edelstyn et al., 2001), antisocial behaviour (Mychack et al., 2001), and behavioural dysfunction in general (Miller et al., 1993; Edwards-Lee et al., 1997; Thompson et al., 2003b; Liu et al.,…”
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Rabinovici, G. D., & Miller, B. L. (2010) · CNS Drugs · doi:10.2165/11533100-000000000-00000 · Cited by 519
“There is a marked loss of empathy and interest in others, and social behaviour is described by informants as awkward, tactless and impervious to social cues.[56,63] Rigidity is common and manifests with strict schedules and routines, clock watching and restrictive dieting or food fads.”
BackgroundSocial cognition and the anterior temporal lobes: a review and theoretical framework
Olson, I. R., McCoy, D., Klobusicky, E., & Ross, L. A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss119 · Cited by 452
“These patients exhibit fixed facial expressions and dramatic changes in personality, making social interactions uncomfortable for both strangers and family members (Mychack et al., 2001).”
Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia
Irish, M., Addis, D. R., Hodges, J. R., & Piguet, O. (2012) · Brain · doi:10.1093/brain/aws119 · Cited by 405
“This becomes particularly important given the pervasive lack of empathy commonly reported by caregivers of patients with semantic dementia (Mychack et al., 2001; Rankin et al., 2006).”
Background
Metadata
- Authors
- Mychack, P., Kramer, J. H., Boone, K. B., & Miller, B. L.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Neurology
- Published
- 2001-06-12
- Volume
- 56
- Issue
- suppl_4
- Pages
- S11-5
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1979781351
- Cited by
- 168
- References
- 33
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, right hemisphere dominance, aggression, antisocial behavior, hemispheric lateralization, social behavior, SPECT imaging
- MeSH terms
- Aggression, Crime, Dementia, Humans, Functional Laterality, Social Alienation, Social Behavior Disorders, Chi-Square Distribution
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