Neuroanatomical correlates of behavioural disorders in dementia

Rosen, Howard J.; Allison, Stephen C.; Schauer, Guido F.; Gorno-Tempini, Maria Luisa; Weiner, Michael W.; Miller, Bruce L.

doi:10.1093/brain/awh628

Cited by 497Dementia and Cognitive Impairment ResearchNeural and Behavioral Psychology StudiesHistorical and Modern Theater Studies

Neuroanatomical correlates of behavioural disorders in dementia

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Rosen, Howard J., Allison, Stephen C., Schauer, Guido F., Gorno-Tempini, Maria Luisa, Weiner, Michael W., Miller, Bruce L.·2005·Brain

DOI 10.1093/brain/awh628PMC PMC1820861

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Abstract

Neurodegenerative diseases are associated with profound changes in social and emotional function. The emergence of increasingly sophisticated methods for measuring brain volume has facilitated correlation of local changes in tissue content with cognitive and behavioural changes in neurodegenerative disease. The current study examined neuroanatomical correlates of behavioural abnormalities, as measured by the Neuropsychiatric Inventory, in 148 patients with dementia using voxel-based morphometry. Of 12 behaviours examined, 4 correlated with tissue loss: apathy, disinhibition, eating disorders and aberrant motor behaviour. Increasing severity across these four behaviours was associated with tissue loss in the ventral portion of the right anterior cingulate cortex (vACC) and adjacent ventromedial superior frontal gyrus (vmSFG), the right ventromedial prefrontal cortex (VMPC) more posteriorly, the right lateral middle frontal gyrus, the right caudate head, the right orbitofrontal cortex and the right anterior insula. In addition, apathy was independently associated with tissue loss in the right vmSFG, disinhibition with tissue loss in the right subgenual cingulate gyrus in the VMPC, and aberrant motor behaviour with tissue loss in the right dorsal ACC and left premotor cortex. These data strongly support the involvement of the right hemisphere in mediating social and emotional behaviour and highlight the importance of distinct regions on the medial wall of the right frontal lobe in regulating different behaviours. Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions.

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The FTD finding may be uniquely related to high rates of neuropsychiatric symptoms such as apathy consistently observed in FTD patients.
“This finding may also be uniquely related to the high rates of neuropsychiatric symptoms such as apathy consistently observed in FTD patients, particularly since neuroimaging studies previously related such behavioral changes to mPFC‐specific gray matter atrophy. 59 , 60 , 61”
From High vulnerability of medial prefrontal pyramidal neurons in post-stroke, vascular, Alzheimer's disease, and aging-related dementias (2026) · cites this paper as [60]
Frontotemporal dementia with orbitofrontal cortex pathology is marked by compulsive consummatory behaviors including hyperphagia, gambling, and substance abuse.
“Cases of frontotemporal dementia with OFC pathology are also marked by compulsive consummatory behaviors, including hyperphagia, gambling, and substance abuse (Gorno-Tempini et al., 2004; Ikeda et al., 2002; Rosen et al., 2005; Thompson et al., 2003; Whitwell et al., 2007; Williams et al., 2005; Woolley et al., 2007).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Rosen et al., 2005

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Authors: Rosen, H. J., Allison, S. C., Schauer, G. F., Gorno-Tempini, M. L., Weiner, M. W., & Miller, B. L.
Affiliations: University of California, San Francisco (US)
Pediatrics and Genetics (US)
Corresponding author: Rosen, Howard J.
ORCID: Rosen, Howard J.
Allison, Stephen C.
Weiner, Michael W.
Miller, Bruce L.
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2005-09-29
Volume: 128
Issue: 11
Pages: 2612-2625
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awh628
PMC: PMC1820861
OpenAlex: W2006412233
Cited by: 497
References: 118
Citations by year: 2026: 10 · 2025: 17 · 2024: 17 · 2023: 14 · 2022: 20 · 2021: 19 · 2020: 23 · 2019: 19 · 2018: 15 · 2017: 22 · 2016: 36 · 2015: 27 · 2014: 31 · 2013: 32 · 2012: 34
FWCI: 12.63
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Brain (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5k08ag020760-03, 5m01rr000079-42)
University of California, San Francisco
National Institute on Aging (P30AG010129, 1K08AG020760-01, K08 AG020760, P50AG016570, AG 16570, P50-AG05142, AG-10129, P50AG005142, R01AG010897, P01AG019724)
National Center for Research Resources (M01-RR000079, M01 RR-00079)
NIH Clinical Center
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords: dementia, behavioural disorders, neuropsychiatric symptoms, apathy, disinhibition, eating disorders, brain tissue loss, right hemisphere, anterior cingulate cortex, ventromedial prefrontal cortex, orbitofrontal cortex, anterior insula, premotor cortex, caudate nucleus, voxel-based morphometry
MeSH terms: Aged, Feeding and Eating Disorders, Brain Mapping, Dementia, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motivation, Neuropsychological Tests, Psychometrics, Psychomotor Performance, Social Behavior Disorders

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Neuroanatomical correlates of behavioural disorders in dementia

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