On the definition of a confounder
Open accessAbstract
The causal inference literature has provided a clear formal definition of confounding expressed in terms of counterfactual independence. The literature has not, however, come to any consensus on a formal definition of a confounder, as it has given priority to the concept of confounding over that of a confounder. We consider a number of candidate definitions arising from various more informal statements made in the literature. We consider the properties satisfied by each candidate definition, principally focusing on (i) whether under the candidate definition control for all “confounders” suffices to control for “confounding” and (ii) whether each confounder in some context helps eliminate or reduce confounding bias. Several of the candidate definitions do not have these two properties. Only one candidate definition of those considered satisfies both properties. We propose that a “confounder” be defined as a pre-exposure covariate $C$ for which there exists a set of other covariates $X$ such that effect of the exposure on the outcome is unconfounded conditional on $(X,C)$ but such that for no proper subset of $(X,C)$ is the effect of the exposure on the outcome unconfounded given the subset. We also provide a conditional analogue of the above definition; and we propose a variable that helps reduce bias but not eliminate bias be referred to as a “surrogate confounder.” These definitions are closely related to those given by Robins and Morgenstern [Comput. Math. Appl. 14 (1987) 869–916]. The implications that hold among the various candidate definitions are discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A great deal of variability in cellular responses to treatment may be attributable to underlying confounding variation.
“A great deal of variability in cellular responses to treatment may be attributable to underlying confounding variation10.”
From Causal identification of single-cell experimental perturbation effects with CINEMA-OT (2023) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The central role of the propensity score in observational studies for causal effects
ROSENBAUM, P. R., & RUBIN, D. B. (1983) · Biometrika · doi:10.1093/biomet/70.1.41 · Cited by 31,241 · cited 2× · see citing works
“M E ] 2 A pr 2 01 3 The Annals of Statistics 2013, Vol. 41, No. 1, 196–220 DOI: 10.1214/12-AOS1058 c© Institute of Mathematical Statistics, 2013 ON THE DEFINITION OF A CONFOUNDER1 By Tyler J. VanderWeele and Ilya Shpitser”
InfluentialCausality : Models , Reasoning , and Inference
Bentler, P., Heslenfeld, D., Molenaar, P., & Mcdonald, R. (2002) · Choice Reviews Online · doi:10.5860/choice.47-3771 · Cited by 13,039 · see citing works
Causality: Models, Reasoning, and Inference
Pearl, J. (2009) · doi:10.1017/cbo9780511803161 · Cited by 11,653 · see citing works
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
Breslow, N. E., & Day, N. E. (1980) · PubMed · Cited by 4,895 · see citing works
Causation, Prediction, and Search
Spirtes, P., Glymour, C., & Scheines, R. (1993) · Lecture Notes in Statistics · doi:10.1007/978-1-4612-2748-9 · Cited by 4,617 · see citing works
Causal Diagrams for Epidemiologic Research
Greenland, S., Pearl, J., & Robins, J. M. (1999) · Epidemiology · doi:10.1097/00001648-199901000-00008 · Cited by 3,728 · cited 1× · see citing works
“M E ] 2 A pr 2 01 3 The Annals of Statistics 2013, Vol. 41, No. 1, 196–220 DOI: 10.1214/12-AOS1058 c© Institute of Mathematical Statistics, 2013 ON THE DEFINITION OF A CONFOUNDER1 By Tyler J. VanderWeele and Ilya Shpitser”
InfluentialThe Central Role of the Propensity Score in Observational Studies for Causal Effects
Rosenbaum, P. R., & Rubin, D. B. (1983) · Biometrika · doi:10.2307/2335942 · Cited by 3,495 · see citing works
Air Pollution and Hospital Admissions for Heart Disease in Eight U.S. Counties
Schwartz, J. D. (1999) · Epidemiology · doi:10.1097/00001648-199901000-00005 · Cited by 3,044 · see citing works
Nonparametric Estimation of Average Treatment Effects Under Exogeneity: A Review
Imbens, G. W. (2004) · Review of Economics and Statistics · doi:10.1162/003465304323023651 · Cited by 2,994 · see citing works
Epidemiologic Research: Principles and Quantitative Methods.
Mayer, L. S., Kleinbaum, D. G., Kupper, L. L., & Morgenstern, H. (1984) · Journal of the American Statistical Association · doi:10.2307/2288427 · Cited by 2,905 · see citing works
Bayesian inference for causal effects: The role of randomization
Rubin, D. B. (1978) · The Annals of Statistics · doi:10.1214/aos/1176344064 · Cited by 2,503 · cited 3× · see citing works
“Such absence of confounding is alternatively referred to as “ignorability” or “ignorable treatment assignment” [Rubin (1978)], “exchangeability” [Greenland and Robins (1986)], “no unmeasured confounding” [Robins (1992)], “selection on observables” [Barnow, Cain and Goldberger (1980), Imbens (2004)]…”
InfluentialThe analysis of case-control studies
Breslow, N. E., & Day, N. E. (1980) · International Agency for Research on Cancer eBooks · Cited by 2,415 · see citing works
Causal diagrams for empirical research
PEARL, J. (1995) · Biometrika · doi:10.1093/biomet/82.4.669 · Cited by 2,355 · cited 15× · see citing works
“As noted in the penultimate section of the paper, the restriction to pre-exposure covariates could, in the context of causal diagrams [Pearl (1995, 2009)], be replaced to that of nondescendents of exposure A.”
InfluentialEpidemiologic Research: Principles and Quantitative Methods.
Pocock, S., Kleinbaum, D. G., Kupper, L. L., & Morgenstern, H. (1983) · Biometrics · doi:10.2307/2531133 · Cited by 1,893 · cited 1× · see citing works
“Kleinbaum et al. (1982), in a textbook on epidemiologic research, gave as a de nition of a "confounder" a variable that is "a member of a su¢ cient confounder group" where a su¢ cient confounder group is de ned as "a minimal set of one or more risk factors whose simultaneous control in the analysis will correct for jo…”
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies
(1983) · Food and Chemical Toxicology · doi:10.1016/0278-6915(83)90281-8 · Cited by 1,726 · see citing works
Hernan, M. A. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.2.176 · Cited by 1,445 · cited 3× · see citing works
“The authors thank Sander Greenland, James Robins and Miguel Hernán for helpful comments on this paper.”
(1958) · Medical Entomology and Zoology · Cited by 1,059 · see citing works
Confounding and Collapsibility in Causal Inference
Greenland, S., Pearl, J., & Robins, J. M. (1999) · Statistical Science · doi:10.1214/ss/1009211805 · Cited by 933 · cited 1× · see citing works
“Hernán (2008) accordingly speaks of a confounder as a variable that "can be used to block a backdoor path between exposure and outcome" (p.”
Quantifying Biases in Causal Models: Classical Confounding vs Collider-Stratification Bias
Greenland, S. (2003) · Epidemiology · doi:10.1097/01.ede.0000042804.12056.6c · Cited by 810 · see citing works
Identifiability, Exchangeability, and Epidemiological Confounding
GREENLAND, S., & ROBINS, J. M. (1986) · International Journal of Epidemiology · doi:10.1093/ije/15.3.413 · Cited by 686 · cited 3× · see citing works
“Such absence of confounding is alternatively referred to as “ignorability” or “ignorable treatment assignment” [Rubin (1978)], “exchangeability” [Greenland and Robins (1986)], “no unmeasured confounding” [Robins (1992)], “selection on observables” [Barnow, Cain and Goldberger (1980), Imbens (2004)]…”
Causal Inference from Complex Longitudinal Data
Robins, J. M. (1997) · Lecture Notes in Statistics · doi:10.1007/978-1-4612-1842-5_4 · Cited by 510 · see citing works
Formal mode of statistical inference for causal effects
Rubin, D. B. (1990) · Journal of Statistical Planning and Inference · doi:10.1016/0378-3758(90)90077-8 · Cited by 483 · cited 2× · see citing works
“This assumption is sometimes referred to as SUTVA, the stable unit treatment value assumption [Rubin (1990)] or as a no-interference assumption [Cox (1958)].”
InfluentialA New Criterion for Confounder Selection
VanderWeele, T. J., & Shpitser, I. (2011) · Biometrics · doi:10.1111/j.1541-0420.2011.01619.x · Cited by 434 · cited 1× · see citing works
“VanderWeele and Shpitser (2011) note that if for covariate set S we have that Ya ⊥⊥A|S, then if a backward selection procedure is applied to S such that variables are iteratively discarded that are independent of Y conditional on both exposure A and the members of S that have not yet been…”
Self-citationConfounding in Health Research
Greenland, S., & Morgenstern, H. (2001) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.22.1.189 · Cited by 390 · cited 7× · see citing works
“Note, however, that some authors also consider “confounding” to be scale-dependent [Greenland and Robins (1986, 2009), Greenland and Morgenstern (2001)] and use “ignorability” to refer to the notion of unconfoundedness in the distribution of counterfactuals as given above.”
InfluentialCONFOUNDING AND EFFECT-MODIFICATION
Miettinen, O. S. (1974) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112044 · Cited by 352 · cited 2× · see citing works
“Statisticians and epidemiologists had traditionally conceived of a confounder as a pre-exposure variable that was associated with exposure and associated also with the outcome conditional on the exposure, possibly conditional also on other covariates [Miettinen (1974)].”
STRATIFICATION BY A MULTIVARIATE CONFOUNDER SCORE
Miettinen, O. S. (1976) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112339 · Cited by 351 · cited 1× · see citing works
“Confounders have also sometimes been defined in terms of empirical collapsibility [Miettinen (1976), Breslow and Day (1980)], that is, if one obtains the same estimate with or without adjustment for a variable, then it is not a confounder.”
CONFOUNDING: ESSENCE AND DETECTION1
Miettinen, O. S., & Cook, E. F. (1981) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113225 · Cited by 350 · cited 2× · see citing works
“Miettinen and Cook (1981) conceive of a confounder as any variable that is helpful in reducing bias.”
Causal Diagrams for Empirical Research
Pearl, J. (1995) · Biometrika · doi:10.2307/2337329 · Cited by 298 · see citing works
THE ROLE OF MODEL SELECTION IN CAUSAL INFERENCE FROM NONEXPERIMENTAL DATA
Robins, J. M., & Greenland, S. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114254 · Cited by 201 · cited 1× · see citing works
“M E ] 2 A pr 2 01 3 The Annals of Statistics 2013, Vol. 41, No. 1, 196–220 DOI: 10.1214/12-AOS1058 c© Institute of Mathematical Statistics, 2013 ON THE DEFINITION OF A CONFOUNDER1 By Tyler J. VanderWeele and Ilya Shpitser”
InfluentialRobins, J. M. (1992) · Biometrika · doi:10.1093/biomet/79.2.321 · Cited by 180 · cited 2× · see citing works
“Such absence of confounding is alternatively referred to as "ignorability" or "ignorable treatment assignment" (Rubin, 1978), "exchangeability" (Greenland and Robins, 1986), "no unmeasured confounding" (Robins, 1992), "selection on observables" (Barnow et al.”
Identifiability, exchangeability and confounding revisited
Greenland, S., & Robins, J. M. (2009) · Epidemiologic Perspectives & Innovations · doi:10.1186/1742-5573-6-4 · Cited by 155 · cited 1× · see citing works
“Note, however, that some authors also consider “confounding” to be scale-dependent [Greenland and Robins (1986, 2009), Greenland and Morgenstern (2001)] and use “ignorability” to refer to the notion of unconfoundedness in the distribution of counterfactuals as given above.”
Causality and Psychopathology: Finding the Determinants of Disorders and their Cures
Shrout, P. E., Keyes, K. M., & Ornstein, K. A. (2010) · Cited by 147 · see citing works
Alternative Graphical Causal Models and the Identification of Direct Effects
Robins, J. M., & Richardson, T. S. (2011) · Oxford University Press eBooks · doi:10.1093/oso/9780199754649.003.0011 · Cited by 133 · see citing works
On the Validity of Covariate Adjustment for Estimating Causal EffectsPreprint
Shpitser, I., VanderWeele, T. J., & Robins, J. M. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1203.3515 · Cited by 124 · see citing works
Self-citationAdjustments and their Consequences-Collapsibility Analysis using Graphical Models
Greenland, S., & Pearl, J. (2011) · International Statistical Review · doi:10.1111/j.1751-5823.2011.00158.x · Cited by 94 · cited 1× · see citing works
“See Greenland and Pearl (2011) and Ogburn and VanderWeele (2012) for properties of such surrogate confounders.”
Confounding and effect modification: distribution and measure
Vanderweele, T. (2012) · Epidemiologic Methods · doi:10.1515/2161-962x.1004 · Cited by 74 · cited 3× · see citing works
“See Greenland and Pearl (2011) and Ogburn and VanderWeele (2012) for properties of such surrogate confounders.”
Self-citationThe foundations of confounding in epidemiology
Robins, J. M., & Morgenstern, H. (1987) · Computers & Mathematics with Applications · doi:10.1016/0898-1221(87)90236-7 · Cited by 69 · see citing works
On the Nondifferential Misclassification of a Binary Confounder
Ogburn, E., & VanderWeele, T. (2012) · Epidemiology · doi:10.1097/ede.0b013e31824d1f63 · Cited by 67 · cited 1× · see citing works
“See Greenland and Pearl (2011) and Ogburn and VanderWeele (2012) for properties of such surrogate confounders.”
Self-citationCausal diagrams for empirical research
Pearl, J. (1995) · Biometrika · doi:10.1093/biomet/82.4.702 · Cited by 67 · see citing works
History of the modern epidemiological concept of confounding
Morabia, A. (2010) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2010.112565 · Cited by 35 · cited 2× · see citing works
“and Robins (1999), Glymour and Greenland (2008), Pearl (2009)]. The literature has moved away from formal language about “confounders” and instead places the conceptual emphasis on “confounding.” See Morabia (2011) for historical discussion of this point. The causal inference literature has provided a formal definition…”
Formal modes of statistical inference for causal effects
Rubin, D. B. (1991) · Quality Engineering · Cited by 32 · see citing works
Criteria for Confounders in Epidemiological Studies
Geng, Z., Guo, J., & Fung, W. (2002) · Journal of the Royal Statistical Society Series B (Statistical Methodology) · doi:10.1111/1467-9868.00321 · Cited by 27 · cited 4× · see citing works
“Geng et al. (2002) for example, considered the analogous definition for the effect of the exposure on the exposed rather than the overall effect of the exposure on the population; one could likewise consider the analogue of definition in 5 for effects conditional on X rather than standardized over X or alternatively f…”
InfluentialRobins, J. M. (1992) · Biometrika · doi:10.2307/2336843 · Cited by 17 · see citing works
CONFOUNDING, HOMOGENEITY AND COLLAPSIBILITY FOR CAUSAL EFFECTS IN EPIDEMIOLOGIC STUDIES
Geng, Z., Guo, J., Lau, T. S., & Fung, W. (2001) · Cited by 12 · see citing works
Geng, Z., & LI, G. (2001) · Scandinavian Journal of Statistics · doi:10.1111/1467-9469.00087 · Cited by 10 · cited 1× · see citing works
“See Greenland, Robins and Pearl (1999), Geng et al. (2001) and Geng and Li (2002) for further discussion of the relationship between, and general nonequivalence of, confounding and collapsibility.”
Hernán, M. Á. (2008) · Encyclopedia of Quantitative Risk Analysis and Assessment · doi:10.1002/9780470061596.risk0642 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Glymour MM Greenland S Rothman KJ Greenland S Lash TL Causal diagrams Modern Epidemiology 2008 Chapter 12 Lippincott Williams and Wilkins Philadelphia 3rd edition
- Greenland S Pearl J Boslaugh S Causal Diagrams Encyclopedia of Epidemiology 2007 149 156 Sage Publications Thousand Oaks, CA
- Hernán MA Everitt B Melnick E Confounding Encyclopedia of Quantitative Risk Assessment and Analysis 2008 353 362 John Wiley & Sons Chichester, United Kingdom
Cited by
Sorted by citations
Johnston, R., Jones, K., & Manley, D. (2018) · Quality & Quantity · doi:10.1007/s11135-017-0584-6 · Cited by 1,181 · see citing works
“The result is frequently termed confounding, the situation when the relationship between two variables is distorted because of the strength of the relationships between either one or both of them and a third variable included in the analysis (see, for example, Kish 1959; Morabia 2011; VanderWheele and Shpitser 2013).”
BackgroundTennant, P. W. G., Murray, E. J., Arnold, K. F., Berrie, L., Fox, M. P., Gadd, S. C., Harrison, W. J., Keeble, C. M., Ranker, L. R., Textor, J. C., et al. (2020) · International Journal of Epidemiology · doi:10.1093/ije/dyaa213 · Cited by 1,065 · see citing works
“Competing exposures are not always included in sufficient adjustment sets, unless they are caused by one or more unobserved confounders for which they can serve as a surrogate confounder.(22)”
BackgroundThe contribution of health behaviors to socioeconomic inequalities in health: A systematic review
Petrović, D., de Mestral, C., Bochud, M., Bartley, M., Mika Kivimaki, B., Vineis, P., Mackenbach, J. P., & Stringhini, S. (2018) · Preventive Medicine · doi:10.1016/j.ypmed.2018.05.003 · Cited by 507 · see citing works
Best (but oft-forgotten) practices: mediation analysis ,
Fairchild, A. J., & McDaniel, H. L. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.152546 · Cited by 512 · see citing works
“(29) and VanderWeele and Shpitser (30).”
Addressing context dependence in ecology.
Catford, J., Wilson, J. R. U., Pyšek, P., Hulme, P., & Duncan, R. (2021) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2021.09.007 · Cited by 296 · see citing works
“Type: apparent; source: (ii) confounding factors Confounding occurs when two ormore independent variables, X and C, are correlated such that their effects on dependent variable Y cannot be disentangled [40,41].”
BackgroundSullivan, S. G., Tchetgen, E. J. T., & Cowling, B. J. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww064 · Cited by 316 · see citing works
“However, while controlling for a variable that represents an imperfect measure of a confounder may not eliminate bias, it can reduce it (41, 42).”
BackgroundChow, J. H., Khanna, A. K., Kethireddy, S., Yamane, D. P., Levine, A. R., Jackson, A. M., McCurdy, M. T., Tabatabai, A., Kumar, G., Park, P., et al. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005292 · Cited by 310 · see citing works
“Selection of confounders was based on recommendations in the published epidemiology literature.(26,27) We adjusted for variables that were pre-existing and were associated with aspirin use and the outcome or solely the outcome including: age, gender, BMI, race, hypertension, diabetes mellitus, coronary artery disease,…”
MethodOutcome modelling strategies in epidemiology: traditional methods and basic alternatives
Greenland, S., Daniel, R., & Pearce, N. E. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw040 · Cited by 294 · see citing works
Nakayasu, E. S., Gritsenko, M., Piehowski, P., Gao, Y., Orton, D., Schepmoes, A., Fillmore, T., Frohnert, B. I., Rewers, M., Krischer, J. P., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00566-6 · Cited by 281 · see citing works
Navigating the pitfalls of applying machine learning in genomics
Whalen, S., Schreiber, J. M., Noble, W. S., & Pollard, K. S. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00434-9 · Cited by 278 · see citing works
Meaningful associations in the adolescent brain cognitive development study
Dick, A. S., Lopez, D. A., Watts, A. L., Heeringa, S. G., Reuter, C., Bartsch, H., Fan, C. C., Kennedy, D. N., Palmer, C. E., Marshall, A. T., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118262 · Cited by 234 · see citing works
“…variable (DV) are that the factor is associated with both the exosure and the outcome in the population, but not causally affected by ither ( VanderWeele and Shpitser, 2013 ) (if a variable is causally downtream of the IV or the DV or both, it may be a collider or a mediator Rothman et al.,…”
Statistical Control Requires Causal Justification
Wysocki, A. C., Lawson, K. M., & Rhemtulla, M. (2020) · Advances in Methods and Practices in Psychological Science · doi:10.1177/25152459221095823 · Cited by 236 · see citing works
“Some other definitions of a confounder (e.g., VanderWeele & Shpitser, 2013) do not draw a distinction between confounders and confound-blockers.”
BackgroundThe Blessings of Multiple Causes
Wang, Z., & Blei, D. M. (2019) · Journal of the American Statistical Association · doi:10.1080/01621459.2019.1686987 · Cited by 225 · see citing works
“(Its technical definition stems from Definition 4 of VanderWeele and Shpitser (2013); see Appendix E.”
BackgroundDubey, R., Gunasekaran, A., Helo, P., Παπαδόπουλος, Θ., Childe, S. J., & Sahay, B. S. (2016) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2016.09.035 · Cited by 167 · see citing works
Confounding and regression adjustment in <scp>difference‐in‐differences</scp> studies
Zeldow, B., & Hatfield, L. A. (2021) · Health Services Research · doi:10.1111/1475-6773.13666 · Cited by 153 · see citing works
“VanderWeele and Shpitser noted the lack of rigor in the definition of a confounder.(3) In this spirit, we examine confounding in diff-in-diff.”
BackgroundAdversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Marini, S., Davis, K. A., Soare, T. W., Zhu, Y., Suderman, M. J., Simpkin, A. J., Smith, A. D. A. C., Wolf, E. J., Relton, C. L., & Dunn, E. C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104484 · Cited by 140 · see citing works
Mediation Analysis for Health Disparities Research
Naimi, A. I., Schnitzer, M. E., Moodie, E. E. M., & Bodnar, L. M. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kwv329 · Cited by 131 · see citing works
Matching Methods for Confounder Adjustment: An Addition to the Epidemiologist’s Toolbox
Greifer, N., & Stuart, E. A. (2021) · Epidemiologic Reviews · doi:10.1093/epirev/mxab003 · Cited by 124 · see citing works
Confounding in statistical mediation analysis: What it is and how to address it.
Valente, M. J., Pelham, W. E., Smyth, H. L., & MacKinnon, D. P. (2017) · Journal of Counseling Psychology · doi:10.1037/cou0000242 · Cited by 113 · see citing works
Stop ‘controlling’ for sex and gender in global health research
Shapiro, J. R., Klein, S. L., & Morgan, R. (2021) · BMJ Global Health · doi:10.1136/bmjgh-2021-005714 · Cited by 100 · see citing works
Vinciguerra, R., Rehman, S., Vallabh, N. A., Batterbury, M., Czanner, G., Choudhary, A., Cheeseman, R., Elsheikh, A., & Willoughby, C. E. (2019) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2018-313493 · Cited by 96 · see citing works
“28 CCT was purposely not added into the model because it does not meet all the criteria of confounding 29 and hence would lead to a bias.”
MethodAmoah, J., Stuart, E. A., Cosgrove, S. E., Harris, A. D., Han, J., Lautenbach, E., & Tamma, P. D. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa169 · Cited by 95 · see citing works
“Confounders were defined as variables that likely influenced the decision to switch to oral therapy and also impacted the likelihood of death within 30 days changing the measure of association (ie, the odds ratio) by at least 10% and distorting the true relationship between the exposure and outcome [9, 10].”
BackgroundMethods to control for unmeasured confounding in pharmacoepidemiology: an overview
Uddin, M. J., Groenwold, R. H. H., Ali, M. S., de Boer, A., Roes, K. C. B., Chowdhury, M. A. B., & Klungel, O. H. (2016) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-016-0299-0 · Cited by 94 · see citing works
“Moreover, a confounder may bias the observed effect of the exposure on the outcome [12, 13].”
Causal identification of single-cell experimental perturbation effects with CINEMA-OT
Dong, M., Wang, B., Wei, J., de O. Fonseca, A. H., Perry, C. J., Frey, A., Ouerghi, F., Foxman, E. F., Ishizuka, J. J., Dhodapkar, R. M., et al. (2023) · Nature Methods · doi:10.1038/s41592-023-02040-5 · Cited by 94 · see citing works
“We may also employ clustering techniques, such as Leiden clustering [23] to group cells by similarity of treatment responses.”
BackgroundMethodLeveraging external data in the design and analysis of clinical trials in neuro-oncology
Rahman, R. M., Ventz, S., McDunn, J., Louv, B., Reyes‐Rivera, I., Polley, M. C., Merchant, F., Abrey, L. E., Allen, J. E., Aguilar, L. K., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00488-5 · Cited by 86 · see citing works
Trace Minerals, Heavy Metals, and Preeclampsia: Findings from the Boston Birth Cohort
Liu, T., Zhang, M., Güallar, E., Wang, G., Hong, X., Wang, X., & Mueller, N. T. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012436 · Cited by 76 · see citing works
“To assess confounding, we began with an unadjusted model (model 1) and then added confounders (model 2) defined as covariates known to be associated with both chemical elements and preeclampsia but not in the causal pathway.(25) Confounders included age at delivery (continuous), self-reported race (black, nonblack), e…”
MethodStatistics, Adjusted Statistics, and Maladjusted Statistics
Kaufman, J. S. (2017) · American Journal of Law & Medicine · doi:10.1177/0098858817723659 · Cited by 75 · see citing works
Challenges in estimating influenza vaccine effectiveness
Ainslie, K. E. C., Haber, M., & Orenstein, W. (2019) · Expert Review of Vaccines · doi:10.1080/14760584.2019.1622419 · Cited by 70 · see citing works
“However, using imperfect proxy variables have been shown to reduce bias (85, 86).”
MethodTo Adjust or Not to Adjust? When a “Confounder” Is Only Measured After Exposure
Groenwold, R. H. H., Palmer, T., & Tilling, K. M. (2021) · Epidemiology · doi:10.1097/ede.0000000000001312 · Cited by 69 · see citing works
Bias Analysis for Uncontrolled Confounding in the Health Sciences
Arah, O. A. (2015) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-032315-021644 · Cited by 69 · see citing works
An empirical investigation on the relationship between design and architecture smells
Sharma, T., Singh, P., & Spinellis, D. D. (2020) · Empirical Software Engineering · doi:10.1007/s10664-020-09847-2 · Cited by 67 · see citing works
“While computing causality relationship between design and architecture smell instances over a period of time, there could be some confounding factors (VanderWeele and Shpitser 2013) that influence both design and architecture smell instances time-series.”
BackgroundWhat Is the Causal Interpretation of Sibling Comparison Designs?
Petersen, A. H., & Lange, T. (2019) · Epidemiology · doi:10.1097/ede.0000000000001108 · Cited by 60 · see citing works
RegressionExplorer: Interactive Exploration of Logistic Regression Models with Subgroup Analysis
Dingen, D., Veer, M. V. ’., Houthuizen, P., Mestrom, E. H. J., Korsten, E. H. H. M., Bouwman, R. A., & van Wijk, J. J. (2018) · IEEE Transactions on Visualization and Computer Graphics · doi:10.1109/tvcg.2018.2865043 · Cited by 58 · see citing works
“More recently even this method is increasingly being criticized [27].”
BackgroundMethodGao, Y., Xiang, L., Yi, H., Song, J., Sun, D., Xu, B., Zhang, G., & Wu, X. (2025) · BMC Medicine · doi:10.1186/s12916-025-03957-8 · Cited by 54 · see citing works
Propensity scores using missingness pattern information: a practical guide
Blake, H. A., Leyrat, C., Mansfield, K. E., Seaman, S. R., Tomlinson, L. A., Carpenter, J. R., & Williamson, E. (2020) · Statistics in Medicine · doi:10.1002/sim.8503 · Cited by 49 · see citing works
Shantha, K. V. (2019) · Sustainability · doi:10.3390/su11051448 · Cited by 52 · see citing works
“However, the examination of the association of these socio-demographic variables with trading experience and self-reflection constructs reveals that these variables are not really confounders to be controlled in the analysis [48].”
BackgroundSeaport status, port access, and regional economic development in Indonesia
Yudhistira, M. H., & Sofiyandi, Y. (2017) · Maritime Economics & Logistics · doi:10.1057/s41278-017-0089-1 · Cited by 48 · see citing works
Masukume, G., O’Neill, S. M., Baker, P. N., Kenny, L. C., Morton, S., & Khashan, A. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33482-z · Cited by 46 · see citing works
Confounding and effect measure modification in reproductive medicine research
Correia, K. F. B., Dodge, L. E., Farland, L. V., Hacker, M. R., Ginsburg, E. S., Whitcomb, B. W., Wise, L. A., & Missmer, S. A. (2020) · Human Reproduction · doi:10.1093/humrep/deaa051 · Cited by 46 · see citing works
“More technical definitions of confounding and confounders can be found in Rothman (1986), Greenland (2001), Rothman et al. (2008), Vanderweele (2013) and Hernan & Robins (2019), among others.”
BackgroundInstrumental Variable Estimation with a Stochastic Monotonicity Assumption
Small, D. S., Tan, Z., Ramsahai, R. R., Lorch, S. A., & Brookhart, M. A. (2017) · Statistical Science · doi:10.1214/17-sts623 · Cited by 45 · see citing works
“Assume that BA1, BA2, CF-CA1, CF-CA-2, CF-CA-3, SCC-IVA1 and SCC-IVA2 hold for a U that satisfies (3) and that the following extended versions of SCC-IVA1 and (3) involving A hold: { Y(0), Y (1),A } ⊥ D|Z,U,(9) { Y(0), Y (1),U,A } ⊥ Z.(10) Then, EQ[A] (11) = E(DA|Z = 1) − E(DA|Z = 0) P (D = 1|Z = 1) − P(D = 1|Z = 0) .”
BackgroundInfluentialTowards Causal Benchmarking of Bias in Face Analysis Algorithms
Balakrishnan, G., Xiong, Y., Xia, W., & Perona, P. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-58523-5_32 · Cited by 45 · see citing works
Liu, T., Zhang, M., Rahman, M. L., Wang, X., Hinkle, S. N., Zhang, C., & Mueller, N. T. (2021) · Environment International · doi:10.1016/j.envint.2021.106508 · Cited by 45 · see citing works
“We defined confounders as covariates that have been associated with both chemical concentrations and BP/HDP, based on previous studies, but not in the causal pathway (VanderWeele and Shpitser, 2013).”
Commentary: Causal Inference for Social Exposures
Kaufman, J. S. (2019) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040218-043735 · Cited by 46 · see citing works
Matched Versus Unmatched Analysis of Matched Case-Control Studies
Wan, F., Colditz, G. A., & Sutcliffe, S. S. (2021) · American Journal of Epidemiology · doi:10.1093/aje/kwab056 · Cited by 42 · see citing works
A Model for Joint Probabilistic Forecast of Solar Photovoltaic Power and Outdoor Temperature
Ramakrishna, R., Scaglione, A., Vittal, V., Dall’Anese, E., & Bernstein, A. (2019) · IEEE Transactions on Signal Processing · doi:10.1109/tsp.2019.2954973 · Cited by 41 · see citing works
“The premise is that solar irradiation is the cause of both solar PV power and temperature and therefore acts as a cofounding or lurking variable [6].”
BackgroundA spotlight on cross-sectional research: Addressing the issues of confounding and adjustment
Asiamah, N., Mends-Brew, E., & Boison, B. T. K. (2019) · International Journal of Healthcare Management · doi:10.1080/20479700.2019.1621022 · Cited by 42 · see citing works
“In randomization, the researcher reduces confounding by randomly assigning study participants to control or/ and experimental groups [4,7].”
BackgroundMethodInfluentialLin, C., Lee, Y., Fang, W., Lou, Y.-S., Kuo, F.-C., Lee, C., & Lin, C. S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11080725 · Cited by 39 · see citing works
“These relationships have led us to consider the possibility of confounding effects whenever these factors causally influence both ECG and HbA1c [56].”
BackgroundFogarty, C. B., & Small, D. S. (2015) · Journal of the American Statistical Association · doi:10.1080/01621459.2015.1120675 · Cited by 38 · see citing works
“In order for these factors to affect the performed inference (and hence, to be confounders in the sense of VanderWeele and Shpitser (2013)), these factors must also impact the treatment © American Statistical Association Figure .”
BackgroundCausal Interventional Training for Image Recognition
Qin, W., Zhang, H., Hong, R., Lim, E., & Sun, Q. (2021) · IEEE Transactions on Multimedia · doi:10.1109/tmm.2021.3136717 · Cited by 36 · see citing works
Dzhambov, A. M., Dimitrova, V., Germanova, N., Burov, A., Brezov, D. S., Hlebarov, I., & Dimitrova, R. N. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116087 · Cited by 37 · see citing works
Dietary factors and risk of mortality among patients with esophageal cancer: a systematic review
Sun, L. L., Yan, L., Liu, Z., Zhao, W., Zhang, C., Chen, Y.-M., Lao, X. Q., & Liu, X. (2020) · BMC Cancer · doi:10.1186/s12885-020-06767-8 · Cited by 33 · see citing works
“Without adjustments, confounding factors could lead to misinterpretation of the association between independent variables and dependent variables [35].”
BackgroundA non-technical explanation of the counterfactual definition of confounding.
Bours, M. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2020.01.021 · Cited by 30 · see citing works
Ling, Y., Upadhyaya, P., Chen, L., Jiang, X., & Kim, Y. (2022) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2022.104256 · Cited by 31 · see citing works
“It is one of the major sources of bias that can mislead us to draw a wrong conclusion that the treatment has effects on the outcome when it does not.[2] A statistical approach to reducing such bias in observational data for treatment effect estimation has long been studied in multiple disciplines.”
BackgroundEndometriosis is associated with pregnancy loss: a nationwide historical cohort study
Boje, A. D., Egerup, P., Westergaard, D., Bertelsen, M.-L. M. F., Nyegaard, M., Hartwell, D., Lidegaard, Ø., & Nielsen, H. S. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.12.042 · Cited by 31 · see citing works
Ruiz‐Tagle, A., Droguett, E. L., & Groth, K. M. (2021) · Risk Analysis · doi:10.1111/risa.13711 · Cited by 30 · see citing works
Lin, C. S., Lin, C., Lee, D.-J., Lee, C., Chen, S., Tsai, S., Kuo, F.-C., Chau, T., & Lin, S. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab120 · Cited by 30 · see citing works
“Previous studies had shown correlations between age [38], K + [29], and ECG, raising the possibility of confounding effects on both the ECG and TPP [39].”
ResultStatistical Control Requires Causal JustificationPreprint
Wysocki, A. C., Lawson, K. M., & Rhemtulla, M. (2020) · doi:10.31234/osf.io/j9vw4 · Cited by 30 · see citing works
Forman‐Rabinovici, A., & Sommer, U. (2019) · Democratization · doi:10.1080/13510347.2019.1661993 · Cited by 29 · see citing works
Schuurman, N. K. (2023) · doi:10.31234/osf.io/7zgkx · Cited by 28 · see citing works
The Structure and Function of Experimental Control in the Life Sciences
Schickore, J. (2018) · Philosophy of Science · doi:10.1086/701952 · Cited by 27 · see citing works
Piaggio, D., Zarro, M., Pagliara, S. M., Andellini, M., Almuhini, A., Maccaro, A., & Pecchia, L. (2023) · American Journal of Infection Control · doi:10.1016/j.ajic.2023.03.005 · Cited by 33 · see citing works
“Addressing confounders is important to avoid misinterpretation of findings, due to spurious associations [35, 36].”
BackgroundDiagnostics for Confounding of Time-varying and Other Joint Exposures
Jackson, J. W. (2016) · Epidemiology · doi:10.1097/ede.0000000000000547 · Cited by 26 · see citing works
Using Causal Diagrams for Biomedical Research
Kyriacou, D. N., Greenland, P., & Mansournia, M. A. (2022) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2022.08.014 · Cited by 26 · see citing works
Cheng, H. L., McGovern, M. P., Garneau, H. C., Hurley, B., Fisher, T., Copeland, M., & Almirall, D. (2022) · Implementation Science Communications · doi:10.1186/s43058-022-00306-1 · Cited by 25 · see citing works
“To reduce the possibility of bias (in the estimated effect of early engagement on outcomes) due to common correlates of the outcomes and engagement [50, 51], all models included two types of variables as baseline covariates: (i) a theory-informed list of pre-implementation variables that were hypothesized to be associ…”
MethodLeviton, A., Allred, E. N., Fichorova, R. N., O’Shea, T. M., Fordham, L. A., Kuban, K., & Dammann, O. (2018) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2018.01.018 · Cited by 24 · see citing works
Zhang, M., Michos, E. D., Wang, G., Wang, X., & Mueller, N. T. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19046 · Cited by 23 · see citing works
Barberio, J., Ahern, T. P., MacLehose, R. F., Collin, L. J., Cronin-Fenton, D. P., Damkier, P., Sørensen, H. T., & Lash, T. L. (2021) · Clinical Epidemiology · doi:10.2147/clep.s313613 · Cited by 23 · see citing works
“in a minimally sufficient set of variables that will leave no open backdoor path between the exposure and the outcome.(2) Valid estimation of a causal effect of an”
BackgroundA calibration approach to transportability and data‐fusion with observational data
Josey, K., Yang, F., Ghosh, D., & Raghavan, S. (2022) · Statistics in Medicine · doi:10.1002/sim.9523 · Cited by 29 · see citing works
“If both Assumptions 8 and 9 are violated, then Si behaves like a surrogate confounder (VanderWeele and Shpitser, 2013) and omitting it from either the potential outcome models or the propensity score model may lead to biased effect estimates.”
BackgroundNuzzo, J. L., Finn, H. T., & Herbert, R. (2019) · Sports Medicine · doi:10.1007/s40279-019-01131-8 · Cited by 23 · see citing works
Jordan, S. E., Bromley, R., Damase‐Michel, C., Given, J. E., Komninou, S., Loane, M. A., Marfell, N., & Dolk, H. M. (2022) · International Breastfeeding Journal · doi:10.1186/s13006-022-00494-5 · Cited by 22 · see citing works
“The definition of confounderglossary most widely adopted is: “a factor associated with both the exposure and the outcome, and not part of the causal pathway from exposure to outcome” [8], blurring effects [7, 69, 70] (Table 1).”
BackgroundConfound-leakage: confound removal in machine learning leads to leakage
Hamdan, S., Love, B. C., von Polier, G. G., Weis, S., Schwender, H. R., Eickhoff, S. B., & Patil, K. R. (2022) · GigaScience · doi:10.1093/gigascience/giad071 · Cited by 23 · see citing works
“It is important to note that we use a practitioner-oriented operational definition of confounds as a set of variables suspected to share an unwanted effect with both the features and target, which does not imply a causal link as in more formal definitions [18].”
Xia, X., Jiang, B., Li, J., & Zhang, W. (2015) · Lifetime Data Analysis · doi:10.1007/s10985-015-9350-z · Cited by 21 · see citing works
“2009) that may be regarded as confounders (VanderWeele and Shpitser 2013).”
BackgroundA counterfactual approach to bias and effect modification in terms of response types
Suzuki, E., Mitsuhashi, T., Tsuda, T., & Yamamoto, E. (2013) · BMC Medical Research Methodology · doi:10.1186/1471-2288-13-101 · Cited by 21 · see citing works
“Recently, VanderWeele and Shpitser [29,30] further discussed the definition of a confounder.”
BackgroundInfluentialHe, J., Zhong, Y., Song, Y., Luo, J., Lin, C., Wu, Y., Pan, L., Cen, Y., Zhao, J., Gou, S., et al. (2025) · BMC Public Health · doi:10.1186/s12889-025-23383-y · Cited by 20 · see citing works
“Confounders (or covariates) are variables that impact both the outcome and grouping variables [32].”
Testing group differences for confounder selection in nonrandomized studies: flawed practice
Sourial, N., Vedel, I., Berre, M. L., & Schuster, T. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.190085 · Cited by 20 · see citing works
CoCoA-diff: counterfactual inference for single-cell gene expression analysis
Park, Y., & Kellis, M. (2021) · Genome biology · doi:10.1186/s13059-021-02438-4 · Cited by 17 · see citing works
“We define that a variable can confound a disease label (W) and gene expressions (λ and Y) if (1) it is associated with the disease and gene expression variables and (2) it is still associated with the expression even after conditioning on the disease label [26].”
BackgroundEffects of statins and aspirin on HCC risk in alcohol-related cirrhosis: nationwide emulated trials
Kraglund, F., Christensen, D. H., Eiset, A. H., Villadsen, G. E., West, J., & Jepsen, P. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000013 · Cited by 20 · see citing works
“Furthermore, most studies have not utilized a new user design, and prior studies have not specified the minimally sufficient adjustment set of confounders.[19] Two prior studies have investigated the effects of both statins and aspirin, and in both cases, the effect of statins was more protective.”
BackgroundSet-Based Tests for the Gene–Environment Interaction in Longitudinal Studies
He, Z., Zhang, M., Lee, S., Smith, J. A., Kardia, S. L. R., Roux, A. V. D., & Mukherjee, B. (2016) · Journal of the American Statistical Association · doi:10.1080/01621459.2016.1252266 · Cited by 20 · see citing works
Decoupling global biases and local interactions between cell biological variables
Zaritsky, A., Obolski, U., Gan, Z., Reis, C. R., Kadlecová, Z., Du, Y., Schmid, S. L., & Danuser, G. M. (2017) · eLife · doi:10.7554/elife.22323 · Cited by 20 · see citing works
“6 (VanderWeele and Shpitser, 2013) that must be eliminated for more accurate assessment of the true local interaction, but ignore the possibility that the global bias contains by-itself valuable mechanistic information to cell behavior.”
BackgroundTichelman, E., Warmink-Perdijk, W. D. B., Henrichs, J., Peters, L., Schellevis, F., Berger, M. Y., & Burger, H. (2021) · Midwifery · doi:10.1016/j.midw.2021.103045 · Cited by 21 · see citing works
Zawadzki, R. S., Grill, J. D., Gillen, D. L., & Initiative, A. F. T. A. D. N. (2023) · BMC Medical Research Methodology · doi:10.1186/s12874-023-01936-2 · Cited by 19 · see citing works
“[17][18] Alternatively, we may identify the treatment effect through an IV denoted as Z.”
Causal Etiology of the Research of James M. Robins
Richardson, T. S., & Rotnitzky, A. G. (2014) · Statistical Science · doi:10.1214/14-sts505 · Cited by 19 · see citing works
“As one example, he offered a precise mathematical definition for the informal epidemiologic concept of a “confounding variable” that has apparently stood the test of time (see VanderWeele and Shpitser, 2013).”
BackgroundWilson, A., Zigler, C. M., Patel, C. J., & Dominici, F. (2018) · Biometrics · doi:10.1111/biom.12860 · Cited by 18 · see citing works
“We consider a minimal set of covariates sufficient to satisfy (2) as the confounders (VanderWeele and Shpitser, 2013), denoted by C∗ ⊆ C.”
BackgroundMalec, S. A., Taneja, S. B., Albert, S. M., Shaaban, C. E., Karim, H. T., Levine, A. S., Munro, P., Callahan, T. J., & Boyce, R. D. (2023) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2023.104368 · Cited by 19 · see citing works
Conditional or unconditional logistic regression for frequency matched case‐control design?
Wan, F. (2022) · Statistics in Medicine · doi:10.1002/sim.9313 · Cited by 17 · see citing works
Methods Commentary: Uncovering Unobserved Data Patterns With Latent Variable Mixture Modeling
Berlin, K. S., Ankney, R. L., & Rybak, T. M. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsy042 · Cited by 16 · see citing works
Yu, Y., Li, H., Sun, X., Liu, X., Yang, F., Hou, L., Liu, L., Yan, R., Yu, Y., Jing, M., et al. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa172 · Cited by 15 · see citing works
Chan, G., Sun, T., Stjepanović, D., Vu, G. T., Hall, W., Connor, J. P., & Leung, J. (2024) · Addiction · doi:10.1111/add.16442 · Cited by 15 · see citing works
Educational attainment by children with parental alcohol problems in Denmark and Finland
Raitasalo, K., Østergaard, J., & Andrade, S. B. (2020) · Nordic Studies on Alcohol and Drugs · doi:10.1177/1455072520968343 · Cited by 15 · see citing works
Leviton, A., Dammann, O., Allred, E. N., Joseph, R. M., Fichorova, R. N., O’Shea, T. M., & Kuban, K. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.01.001 · Cited by 16 · see citing works
“Inflammation is a broad and complex phenomenon (VanderWeele and Shpitser, 2013; Zak and Aderem, 2015) and we have assessed only a very small part of it.”
BackgroundLong-term causal effects of far-right terrorism in New Zealand
Bulbulia, J. A., Afzali, M. U., Yogeeswaran, K., & Sibley, C. G. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad242 · Cited by 15 · see citing works
Using negative controls to adjust for unmeasured confounding bias in time series studies
Hu, J. K., Tchetgen, E. J. T., & Dominici, F. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00249-4 · Cited by 14 · see citing works
Patterns of resilient functioning in early life: Identifying distinct groups and associated factors
Cahill, S., Hager, R., & Shryane, N. M. (2023) · Development and Psychopathology · doi:10.1017/s0954579423001165 · Cited by 16 · see citing works
“All ACE predictors were entered into each regression model to capture the cumulative impact of all ACEs on resilience (VanderWeele & Shpitser, 2013).”
MethodAlMaghlouth, I. A., Pullenayegum, E., Gladman, D. D., Urowitz, M. B., & Johnson, S. R. (2020) · The Journal of Rheumatology · doi:10.3899/jrheum.200254 · Cited by 14 · see citing works
Marcello, M., Denham, J. W., Kennedy, A., Haworth, A., Steigler, A., Greer, P. B., Holloway, L. C., Dowling, J., Jameson, M., Roach, D., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01174 · Cited by 14 · see citing works
“Age, prescribed dose, disease risk, cancer stage, baseline PSA concentration and number of treatment beams were patient baseline characteristics investigated as potential control variables in each model, attempting to eliminate their confounding influence at each voxel (30, 31).”
BackgroundMalec, S. A., Wei, P., Bernstam, E. V., Boyce, R. D., & Cohen, T. (2021) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2021.103719 · Cited by 14 · see citing works
Aarabi, G., Walther, C., Kaymaz, K., Spinler, K., Buczak‐Stec, E., König, H., & Hajek, A. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-02051-2 · Cited by 14 · see citing works
“In directed acyclic graphs (DAG) notation, our aim was to block the backdoor path (i.e., a non-causal path from X to Y ; usually common causes of X and Y [20]) between personality factors and regular dental visit attendance via sociodemographic and health-related factors.”
tipr: An R package for sensitivity analyses for unmeasured confounders
McGowan, L. D. (2022) · The Journal of Open Source Software · doi:10.21105/joss.04495 · Cited by 14 · see citing works
Marcello, M., Ebert, M. A., Haworth, A., Steigler, A., Kennedy, A., Joseph, D. J., & Denham, J. W. (2017) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2017.10.021 · Cited by 14 · see citing works
Research Note: Causal inference
Herbert, R. (2020) · Journal of physiotherapy · doi:10.1016/j.jphys.2020.07.010 · Cited by 14 · see citing works
- Authors
- VanderWeele, T. J., & Shpitser, I.
- Affiliations
- Harvard University (US)
- Venue
- The Annals of Statistics
- Publisher
- Institute of Mathematical Statistics
- Published
- 2013-02-01
- Volume
- 41
- Issue
- 1
- Pages
- 196-220
- ISSN
- 0090-5364 (ISSN-L)
- 2168-8966
- PMC
- PMC4276366
- OpenAlex
- W2067177016
- Cited by
- 268
- References
- 46
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 28 · 2023: 25 · 2022: 23 · 2021: 46 · 2020: 33 · 2019: 20 · 2018: 17 · 2017: 15 · 2016: 11 · 2015: 5 · 2014: 3 · 2013: 1
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Annals of Statistics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- arXiv (Cornell University) (submittedVersion)
- Collection of Biostatistics Research Archive (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Project Euclid (Cornell University) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- arXiv (Cornell University)
- Funders
- National Institutes of Health (ES017876)
- National Institute of Environmental Health Sciences (R01ES017876, R56ES017876)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03HD060696)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Inference
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Keywords
- confounding, causal inference, unconfoundedness, covariate control
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review