The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites
Abstract
The complex, yet highly ordered and predictable, structure of the neural retina is one of the most conserved features of the vertebrate central nervous system. In all vertebrate classes, retinal neurons are organized into laminae with each neuronal class adopting specific morphologies and patterns of connectivity. Using genetic analyses in zebrafish, we demonstrate that N-cadherin (Ncad) has several distinct and crucial functions during the establishment of retinal organization. Although the location of cell division is disorganized in embryos with reduced or no Ncad function, different classes of retinal neurons are generated. However, these neurons fail to organize into correct laminae, most probably owing to compromised adhesion between retinal cells. In addition, amacrine cells exhibit exuberant and misdirected outgrowth of neurites that contributes to severe disorganization of the inner plexiform layer. Retinal ganglion cells also exhibit defects in process outgrowth, with axons exhibiting fasciculation defects and adopting incorrect ipsilateral trajectories. At least some of these defects are likely to be due to a failure to maintain compartment boundaries between eye, optic nerve and brain. Although in vitro studies have implicated Fgf receptors in modulating the axon outgrowth promoting properties of Ncad, most aspects of the Ncad mutant phenotype are not phenocopied by treatments that block Fgf receptor function.
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Citations
Cites
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N-cadherin mediates cortical organization in the mouse brain
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Neural control and modulation of swimming speed in the larval zebrafish
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“The OMR is known to persist in the absence of the optic tectum, the largest of these processing areas (Roeser and Baier, 2003), and when we imaged larvae expressing the fluorescent protein dendra under the control of a promoter that drives expression in RGCs (atoh7/ath5) (Kay et al., 2001; Masai et al., 2003) we saw n…”
N-cadherin Mediates Endocytosis of Candida albicans by Endothelial Cells
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Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives
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Self-citation
Metadata
- Authors
- Masai, I., Lele, Z., Yamaguchi, M., Komori, A., Nakata, A., Nishiwaki, Y., Wada, H., Tanaka, H., Nojima, Y., Hammerschmidt, M., Wilson, S. W., & Okamoto, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-06-01
- Volume
- 130
- Issue
- 11
- Pages
- 2479-2494
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2146404892
- Cited by
- 256
- References
- 70
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
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