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Cited by 256

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites

Masai, Ichiro, Lele, Zsolt, Yamaguchi, Masahiro, Komori, Atsuko, Nakata, Asuka, Nishiwaki, Yuko, Wada, Hironori, Tanaka, Hideomi, Nojima, Yasuhiro, Hammerschmidt, Matthias, Wilson, Stephen W., Okamoto, Hitoshi·2003·Development
DOI 10.1242/dev.00465
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Abstract

The complex, yet highly ordered and predictable, structure of the neural retina is one of the most conserved features of the vertebrate central nervous system. In all vertebrate classes, retinal neurons are organized into laminae with each neuronal class adopting specific morphologies and patterns of connectivity. Using genetic analyses in zebrafish, we demonstrate that N-cadherin (Ncad) has several distinct and crucial functions during the establishment of retinal organization. Although the location of cell division is disorganized in embryos with reduced or no Ncad function, different classes of retinal neurons are generated. However, these neurons fail to organize into correct laminae, most probably owing to compromised adhesion between retinal cells. In addition, amacrine cells exhibit exuberant and misdirected outgrowth of neurites that contributes to severe disorganization of the inner plexiform layer. Retinal ganglion cells also exhibit defects in process outgrowth, with axons exhibiting fasciculation defects and adopting incorrect ipsilateral trajectories. At least some of these defects are likely to be due to a failure to maintain compartment boundaries between eye, optic nerve and brain. Although in vitro studies have implicated Fgf receptors in modulating the axon outgrowth promoting properties of Ncad, most aspects of the Ncad mutant phenotype are not phenocopied by treatments that block Fgf receptor function.

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Cites

Research works printed but not linked: 2

  1. Lom, B., Höpker, V., McFarlane, S., Bixby, J. L. and Holt,C. E. (1998). Fibroblast growth factor receptor signaling in Xenopus retinal axon extension. J. Neurobiol.37,633-641. · doi:10.1002/(sici)1097-4695(199812)37:4<633::aid-neu11>3.0.co;2-l
  2. Westerfield, M. (1995). The Zebrafish Book. Salem, OR: University of Oregon Press.

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Metadata

Authors
Masai, I., Lele, Z., Yamaguchi, M., Komori, A., Nakata, A., Nishiwaki, Y., Wada, H., Tanaka, H., Nojima, Y., Hammerschmidt, M., Wilson, S. W., & Okamoto, H.
Venue
Development
Publisher
The Company of Biologists
Published
2003-06-01
Volume
130
Issue
11
Pages
2479-2494
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.00465
OpenAlex
W2146404892
Cited by
256
References
70
FWCI
7.22
Type
journal article
Language
en
Open access
closed

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