The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration
Abstract
Planarians can be cut into irregularly shaped fragments capable of regenerating new and complete organisms. Such regenerative capacities involve a robust ability to restore bilateral symmetry. We have identified three genes needed for bilaterally asymmetric fragments to regenerate missing body parts. These genes are candidate components of a signaling pathway that controls the dorsal-ventral patterning of many animal embryos: a BMP1/Tolloid-like gene(smedolloid-1), a SMAD4-like gene (smedsmad4-1), and a BMP2/4/DPP-like gene (smedbmp4-1). BMP signaling was involved in the formation of new tissues at the midline of regeneration, the dorsal-ventral patterning of new tissues, and the maintenance of the dorsal-ventral pattern of existing adult tissue in homeostasis. smedbmp4-1 was normally expressed at the dorsal midline. Asymmetric fragments lacking a midline displayed new smedbmp4-1 expression prior to formation of a regenerative outgrowth (blastema). Asymmetric fragments containing the midline displayed expanded smedbmp4-1 expression towards the wound. We suggest injured animals that lack left-right symmetry reset their midline through modulation of BMP activity as an early and necessary event in regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS
De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671
The new animal phylogeny: Reliability and implications
Adoutte, A., Balavoine, G., Lartillot, N., Lespinet, O., Prud'homme, B., & de Rosa, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4453 · Cited by 512
Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanisms
Holley, S. A., & Ferguson, E. L. (1997) · BioEssays · doi:10.1002/bies.950190404 · Cited by 122
Cited by
Cell type transcriptome atlas for the planarian Schmidtea mediterranea
Fincher, C. T., Wurtzel, O., de Hoog, T., Kravarik, K. M., & Reddien, P. W. (2018) · Science · doi:10.1126/science.aaq1736 · Cited by 436
Self-citationAdvances in understanding tissue regenerative capacity and mechanisms in animals
Poss, K. D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2879 · Cited by 416
BMP gradients: A paradigm for morphogen-mediated developmental patterning
Bier, E., & De Robertis, E. M. (2015) · Science · doi:10.1126/science.aaa5838 · Cited by 311
Muscle cells provide instructions for planarian regeneration
Witchley, J. N., Mayer, M., Wagner, D. E., Owen, J. H., & Reddien, P. W. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.022 · Cited by 264
Self-citationA wound-induced Wnt expression program controls planarian regeneration polarity
Petersen, C. P., & Reddien, P. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906823106 · Cited by 251
Self-citationStückemann, T., Cleland, J. P., Werner, S., Thi-Kim Vu, H., Bayersdorf, R., Liu, S.-Y., Friedrich, B., Jülicher, F., & Rink, J. C. (2017) · Developmental Cell · doi:10.1016/j.devcel.2016.12.024 · Cited by 133
Scimone, M. L., Lapan, S. W., & Reddien, P. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1003999 · Cited by 95
Self-citationThe stem cell system in demosponges: Insights into the origin of somatic stem cells
Funayama, N. (2010) · Development, Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01162.x · Cited by 95
zic-1 expression in planarian neoblasts after injury controls anterior pole regeneration
Vásquez-Doorman, C., & Petersen, C. P. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004452 · Cited by 83
Funayama, N. (2013) · Development Genes and Evolution · doi:10.1007/s00427-012-0417-5 · Cited by 82
Wnt and TGFβ coordinate growth and patterning to regulate size-dependent behaviour
Arnold, C. P., Benham-Pyle, B. W., Lange, J. J., Wood, C. J., & Sánchez Alvarado, A. (2019) · Nature · doi:10.1038/s41586-019-1478-7 · Cited by 65
Lin, A. Y. T., & Pearson, B. J. (2014) · Development · doi:10.1242/dev.101915 · Cited by 57
pbx is required for pole and eye regeneration in planarians
Chen, C.-C. G., Wang, I. E., & Reddien, P. W. (2013) · Development · doi:10.1242/dev.083741 · Cited by 56
Self-citationYorkie is required to restrict the injury responses in planarians
Lin, A. Y. T., & Pearson, B. J. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006874 · Cited by 38
Metadata
- Authors
- Reddien, P. W., Bermange, A. L., Kicza, A. M., & Sánchez Alvarado, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-11-15
- Volume
- 134
- Issue
- 22
- Pages
- 4043-4051
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2134880341
- Cited by
- 173
- References
- 4
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
