Ribosomal protein L24 defect in Belly spot and tail (Bst), a mouse Minute
Open accessAbstract
Ribosomal protein mutations, termed Minutes, have been instrumental in studying the coordination of cell and tissue growth in Drosophila. Although abundant in flies, equivalent defects in mammals are relatively unknown. Belly spot and tail (Bst) is a semidominant mouse mutation that disrupts pigmentation, somitogenesis and retinal cell fate determination. Here, we identify Bst as a deletion within the Rpl24 riboprotein gene. Bst significantly impairs Rpl24 splicing and ribosome biogenesis. Bst/+ cells have decreased rates of protein synthesis and proliferation, and are outcompeted by wild-type cells in C57BLKS↔ROSA26 chimeras. Bacterial artificial chromosome (BAC) and cDNA transgenes correct the mutant phenotypes. Our findings establish Bst as a mouse Minute and provide the first detailed characterization of a mammalian ribosomal protein mutation.
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Several mouse coat color mutants are ribosomal proteins, although they are not the ribosomal components enriched here.
“Pigment cell enrichment of ribosomal components is not surprising, considering several mouse coat color mutants are ribosomal proteins, although they are not the ribosomal components enriched here [50]–[53].”
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- Authors
- Oliver, E. R., Saunders, T. L., Tarlé, S. A., & Glaser, T.
- Affiliations
- University of Michigan (US)
- Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-08-15
- Volume
- 131
- Issue
- 16
- Pages
- 3907-3920
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC2262800
- OpenAlex
- W2145557606
- Cited by
- 288
- References
- 0
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 13 · 2023: 8 · 2022: 21 · 2021: 17 · 2020: 15 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 12 · 2014: 22 · 2013: 23 · 2012: 11
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (EY14259, R01EY014259, R01EY011729, EY12994, R01EY012994)
- National Institute of General Medical Sciences (GM067840, T32GM007863, R01GM067840)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK20572, P60DK020572, P30DK020572)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-07505, T32HD007505)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- ribosomal protein L24, ribosome biogenesis, somitogenesis, protein synthesis, cell proliferation, semi-dominant mutation, transgenic rescue
- MeSH terms
- Animals, Fibroblasts, Mice, Transgenic, Mutation, Ribosomal Proteins, Ribosomes, RNA Splicing, Skin Abnormalities, Tail, Mice
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