The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity
Open accessAbstract
The establishment and stability of cell fates during development depend on the integration of multiple signals, which ultimately modulate specific patterns of gene expression. While there is ample evidence for this integration at the level of gene regulatory sequences, little is known about its operation at other levels of cellular activity. Wnt and Notch signalling are important elements of the circuitry that regulates gene expression in development and disease. Genetic analysis has suggested that in addition to convergence on the transcription of specific genes, there are modulatory cross-regulatory interactions between these signalling pathways. We report that the nodal point of these interactions is an activity of Notch that regulates the activity and the amount of the active/oncogenic form of Armadillo/β-catenin. This activity of Notch is independent of that induced upon cleavage of its intracellular domain and which mediates transcription through Su(H)/CBF1. The modulatory function of Notch described here, contributes to the establishment of a robust threshold for Wnt signalling which is likely to play important roles in both normal and pathological situations.
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Cites
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286 · cited 10×
“This form of Armadillo lacks the Shaggy/GSK3β phosphorylation sites and provides Wingless-independent signalling by escaping degradation by the Axin-based destruction complex (Pai et al., 1997).”
BackgroundInfluentialTolwinski, N. S., & Wieschaus, E. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.02.003 · Cited by 151 · cited 3×
“While the central role of Armadillo/β-catenin is well established, the mechanism by which it is activated remains open to discussion (Giles et al., 2003; Tolwinski and Wieschaus, 2004b).”
Background
Cited by
Notch signaling: simplicity in design, versatility in function
Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
Wnt/β-catenin signaling in cancers and targeted therapies
Yu, F., Yu, C., Li, F., Zuo, Y., Wang, Y., Yao, L., Wu, C., Wang, C., & Ye, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00701-5 · Cited by 734
Signaling Involved in Hair Follicle Morphogenesis and Development
Rishikaysh, P., Dev, K., Diaz, D., Qureshi, W., Filip, S., & Mokry, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011647 · Cited by 393
Cell and molecular biology of Notch
Fiúza, U.-M., & Arias, A. M. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0242 · Cited by 371
Self-citationThe Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, A. E., Xu, J., & Gridley, T. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020004 · Cited by 290
Metadata
- Authors
- Hayward, P., Brennan, K., Sanders, P., Balayo, T., DasGupta, R., Perrimon, N., & Arias, A. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-04-15
- Volume
- 132
- Issue
- 8
- Pages
- 1819-1830
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2035521614
- Cited by
- 204
- References
- 3
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- green
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