The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity
Open accessAbstract
The establishment and stability of cell fates during development depend on the integration of multiple signals, which ultimately modulate specific patterns of gene expression. While there is ample evidence for this integration at the level of gene regulatory sequences, little is known about its operation at other levels of cellular activity. Wnt and Notch signalling are important elements of the circuitry that regulates gene expression in development and disease. Genetic analysis has suggested that in addition to convergence on the transcription of specific genes, there are modulatory cross-regulatory interactions between these signalling pathways. We report that the nodal point of these interactions is an activity of Notch that regulates the activity and the amount of the active/oncogenic form of Armadillo/β-catenin. This activity of Notch is independent of that induced upon cleavage of its intracellular domain and which mediates transcription through Su(H)/CBF1. The modulatory function of Notch described here, contributes to the establishment of a robust threshold for Wnt signalling which is likely to play important roles in both normal and pathological situations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286 · cited 10×
“This form of Armadillo lacks the Shaggy/GSK3β phosphorylation sites and provides Wingless-independent signalling by escaping degradation by the Axin-based destruction complex (Pai et al., 1997).”
BackgroundInfluentialTolwinski, N. S., & Wieschaus, E. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.02.003 · Cited by 151 · cited 3×
“While the central role of Armadillo/β-catenin is well established, the mechanism by which it is activated remains open to discussion (Giles et al., 2003; Tolwinski and Wieschaus, 2004b).”
Background
Cited by
Notch signaling: simplicity in design, versatility in function
Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
Wnt/β-catenin signaling in cancers and targeted therapies
Yu, F., Yu, C., Li, F., Zuo, Y., Wang, Y., Yao, L., Wu, C., Wang, C., & Ye, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00701-5 · Cited by 734
Signaling Involved in Hair Follicle Morphogenesis and Development
Rishikaysh, P., Dev, K., Diaz, D., Qureshi, W., Filip, S., & Mokry, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011647 · Cited by 393
Cell and molecular biology of Notch
Fiúza, U.-M., & Arias, A. M. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0242 · Cited by 371
Self-citationThe Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, A. E., Xu, J., & Gridley, T. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020004 · Cited by 290
Notch inhibitors for cancer treatment
Espinoza, I., & Miele, L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.02.003 · Cited by 273
Filtering transcriptional noise during development: concepts and mechanisms
Arias, A. M., & Hayward, P. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1750 · Cited by 262
Self-citationJagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis
Estrach, S., Ambler, C. A., Lo Celso, C. L., Hozumi, K., & Watt, F. M. (2006) · Development · doi:10.1242/dev.02644 · Cited by 254
Cutaneous barrier dysfunction in allergic diseases
Leung, D. Y. M., Berdyshev, E., & Goleva, E. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.021 · Cited by 190
Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis
Siveke, J. T., Lubeseder–Martellato, C., Lee, M., Mazur, P. K., Nakhai, H., Radtke, F., & Schmid, R. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.003 · Cited by 162
Metadata
- Authors
- Hayward, P., Brennan, K., Sanders, P., Balayo, T., DasGupta, R., Perrimon, N., & Arias, A. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-04-15
- Volume
- 132
- Issue
- 8
- Pages
- 1819-1830
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2035521614
- Cited by
- 204
- References
- 3
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
