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The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription
Abstract
The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, and, as such, is a model system in developmental biology for studying how a single initiating event can orchestrate a highly complex and predictable response. Recent findings indicate that Myod functions in an instructive chromatin context and directly regulates genes that are expressed throughout the myogenic program, achieving promoter-specific regulation of its own binding and activity through a feed-forward mechanism. These studies are beginning to merge our understanding of how lineage-specific information is encoded in chromatin with how master regulatory factors drive programs of cell differentiation.
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Cited by
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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
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MEF2: a central regulator of diverse developmental programs
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Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
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Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
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Reprogramming cell fates: reconciling rarity with robustness
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Dynamics of the skeletal muscle secretome during myoblast differentiation
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The IKK complex contributes to the induction of autophagy
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Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicans
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Circadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211
Historical origins of transdifferentiation and reprogramming
Graf, T. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.012 · Cited by 194
Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Baig, M. H., Ahmad, K., Moon, J. S., Park, S.-Y., Ho Lim, J., Chun, H. J., Qadri, A. F., Hwang, Y. C., Jan, A. T., Ahmad, S. S., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.876078 · Cited by 135
“…by Myf5, drives cells to the myogenic lineage, and MYOG seems to work downstream of Myf5 and MyoD, and it is necessary for the establishment of the myogenic lineage as well as terminal differentiation of myoblasts (Lindon et al., 1998; Tapscott, 2005; Londhe and Davie, 2011; Ganassi et al., 2020).”
BackgroundP38-γ–dependent gene silencing restricts entry into the myogenic differentiation program
Gillespie, M. A., Le Grand, F., Scimè, A., Kuang, S., von Maltzahn, J., Seale, V., Cuenda, A., Ranish, J. A., & Rudnicki, M. A. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907037 · Cited by 131
Alway, S. E., Pereira, S. L., Edens, N. K., Hao, Y., & Bennett, B. T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.005 · Cited by 114
Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity
Wilkinson, A. C., Nakauchi, H., & Göttgens, B. (2017) · Cell Systems · doi:10.1016/j.cels.2017.07.004 · Cited by 76
Watanabe, S., Hirai, H., Asakura, Y., Tastad, C., Verma, M., Keller, C., Dutton, J. R., & Asakura, A. (2011) · Stem Cells · doi:10.1002/stem.598 · Cited by 44
Long Range Interactions Regulate Igf2 Gene Transcription during Skeletal Muscle Differentiation
Alzhanov, D. T., McInerney, S. F., & Rotwein, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.160986 · Cited by 44
Beffy, P., Del Carratore, R., Masini, M., Furling, D., Puymirat, J., Masiello, P., & Simili, M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.010 · Cited by 42
Lee, H., Tuong, L. T., Jeong, J. H., Lee, S.-J., Bae, G.-U., & Ryu, J.-H. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.02.003 · Cited by 19
Metadata
- Authors
- Tapscott, S. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-06-15
- Volume
- 132
- Issue
- 12
- Pages
- 2685-2695
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2083441653
- Cited by
- 763
- References
- 4
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- closed
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