The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Molecular characterization of melanocyte stem cells in their niche
Open accessAbstract
Emerging evidence from stem cell (SC) research has strengthened the idea that SC fate is determined by a specialized environment, known as the SC niche. However, because of the difficulty of identifying individual stem cells and their surrounding components in situ, the exact mechanisms underlying SC regulation by the niche remain elusive. To overcome this difficulty, we employed melanocyte stem cells (MSCs), which allow the identification of individual SCs in the niche, the lower permanent portion of the hair follicle(HF). Here, we present molecular makers that can distinguish MSCs from other melanocyte (MC) subsets in the HF. We also describe a simple and robust method that allows gene expression profiling in individual SCs. After isolating individual MSCs from transgenic mice in which the MCs are marked by green fluorescence protein (GFP), we performed single-cell transcript analysis to obtain the molecular signature of individual MSCs in the niche. The data suggest the existence of a mechanism that induces the downregulation of various key molecules for MC proliferation or differentiation in MSCs located in the niche. By integrating these data, we propose that the niche is an environment that insulates SCs from various activating stimuli and maintains them in a quiescent state.
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Cites
Stochastic Gene Expression in a Single Cell
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Defining the Epithelial Stem Cell Niche in Skin
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Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
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Single-Cell Transcriptional Analysis of Neuronal Progenitors
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Cited by
The melanocyte lineage in development and disease
Mort, R. L., Jackson, I. J., & Patton, E. E. (2015) · Development · doi:10.1242/dev.106567 · Cited by 416
Afamelanotide for Erythropoietic Protoporphyria
Langendonk, J. G., Balwani, M., Anderson, K. E., Bonkovsky, H. L., Anstey, A. V., Bissell, D. M., Bloomer, J., Edwards, C., Neumann, N. J., Parker, C., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411481 · Cited by 283
Stripes and belly-spots—A review of pigment cell morphogenesis in vertebrates
Kelsh, R. N., Harris, M. L., Colanesi, S., & Erickson, C. A. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.10.001 · Cited by 202
Johnson, S. L., Nguyen, A. N., & Lister, J. A. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.004 · Cited by 85
Qiu, W., Chuong, C., & Lei, M. (2019) · Experimental Dermatology · doi:10.1111/exd.13856 · Cited by 78
Metadata
- Authors
- Osawa, M., Egawa, G., Mak, S.-S., Moriyama, M., Freter, R., Yonetani, S., Beermann, F., & Nishikawa, S.-I.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-12-15
- Volume
- 132
- Issue
- 24
- Pages
- 5589-5599
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2044560586
- Cited by
- 209
- References
- 7
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Osawa, M., Egawa, G., Mak, S.-S., Moriyama, M., Freter, R., Yonetani, S., Beermann, F., & Nishikawa, S.-I. (2005). Molecular characterization of melanocyte stem cells in their niche. Development. https://doi.org/10.1242/dev.02161
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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