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Cited by 485

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Vascular wall resident progenitor cells: a source for postnatal vasculogenesis

Zengin, Elvin, Chalajour, Fariba, Gehling, Ursula M., Ito, Wulf D., Treede, Hendrik, Lauke, Heidrun, Weil, Joachim, Reichenspurner, Hermann, Kilic, Nerbil, Ergün, Süleyman·2006·Development
DOI 10.1242/dev.02315
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Abstract

Here, we report the existence of endothelial precursor (EPC) and stem cells in a distinct zone of the vascular wall that are capable to differentiate into mature endothelial cells, hematopoietic and local immune cells, such as macrophages. This zone has been identified to be localized between smooth muscle and adventitial layer of human adult vascular wall. It predominantly contains CD34-positive (+) but CD31-negative (-) cells, which also express VEGFR2 and TIE2. Only few cells in this zone of the vascular wall are positive for CD45. In a ring assay using the fragments of human internal thoracic artery (HITA), we show here that the CD34+ cells of the HITA-wall form capillary sprouts ex vivo and are apparently recruited for capillary formation by tumor cells. New vessels formed by these vascular wall resident EPCs express markers for angiogenically activated endothelial cells, such as CEACAM1, and also for mature endothelial cells, such as VE-cadherin or occludin. Vascular wall areas containing EPCs are found in large and middle sized arteries and veins of all organs studied here. These data suggest the existence of a `vasculogenic zone' in the wall of adult human blood vessels,which may serve as a source for progenitor cells for postnatal vasculogenesis,contributing to tumor vascularization and local immune response.

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Metadata

Authors
Zengin, E., Chalajour, F., Gehling, U. M., Ito, W. D., Treede, H., Lauke, H., Weil, J., Reichenspurner, H., Kilic, N., & Ergün, S.
Venue
Development
Publisher
The Company of Biologists
Published
2006-04-15
Volume
133
Issue
8
Pages
1543-1551
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.02315
OpenAlex
W2132919634
Cited by
485
References
29
FWCI
10.56
Type
journal article
Language
en
Open access
closed

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