The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis
Open accessAbstract
The Wnt and Notch signalling pathways regulate hair follicle maintenance,but how they intersect is unknown. We show that Notch signalling is active in the hair follicle pre-cortex, a region of high Wnt activity, where commitment to hair lineages occurs. Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing interfollicular epidermal differentiation. Conversely, activation of Notch in adult epidermis triggers expansion of the base of the hair follicle, sebaceous gland enlargement and abnormal clumping of the follicles. In adult epidermis, the induction of new hair follicle formation by β-catenin is prevented by blocking Notch signalling pharmacologically or through Jag1 deletion. Conversely, activation of both pathways accelerates growth and differentiation of ectopic follicles.β-catenin stimulates Notch signalling by inducing Jag1transcription. We conclude that the Notch pathway acts downstream of the Wnt/β-catenin pathway to determine epidermal cell fate.
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Cites
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WNT Signals Are Required for the Initiation of Hair Follicle Development
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Cited by
Notch signaling: simplicity in design, versatility in function
Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation
Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H.-A., Lai, K., Ahn, R., Corbin, K., Lowe, M. M., Scharschmidt, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.002 · Cited by 680
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
Kode, A., Manavalan, J. S., Mosialou, I., Bhagat, G., Rathinam, C. V., Luo, N., Khiabanian, H., Lee, A., Murty, V. V., Friedman, R., et al. (2014) · Nature · doi:10.1038/nature12883 · Cited by 532
Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
Mizutani, K.-I., Yoon, K., Dang, L., Tokunaga, A., & Gaiano, N. (2007) · Nature · doi:10.1038/nature06090 · Cited by 521
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
Rodilla, V., Villanueva, A., Obrador-Hevia, A., Robert-Moreno, À., Fernández-Majada, V., Grilli, A., López-Bigas, N., Bellora, N., Albà, M. M., Torres, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813221106 · Cited by 384
Metadata
- Authors
- Estrach, S., Ambler, C. A., Lo Celso, C. L., Hozumi, K., & Watt, F. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-11-15
- Volume
- 133
- Issue
- 22
- Pages
- 4427-4438
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2094394048
- Cited by
- 254
- References
- 50
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis. https://app.cochat.ai/papers/10.1242/dev.02644
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- Estrach, S., Ambler, C. A., Lo Celso, C. L., Hozumi, K., & Watt, F. M. (2006). Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development. https://doi.org/10.1242/dev.02644
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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