Vascular endothelial growth factors (VEGFs) and stroke

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

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Neuronal replacement from endogenous precursors in the adult brain after stroke

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Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

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Vascular endothelial growth factor (VEGF) stimulates neurogenesis <i>in vitro</i> and <i>in vivo</i>

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VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain

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VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

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VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

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Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat

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Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

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Pathophysiological consequences of VEGF-induced vascular permeability

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Role of angiogenesis in patients with cerebral ischemic stroke.

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Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System

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Extensive Cortical Rewiring after Brain Injury

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Vascular endothelial growth factor: Direct neuroprotective effect in <i>in vitro</i> ischemia

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Evidence for stroke-induced neurogenesis in the human brain

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Cellular and molecular mechanisms of neural repair after stroke: making waves

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Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia

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Vascular Endothelial Growth Factor 165 Gene Transfer Augments Circulating Endothelial Progenitor Cells in Human Subjects

Kalka, C., Masuda, H., Takahashi, T., Gordon, R., Tepper, O. M., Gravereaux, E. C., Pieczek, A., Iwaguro, H., Hayashi, S.-I., Isner, J. M., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1198 · Cited by 564 · see citing works

From angiogenesis to neuropathology

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Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum

Jin, K., Sun, Y., Xie, L., Peel, A. L., Mao, X. O., Parmentier‐Batteur, S., & Greenberg, D. A. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00159-3 · Cited by 515 · see citing works

Neocortical Neural Sprouting, Synaptogenesis, and Behavioral Recovery After Neocortical Infarction in Rats

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Vascular endothelial growth factor B controls endothelial fatty acid uptake

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VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

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Reorganization of Remote Cortical Regions After Ischemic Brain Injury: A Potential Substrate for Stroke Recovery

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VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works

Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex

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Correlation of VEGF and Angiopoietin Expression with Disruption of Blood–Brain Barrier and Angiogenesis after Focal Cerebral Ischemia

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Collateral circulation

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Impact of collateral flow on tissue fate in acute ischaemic stroke

Bang, O. Y., Saver, J. L., Buck, B. H., Alger, J. R., Starkman, S., Ovbiagele, B. I., Kim, D., Jahan, R., Duckwiler, G., Yoon, S. R., et al. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.132100 · Cited by 383 · see citing works

Activated Neural Stem Cells Contribute to Stroke-Induced Neurogenesis and Neuroblast Migration toward the Infarct Boundary in Adult Rats

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Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis

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Postinfarct Cortical Plasticity and Behavioral Recovery

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Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk‐1 receptor

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Mechanisms of Angiogenesis in the Brain

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VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization

Li, B., Sharpe, E. E., Maupin, A. B., Teleron, A. A., Pyle, A. L., Carmeliet, P., & Young, P. P. (2006) · The FASEB Journal · doi:10.1096/fj.05-5137fje · Cited by 324 · see citing works

Rapid Induction of Vascular Endothelial Growth Factor Gene Expression After Transient Middle Cerebral Artery Occlusion in Rats

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Reduction of Ischemic Damage by Application of Vascular Endothelial Growth Factor in Rat Brain after Transient Ischemia

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New Patterns of Intracortical Projections after Focal Cortical Stroke

Carmichael, S. T., Wei, L., Rovainen, C. M., & Woolsey, T. A. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0425 · Cited by 302 · see citing works

Nitric Oxide Enhances Angiogenesis via the Synthesis of Vascular Endothelial Growth Factor and cGMP After Stroke in the Rat

Zhang, R., Wang, L., Li, Z., Chen, J., Zhu, Z., Zhang, Z., & Chopp, M. (2003) · Circulation Research · doi:10.1161/01.res.0000056757.93432.8c · Cited by 298 · see citing works

Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia

Liu, H. (2006) · Brain · doi:10.1093/brain/awl207 · Cited by 292 · see citing works

Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor.

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Neuroprotection by Hypoxic Preconditioning Requires Sequential Activation of Vascular Endothelial Growth Factor Receptor and Akt

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VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease

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VEGF and flt

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Vascular endothelial growth factor rescues hippocampal neurons from glutamate‐induced toxicity: signal transduction cascades

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Paracrine and Autocrine Functions of Neuronal Vascular Endothelial Growth Factor (VEGF) in the Central Nervous System

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Diverse roles for VEGF-A in the nervous system

Mackenzie, F., & Ruhrberg, C. (2012) · Development · doi:10.1242/dev.072348 · Cited by 266 · see citing works

Cortical Neurogenesis in Adult Rats after Reversible Photothrombotic Stroke

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Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair

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Human Neural Stem Cells Over-Expressing VEGF Provide Neuroprotection, Angiogenesis and Functional Recovery in Mouse Stroke Model

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Cell Type Specific Upregulation of Vascular Endothelial Growth Factor in an MCA-occlusion Model of Cerebral Infarct

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Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures

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Expression of Vascular Endothelial Growth Factor (VEGF) and its Receptors (Flt-1 and Flk-1) following Permanent and Transient Occlusion of the Middle Cerebral Artery in the Rat

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The Increase of Circulating Endothelial Progenitor Cells After Acute Ischemic Stroke Is Associated With Good Outcome

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Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice

Jin, K., Wang, X., Xie, L., Mao, X. O., & Greenberg, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000154107 · Cited by 225 · see citing works

VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena

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Neurotrophic Effects of Vascular Endothelial Growth Factor on Organotypic Cortical Explants and Primary Cortical Neurons

Rosenstein, J. M., Mani, N., Khaibullina, A., & Krum, J. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11036.2003 · Cited by 220 · see citing works

Irradiation attenuates neurogenesis and exacerbates ischemia‐induced deficits

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Endothelial Progenitor Cells During Cerebrovascular Disease

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Vascular Endothelial Growth Factor-A Specifies Formation of Native Collaterals and Regulates Collateral Growth in Ischemia

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Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration

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Regulation of hypoxia-inducible factor 1α and induction of vascular endothelial growth factor in a rat neonatal stroke model

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Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice

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VEGF Protects Brain against Focal Ischemia without Increasing Blood–Brain Permeability When Administered Intracerebroventricularly

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Endogenous Neurogenesis in the Human Brain following Cerebral Infarction

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Activated Microvessels Express Vascular Endothelial Growth Factor and Integrin α v β 3 During Focal Cerebral Ischemia

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Induction of vascular endothelial growth factor and hypoxia-inducible factor-1α by global ischemia in rat brain

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Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling

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Vascular Endothelial Growth Factor Is Required for Coronary Collateral Growth in the Rat

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Vascular Endothelial Growth Factor Protects Cultured Rat Hippocampal Neurons Against Hypoxic Injury via an Antiexcitotoxic, Caspase-Independent Mechanism

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Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat

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Vascular Endothelial Growth Factor Antagonist Reduces Brain Edema Formation and Venous Infarction

Kimura, R., Nakase, H., Tamaki, R., & Sakaki, T. (2005) · Stroke · doi:10.1161/01.str.0000165925.20413.14 · Cited by 117 · see citing works

Vascular Endothelial Growth Factor Rescues HN33 Neural Cells from Death Induced by Serum Withdrawal

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Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures

Khaibullina, A. A., Rosenstein, J. M., & Krum, J. M. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.09.022 · Cited by 114 · see citing works

Therapeutic Induction of Arteriogenesis in Hypoperfused Rat Brain Via Granulocyte-Macrophage Colony-Stimulating Factor

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Vascular Endothelial Growth Factor Receptor-2 Inhibition Promotes Cell Death and Limits Endothelial Cell Proliferation in a Neonatal Rodent Model of Stroke

Shimotake, J., Derugin, N., Wendland, M. F., Vexler, Z. S., & Ferriero, D. M. (2010) · Stroke · doi:10.1161/strokeaha.109.564229 · Cited by 110 · see citing works

Arteriogenesis in Hypoperfused Rat Brain

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Electrophysiological transcortical diaschisis after middle cerebral artery occlusion (MCAO) in rats

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Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct.

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Murine Neural Stem/Progenitor Cells Protect Neurons against Ischemia by HIF-1α–Regulated VEGF Signaling

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Increased Severity of Cerebral Ischemic Injury in Vascular Endothelial Growth Factor-B–Deficient Mice

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Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor

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Development of Collaterals in the Cerebral Circulation

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Combined treatment of vascular endothelial growth factor and human neural stem cells in experimental focal cerebral ischemia

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Expression of vascular endothelial growth factor mRNA following transient forebrain ischemia in rats

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Transplantation of Vascular Endothelial Growth Factor-transfected Neural Stem Cells into the Rat Brain Provides Neuroprotection after Transient Focal Cerebral Ischemia

Zhu, W. P., Mao, Y. Q., Zhao, Y., Zhou, L., Wang, Y., Zhu, J., Zhu, Y., & Yang, G. (2005) · Neurosurgery · doi:10.1227/01.neu.0000166682.50272.bc · Cited by 72 · see citing works

Neuroprotective Effects of Vascular Endothelial Growth Factor Following Hypoxic Ischemic Brain Injury in Neonatal Rats

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Human endothelial stem/progenitor cells, angiogenic factors and vascular repair

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DNA Vaccination Against VEGF Receptor 2 Reduces Atherosclerosis in LDL Receptor–Deficient Mice

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