The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors
Open accessAbstract
Severe traumatic injury to the adult mammalian CNS leads to life-long loss of function. By contrast, several non-mammalian vertebrate species, including adult zebrafish, have a remarkable ability to regenerate injured organs, including the CNS. However, the cellular and molecular mechanisms that enable or prevent CNS regeneration are largely unknown. To study brain regeneration mechanisms in adult zebrafish, we developed a traumatic lesion assay, analyzed cellular reactions to injury and show that adult zebrafish can efficiently regenerate brain lesions and lack permanent glial scarring. Using Cre-loxP-based genetic lineage-tracing, we demonstrate that her4.1-positive ventricular radial glia progenitor cells react to injury, proliferate and generate neuroblasts that migrate to the lesion site. The newly generated neurons survive for more than 3 months, are decorated with synaptic contacts and express mature neuronal markers. Thus, regeneration after traumatic lesion of the adult zebrafish brain occurs efficiently from radial glia-type stem/progenitor cells.
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Cites
Neuronal replacement from endogenous precursors in the adult brain after stroke
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Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
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“…it relies on the observation of upregulated proliferation and neurogenesis after lesion in the ventricular zone and enhanced migration of newborn neurons to the lesion site (Endo et al., 2007; Font et al., 2001; Kaslin et al., 2008; Kirsche, 1965; Romero-Aleman et al., 2004; Zupanc and Ott, 1999).”
The bright side of the glial scar in CNS repair
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Self-citation
Cited by
Key, B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1011 · Cited by 318
Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration
Wei, X., Fu, S., Li, H., Liu, Y., Wang, S., Feng, W., Yang, Y., Liu, X., Zeng, Y.-Y., Cheng, M., et al. (2022) · Science · doi:10.1126/science.abp9444 · Cited by 311
Insects have the capacity for subjective experience
Klein, C., & Barron, A. B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1113 · Cited by 243
β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina
Meyers, J. R., Hu, L., Moses, A., Kaboli, K., Papandrea, A., & Raymond, P. A. (2012) · Neural Development · doi:10.1186/1749-8104-7-30 · Cited by 144
Cosacak, M. I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., & Kizil, C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.090 · Cited by 116
Metadata
- Authors
- Kroehne, V., Freudenreich, D., Hans, S., Kaslin, J., & Brand, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-11-15
- Volume
- 138
- Issue
- 22
- Pages
- 4831-4841
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2042178048
- Cited by
- 452
- References
- 12
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kroehne, V., Freudenreich, D., Hans, S., Kaslin, J., & Brand, M. (2011). Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors. Development. https://doi.org/10.1242/dev.072587
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