The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Notch3 establishes brain vascular integrity by regulating pericyte number
Open accessAbstract
Brain pericytes are important regulators of brain vascular integrity, permeability and blood flow. Deficiencies of brain pericytes are associated with neonatal intracranial hemorrhage in human fetuses, as well as stroke and neurodegeneration in adults. Despite the important functions of brain pericytes, the mechanisms underlying their development are not well understood and little is known about how pericyte density is regulated across the brain. The Notch signaling pathway has been implicated in pericyte development, but its exact roles remain ill defined. Here, we report an investigation of the Notch3 receptor using zebrafish as a model system. We show that zebrafish brain pericytes express notch3 and that notch3 mutant zebrafish have a deficit of brain pericytes and impaired blood-brain barrier function. Conditional loss- and gain-of-function experiments provide evidence that Notch3 signaling positively regulates brain pericyte proliferation. These findings establish a new role for Notch signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population.
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Pericytes regulate the blood–brain barrier
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Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
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ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway
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Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
Yang, C., Hawkins, K. E., Doré, S., & Candelario-Jalil, E. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00136.2018 · Cited by 871
Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
Kirita, Y., Wu, H., Uchimura, K., Wilson, P. C., & Humphreys, B. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005477117 · Cited by 650
Zepp, J. A., Zacharias, W. J., Frank, D. B., Cavanaugh, C. A., Zhou, S., Morley, M. P., & Morrisey, E. E. (2017) · Cell · doi:10.1016/j.cell.2017.07.034 · Cited by 567
Origin and differentiation of vascular smooth muscle cells
Wang, G., Jacquet, L., Karamariti, E., & Xu, Q. (2015) · The Journal of Physiology · doi:10.1113/jp270033 · Cited by 299
Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline
Østergaard, L., Engedal, T. S., Moreton, F., Hansen, M. B., Wardlaw, J. M., Dalkara, T., Markus, H. S., & Muir, K. W. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15606723 · Cited by 283
Metadata
- Authors
- Wang, Y., Pan, L., Moens, C. B., & Appel, B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2014-01-15
- Volume
- 141
- Issue
- 2
- Pages
- 307-317
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1968199365
- Cited by
- 222
- References
- 12
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
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