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The molecular basis for metameric pattern in the Drosophila embryo

Akam, Michael·1987·Development
DOI 10.1242/dev.101.1.1
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Abstract

The metameric organization of the Drosophila embryo is generated in the first 5 h after fertilization. An initially rather simple pattern provides the foundation for subsequent development and diversification of the segmented part of the body. Many of the genes that control the formation of this pattern have been identified and at least twenty have been cloned. By combining the techniques of genetics, molecular biology and experimental embryology, it is becoming possible to unravel the role played by each of these genes. The repeating segment pattern is defined by the persistent expression of engrailed and of other genes of the ‘segment polarity’ class. The establishment of this pattern is directed by a transient molecular prepattern that is generated in the blastoderm by the activity of the ‘pair-rule’ genes. Maternal determinants at the poles of the egg coordinate this prepattern and define the anteroposterior sequence of pattern elements. The primary effect of these determinants is not known, but genes required for their production have been identified and the product of one of these, bicoid is known to be localized at the anterior of the egg. One early consequence of their activity is to define domains along the A–P axis within which a series of ‘cardinal’ genes are transcribed. The activity of the cardinal genes is required both to coordinate the process of segmentation and to define the early domains of horneotic gene expression. Further interactions between the homeotic genes and other classes of segmentation genes refine the initial establishment of segment identities.

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Research works printed but not linked: 163

  1. Akam, 1985, Segments, lineage boundaries and the domains of expression of homeotic genes, Phil, trans. Roy. Soc. Land. B, 312, 179, 10.1098/rstb.1985.0187 · DOI
  2. Akam, 1985, The distribution of Ultrabithorax transcripts in Drosophila embryos, EMBO J, 4, 1689, 10.1002/j.1460-2075.1985.tb03838.x · DOI · Paper page
  3. Anderson, 1972, The development of hemimetabolous insects, 96
  4. Anderson, 1973, Embryology and Phylogeny in Annelids and Arthropods
  5. Anderson, 1987, Dorsal-ventral embryonic pattern genes of Drosophila. Trends in Genetics, 91
  6. Anderson, 1984, Genetic analysis of dorsal-ventral embryonic pattern in Drosophila. In Pattern Formation, 269
  7. Baker, 1987, Embryonic and imaginai requirements for wingless, a segment polarity gene in Drosophila. Devi Biol, (in press)
  8. Baker, 1987, Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos, 1765
  9. Bender, 1987, A developmental genetic analysis of the gene Regulator of postbithorax in Drosophila melanogaster., Devi Biol, 119, 418, 10.1016/0012-1606(87)90046-7 · doi:10.1016/0012-1606(87)90046-7
  10. Bender, 1983, Molecular genetics of the bithorax complex in Drosophila melanogaster., Science, 221, 23, 10.1126/science.221.4605.23 · DOI · Paper page
  11. Bopp, 1986, Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophda., Cell, 47, 1033, 10.1016/0092-8674(86)90818-4 · DOI · Paper page
  12. Boswell, 1985, tudor, a gene required for assembly of the germ plasm in Drosophila., Cell, 43, 97, 10.1016/0092-8674(85)90015-7 · DOI · Paper page
  13. Bridges, 1923, The third chromosome group of mutant characters of Drosophila melanogaster. Carnegie Inst. Wash. Publ. No, 327, 137
  14. Bull, 1966, Bicaudal, a genetic factor which affects the polarity of the embryo in Drosophila melanogaster., J. exp. Zool, 161, 221, 10.1002/jez.1401610207 · DOI
  15. Campos-Ortega, 1985, The Embryonic Development of Drosophila melanogaster, 10.1007/978-3-662-02454-6 · DOI · Paper page
  16. Carroll, 1986, The localization and regulation of Antennapedia protein expression in Drosophila embryos, 113
  17. Carroll, 1985, Localisation of the fushi-tarazu protein during Drosophila embryogenesis, Cell, 43, 47, 10.1016/0092-8674(85)90011-X · DOI · Paper page
  18. Carroll, 1986, Zygotically active genes that affect the spatial expression of the fushi-tarazu segmentation gene during early Drosophila embryogenesis, Cell, 45, 113, 10.1016/0092-8674(86)90543-X · DOI · Paper page
  19. Carroll, 1986, Maternal control of Drosophila segmentation gene expression, Nature, Lond, 323, 278, 10.1038/323278a0 · doi:10.1038/323278a0
  20. Casanova, 1985, Prothoracic transformation and functional structure of the Ultrabithorax gene in Drosophila., Cell, 42, 663, 10.1016/0092-8674(85)90123-0 · DOI
  21. Casanova, 1986, Identification and characterization of a parasegment specific regulatory element of the Abdominal-B gene of Drosophila., Cell, 47, 627, 10.1016/0092-8674(86)90627-6 · DOI
  22. Chadwick, 1987, Temporal and spatial distribution of transcripts from the Deformed gene of Drosophda., EMBO J, 6, 779, 10.1002/j.1460-2075.1987.tb04820.x · DOI
  23. Cote, 1987, The gooseberryzipper region of Drosophila: five genes encode different spatially restricted transcripts in the embryo
  24. Dambly-Chaudière, 1986, The sense organs in the Drosophda larva and their relation to the embryonic pattern of sensory neurons, Wilhelm Roux Arch devl Biol, 195, 222, 10.1007/BF02438954 · doi:10.1007/bf02438954
  25. Degelman, 1986, Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal effect locus, Devi Biol, 115, 479, 10.1016/0012-1606(86)90268-X · DOI
  26. Dinardo, 1985, Development of embryonic pattern in Drosophda melanogaster as revealed by accumulation of the nuclear engrailed protein, Cell, 43, 59, 10.1016/0092-8674(85)90012-1 · DOI · Paper page
  27. Duncan, 1986, Control of bithorax complex functions by the segmentation gene fushi-tarazu of Drosophda melanogaster., Cell, 47, 297, 10.1016/0092-8674(86)90452-6 · DOI
  28. Duncan, 1982, Genetic control of body segment differentiation in Drosophda. In Developmental Order: Its Origin and Regulation, 533
  29. Dura, 1985, Polyhomeotic: A gene of Drosophila melanogaster required for correct expression of segmental identity, Molec. gen. Genet, 198, 213, 10.1007/BF00382998 · DOI
  30. Edgar, 1986, Parameters controlling Transcriptional Activation during Early Drosophila Development, Cell, 44, 871, 10.1016/0092-8674(86)90009-7 · DOI · Paper page
  31. Edgar, 1986, Repression and turnover pattern of fushi-tarazu RNA in the early Drosophila embryo, Cell, 47, 747, 10.1016/0092-8674(86)90517-9 · DOI
  32. Fjose, 1985, Isolation of a homeobox containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts, Nature, Land, 313, 284, 10.1038/313284a0 · DOI · Paper page
  33. Foe, 1983, Studies of nuclear and cytoplasmic behaviour in the five mitotic cycles that precede gastrulation in Drosophila embryogenesis, J. Cell Sci, 61, 31, 10.1242/jcs.61.1.31 · DOI · Paper page
  34. Frasch, 1987, Characterization and localization of the even-skipped protein of Drosophila., EMBO J, 6, 749, 10.1002/j.1460-2075.1987.tb04817.x · DOI · Paper page
  35. Frigerio, 1986, Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network, Cell, 47, 735, 10.1016/0092-8674(86)90516-7 · DOI · Paper page
  36. Frohnhôfer, 1986, Manipulating the anteroposterior pattern of the Drosophila embryo, 169
  37. Frohnhôfer, 1986, The organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid., Nature, Lond, 324, 120, 10.1038/324120a0 · DOI · Paper page
  38. Gans, 1975, Isolation and characterization of sex linked lethal mutations of Drosophila melanogaster., Genetics, 81, 683, 10.1093/genetics/81.4.683 · DOI · Paper page
  39. Garber, 1983, Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila., EMBO J, 2, 2027, 10.1002/j.1460-2075.1983.tb01696.x · DOI
  40. Garcia-Bellido, 1972, Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster., Genetics, 72, 87, 10.1093/genetics/72.1.87 · DOI · Paper page
  41. Gergen, 1986, Segmental pattern and blastoderm cell identities, 195
  42. Gergen, 1985, The localized requirements for a gene affecting segmentation in Drosophila’, analysis of larvae mosaic for runt., Devi Biol, 109, 321, 10.1016/0012-1606(85)90459-2 · DOI
  43. Gergen, 1986, Dosage requirements for runt in the segmentation of Drosophila embryos, Cell, 45, 289, 10.1016/0092-8674(86)90393-4 · DOI
  44. Gergen, 19866, Localized requirements for gene activity in segmentation of Drosophila embryos: analysis of armadillo, fused, giant and unpaired mutations in mosaic embryos, Wilhelm Roux Arch, devl Biol, 195, 49, 10.1007/BF00444041 · doi:10.1007/bf00444041
  45. Ghysen, 1986, Sensory neurons and peripheral pathways in Drosophila embryos, Wilhelm Roux Arch, devl Biol, 195, 281, 10.1007/BF00376060 · DOI · Paper page
  46. Gloor, 1950, Schadigungsmuster eines Letalfaktors (Kr) von Drosophila melanogaster., Arch. Jul. Klaus Stiftung, 29, 277
  47. Hafen, 1984, Spatial distribution of transcripts from the segmentation gene fushi-tarazu during Drosophila embryonic development, Cell, 37, 833, 10.1016/0092-8674(84)90418-5 · DOI · Paper page
  48. Hafen, 1983, An improved in situ hybridization method for the detection of cellular RNAs in Drosophila tissue sections, and its application for localizing transcripts of the homeotic Antennapedia gene complex, EMBO J, 2, 617, 10.1002/j.1460-2075.1983.tb01472.x · doi:10.1002/j.1460-2075.1983.tb01472.x
  49. Hafen, 1984, Regulation of Antennapedia transcript distribution by the bithorax complex of Drosophila., Nature, Lond, 307, 287, 10.1038/307287a0 · DOI · Paper page
  50. Harding, 1986, Cross-regulatory Interactions among Pair-rule Genes in Drosophila., Science, 233, 953, 10.1126/science.3755551 · DOI
  51. Harding, 1985, Spatially regulated expression of homeotic genes in Drosophila., Science, 229, 1236, 10.1126/science.3898362 · DOI · Paper page
  52. Hiromi, 1985, Control elements of the Drosophila segmentation gene fushi-tarazu, Cell, 43, 603, 10.1016/0092-8674(85)90232-6 · DOI · Paper page
  53. Hoey, 1986, Horneo box gene expression in anterior and posterior regions of the Drosophila embryo, Proc. natn. Acad. Sci. U.S.A, 83, 4809, 10.1073/pnas.83.13.4809 · DOI
  54. Hogness, 1985, Regulation and products of the Ultrabithorax domain of the bithorax complex, Cold Spring Harbour Symp. Quant. Biol, 50, 181, 10.1101/SQB.1985.050.01.024 · DOI
  55. Holmgren, 1984, Cloning sequences from the hairy gene of Drosophila., EMBO J, 3, 833, 10.1002/j.1460-2075.1984.tb01849.x · doi:10.1002/j.1460-2075.1984.tb01849.x
  56. Hooper, 1986, Homeotic gene function in the muscles of Drosophila larvae, EMBO J, 5, 2321, 10.1002/j.1460-2075.1986.tb04500.x · DOI
  57. Howard, 1986, Regulatory interactions between the segmentation genes fushi-tarazu, hairy and engrailed in the Drosophila blastoderm, Cell, 44, 949, 10.1016/0092-8674(86)90018-8 · DOI · Paper page
  58. Ingham, 1984, A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila., Cell, 37, 815, 10.1016/0092-8674(84)90416-1 · DOI · Paper page
  59. Ingham, 1985, The regulation of the bithorax complex, Trends in Genetics, 1, 112, 10.1016/0168-9525(85)90043-5 · doi:10.1016/0168-9525(85)90043-5
  60. Ingham, 1985, Transcription pattern of the Drosophila segmentation gene hairy., Nature, Lond, 318, 439, 10.1038/318439a0 · DOI · Paper page
  61. Ingham, 1986, Correlative changes in homeotic and segmentation gene expression in Kriippel mutant embryos in Drosophila., EMBO J, 5, 1659, 10.1002/j.1460-2075.1986.tb04409.x · DOI
  62. Ingham, 1986, The correct activation of Antennapedia and bithorax complex genes requires the fushi-tarazu gene, Nature, Lond, 324, 592, 10.1038/324592a0 · DOI · Paper page
  63. Ingham, 1985, Expression of engrailed in the parasegment of Drosophila., 634
  64. Ingham, 1985, Genetic analysis of the hairy locus in Drosophila melanogaster., Genetics, 111, 463, 10.1093/genetics/111.3.463 · DOI
  65. Ish-Horowicz, 1985, Molecular and Genetic analysis of the hairy locus in Drosophila., Cold Spring Harbor Symp. Quant. Biol, 50, 135, 10.1101/SQB.1985.050.01.019 · DOI
  66. Jàckle, 1986, Cross regulatory interactions among the gap genes of Drosophila., Nature, Lond, 324, 668, 10.1038/324668a0 · DOI · Paper page
  67. Jura, 1972, Development of apterygote insects, 49
  68. Jürgens, 1985, A group of genes controlling the expression of the bithorax complex in Drosophila., Nature, Lond, 316, 153, 10.1038/316153a0 · DOI · Paper page
  69. Jürgens, 1987, Segmental organization of the tail region in the embryo of Drosophila melanogaster. A blastoderm fate map of the cuticle structures of the larval tail region, Wilhelm Roux Arch, devl Biol, 196, 141, 10.1007/BF00376308 · doi:10.1007/bf00376308
  70. Jürgens, 1984, Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. II. Zygotic loci on the third chromosome, Wilhelm Roux Arch, devl Biol, 193, 283, 10.1007/BF00848157 · DOI · Paper page
  71. Karch, 1985, The abdominal region of the bithorax complex, Cell, 43, 81, 10.1016/0092-8674(85)90014-5 · DOI · Paper page
  72. Kaufman, 1983, The genetic regulation of segmentation in Drosophila melanogaster. In Time, Space and Pattern in Embryonic Development, 365
  73. Kaufman, 1984, Homeotic genes and the specification of segment identity in the embryo and adult thorax of Drosophila melanogaster. In Molecular Aspects of Development, 182
  74. Kilcherr, 1986, Isolation of the paired gene of Drosophila and its spatial expression during early embryogenesis. Nature, Lond, 493
  75. Knipple, 1985, Spatial and temporal patterns of Kriippel gene expression in early Drosophila embryos, 40
  76. Kornberg, 1981, engrailed: a gene controlling compartment and segment formation in Drosophila., Proc. natn. Acad. Sci. U.S.A, 78, 1095, 10.1073/pnas.78.2.1095 · DOI · Paper page
  77. Kornberg, 1985, The engrailed locus of Drosophila: In situ localization of transcripts reveals compartment specific expression. Cell, 40, 45, 10.1016/0092-8674(85)90307-1 · DOI · Paper page
  78. Kuroiwa, 1984, Cloning and transcriptional analysis of the segmentation gene fushi-tarazu of Drosophila., Cell, 37, 825, 10.1016/0092-8674(84)90417-3 · DOI
  79. Kuroiwa, 1985, Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts, EMBO J, 4, 3757, 10.1002/j.1460-2075.1985.tb04145.x · DOI
  80. Laughon, 1986, The structure of transcripts from the homeotic Antennapedia gene of Drosophila: two promoters control the major proteincoding region, Molec. Cell. Biol, 6, 6476
  81. Laughon, 1984, The sequence of a Drosophila segmentation gene: Protein Structure homology with DNA binding proteins, Nature, Lond, 308, 25, 10.1038/310025a0 · DOI · Paper page
  82. Lawrence, 1987, The fushi-tarazu and even-skipped genes delimit the borders of parasegments in Drosophila embryos
  83. Lehmann, 1986, Abdominal segmentation, pole cell formation and embryonic polarity require the localized activity of oskar, a maternal gene in Drosophila., Cell, 47, 141, 10.1016/0092-8674(86)90375-2 · DOI · Paper page
  84. Lehmann, 1987, hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo, Devl Biol, 119, 402, 10.1016/0012-1606(87)90045-5 · DOI · Paper page
  85. Levine, 1983, Spatial distribution of Antennapedia transcripts during Drosophila development, EMBO J, 2, 2037, 10.1002/j.1460-2075.1983.tb01697.x · DOI · Paper page
  86. Lewis, 1963, Genes and developmental pathways, Am. Zool, 3, 33, 10.1093/icb/3.1.33 · DOI · Paper page
  87. Lewis, 1978, A gene complex controlling segmentation in Drosophila., Nature, Lond, 276, 565, 10.1038/276565a0 · DOI · Paper page
  88. Lewis, 1981, Developmental genetics of the bithorax complex in Drosophila. In Developmental Biology using Purified Genes. ICN-UCLA symposia 23, 189, 10.1016/B978-0-12-137420-4.50022-X · DOI
  89. Lohs-Schardin, 1982, Dicephalic - a Drosophila mutant affecting polarity in follicle organization and embryonic patterning, 28
  90. Macbride, 1914, Textbook of Embryology, vol 1
  91. Macdonald, 1986, Isolation, structure and expression of even-skipped: a second pair rule gene of Drosophila containing a homeobox, 721
  92. Macdonald, 1986, A molecular gradient in early Drosophila embryos and its role in specifying the body pattern, Nature, Lond, 324, 537, 10.1038/324537a0 · DOI · Paper page
  93. Mahoney, 1987, The zygotic segmentation mutant tadless alters the blastoderm fate map of Drosophila embryos
  94. Martinez-Arias, 1985, The development of fused− embryos of Drosophila melanogaster., J. Embryol. exp. Morph, 87, 99
  95. Martinez-Arias, 1986, The Antennapedia gene is required and expressed in parasegments 4 and 5 of the Drosophila embryo, EMBO J, 5, 135, 10.1002/j.1460-2075.1986.tb04187.x · DOI
  96. Martinez-Arias, 1987, On the developmental and evolutionary role of some genes from the Antennapedia complex, Molecular Approaches to Developmental Biology, 51, 131
  97. Martinez-Arias, 1985, The origin of pattern duplications in segment polarity mutants of Drosophila melanogaster., J. Embryol. exp. Morph, 87, 129
  98. Martinez-Arias, 1987, The spatial and temporal deployment of Dfd and Scr transcripts throughout development of Drosophila., Development, 100, 673, 10.1242/dev.100.4.673 · DOI
  99. Martinez-Arias, 1985, Parasegments and compartments in the Drosophila embryo, Nature, Lond, 313, 639, 10.1038/313639a0 · DOI · Paper page
  100. Martinez-Arias, 1987, Ultrabithorax and engrailed expression in Drosophila embryos mutant for the pair rule class of segmentation genes
  101. Mcginnis, 1984, A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes, Nature, Lond, 308, 428, 10.1038/308428a0 · DOI · Paper page
  102. Mcginnis, 1985, Homeobox sequences of the Antennapedia class are conserved only in higher animal genomes, Cold Spring Harbor Symp. Quant. Biol, 50, 263, 10.1101/SQB.1985.050.01.033 · DOI
  103. Meinhardt, 1982, Models for Biological Pattern Formation
  104. Meinhardt, 1986, Hierarchical inductions of cell states - a model for segmentation in Drosophila., 357
  105. Mlodzik, 1985, Isolation of caudal, a Drosophila homeobox containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage, EMBO J, 4, 2961, 10.1002/j.1460-2075.1985.tb04030.x · DOI
  106. Mlodzik, 1987, Expression of the caudal gene in Drosophila: Formation of an RNA and protein gradient during early embryogenesis, Cell, 48, 465, 10.1016/0092-8674(87)90197-8 · DOI · Paper page
  107. Mohler, 1986, Dominant maternal effect mutations of Drosophila melanogaster causing the production of double-abdomen embryos, Genetics, 112, 803, 10.1093/genetics/112.4.803 · DOI · Paper page
  108. Morata, 1983, Homeotic transformations of the abdominal segments of Drosophila caused by breaking or deleting a central portion of the bithorax complex, J. Embryol. exp. Morph, 78, 319
  109. Morata, 1975, Control of compartment development by the engrailed gene in Drosophila., Nature, Lond, 255, 614, 10.1038/255614a0 · DOI · Paper page
  110. Nüsslein-Volhard, 1977, Genetic analysis of pattern formation in the embryo of Drosophila melanogaster: Characterization of the maternal effect mutant bicaudal., Wilhelm Roux Arch, devl Biol, 183, 249, 10.1007/BF00867325 · DOI
  111. Nüsslein-Volhard, 1985, Genes affecting the segmental subdivision of the Drosophila embryo, Cold Spring harbor Symp. Quant. Biol, 50, 145, 10.1101/SQB.1985.050.01.020 · DOI
  112. Nüsslein-Volhard, 1980, Mutations affecting segment number and polarity in Drosophila., Nature, Lond, 287, 795, 10.1038/287795a0 · DOI · Paper page
  113. Nüsslein-Volhard, 1982, Segmentierung bei Drosophila-, eine genetische analyse, Verb. Dtsch. Zool. Ges, 1982, 91
  114. Nüsslein-Volhard, 1984, Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome, Wilhelm Roux Arch, devl Biol, 193, 267, 10.1007/BF00848156 · DOI · Paper page
  115. O’farrell, 1986, Spatial programming of gene expression in early Drosophila embryogenesis, Ann. Rev. Cell Biol, 2, 49, 10.1146/annurev.cb.02.110186.000405 · DOI
  116. Perrimon, 1984, The effects of zygotic lethal mutations on female germ line functions in Drosophila., Devl Biol, 105, 404, 10.1016/0012-1606(84)90297-5 · DOI
  117. Perrimon, 1986, l(l)hopscotch, a larval pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila., Devl Biol, 118, 28, 10.1016/0012-1606(86)90070-9 · DOI
  118. Perrimon, 1987, Multiple functions of segment polarity genes in Drosophila., Devl Biol, 119, 587, 10.1016/0012-1606(87)90061-3 · DOI · Paper page
  119. Petschek, 1987, Region specific defects in l(l)giant embryos of Drosophila melanogaster., Devl Biol, 119, 175, 10.1016/0012-1606(87)90219-3 · doi:10.1016/0012-1606(87)90219-3
  120. Poole, 1985, The engrailed locus of Drosophila: structural analysis of an embryonic transcript, Cell, 40, 37, 10.1016/0092-8674(85)90306-X · DOI · Paper page
  121. Poulson, 1950, Histogenesis, organogenesis, and differentiation in the embryo of Drosophila melanogaster Meigen, 168
  122. Preiss, 1985, Molecular genetics of Krüppel, a gene required for segmentation of the Drosophila embryo, 27
  123. Regulski, 1985, Horneo Box genes of the Antennapedia and bithorax complexes of Drosophila., Cell, 43, 71, 10.1016/0092-8674(85)90013-3 · DOI · Paper page
  124. Regulski, 1987, Developmental and molecular analysis of Deformed; a homeotic gene controlling Drosophila head development, EMBO J, 6, 767, 10.1002/j.1460-2075.1987.tb04819.x · DOI
  125. Rickoll, 1976, Cytoplasmic continuity between embryonic cells and the primitive yolk sac during early gastrulation in Drosophila melanogaster., Devl Biol, 49, 304, 10.1016/0012-1606(76)90278-5 · DOI
  126. Rosenberg, 1986, Structural homology of the product of the Drosophila Krüppel gene with Xenopus transcription factor IIIA, Nature, Lond, 319, 336, 10.1038/319336a0 · DOI · Paper page
  127. Sanchez-Herrero, 1985, Genetic organization of Drosophila bithorax complex, Nature, Lond, 313, 108, 10.1038/313108a0 · DOI · Paper page
  128. Sander, 1976, Specification of the basic body pattern in insect embryogenesis, Adv. Insect Physiol, 12, 125, 10.1016/S0065-2806(08)60255-6 · DOI · Paper page
  129. Sander, 1984, Embryonic pattern formation in insects: Basic concepts and their experimental foundations, 245
  130. Schneuwly, 1986, Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster., 733
  131. Schubiger, 1977, Interaction of different egg parts in determination of different body regions in Drosophila melanogaster., Proc, natn. Acad. Sci. U.S.A, 74, 2050, 10.1073/pnas.74.5.2050 · doi:10.1073/pnas.74.5.2050
  132. Schubiger, 1982, Determination in Drosophda embryos, Am. Zool, 22, 47, 10.1093/icb/22.1.47 · doi:10.1093/icb/22.1.47
  133. Schupbach, 1986, Maternal effect mutations affecting the segmental pattern of Drosophila., Wilhelm Roux Arch, devl Biol, 195, 302, 10.1007/BF00376063 · DOI · Paper page
  134. Scott, 1984, Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax and fushi-tarazu loci of Drosophila., Proc, natn. Acad. Sci. U.S.A, 81, 4115, 10.1073/pnas.81.13.4115 · DOI · Paper page
  135. Scott, 1983, The molecular organization of the Antennapedia locus of Drosophila., Cell, 35, 763, 10.1016/0092-8674(83)90109-5 · DOI
  136. Seifert, 1986, Spatial distribution and local requirement for Krüppel gene activity in Drosophila embryos, Nature, Lond, 344, 668
  137. Simcox, 1983, When does determination occur in Drosophda embryos?, Devl Biol, 97, 212, 10.1016/0012-1606(83)90078-7 · DOI
  138. Snodgrass, 1935, Principles of Insect Morphology
  139. Stern, 1968, Developmental genetics of pattern, 130, 10.4159/harvard.9780674592834.c5 · doi:10.4159/harvard.9780674592834.c5
  140. Strecker, 1986, The zygotic mutant tailless affects the anterior and posterior ectodermal regions of the Drosophila embryo, 64
  141. Struhl, 1981, A gene product required for the correct initiation of segment determination in Drosophila., Nature, Lond, 293, 36, 10.1038/293036a0 · DOI · Paper page
  142. Struhl, 1983, Role of the esc+ gene product in ensuring the selective expression of segment specific homeotic genes in Drosophila., J. Embryol. exp. Morph, 76, 297
  143. Struhl, 1985, Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila. EMBO J, 4, 3259
  144. Struhl, 1985, Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes, Cell, 43, 507, 10.1016/0092-8674(85)90180-1 · DOI · Paper page
  145. Sullivan, 1987, Independence offushi tarazu expression with respect to cellular density in Drosophila embryos, Nature, Lond, 327, 164, 10.1038/327164a0 · doi:10.1038/327164a0
  146. Tautz, 1987, Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes, Nature, Lond, 327, 383, 10.1038/327383a0 · DOI · Paper page
  147. Technau, 1987, A single cell approach to problems of cell lineage and commitment during embryogenesis of Drosophila melanogaster., Development, 100, 1, 10.1242/dev.100.1.1 · DOI
  148. Tiong, 1985, Recessive lethal mutations within the bithorax complex in Drosophila melanogaster., Molec. gen. Genet, 200, 335, 10.1007/BF00425445 · DOI
  149. Tokunaga, 1962, Cell lineage and differentiation in the male foreleg of Drosophila melanogaster., Devl Biol, 4, 489, 10.1016/0012-1606(62)90054-4 · DOI
  150. Turner, 1977, Scanning electron microscopy of Drosophda embryogenesis. II. Gastrulation and segmentation, Devl Biol, 57, 403, 10.1016/0012-1606(77)90225-1 · DOI · Paper page
  151. Turner, 1979, Scanning electron microscopy of Drosophila embryogenesis. HI. Formation of the head and caudal segments, Devl Biol, 68, 96, 10.1016/0012-1606(79)90246-X · DOI
  152. Wakimoto, 1981, Analysis of larval segmentation in lethal genotypes associated with the Antennapedia gene complex in Drosophila melanogaster., Devl Biol, 81, 51, 10.1016/0012-1606(81)90347-X · DOI · Paper page
  153. Wedeen, 1986, Spatial regulation of Antennapedia and bithorax gene expression by the polycomb locus, Cell, 44, 739, 10.1016/0092-8674(86)90840-8 · DOI · Paper page
  154. Weiner, 1984, A molecular analysis of fushi-tarazu, a gene in Drosophda melanogaster that encodes a product affecting segment number and cell fate, Cell, 37, 843, 10.1016/0092-8674(84)90419-7 · DOI
  155. Weinzierl, 1987, Ultrabithorax mutations in constant and variable regions of the protein coding sequence. Genes and Development, 1, 386
  156. Weir, 1985, Patterns of engrailed and fushi-tarazu transcripts reveal novel intermediate stages in Drosophila segmentation, Nature, Lond, 318, 433, 10.1038/318433a0 · DOI
  157. White, 1986, A gap gene, hunchback, regulates the spatial expression of Ultrabithorax., Cell, 47, 311, 10.1016/0092-8674(86)90453-8 · DOI · Paper page
  158. White, 1985, The distribution of Ultrabithorax proteins in Drosophila., EMBO J, 4, 2035, 10.1002/j.1460-2075.1985.tb03889.x · DOI
  159. Wieschaus, 1984, Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the X chromosome and the fourth chromosome, Wilhelm Roux Arch, devl Biol, 193, 267, 10.1007/BF00848156 · DOI · Paper page
  160. Wieschaus, 1984, Kriippel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation. Devl Biol, 104, 172
  161. Wieschaus, 1987, Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis, Cell, 49, 177, 10.1016/0092-8674(87)90558-7 · DOI
  162. Wilson, 1892, The cell lineage of Nereis. J. Morph, 6, 361
  163. Zalokar, 1975, Developmental defects of female sterile Mutants of Drosophila melanogaster., Devl Biol, 47, 419, 10.1016/0012-1606(75)90295-X · doi:10.1016/0012-1606(75)90295-x

Cited by

See all 1,022

Metadata

Authors
Akam, M.
Venue
Development
Publisher
The Company of Biologists
Published
1987-09-01
Volume
101
Issue
1
Pages
1-22
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.101.1.1
OpenAlex
W1815472980
Cited by
1,022
References
2
FWCI
37.12
Type
journal article
Language
en
Open access
closed
Licence
www.biologists.com/user-licence-1-1/ (vor)

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CoChat. (2026). Citation check: The molecular basis for metameric pattern in the Drosophila embryo. https://app.cochat.ai/papers/10.1242/dev.101.1.1
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Akam, M. (1987). The molecular basis for metameric pattern in the Drosophila embryo. Development. https://doi.org/10.1242/dev.101.1.1

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