Cuff electrode implantation around the sciatic nerve is associated with an upregulation of TNF-α and TGF-β1
Abstract
Epineurial fibrosis, fiber loss, limited reproducibility of recordings and variability of stimulation conditions have been documented after extraneural cuff electrode implantation. These morphological and electrophysiological modifications could be due to the local release of cytokines. We report the expression of two cytokines, tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 (TGF-beta1) in the rat sciatic nerve after 'cuff' implantation for 18 h, 7 days and 1 month. Immunohistochemical and Western blot analyses showed a transient upregulation of TNF-alpha, during the first week, and a prolonged increase of TGF-beta1, over the 1-month period duration of this study. Considering the known pro-inflammatory roles of TNF-alpha and the pro-fibrotic action of TGF-beta, our results strongly suggest that these cytokines may contribute to nerve alterations occurring within the acute and sub-acute phases after cuff electrode implantation.
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Nerve compression is associated with axonal death and inflammation.
“Nerve compression is associated with axonal death and inflammation (Krarup et al., 1989; Grill and Mortimer, 2000; Vince et al., 2005), which can in turn exacerbate FBR to the implant (Romero et al., 2001).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Vince et al., 2005
Excessive pressure to fasten a rigid-substrate electrode to tissue causes serious damage, including inflammation and nerve degeneration.
“This pressure has been reported to cause serious damage to the tissues, including inflammation and nerve degeneration20–22.”
From A flexible three-dimensional electrode mesh: An enabling technology for wireless brain–computer interface prostheses (2016) · cites this paper as [21]
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Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics
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“Nerve compression is associated with axonal death and inflammation (Krarup et al., 1989; Grill and Mortimer, 2000; Vince et al., 2005), which can in turn exacerbate FBR to the implant (Romero et al.”
BackgroundThe foreign body response to the Utah Slant Electrode Array in the cat sciatic nerve
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- Authors
- Vince, V., Thil, M.-A., Gérard, A.-C., Veraart, C., Delbeke, J., & Colin, I. M.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Colin, Ides M.
- ORCID
- Delbeke, Jean
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 159
- Issue
- 1-2
- Pages
- 75-86
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1966418380
- Cited by
- 35
- References
- 44
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- sciatic nerve, TNF-α, TGF-β1, cytokine expression, peripheral nerve injury, nerve regeneration, peripheral nerve stimulation
- MeSH terms
- Animals, Body Weight, Electrodes, Implanted, Fibrosis, Gait, Immunohistochemistry, Male, Organ Specificity, Peripheral Nerves, Posture, Sciatic Nerve, Tumor Necrosis Factor-alpha, Blotting, Western, Up-Regulation, Transforming Growth Factor beta, Inflammation Mediators, Rats, Transforming Growth Factor beta1
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