The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Pax-6, a murine paired box gene, is expressed in the developing CNS
Abstract
A multigene family of paired-box-containing genes (Pax genes) has been identified in the mouse. In this report, we describe the expression pattern of Pax-6 during embryogenesis and the isolation of cDNA clones spanning the entire coding region. The Pax-6 protein consists of 422 amino acids as deduced from the longest open reading frame and contains, in addition to the paired domain, a paired-type homeodomain. Beginning with day 8 of gestation, Pax-6 is expressed in discrete regions of the forebrain and the hindbrain. In the neural tube, expression is mainly confined to mitotic active cells in the ventral ventricular zone along the entire anteroposterior axis starting at day 8.5 of development. Pax-6 is also expressed in the developing eye, the pituitary and the nasal epithelium.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,887
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,087
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460
Current protocols in molecular biology
(1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90131-4 · Cited by 4,160
Manipulating the mouse embryo: A laboratory manual
Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,245
The molecular genetics of embryonic pattern formation in Drosophila
Ingham, P. W. (1988) · Nature · doi:10.1038/335025a0 · Cited by 1,045
The molecular basis for metameric pattern in the Drosophila embryo
Akam, M. (1987) · Development · doi:10.1242/dev.101.1.1 · Cited by 1,022
An autoradiographic analysis of histogenesis in the mouse cerebellum
Miale, I. L., & Sidman, R. L. (1961) · Experimental Neurology · doi:10.1016/0014-4886(61)90055-3 · Cited by 1,009
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.
Goulding, M. D., Chalepakis, G., Deutsch, U., Erselius, J. R., & Gruss, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08054.x · Cited by 908
Self-citationYamada, T., Placzek, M., Tanaka, H., Dodd, J., & Jessell, T. M. (1991) · Cell · doi:10.1016/0092-8674(91)90247-v · Cited by 707
Murine Developmental Control Genes
Kessel, M., & Gruss, P. (1990) · Science · doi:10.1126/science.1974085 · Cited by 585
Self-citationPax2, a new murine paired-box-containing gene and its expression in the developing excretory system
Dressler, G. R., Deutsch, U., Chowdhury, K., Nornes, H. O., & Gruss, P. (1990) · Development · doi:10.1242/dev.109.4.787 · Cited by 566
Self-citationA single amino acid can determine the DNA binding specificity of homeodomain proteins
Trelsman, J., Gönczy, P., Vashishtha, M., Harris, E., & Desplan, C. (1989) · Cell · doi:10.1016/0092-8674(89)90038-x · Cited by 522
Matsui, Y., Zsebo, K. M., & Hogan, B. L. M. (1990) · Nature · doi:10.1038/347667a0 · Cited by 515
The Development of the Rat Spinal Cord
Altman, J., & Bayer, S. A. (1984) · Advances in Anatomy Embryology and Cell Biology · doi:10.1007/978-3-642-69537-7 · Cited by 507
Bopp, D., Burri, M., Baumgartner, S., Frigerio, G., & Noll, M. (1986) · Cell · doi:10.1016/0092-8674(86)90818-4 · Cited by 487
Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland
Plachov, D., Chowdhury, K., Walther, C., Simon, D., Guenet, J.-L., & Gruss, P. (1990) · Development · doi:10.1242/dev.110.2.643 · Cited by 479
Self-citationSidman, R. L., Miale, I. L., & Feder, N. (1959) · Experimental Neurology · doi:10.1016/0014-4886(59)90024-x · Cited by 433
Pax: A murine multigene family of paired box-containing genes
Walther, C., Guenet, J.-L., Simon, D., Deutsch, U., Jostes, B., Goulding, M. D., Plachov, D., Balling, R., & Gruss, P. (1991) · Genomics · doi:10.1016/0888-7543(91)90151-4 · Cited by 427
Self-citationSpatially and temporally restricted expression of Pax2 during murine neurogenesis
Nornes, H. O., Dresslert, G. R., Knapik, E. W., Deutsch, U., & Gruss, P. (1990) · Development · doi:10.1242/dev.109.4.797 · Cited by 398
Self-citationJostes, B., Walther, C., & Gruss, P. (1990) · Mechanisms of Development · doi:10.1016/0925-4773(90)90132-6 · Cited by 397
Self-citationDavis, C. A., & Joyner, A. L. (1988) · Genes & Development · doi:10.1101/gad.2.12b.1736 · Cited by 384
Embryonic induction - molecular prospects
Gurdon, J. B. (1987) · Development · doi:10.1242/dev.99.3.285 · Cited by 380
Variations of cervical vertebrate after expression of a Hox-1.1 transgene in mice
Kessel, M., Balling, R., & Gruss, P. (1990) · Cell · doi:10.1016/0092-8674(90)90810-2 · Cited by 367
Self-citationThe paired box encodes a second DNA-binding domain in the paired homeo domain protein.
Treisman, J., Harris, E., & Desplan, C. (1991) · Genes & Development · doi:10.1101/gad.5.4.594 · Cited by 343
Keshet, E., Lyman, S. D., Williams, D. E., Anderson, D. M., Jenkins, N. A., Copeland, N. G., & Parada, L. F. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07782.x · Cited by 340
Balling, R., Deutsch, U., & Gruss, P. (1988) · Cell · doi:10.1016/0092-8674(88)90039-6 · Cited by 322
Self-citationFine Structure of the Developing Avian Cornea
Hay, E. D., & Revel, J.-P. (1969) · Monographs in Developmental Biology · doi:10.1159/isbn.978-3-8055-0443-0 · Cited by 313
Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord
Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessell, T., & Dodd, J. (1990) · Science · doi:10.1126/science.2237443 · Cited by 302
Deutsch, U., Dressler, G. R., & Gruss, P. (1988) · Cell · doi:10.1016/0092-8674(88)90577-6 · Cited by 299
Self-citationPolarizing activity and retinoid synthesis in the floor plate of the neural tube
Wagner, M., Thaller, C., Jessell, T., & Eichele, G. (1990) · Nature · doi:10.1038/345819a0 · Cited by 289
The segmentation and homeotic gene network in early Drosophila development
Scott, M. P., & Carroll, S. B. (1987) · Cell · doi:10.1016/0092-8674(87)90092-4 · Cited by 277
A mouse gene related to Distal-less shows a restricted expression in the developing forebrain
Price, M., Lemaistre, M., Pischetola, M., Di Lauro, R., & Duboule, D. (1991) · Nature · doi:10.1038/351748a0 · Cited by 274
Nornes, H. O., & Das, G. D. (1974) · Brain Research · doi:10.1016/0006-8993(74)91011-7 · Cited by 271
The molecular basis of the undulated/Pax-1 mutation
Chalepakis, G., Fritsch, R., Fickenscher, H., Deutsch, U., Goulding, M., & Gruss, P. (1991) · Cell · doi:10.1016/0092-8674(91)90434-z · Cited by 269
Self-citationPuelles, L., Amat, J. A., & Martinez‐de‐la‐Torre, M. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902660210 · Cited by 261
The prenatal development of the mouse eye
Pei, Y. F., & Rhodin, J. A. G. (1970) · The Anatomical Record · doi:10.1002/ar.1091680109 · Cited by 235
Differential Expression of the ras Gene Family in Mice
León, J., Guerrero, I., & Pellicer, À. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.4.1535 · Cited by 225
Conservation of the paired domain in metazoans and its structure in three isolated human genes.
Burri, M., Tromvoukis, Y., Bopp, D., Frigerio, G., & Noll, M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03490.x · Cited by 213
Baumgartner, S., Bopp, D., Burri, M., & Noll, M. (1987) · Genes & Development · doi:10.1101/gad.1.10.1247 · Cited by 211
The Segmentation of the Primitive Neural Tube in Chick Embryos (Gallus domesticus)
Vaage, S. (1969) · Springer eBooks · doi:10.1007/978-3-662-29669-1 · Cited by 193
Neurogenesis in spinal cord of mouse: an autoradiographic analysis
Nornes, H. O., & Carry, M. (1978) · Brain Research · doi:10.1016/0006-8993(78)90105-1 · Cited by 191
Altman, J., & Bayer, S. A. (1986) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-71301-9_1 · Cited by 188
Isolation of two tissue‐specific Drosophila paired box genes, Pox meso and Pox neuro.
Bopp, D., Jamet, É., Baumgartner, S., Burri, M., & Noll, M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08509.x · Cited by 161
Davidson, D. R., Graham, E., Sime, C., & Hill, R. E. (1988) · Development · doi:10.1242/dev.104.2.305 · Cited by 144
Transcription of H‐2 and Qa genes in embryonic and adult mice.
Fahrner, K. A., Hogan, B. L., & Flavell, R. A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02363.x · Cited by 131
Wright, C. V. E., Cho, K. W. Y., Hardwicke, J., Collins, R. H., & Robertis, E. M. D. (1989) · Cell · doi:10.1016/0092-8674(89)90871-4 · Cited by 131
McAvoy, J. W. (1980) · Differentiation · doi:10.1111/j.1432-0436.1980.tb01091.x · Cited by 114
Positional signalling by Hensen’s node when grafted to the chick limb bud
Hornbruch, A., & Wolpert, L. (1986) · Development · doi:10.1242/dev.94.1.257 · Cited by 111
Effect of the notochord on proliferation and differentiation in the neural tube of the chick embryo
van Straaten, H. W. M., Hekking, J. W. M., Beursgens, J. P. W. M., Terwindt‐Rouwenhorst, E., & Drukker, J. (1989) · Development · doi:10.1242/dev.107.4.793 · Cited by 102
The Effect of the Floor Plate on Pattern and Polarity in the Developing Central Nervous System
Hirano, S., Fuse, S., & Sohal, G. S. (1991) · Science · doi:10.1126/science.1987648 · Cited by 77
Gardette, R., Courtois, M., & Bisconte, J.-C. (1982) · PubMed · Cited by 56
The ontogenetic development of the diencephalon of the mouse.
Niimi, K., HARADA, I., Kusaka, Y., & KISHI, S. (1961) · PubMed · Cited by 44
Cited by
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila
Halder, G., Callaerts, P., & Gehring, W. J. (1995) · Science · doi:10.1126/science.7892602 · Cited by 1,573
Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans
Quiring, R., Walldorf, U., Kloter, U., & Gehring, W. J. (1994) · Science · doi:10.1126/science.7914031 · Cited by 1,100
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863
Glial cells generate neurons: the role of the transcription factor Pax6
Heins, N., Malatesta, P., Cecconi, F., Nakafuku, M., Tucker, K. L., Hack, M. A., Chapouton, P., Barde, Y.-A., & Götz, M. (2002) · Nature Neuroscience · doi:10.1038/nn828 · Cited by 775
Metadata
- Authors
- Walther, C., & Gruss, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-12-01
- Volume
- 113
- Issue
- 4
- Pages
- 1435-1449
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2161687343
- Cited by
- 1,255
- References
- 57
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
