The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans
Abstract
Early embryogenesis in Caenorhabditis elegans is characterized by a series of unequal cleavages that mark the stepwise separation of somatic and germ lineages. We have developed an in situ hybridization protocol to examine the localization of specific maternal and embryonically transcribed messenger RNAs during these early cleavages. We detected three classes of maternal RNAs: RNAs that are maintained in all cells, RNAs that are maintained in germline cells but are lost from somatic cells, and a population of RNAs that are associated with the germlinespecific P granules. We observed embryonically transcribed RNAs in somatic cells as early as the 4-cell stage. These transcripts were not detected in germline cells. These observations suggest that mechanisms which distinguish between soma and germline cause asymmetries in mRNA stability and transcription within the first few cleavages of C. elegans embryogenesis.
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Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
A major developmental transition in early xenopus embryos: II. control of the onset of transcription
Newport, J., & Kirschner, M. (1982) · Cell · doi:10.1016/0092-8674(82)90273-2 · Cited by 1,055
Cited by
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Self-citationMuseum of spatial transcriptomics
Moses, L., & Pachter, L. (2022) · Nature Methods · doi:10.1038/s41592-022-01409-2 · Cited by 1,255
cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family
Kipreos, E. T., Lander, L. E., Wing, J. P., He, W. W., & Hedgecock, E. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81267-2 · Cited by 448
The maternal-to-zygotic transition revisited
Vastenhouw, N. L., Cao, W. X., & Lipshitz, H. D. (2019) · Development · doi:10.1242/dev.161471 · Cited by 445
Tenenhaus, C., Subramaniam, K., Dunn, M. A., & Seydoux, G. (2001) · Genes & Development · doi:10.1101/gad.876201 · Cited by 357
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Metadata
- Authors
- Seydoux, G., & Fire, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-10-01
- Volume
- 120
- Issue
- 10
- Pages
- 2823-2834
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2125471204
- Cited by
- 345
- References
- 2
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seydoux, G., & Fire, A. (1994). Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans. Development. https://doi.org/10.1242/dev.120.10.2823
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