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The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation
Abstract
Oogenesis in Drosophila takes place within germline cysts that support polarized transport through ring canals inter-connecting their 15 nurse cells and single oocyte. Developing cystocytes are spanned by a large cytoplasmic structure known as the fusome that has been postulated to help form ring canals and determine the pattern of nurse cell-oocyte interconnections. We identified the adducin-like hts product and α-spectrin as molecular components of fusomes, discovered a related structure in germline stem cells and documented regular associations between fusomes and cystocyte centrosomes. hts mutations completely eliminated fusomes, causing abnormal cysts containing a reduced number of cells to form. Our results imply that Drosophila fusomes are required for ovarian cyst formation and suggest that membrane skeletal proteins regulate cystocyte divisions.
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Citations
Cited by
Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues
Bennett, V., & Baines, A. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 930
Lin, H., & Spradling, A. C. (1997) · Development · doi:10.1242/dev.124.12.2463 · Cited by 698
Self-citationIdentification and behavior of epithelial stem cells in the Drosophila ovary
Margolis, J., & Spradling, A. (1995) · Development · doi:10.1242/dev.121.11.3797 · Cited by 454
Self-citationSong, X., Wong, M. D., Kawase, E., Xi, R., Ding, B. C., McCarthy, J. J., & Xie, T. (2004) · Development · doi:10.1242/dev.01026 · Cited by 416
The stem-cell niche theory: lessons from flies
Lin, H. (2002) · Nature Reviews Genetics · doi:10.1038/nrg952 · Cited by 354
Self-citationRNA LOCALIZATION IN DEVELOPMENT
Bashirullah, A., Cooperstock, R. L., & Lipshitz, H. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.335 · Cited by 339
Comparative Aspects of Animal Oogenesis
Matova, N., & Cooley, L. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0120 · Cited by 318
Gunsalus, K. C., Bonaccorsi, S., Williams, E., Verni, F., Gatti, M., & Goldberg, M. L. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.5.1243 · Cited by 318
GERMLINE CYST FORMATION IN DROSOPHILA
de Cuevas, M., Lilly, M., & Spradling, A. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.405 · Cited by 305
Self-citationForbes, A. J., Lin, H., Ingham, P. W., & Spradling, A. C. (1996) · Development · doi:10.1242/dev.122.4.1125 · Cited by 278
Self-citationDecline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis
Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268
Deng, W., & Lin, H. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8669 · Cited by 261
Self-citationStem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Pan, L., Chen, S., Weng, C., Call, G., Zhu, D., Tang, H., Zhang, N., & Xie, T. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.09.010 · Cited by 211
Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage
Zhang, Q., Shalaby, N. A., & Buszczak, M. (2014) · Science · doi:10.1126/science.1246384 · Cited by 192
Yang, H., & Yamashita, Y. M. (2015) · Development · doi:10.1242/dev.122663 · Cited by 55
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Lu, K. L., & Yamashita, Y. M. (2017) · eLife · doi:10.7554/elife.27960 · Cited by 52
Metadata
- Authors
- Lin, H., Yue, L., & Spradling, A. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1994-04-01
- Volume
- 120
- Issue
- 4
- Pages
- 947-956
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2101027598
- Cited by
- 511
- References
- 0
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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