The regulated elimination of transit-amplifying cells preserves tissue homeostasis during protein starvation in Drosophila testis
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How tissues adapt to varying nutrient conditions is of fundamental importance for robust tissue homeostasis throughout the life of an organism, but the underlying mechanisms are poorly understood. Here, we show that Drosophila testis responds to protein starvation by eliminating transit-amplifying spermatogonia (SG) while maintaining a reduced pool of actively proliferating germline stem cells (GSCs). During protein starvation, SG die in a manner that is mediated by the apoptosis of somatic cyst cells (CCs) that encapsulate SG and regulate their development. Strikingly, GSCs cannot be maintained during protein starvation when CC-mediated SG death is inhibited, leading to an irreversible collapse of tissue homeostasis. We propose that the regulated elimination of transit-amplifying cells is essential to preserve stem cell function and tissue homeostasis during protein starvation.
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A type of RCD highly reminiscent of lysosome-dependent cell death, dubbed germ cell death, appears to play a critical role in physiological elimination of a fraction of emerging male germ cells at least in D. melanogaster.
“a type of RCD that is highly reminiscent of lysosome-dependent cell death, which has been dubbed “germ cell death”, appears to play a critical role in the physiological elimination of a fraction of emerging male germ cells (at least in D. melanogaster) [753–756].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [754]
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- Yang, H., & Yamashita, Y. M.
- Affiliations
- University of Michigan (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Yang, Heiko
- Yamashita, Yukiko M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-05-15
- Volume
- 142
- Issue
- 10
- Pages
- 1756-1766
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC4440929
- OpenAlex
- W2273659593
- Cited by
- 55
- References
- 49
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 1
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (F30AG045021)
- National Heart, Lung, and Blood Institute (R01HL115158)
- National Institute of General Medical Sciences (T32GM007863, T32GM007315)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- protein starvation, testis, spermatogonia, germline stem cells, transit amplifying cells, cyst cells, apoptosis, tissue homeostasis, stem cell maintenance, nutrient sensing, Drosophila
- MeSH terms
- Animals, Drosophila, Male, Spermatogonia, Stem Cells, Testis, Apoptosis, Drosophila Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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