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Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome
Abstract
MRF4 (herculin/Myf-6) is one of the four member MyoD family of transcription factors identified by their ability to enforce skeletal muscle differentiation upon a wide variety of nonmuscle cell types. In this study the mouse germline MRF4 gene was disrupted by targeted recombination. Animals homozygous for the MRF4bh1 allele, a deletion of the functionally essential bHLH domain, displayed defective axial myogenesis and rib pattern formation, and they died at birth. Differences in somitogenesis between homozygous MRF4bh1 embryos and their wild-type littermates provided evidence for three distinct myogenic regulatory programs (My1-My3) in the somite, which correlate temporally and spatially with three waves of cellular recruitment to the expanding myotome. The first program (My1), marked initially by Myf-5 expression and followed by myogenin, began on schedule in the MRF4bh1/bh1 embryos at day 8 post coitum (E8). A second program (My2) was highly deficient in homozygous mutant MRF4 embryos, and normal expansion of the myotome failed. Moreover, expression of downstream muscle-specific genes, including FGF-6, which is a candidate regulator of inductive interactions, did not occur normally. The onset of MyoD expression around E10.5 in wild-type embryos marks a third myotomal program (My3), the execution of which was somewhat delayed in MRF4 mutant embryos but ultimately led to extensive myogenesis in the trunk. By E15 it appeared to have largely compensated for the defective My2 program in MRF4 mutants. Homozygous MRF4bh1 animals also showed improper rib pattern formation perhaps due to the absence of signals from cells expressing the My2 program. Finally, a later and relatively mild phenotype was detected in intercostal muscles of newborn animals.
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Citations
Cites
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
Cited by
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & RUDNICKI, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,680
Myogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,644
Zammit, P. S. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.11.011 · Cited by 887
Tajbakhsh, S., Rocancourt, D., Cossu, G., & Buckingham, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80189-0 · Cited by 844
MyoD is required for myogenic stem cell function in adult skeletal muscle
Megeney, L. A., Kablar, B., Garrett, K., Anderson, J. E., & Rudnicki, M. A. (1996) · Genes & Development · doi:10.1101/gad.10.10.1173 · Cited by 724
Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4
Olson, E. N., Arnold, H.-H., Rigby, P. W. J., & Wold, B. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81073-9 · Cited by 577
Self-citationHox genes and regional patterning of the vertebrate body plan
Mallo, M., Wellik, D. M., & Deschamps, J. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.04.024 · Cited by 536
Ma, Q., Fode, C., Guillemot, F., & Anderson, D. J. (1999) · Genes & Development · doi:10.1101/gad.13.13.1717 · Cited by 508
Muscle stem cells in development, regeneration, and disease
Shi, X., & Garry, D. J. (2006) · Genes & Development · doi:10.1101/gad.1419406 · Cited by 506
Yoshida, N., Yoshida, S., Koishi, K., Masuda, K., & Nabeshima, Y.-I. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.6.769 · Cited by 425
Molecular mechanisms regulating myogenic determination and differentiation
Perry, R. (2000) · Frontiers in Bioscience · doi:10.2741/perry · Cited by 369
Looking back to the embryo: defining transcriptional networks in adult myogenesis
Parker, M. H., Seale, P., & Rudnicki, M. A. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1109 · Cited by 366
Liu, C. Y., Flesken-Nikitin, A., Li, S., Zeng, Y., & Lee, W. H. (1996) · Genes & Development · doi:10.1101/gad.10.14.1835 · Cited by 323
Wnt signaling and the activation of myogenesis in mammals
Cossu, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.6867 · Cited by 311
MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle
Kablar, B., Krastel, K., Ying, C., Asakura, A., Tapscott, S. J., & Rudnicki, M. A. (1997) · Development · doi:10.1242/dev.124.23.4729 · Cited by 291
The genetics of vertebrate myogenesis
Bryson-Richardson, R. J., & Currie, P. D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2369 · Cited by 291
The extracellular matrix dimension of skeletal muscle development
Thorsteinsdóttir, S., Deries, M., Cachaço, A. S., & Bajanca, F. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.03.015 · Cited by 167
ERK2 is required for efficient terminal differentiation of skeletal myoblasts
Li, J., & Johnson, S. E. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.051 · Cited by 137
Vinagre, T., Moncaut, N., Carapuço, M., Nóvoa, A., Bom, J., & Mallo, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.011 · Cited by 90
Metadata
- Authors
- Patapoutian, A., Yoon, J. K., Miner, J. H., Wang, S., Stark, K., & Wold, B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-10-01
- Volume
- 121
- Issue
- 10
- Pages
- 3347-3358
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2161137799
- Cited by
- 220
- References
- 1
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
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