The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm
Abstract
We describe a novel Xenopus homeobox gene, Xvent-2, which together with the previously identified homeobox gene Xvent-1, defines a novel class of homeobox genes. vent genes are related by sequence homology, expression pattern and gain-of-function phenotype. Evidence is presented for a role of Xvent-2 in the BMP-4 pathway involved in dorsoventral patterning of mesoderm. (1) Xvent-2 is expressed in regions that also express BMP-4. (2) Xvent-2 and BMP-4 interact in a positive feedback loop. (3) Xvent-2 ventralizes dorsal mesoderm in a dose-dependent manner resulting in phenoytpes ranging from microcephaly to Bauchstück pieces, as does BMP-4. (4) Like BMP-4 and gsc, Xvent-2 and gsc are able to interact in a crossregulatory loop to suppress each other. (5) Microinjection of Xvent-2 mRNA can rescue dorsalization by a dominant-negative BMP-4 receptor. The results suggest that Xvent-2 functions in the BMP-4 signalling pathway that antagonizes the Spemann organizer.
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Cites
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Cited by
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
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Techniques and probes for the study of Xenopus tropicalis development
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Metadata
- Authors
- Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., & Niehrs, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-10-01
- Volume
- 122
- Issue
- 10
- Pages
- 3045-3053
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1858153082
- Cited by
- 270
- References
- 52
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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