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The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

Onichtchouk, Darya, Gawantka, Volker, Dosch, Roland, Delius, Hajo, Hirschfeld, Kirsten, Blumenstock, Claudia, Niehrs, Christof·1996·Development

DOI 10.1242/dev.122.10.3045

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Abstract

We describe a novel Xenopus homeobox gene, Xvent-2, which together with the previously identified homeobox gene Xvent-1, defines a novel class of homeobox genes. vent genes are related by sequence homology, expression pattern and gain-of-function phenotype. Evidence is presented for a role of Xvent-2 in the BMP-4 pathway involved in dorsoventral patterning of mesoderm. (1) Xvent-2 is expressed in regions that also express BMP-4. (2) Xvent-2 and BMP-4 interact in a positive feedback loop. (3) Xvent-2 ventralizes dorsal mesoderm in a dose-dependent manner resulting in phenoytpes ranging from microcephaly to Bauchstück pieces, as does BMP-4. (4) Like BMP-4 and gsc, Xvent-2 and gsc are able to interact in a crossregulatory loop to suppress each other. (5) Microinjection of Xvent-2 mRNA can rescue dorsalization by a dominant-negative BMP-4 receptor. The results suggest that Xvent-2 functions in the BMP-4 signalling pathway that antagonizes the Spemann organizer.

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Authors: Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., & Niehrs, C.
Venue: Development
Publisher: The Company of Biologists
Published: 1996-10-01
Volume: 122
Issue: 10
Pages: 3045-3053
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.122.10.3045
OpenAlex: W1858153082
Cited by: 270
References: 52
FWCI: 8.91
Type: journal article
Language: en
Open access: closed

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The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

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