The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila
Abstract
In vertebrates, transcriptional regulators of the GATA family appear to have a conserved function in differentiation and organ development. GATA-1, -2 and -3 are required for different aspects of hematopoiesis, while GATA-4, -5 and -6 are expressed in various organs of endo-dermal origin, such as intestine and liver, and are impli-cated in endodermal differentiation. Here we report that the Drosophila gene serpent (srp) encodes the previously described GATA factor ABF. The multiple functions of srp in Drosophila suggest that it is an ortholog of the entire ver-tebrate Gata family. srp is required for the differentiation and morphogenesis of the endodermal gut. Here we show that it is also essential for Drosophila hematopoiesis and for the formation of the fat body, the insect organ analogous to the liver. These findings imply that some aspects of the molecular mechanisms underlying blood cell development as well as endodermal differentiation are early acquisitions of metazoan evolution and may be common to most higher animals.
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Cites
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558
Cited by
Regulatory phases of early liver development: paradigms of organogenesis
Zaret, K. S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg837 · Cited by 508
Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors
Lebestky, T., Chang, T., Hartenstein, V., & Banerjee, U. (2000) · Science · doi:10.1126/science.288.5463.146 · Cited by 494
GATA transcription factors as potentiators of gut endoderm differentiation
Bossard, P., & Zaret, K. S. (1998) · Development · doi:10.1242/dev.125.24.4909 · Cited by 313
Analysis of Ras-Induced Overproliferation in Drosophila Hemocytes
Asha, H., Nagy, I., Kovacs, G., Stetson, D., Ando, I., & Dearolf, C. R. (2003) · Genetics · doi:10.1093/genetics/163.1.203 · Cited by 296
Stramer, B., Wood, W., Galko, M. J., Redd, M. J., Jacinto, A., Parkhurst, S. M., & Martin, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200405120 · Cited by 285
Metadata
- Authors
- Rehorn, K.-P., Thelen, H., Michelson, A. M., & Reuter, R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1996-12-01
- Volume
- 122
- Issue
- 12
- Pages
- 4023-4031
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2157791218
- Cited by
- 321
- References
- 2
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rehorn, K.-P., Thelen, H., Michelson, A. M., & Reuter, R. (1996). A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila. Development. https://doi.org/10.1242/dev.122.12.4023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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