GATA transcription factors as potentiators of gut endoderm differentiation

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179 · see citing works

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

Clark, K., Halay, E. D., Lai, E., & Burley, S. K. (1993) · Nature · doi:10.1038/364412a0 · Cited by 1,275 · see citing works

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.Preprint

Molkentin, J. D., Lin, Q., Duncan, S. A., & Olson, E. N. (1997) · Genes & Development · doi:10.1101/gad.11.8.1061 · Cited by 1,152 · see citing works

GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.Preprint

Kuo, C. T., Morrisey, E. E., Anandappa, R. T., Sigrist, K. S., Lu, M. M., Parmacek, M. S., Soudais, C., & Leiden, J. M. (1997) · Genes & Development · doi:10.1101/gad.11.8.1048 · Cited by 1,039 · see citing works

HNF-3β is essential for node and notochord formation in mouse development

Ang, S., & Rossant, J. (1994) · Cell · doi:10.1016/0092-8674(94)90522-3 · Cited by 981 · see citing works

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

Mueller, P. R., & Wold, B. J. (1989) · Science · doi:10.1126/science.2814500 · Cited by 926 · see citing works

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo.

Weigel, D., Jürgens, G., Küttner, F., Seifert, E., & Jäckle, H. (1989) · Cell · doi:10.1016/0092-8674(89)90133-5 · Cited by 794 · see citing works

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

Weinstein, D. C., Altaba, A. R. I., Chen, W. S., Hoodless, P. A., Prezioso, V. R., Jessell, T. M., & Darnell, J. E., Jr. (1994) · Cell · doi:10.1016/0092-8674(94)90523-1 · Cited by 783 · see citing works

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

Ramakrishnan, V., Finch, J. T., Graziano, V., Lee, P. L., & Sweet, R. M. (1993) · Nature · doi:10.1038/362219a0 · Cited by 736 · see citing works

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

Tsang, A. P., Visvader, J. E., Turner, C. A., Fujiwara, Y., Yu, C., Weiss, M. J., Crossley, M., & Orkin, S. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80318-9 · Cited by 712 · see citing works

Mouse GATA-4: a Retinoic Acid-Inducible GATA-Binding Transcription Factor Expressed in Endodermally Derived Tissues and Heart

Arceci, R. J., King, A. A., Simon, M. C., Orkin, S. H., & Wilson, D. B. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2235 · Cited by 704 · see citing works

The House Mouse: Atlas of Embryonic Development

Theiler, K., & Westphal, H. (1972) · Medical Entomology and Zoology · Cited by 680 · see citing works

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

Sasaki, H., & Hogan, B. L. M. (1993) · Development · doi:10.1242/dev.118.1.47 · Cited by 672 · see citing works

The cardiac transcription factors Nkx2‐5 and GATA‐4 are mutual cofactors

Durocher, D., Charron, F., Warren, R., Schwartz, R. J., & Nemer, M. J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5687 · Cited by 668 · see citing works

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/<i>forkhead</i> proteins

Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., & Zaret, K. S. (1993) · Development · doi:10.1242/dev.119.4.1301 · Cited by 618 · see citing works

The House Mouse

Theiler, K. (1989) · Springer eBooks · doi:10.1007/978-3-642-88418-4 · Cited by 601 · see citing works

Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.Preprint

Yamamoto, M. P., Ko, L. J., Leonard, M. W., Beug, H., Orkin, S. H., & Engel, J. D. (1990) · Genes & Development · doi:10.1101/gad.4.10.1650 · Cited by 598 · see citing works

Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.Preprint

Gualdi, R., Bossard, P., Zheng, M., Hamada, Y., Coleman, J. R., & Zaret, K. S. (1996) · Genes & Development · doi:10.1101/gad.10.13.1670 · Cited by 590 · see citing works

GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.

Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558 · see citing works

The house mouse

Theiler, K. (1972) · Cited by 550 · see citing works

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

Monaghan, A. P., Kaestner, K. H., Grau, E., & Schütz, G. (1993) · Development · doi:10.1242/dev.119.3.567 · Cited by 497 · see citing works

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.Preprint

Lai, E., Prezioso, V. R., Tao, W., Chen, W. S., & Darnell, J. E., Jr. (1991) · Genes & Development · doi:10.1101/gad.5.3.416 · Cited by 495 · see citing works

Induction of avian cardiac myogenesis by anterior endoderm

Schultheiss, T. M., Xydas, S., & Lassar, A. B. (1995) · Development · doi:10.1242/dev.121.12.4203 · Cited by 477 · see citing works

NMR Structure of a Specific DNA Complex of Zn-Containing DNA Binding Domain of GATA-1

Omichinski, J. G., Clore, G. M., Schaad, O., Felsenfeld, G., Trainor, C. D., Appella, E., Stahl, S. J., & Gronenborn, A. M. (1993) · Science · doi:10.1126/science.8332909 · Cited by 469 · see citing works

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.Preprint

Lai, E., Prezioso, V. R., Smith, E., Litvin, O., Costa, R. H., & Darnell, J. E., Jr. (1990) · Genes & Development · doi:10.1101/gad.4.8.1427 · Cited by 461 · see citing works

An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.Preprint

Pinkert, C. A., Ornitz, D. M., Brinster, R. L., & Palmiter, R. D. (1987) · Genes & Development · doi:10.1101/gad.1.3.268 · Cited by 422 · see citing works

Binding of the winged‐helix transcription factor HNF3 to a linker histone site on the nucleosome

Cirillo, L. A., McPherson, C. E., Bossard, P., Stevens, K., Cherian, S., Shim, E. Y., Clark, K., Burley, S. K., & Zaret, K. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.244 · Cited by 381 · see citing works

Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

Enat, R., Jefferson, D. M., Ruiz‐Opazo, N., Gatmaitan, Z., Leinwand, L. A., & Reid, L. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1411 · Cited by 362 · see citing works

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

Blobel, G. A., Nakajima, T., Eckner, R., Montminy, M., & Orkin, S. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2061 · Cited by 355 · see citing works

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

McPherson, C. E., Shim, E.-Y., Friedman, D. S., & Zaret, K. S. (1993) · Cell · doi:10.1016/0092-8674(93)80079-t · Cited by 327 · see citing works

A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila

Rehorn, K.-P., Thelen, H., Michelson, A. M., & Reuter, R. (1996) · Development · doi:10.1242/dev.122.12.4023 · Cited by 321 · see citing works

Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor

Grépin, C., Nemer, G. M., & Nemer, M. J. (1997) · Development · doi:10.1242/dev.124.12.2387 · Cited by 282 · see citing works

Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro

Soudais, C., Bielińska, M., Heikinheimo, M., MacArthur, C. A., Narita, N., Saffitz, J. E., Simon, M. C., Leiden, J. M., & Wilson, D. B. (1995) · Development · doi:10.1242/dev.121.11.3877 · Cited by 269 · see citing works

An experimental analysis of liver development.

Douarin, N. M. L. (1975) · PubMed · Cited by 268 · see citing works

In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor

Rigaud, G., Roux, J. M., PICTET, R. L., & Grange, T. (1991) · Cell · doi:10.1016/0092-8674(91)90370-e · Cited by 254 · see citing works

Distinct Functions Are Implicated for the GATA-4, -5, and -6 Transcription Factors in the Regulation of Intestine Epithelial Cell Differentiation

Gao, X., Sedgwick, T., Shi, Y., & Evans, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2901 · Cited by 238 · see citing works

The Extracellular Matrix Coordinately Modulates Liver Transcription Factors and Hepatocyte Morphology

DiPersio, C. M., Jackson, D. A., & Zaret, K. S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.9.4405-4414.1991 · Cited by 227 · see citing works

Onset of cell-specific gene expression in the developing mouse pancreas.

Gittes, G. K., & Rutter, W. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.3.1128 · Cited by 224 · see citing works

Wild-Type Endoderm Abrogates the Ventral Developmental Defects Associated with GATA-4 Deficiency in the Mouse

Narita, N., Bielińska, M., & Wilson, D. B. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8684 · Cited by 212 · see citing works

end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryosPreprint

Zhu, J., Hill, R. J., Heid, P. J., Fukuyama, M., Sugimoto, A., Priess, J. R., & Rothman, J. H. (1997) · Genes & Development · doi:10.1101/gad.11.21.2883 · Cited by 208 · see citing works

Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation

Cascio, S. M., & Zaret, K. (1991) · Development · doi:10.1242/dev.113.1.217 · Cited by 204 · see citing works

TheXenopusGATA-4/5/6 Genes Are Associated with Cardiac Specification and Can Regulate Cardiac-Specific Transcription during Embryogenesis

Jiang, Y., & Evans, T. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0071 · Cited by 201 · see citing works

Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate

Altaba, A. R. I., Prezioso, V. R., Darnell, J. E., Jr., & Jessell, T. M. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90060-b · Cited by 186 · see citing works

Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro.

Liu, J. K., DiPersio, C. M., & Zaret, K. S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.2.773 · Cited by 168 · see citing works

The HumanGATA-6Gene: Structure, Chromosomal Location, and Regulation of Expression by Tissue-Specific and Mitogen-Responsive Signals

Suzuki, E., Evans, T., Lowry, J. A., Truong, L. N., Bell, D. W., Testa, J. R., & Walsh, K. (1996) · Genomics · doi:10.1006/geno.1996.0630 · Cited by 147 · see citing works

Modulation of Liver-Specific Transcription by Interactions between Hepatocyte Nuclear Factor 3 and Nuclear Factor 1 Binding DNA in Close Apposition

Jackson, D. A., Rowader, K. E., Stevens, K., Jiang, C., Milos, P. M., & Zaret, K. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2401-2410.1993 · Cited by 135 · see citing works

Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells

Narita, N., Bielińska, M., & Wilson, D. B. (1997) · Development · doi:10.1242/dev.124.19.3755 · Cited by 124 · see citing works

Nucleosome positioning by the winged helix transcription factor HNF3Preprint

Shim, E. Y., Woodcock, C. L. F., & Zaret, K. S. (1998) · Genes & Development · doi:10.1101/gad.12.1.5 · Cited by 122 · see citing works

Initiation of cardiac differentiation occurs in the absence of anterior endoderm

GANNON, M. A., & Bader, D. M. (1995) · Development · doi:10.1242/dev.121.8.2439 · Cited by 100 · see citing works

Conditional enhancement of liver-specific gene transcription.

Zaret, K. S., DiPersio, C. M., Jackson, D. A., Montigny, W. J., & Weinstat, D. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9076 · Cited by 92 · see citing works

Site-directed mutagenesis reveals a liver transcription factor essential for the albumin transcriptional enhancer.

Zaret, K. S., Liu, J. K., & DiPersio, C. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5469 · Cited by 91 · see citing works

Expression of the chicken GATA factor family during early erythroid development and differentiation

Leonard, M. W., Lim, K.-C., & Engel, J. D. (1993) · Development · doi:10.1242/dev.119.2.519 · Cited by 87 · see citing works

elt-2, a Second GATA Factor from the Nematode Caenorhabditis elegans

Hawkins, M. G., & McGhee, J. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14666 · Cited by 84 · see citing works

The N‐terminal fingers of chicken GATA‐2 and GATA–3 are independent sequence‐specific DNA binding domains

Pedone, P. V., Omichinski, J. G., Nony, P., Trainor, C. D., Gronenborn, A. M., Clore, G. M., & Felsenfeld, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2874 · Cited by 83 · see citing works

Atlas of embryonic development

Oppenheimer, S. B., & Rc, C. (1984) · Cited by 64 · see citing works

Extracellular Signals That Regulate Liver Transcription Factors during Hepatic Differentiation In Vitro

Liu, J.-K., DiPersio, C. M., & Zaret, K. S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.2.773-784.1991 · Cited by 56 · see citing works

The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled beta-globin genes.Preprint

Barton, M. C., Madani, N., & Emerson, B. M. (1993) · Genes & Development · doi:10.1101/gad.7.9.1796 · Cited by 53 · see citing works

Functional analyses of albumin expression in a series of hepatocyte cell lines and in primary hepatocytes.

Hu, J., Camper, S. A., Tilghman, S. M., Miller, T., Georgoff, I., Serra, R. A., & Isom, H. C. (1992) · PubMed · Cited by 40 · see citing works

Endoderm and Cardiogenesis

Nascone, N., & Mercola, M. A. (1996) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(96)00086-2 · Cited by 37 · see citing works

Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut

Huggon, I. C., Davies, A., Gove, C., Moscoso, G. J., Moniz, C. F., Foss, Y., Farzaneh, F., & Towner, P. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(97)00049-3 · Cited by 30 · see citing works

In VivoFootprinting with Limiting Amounts of Embryo Tissues: A Role for C/EBPβ in Early Hepatic Development

Bossard, P., McPherson, C. E., & Zaret, K. S. (1997) · Methods · doi:10.1006/meth.1996.0404 · Cited by 26 · see citing works

Expression of a Highly Unstable and Insoluble Transcription Factor inEscherichia coli:Purification and Characterization of thefork headHomolog Hnf3α

Zaret, K. S., & Stevens, K. (1995) · Protein Expression and Purification · doi:10.1006/prep.1995.0014 · Cited by 25 · see citing works

Expression of GATA‐binding transcription factors in rat hepatocytes

Matsuda, K., Kobune, Y., Noda, C., & Ichihara, A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01062-5 · Cited by 19 · see citing works

Pioneer transcription factors: establishing competence for gene expression

Zaret, K. S., & Carroll, J. S. (2011) · Genes &amp; Development · doi:10.1101/gad.176826.111 · Cited by 1,589 · see citing works

Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4

Cirillo, L. A., Lin, F. R., Cuesta, I., Friedman, D., Jarník, M., & Zaret, K. S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00459-8 · Cited by 1,188 · see citing works

The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6

Molkentin, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000029200 · Cited by 880 · see citing works

Organogenesis and development of the liver

Si-Tayeb, K., Lemaigre, F. P., & Duncan, S. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.011 · Cited by 800 · see citing works

Transcription factors as readers and effectors of DNA methylation

Zhu, H., Wang, G., & Qian, J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.83 · Cited by 649 · see citing works

Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endodermPreprint

Rossi, J. M., Dunn, N. R., Hogan, B. L. M., & Zaret, K. S. (2001) · Genes & Development · doi:10.1101/gad.904601 · Cited by 646 · see citing works

A bipotential precursor population for pancreas and liver within the embryonic endoderm

Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611 · see citing works

Pioneer transcription factors in cell reprogrammingPreprint

Iwafuchi, M., & Zaret, K. S. (2014) · Genes & Development · doi:10.1101/gad.253443.114 · Cited by 590 · see citing works

The initiation of liver development is dependent on Foxa transcription factors

Lee, C. S., Friedman, J. R., Fulmer, J. T., & Kaestner, K. H. (2005) · Nature · doi:10.1038/nature03649 · Cited by 581 · see citing works

Vertebrate Endoderm Development

Wells, J. M., & Melton, D. A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.393 · Cited by 522 · see citing works

Regulatory phases of early liver development: paradigms of organogenesis

Zaret, K. S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg837 · Cited by 504 · see citing works

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

Russell, J. O., & Monga, S. P. (2018) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-044010 · Cited by 471 · see citing works

Gata5 is required for the development of the heart and endoderm in zebrafishPreprint

Reiter, J. F., Alexander, J., Rodaway, A., Yelon, D. L., Patient, R. K., Holder, N., & Stainier, D. Y. R. (1999) · Genes & Development · doi:10.1101/gad.13.22.2983 · Cited by 421 · see citing works

Pioneer Transcription Factors Initiating Gene Network Changes

Zaret, K. S. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-030220-015007 · Cited by 398 · see citing works

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

Amit, I., Winter, D. R., & Jung, S. (2015) · Nature Immunology · doi:10.1038/ni.3325 · Cited by 406 · see citing works

Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells

Agarwal, S., Holton, K., & Lanza, R. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1102 · Cited by 402 · see citing works

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

Garber, M., Yosef, N., Goren, A., Raychowdhury, R., Thielke, A., Guttman, M., Robinson, J., Minie, B., Chevrier, N., Itzhaki, Z., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.030 · Cited by 369 · see citing works

Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactorsPreprint

Crispino, J. D., Lodish, M. B., Thurberg, B. L., Litovsky, S. H., Collins, T., Molkentin, J. D., & Orkin, S. H. (2001) · Genes & Development · doi:10.1101/gad.875201 · Cited by 316 · see citing works

The epigenetic basis of cellular heterogeneity

Carter, B. C., & Zhao, K. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-00300-0 · Cited by 314 · see citing works

Embryonic development of the liver†

Zhao, R., & Duncan, S. A. (2005) · Hepatology · doi:10.1002/hep.20691 · Cited by 292 · see citing works

High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states

Blecher-Gonen, R., Barnett-Itzhaki, Z., Jaitin, D., Amann-Zalcenstein, D., Lara-Astiaso, D., & Amit, I. (2013) · Nature Protocols · doi:10.1038/nprot.2013.023 · Cited by 289 · see citing works

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

Zaret, K. S. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2318 · Cited by 285 · see citing works

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

Bort, R., Signore, M., Tremblay, K. D., Martı́nez-Barberá, J. P., & Zaret, K. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.006 · Cited by 285 · see citing works

Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies

Lemaigre, F. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.035 · Cited by 263 · see citing works

GATA transcription factors in development and disease

Tremblay, M. R., Sanchez-Ferras, O., & Bouchard, M. (2018) · Development · doi:10.1242/dev.164384 · Cited by 257 · see citing works

Hepatocyte polarity

Treyer, A., & Müsch, A. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120009 · Cited by 252 · see citing works

Pioneer transcription factors shape the epigenetic landscape

Mayran, A., & Drouin, J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.001232 · Cited by 238 · see citing works

GATA6 Is Essential for Embryonic Development of the Liver but Dispensable for Early Heart Formation

Zhao, R., Watt, A. J., Li, J., Luebke-Wheeler, J. L., Morrisey, E. E., & Duncan, S. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2622-2631.2005 · Cited by 239 · see citing works

An Early Developmental Transcription Factor Complex that Is More Stable on Nucleosome Core Particles Than on Free DNA

Cirillo, L. A., & Zaret, K. S. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80225-7 · Cited by 235 · see citing works

Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA

Sekiya, T., Muthurajan, U. M., Luger, K., Tulin, A. V., & Zaret, K. S. (2009) · Genes &amp; Development · doi:10.1101/gad.1775509 · Cited by 221 · see citing works

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomesPreprint

Caravaca, J. M., Donahue, G., Becker, J. S., He, X., Charles, V., & Zaret, K. S. (2013) · Genes & Development · doi:10.1101/gad.206458.112 · Cited by 218 · see citing works

Vertebrate intestinal endoderm development

Spence, J. R., Lauf, R., & Shroyer, N. F. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22540 · Cited by 217 · see citing works

Dynamic epigenomic landscapes during early lineage specification in mouse embryos

Zhang, Y., Xiang, Y., Yin, Q., Du, Z., Xu, P., Wang, Q., Fidalgo, M., Xia, W., Li, Y., Zhao, Z., et al. (2017) · Nature Genetics · doi:10.1038/s41588-017-0003-x · Cited by 210 · see citing works

Differentiation and Enrichment of Hepatocyte-Like Cells from Human Embryonic Stem Cells In Vitro and In Vivo

Duan, Y., Catana, A. M., Meng, Y., Yamamoto, N., He, S., Gupta, S. K., Gambhir, S. S., & Zern, M. Α. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0291 · Cited by 208 · see citing works

Bmp and Fgf signaling are essential for liver specification in zebrafish

Shin, D., Shin, C. H., Tucker, J. A., Ober, E. A., Rentzsch, F., Poss, K. D., Hammerschmidt, M., Mullins, M. C., & Stainier, D. Y. R. (2007) · Development · doi:10.1242/dev.000281 · Cited by 207 · see citing works

Developmental Competence of the Gut Endoderm: Genetic Potentiation by GATA and HNF3/Fork Head Proteins

Zaret, K. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9228 · Cited by 209 · see citing works

Transcription factors: specific DNA binding and specific gene regulation

Todeschini, A., Georges, A. B., & Veitia, R. A. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.04.002 · Cited by 207 · see citing works

Development of the mammalian liver and ventral pancreas is dependent on GATA4

Watt, A. J., Zhao, R., Li, J., & Duncan, S. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-37 · Cited by 200 · see citing works

Gata4 regulates the formation of multiple organs

Holtzinger, A., & Evans, T. (2005) · Development · doi:10.1242/dev.01978 · Cited by 205 · see citing works

A potentially functional polymorphism in the promoter region of miR‐34b/c is associated with an increased risk for primary hepatocellular carcinoma

Xu, Y., Liu, L., Liu, J., Zhang, Y., Zhu, J., Chen, J., Liu, S., Liu, Z., Shi, H., Shen, H., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25342 · Cited by 189 · see citing works

Development of the bile ducts: Essentials for the clinical hepatologist

Strazzabosco, M., & Fabris, L. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.09.022 · Cited by 187 · see citing works

Hepatocyte differentiation: from the endoderm and beyond

Zaret, K. S. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00234-3 · Cited by 184 · see citing works

Hepatic Differentiation of Murine Embryonic Stem Cells

Jones, E. A., Tosh, D., Wilson, D. I., Lindsay, S., & Forrester, L. M. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5396 · Cited by 183 · see citing works

Liver specification and early morphogenesis

Zaret, K. S. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00326-3 · Cited by 182 · see citing works

Distinct roles for visceral endoderm during embryonic mouse development

Bielińska, M., Narita, N., & Wilson, D. B. (1999) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10410899 · Cited by 182 · see citing works

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomesPreprint

Young, N. P., Kamireddy, A., Nostrand, J. L. V., Eichner, L. J., Shokhirev, M. N., Dayn, Y., & Shaw, R. J. (2016) · Genes & Development · doi:10.1101/gad.274142.115 · Cited by 177 · see citing works

A glimpse into the molecular entrails of endoderm formationPreprint

Stainier, D. Y. R. (2002) · Genes & Development · doi:10.1101/gad.974902 · Cited by 177 · see citing works

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cellsPreprint

Xu, J., Watts, J. A., Pope, S. D., Gadue, P. J., Kamps, M. P., Plath, K., Zaret, K. S., & Smale, S. T. (2009) · Genes & Development · doi:10.1101/gad.1861209 · Cited by 177 · see citing works

Setting appropriate boundaries: Fate, patterning and competence at the neural plate border

Groves, A. K., & LaBonne, C. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.11.027 · Cited by 166 · see citing works

Multiple roles for Gata5 in zebrafish endoderm formation

Reiter, J. F., Kikuchi, Y., & Stainier, D. Y. R. (2001) · Development · doi:10.1242/dev.128.1.125 · Cited by 172 · see citing works

Proliferation and Differentiation of Fetal Liver Epithelial Progenitor Cells after Transplantation into Adult Rat Liver

Dabeva, M. D., Petkov, P. M., Sandhu, J., Oren, R., Laconi, E., Hurston, E., & Shafritz, D. A. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65074-2 · Cited by 171 · see citing works

Genetic determinants and epigenetic effects of pioneer-factor occupancy

Donaghey, J., Thakurela, S., Charlton, J., Chen, J., Smith, Z. D., Gu, H., Pop, R., Clement, K., Stamenova, E. K., Karnik, R., et al. (2018) · Nature Genetics · doi:10.1038/s41588-017-0034-3 · Cited by 169 · see citing works

Mechanisms controlling early development of the liver

Duncan, S. A. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00328-3 · Cited by 169 · see citing works

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.

Xuan, S., Borok, M., Decker, K., Battle, M., Duncan, S., Hale, M. A., MacDonald, R. J., & Sussel, L. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63352 · Cited by 158 · see citing works

Pioneer factors: directing transcriptional regulators within the chromatin environment

Magnani, L., Eeckhoute, J., & Lupien, M. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.07.002 · Cited by 161 · see citing works

Pioneer Factors, Genetic Competence, and Inductive Signaling: Programming Liver and Pancreas Progenitors from the EndodermPreprint

Zaret, K. S., Watts, J. A., Xu, J., Wandzioch, E., Smale, S. T., & Sekiya, T. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.040 · Cited by 159 · see citing works

Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing

Wederell, E. D., Bilenky, M., Cullum, R., Thiessen, N., Dagpinar, M., Delaney, A., Varhol, R., Zhao, Y., Zeng, T., Bernier, B., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn382 · Cited by 150 · see citing works

Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear

Lawoko‐Kerali, G., Rivolta, M. N., & Holley, M. C. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.10088 · Cited by 150 · see citing works

Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer

Wu, D., Sunkel, B. D., Chen, Z., Liu, X., Ye, Z., Li, Q., Grenade, C., Ke, J., Zhang, C., Chen, H., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1382 · Cited by 138 · see citing works

Cytokine regulation of liver development

Kinoshita, T., & Miyajima, A. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00323-3 · Cited by 136 · see citing works

Understanding the marvels behind liver regeneration

Rmilah, A. A. A., Zhou, W., Nelson, E., Li, L., Amiot, B. P., & Nyberg, S. L. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.340 · Cited by 133 · see citing works

Gata4expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element

Rojas, A., Val, S. D., Heidt, A. B., Xu, S.-M., Bristow, J. D., & Black, B. L. (2005) · Development · doi:10.1242/dev.01913 · Cited by 133 · see citing works

The role of GATA2 in lethal prostate cancer aggressiveness

Rodríguez-Bravo, V., Carceles‐Cordon, M., Hoshida, Y., Cordon‐Cardo, C., Galsky, M. D., & Domenech, J. M. D. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.225 · Cited by 126 · see citing works

Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis

IJpenberg, A., Pérez-Pomares, J. M., Guadix, J. A., Carmona, R., Portillo-Sánchez, V., Macías, D., Hohenstein, P., Miles, C., Hastie, N. D., & Muñoz‐Chápuli, R. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.014 · Cited by 126 · see citing works

Defined Human Pluripotent Stem Cell Culture Enables Highly Efficient Neuroepithelium Derivation Without Small Molecule Inhibitors

Lippmann, E. S., Estevez-Silva, M. C., & Ashton, R. S. (2013) · Stem Cells · doi:10.1002/stem.1622 · Cited by 123 · see citing works

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cellsPreprint

Tagoh, H., Himes, R., Clarke, D., Leenen, P. J. M., Riggs, A. D., Hume, D., & Bonifer, C. (2002) · Genes & Development · doi:10.1101/gad.222002 · Cited by 123 · see citing works

The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration

Margagliotti, S., Clotman, F., Pierreux, C. E., Beaudry, J., Jacquemin, P., Rousseau, G. G., & Lemaigre, F. P. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.013 · Cited by 122 · see citing works

Molecular Mechanism of Liver Development and Regeneration

Tanimizu, N., & Miyajima, A. (2007) · International review of cytology · doi:10.1016/s0074-7696(06)59001-1 · Cited by 112 · see citing works

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

Seymour, P. A., Shih, H., Patel, N., Freude, K., Xie, R., Lim, C. J., & Sander, M. (2012) · Development · doi:10.1242/dev.078733 · Cited by 118 · see citing works

Association of Common Genetic Variants in Pre-microRNAs and Neuroblastoma Susceptibility: A Two-Center Study in Chinese Children

He, J., Zou, Y., Liu, X., Zhu, J., Zhang, J., Zhang, R., Yang, T., & Xia, H. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.01.003 · Cited by 105 · see citing works

Crucial role of vHNF1 in vertebrate hepatic specification

Lokmane, L., Haumaître, C., García-Villalba, P., Anselme, I., Schneider-Maunoury, S., & Cereghini, S. (2008) · Development · doi:10.1242/dev.023010 · Cited by 106 · see citing works

Hepatic Erythropoietin Gene Regulation by GATA-4

Dame, C., Sola, M. C., Lim, K.-C., Leach, K. M., Fandrey, J., Ma, Y., Knöpfle, G., Engel, J. D., & Bungert, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310404200 · Cited by 101 · see citing works

Pioneer factors and ATP‐dependent chromatin remodeling factors interact dynamically: A new perspective: Multiple transcription factors can effect chromatin pioneer functions through dynamic interactions with ATP‐dependent chromatin remodeling factors

Swinstead, E. E., Paakinaho, V., Presman, D. M., & Hager, G. L. (2016) · BioEssays · doi:10.1002/bies.201600137 · Cited by 100 · see citing works

Cloning, expression analysis, and chromosomal localization of murine and human homologues of aXenopus Mix gene

Robb, L. G., Hartley, L., Begley, C. G., Brodnicki, T. C., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Elefanty, A. G. (2000) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 78 · see citing works

Molecular Regulation of Vertebrate Early Endoderm Development

Shivdasani, R. A. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0765 · Cited by 98 · see citing works

Regulation of Hex gene expression and initial stages of avian hepatogenesis by Bmp and Fgf signaling

Zhang, W., Yatskievych, T. A., Baker, R. K., & Antin, P. B. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.01.019 · Cited by 97 · see citing works

Novel roles for GATA transcription factors in the regulation of steroidogenesis

Tremblay, J., & Viger, R. S. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00211-5 · Cited by 95 · see citing works

Genetic Mosaic Analysis Reveals That GATA-4 Is Required for Proper Differentiation of Mouse Gastric Epithelium

Jacobsen, C. M., Narita, N., Bielińska, M., Syder, A. J., Gordon, J. I., & Wilson, D. B. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0424 · Cited by 94 · see citing works

The Fox Genes in the Liver: From Organogenesis to Functional Integration

Lay, J. E. L., & Kaestner, K. H. (2010) · Physiological Reviews · doi:10.1152/physrev.00018.2009 · Cited by 91 · see citing works

Transcription Factor FoxA (HNF3) on a Nucleosome at an Enhancer Complex in Liver Chromatin

Chaya, D., Hayamizu, T. F., Bustin, M., & Zaret, K. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108214200 · Cited by 90 · see citing works

Evolution of the mechanisms and molecular control of endoderm formation

Grapin‐Botton, A., & Constam, D. B. (2007) · Mechanisms of Development · doi:10.1016/j.mod.2007.01.001 · Cited by 89 · see citing works

Structure and functions of powerful transactivators: VP16, MyoD and FoxA

Hirai, H., Tani, T., & Kikyo, N. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.103194hh · Cited by 89 · see citing works

Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa

Haveri, H., Westerholm‐Ormio, M., Lindfors, K., Mäki, M., Savilahti, E., Andersson, L. C., & Heikinheimo, M. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-9 · Cited by 89 · see citing works

The Mouse Fetoprotein Transcription Factor (FTF) Gene Promoter Is Regulated by Three GATA Elements with Tandem E Box and Nkx Motifs, and FTF in Turn Activates the Hnf3β, Hnf4α, and Hnf1α Gene Promoters

Paré, J., Roy, S., Galarneau, L., & Bélanger, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010737200 · Cited by 88 · see citing works

Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation

Spear, B. T., Jin, L., Ramasamy, S., & Dobierzewska, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6258-5 · Cited by 87 · see citing works

Anomalous expression of epithelial differentiation-determining GATA factors in ovarian tumorigenesis.

Capo‐chichi, C. D., Roland, I. H., Vanderveer, L., Bao, R., Yamagata, T., Hirai, H., Cohen, C., Hamilton, T. C., Godwin, A. K., & Xu, X. (2003) · PubMed · Cited by 87 · see citing works

Molecular mechanisms of liver development and differentiation

Darlington, G. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00035-6 · Cited by 86 · see citing works

Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones

Iwafuchi, M., Cuesta, I., Donahue, G., Takenaka, N., Osipovich, A. B., Magnuson, M. A., Röder, H., Seeholzer, S. H., Santisteban, P., & Zaret, K. S. (2020) · Nature Genetics · doi:10.1038/s41588-020-0591-8 · Cited by 82 · see citing works

Pioneer factors in embryonic stem cells and differentiation

Smale, S. T. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.06.010 · Cited by 82 · see citing works

Bone morphogenetic protein function is required for terminal differentiation of the heart but not for early expression of cardiac marker genes

Walters, M. J., Wayman, G. A., & Christian, J. L. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00535-9 · Cited by 82 · see citing works

Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition

Pettinato, G., Ramanathan, R., Fisher, R. A., Mangino, M. J., Zhang, N., & Wen, X. (2016) · Scientific Reports · doi:10.1038/srep32888 · Cited by 81 · see citing works

Transcription factor regulation of pancreatic organogenesis, differentiation and maturation

Dassaye, R., Naidoo, S., & Cerf, M. (2016) · Islets · doi:10.1080/19382014.2015.1075687 · Cited by 72 · see citing works

Cellular and Molecular Basis of Liver Development

Shin, D., & Monga, S. P. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120022 · Cited by 90 · see citing works

The Forkhead Factor FoxE1 Binds to the Thyroperoxidase Promoter during Thyroid Cell Differentiation and Modifies Compacted Chromatin Structure

Cuesta, I., Zaret, K. S., & Santisteban, P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00758-07 · Cited by 79 · see citing works

Direct lineage reprogramming via pioneer factors; a detour through developmental gene regulatory networks

Morris, S. A. (2016) · Development · doi:10.1242/dev.138263 · Cited by 80 · see citing works

Specific Interactions of the Wing Domains of FOXA1 Transcription Factor with DNA

Cirillo, L. A., & Zaret, K. S. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.087 · Cited by 79 · see citing works

Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays

Rada-Iglesias, Á., Wallerman, O., Koch, C., Ameur, A., Enroth, S., Clelland, G. K., Wester, K., Wilcox, S., Dovey, O. M., Ellis, P. D., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi378 · Cited by 76 · see citing works

Repressive and restrictive mesodermal interactions with gut endoderm: possible relation to Meckel’s Diverticulum

Bossard, P., & Zaret, K. S. (2000) · Development · doi:10.1242/dev.127.22.4915 · Cited by 75 · see citing works

Modulation of Endogenous GATA-4 Activity Reveals Its Dual Contribution to Mullerian Inhibiting Substance Gene Transcription in Sertoli Cells

Tremblay, J., Robert, N. M., & Viger, R. S. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.9.0692 · Cited by 72 · see citing works

FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression

Zhao, J. C., Fong, K.-W., Jin, H.-J., Yang, Y. A., Kim, J., & Yu, J. (2016) · Oncogene · doi:10.1038/onc.2015.496 · Cited by 71 · see citing works

An endoderm‐specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein–binding sites for function in vivo

Rojas, A., Schachterle, W., Xu, S., & Black, B. L. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22091 · Cited by 30 · see citing works

Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates

Shoichet, S. A., Malik, T. H., Rothman, J. H., & Shivdasani, R. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4076 · Cited by 60 · see citing works

Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer

Rojas, A., Schachterle, W., Xu, S.-M., Martı́n, F., & Black, B. L. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.07.032 · Cited by 50 · see citing works

GATA factors as key regulatory molecules in the development of Drosophila endoderm

Murakami, R., Okumura, T., & Uchiyama, H. (2005) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2005.00836.x · Cited by 58 · see citing works

Developmental Competence of the Gut Endoderm: Genetic Potentiation by GATA and HNF3/Fork Head Proteins

Zaret, K. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9228 · Cited by 209 · see citing works