The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
Abstract
The formation of boundaries between groups of cells is a universal feature of metazoan development. Drosophila fringe modulates the activation of the Notch signal trans-duction pathway at the dorsal-ventral boundary of the wing imaginal disc. Three mammalian fringe-related family members have been cloned and characterized: Manic, Radical and Lunatic Fringe. Expression studies in mouse embryos support a conserved role for mammalian Fringe family members in participation in the Notch signaling pathway leading to boundary determination during segmentation. In mammalian cells, Drosophila fringe and the mouse Fringe proteins are subject to post-translational regulation at the levels of differential secretion and proteolytic processing. When misexpressed in the developing Drosophila wing imaginal disc the mouse Fringe genes exhibit conserved and differential effects on boundary determination.
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Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,612
Genetic Transformation of Drosophila with Transposable Element Vectors
Rubin, G. M., & Spradling, A. C. (1982) · Science · doi:10.1126/science.6289436 · Cited by 3,014
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,307
Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D., & Sklar, J. (1991) · Cell · doi:10.1016/0092-8674(91)90111-b · Cited by 1,696
Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,146
Notch1 is required for the coordinate segmentation of somites
Conlon, R. A., Reaume, A. G., & Rossant, J. (1995) · Development · doi:10.1242/dev.121.5.1533 · Cited by 852
[22] Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts
Wilkinson, D. G., & Nieto, M. A. (1993) · Methods in Enzymology · doi:10.1016/0076-6879(93)25025-w · Cited by 793
The kit ligand: A cell surface molecule altered in steel mutant fibroblasts
Flanagan, J. G., & Leder, P. (1990) · Cell · doi:10.1016/0092-8674(90)90299-t · Cited by 748
Mammalian subtilisins: The long-sought dibasic processing endoproteases
Barr, P. J. (1991) · Cell · doi:10.1016/0092-8674(91)90129-m · Cited by 743
Cheng, H.-J., Nakamoto, M., Bergemann, A. D., & Flanagan, J. G. (1995) · Cell · doi:10.1016/0092-8674(95)90426-3 · Cited by 738
Direct and Long-Range Action of a Wingless Morphogen Gradient
Zecca, M., Basler, K., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81991-1 · Cited by 731
Diversity and Pattern in the Developing Spinal Cord
Tanabe, Y., & Jessell, T. M. (1996) · Science · doi:10.1126/science.274.5290.1115 · Cited by 717
Nielsen, H., Engelbrecht, J., Brunak, S., & Heijne, G. V. (1997) · International Journal of Neural Systems · doi:10.1142/s0129065797000537 · Cited by 700
Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D., & Kintner, C. (1995) · Nature · doi:10.1038/375761a0 · Cited by 675
Jagged: A mammalian ligand that activates notch1
Lindsell, C. E., Shawber, C. J., Boulter, J., & Weinmaster, G. (1995) · Cell · doi:10.1016/0092-8674(95)90294-5 · Cited by 604
Genetic Control of Wing Disc Development in Drosophila
Garcia‐Bellido, A. (1975) · Novartis Foundation Symposia · doi:10.1002/9780470720110.ch8 · Cited by 577
Morphogens, Compartments, and Pattern: Lessons from Drosophila?
Lawrence, P. A., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81297-0 · Cited by 555
Autoproteolysis in hedgehog protein biogenesis
Lee, J., Ekker, S., von Kessler, D., Porter, J., Sun, B., & Beachy, P. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547
Kim, J., Sebring, A., Esch, J. J., Kraus, M. E., Vorwerk, K., Magee, J., & Carroll, S. B. (1996) · Nature · doi:10.1038/382133a0 · Cited by 485
Bettenhausen, B., Hrabê de Angelis, M., Simon, D., Guénet, J.-L., & Gossler, A. (1995) · Development · doi:10.1242/dev.121.8.2407 · Cited by 451
van den Heuvel, M., Nusse, R., Johnston, P., & Lawrence, P. A. (1989) · Cell · doi:10.1016/0092-8674(89)90020-2 · Cited by 444
Processed Vg1 protein is an axial mesoderm inducer in xenopus
Thomsen, G. H., & Melton, D. A. (1993) · Cell · doi:10.1016/0092-8674(93)80045-g · Cited by 413
Diaz-Benjumea, F. J., & Cohen, S. M. (1995) · Development · doi:10.1242/dev.121.12.4215 · Cited by 403
Mechanisms of vertebrate segmentation
Keynes, R. J., & Stern, C. D. (1988) · Development · doi:10.1242/dev.103.3.413 · Cited by 352
SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO
Morisalo, D., & Anderson, K. V. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.002103 · Cited by 347
Irvine, K. D., & Wieschaus, E. (1994) · Cell · doi:10.1016/0092-8674(94)90545-2 · Cited by 341
Self-citationDiffusible factors in vertebrate embryonic induction
Jessell, T. M., & Melton, D. A. (1992) · Cell · doi:10.1016/0092-8674(92)90469-s · Cited by 321
Doherty, D., Feger, G., Younger-Shepherd, S., Jan, L. Y., & Jan, Y. N. (1996) · Genes & Development · doi:10.1101/gad.10.4.421 · Cited by 320
Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
Celis, J. F. D., Garcia-Bellido, A., & Bray, S. J. (1996) · Development · doi:10.1242/dev.122.1.359 · Cited by 303
Hinz, U., Giebel, B., & Campos-Ortega, J. (1994) · Cell · doi:10.1016/0092-8674(94)90174-0 · Cited by 301
Candia, A. F., Hu, J., Crosby, J., Lalley, P. A., Noden, D., Nadeau, J. H., & Wright, C. V. E. (1992) · Development · doi:10.1242/dev.116.4.1123 · Cited by 282
The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.
Bradley, R. S., & Brown, A. M. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08276.x · Cited by 273
Neurogenic genes and vertebrate neurogenesis
Lewis, J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80002-x · Cited by 264
Kim, J., Irvine, K. D., & Carroll, S. B. (1995) · Cell · doi:10.1016/0092-8674(95)90476-x · Cited by 259
Self-citationAmo, F. F. D., Smith, D. E., Swiatek, P. J., Gendron-Maguire, M., Greenspan, R. J., Mcmahon, A. P., & Gridley, T. (1992) · Development · doi:10.1242/dev.115.3.737 · Cited by 249
Nieto, M. A., Gilardi-Hebenstreit, P., Charnay, P., & Wilkinson, D. G. (1992) · Development · doi:10.1242/dev.116.4.1137 · Cited by 221
Rulifson, E. J., & Blair, S. S. (1995) · Development · doi:10.1242/dev.121.9.2813 · Cited by 203
Genetic control of wing disc development in Drosophila
Garcı́a-Bellido, A. (1974) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · Cited by 190
Specification and segmentation of the paraxial mesoderm
Tam, P. L., & Trainor, P. (1994) · Anatomy and Embryology · doi:10.1007/bf00190586 · Cited by 162
K1 killer toxin, a pore‐forming protein from yeast
Bussey, H. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb02079.x · Cited by 138
Transcription of H‐2 and Qa genes in embryonic and adult mice.
Fahrner, K. A., Hogan, B. L., & Flavell, R. A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02363.x · Cited by 131
Boone, C. M., Bussey, H., Greene, D., Thomas, D. Y., & Vernet, T. (1986) · Cell · doi:10.1016/0092-8674(86)90864-0 · Cited by 83
Expression and Characterization of Human CD4: Immunoglobulin Fusion Proteins
Zettlmeißl, G., Gregersen, J., DUPORT, J. M., Mehdi, S., Reiner, G., & Seed, B. (1990) · DNA and Cell Biology · doi:10.1089/dna.1990.9.347 · Cited by 74
The Secreted Product of Xenopus Gene lunatic Fringe , a Vertebrate Signaling Molecule
Wu, J. Y., Wen, L., Zhang, W.-J., & Rao, Y. (1996) · Science · doi:10.1126/science.273.5273.355 · Cited by 58
Bie, I. D., Savaria, D., Roebroek, A., Day, R. W., Lazure, C., de Ven, W. J. M. V., & Seidah, N. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1020 · Cited by 53
Roebroek, A., Ayoubi, T., Creemers, J. W. M., Pauli, I. G. L., & de Ven, W. J. M. V. (1995) · DNA and Cell Biology · doi:10.1089/dna.1995.14.223 · Cited by 22
Cited by
Fringe is a glycosyltransferase that modifies Notch
Moloney, D. J., Panin, V. M., Johnston, S. H., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K. D., Haltiwanger, R. S., et al. (2000) · Nature · doi:10.1038/35019000 · Cited by 852
Self-citationRole of Glycosylation in Development
Haltiwanger, R. S., & Lowe, J. B. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074043 · Cited by 757
Glycosyltransferase activity of Fringe modulates Notch–Delta interactions
Brückner, K., Perez, L., Clausen, H., & Cohen, S. (2000) · Nature · doi:10.1038/35019075 · Cited by 694
Developmental system drift and flexibility in evolutionary trajectories
True, J. R., & Haag, E. S. (2001) · Evolution & Development · doi:10.1046/j.1525-142x.2001.003002109.x · Cited by 678
Fringe modulates Notch–ligand interactions
Panin, V. M., Papayannopoulos, V., Wilson, R., & Irvine, K. D. (1997) · Nature · doi:10.1038/43191 · Cited by 586
Self-citation
Metadata
- Authors
- Johnston, S. H., Rauskolb, C., Wilson, R., Prabhakaran, B., Irvine, K. D., & Vogt, T. F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-06-01
- Volume
- 124
- Issue
- 11
- Pages
- 2245-2254
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2134349499
- Cited by
- 294
- References
- 49
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
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