The DOI matches its Crossref record.
A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1
Abstract
Pbx1 is a homeodomain transcription factor that has the ability to form heterodimers with homeodomain proteins encoded by the homeotic selector (Hox) gene complexes and increase their DNA-binding affinity and specificity. A current hypothesis proposes that interactions with Pbx1 are necessary for Hox proteins to regulate downstream target genes that in turn control growth, differentiation and morphogenesis during development. In pre B cell leukemias containing the t(1;19) chromosome transloca-tion, Pbx1 is converted into a strong transactivator by fusion to the activation domain of the bHLH transcription factor E2A. The E2A-Pbx1 fusion protein should therefore activate transcription of genes normally regulated by Pbx1. We have used the subtractive process of representational difference analysis to identify targets of E2A-Pbx1. We show that E2A-Pbx1 can directly activate transcription of a novel member of the fibroblast growth factor family of intercellular signalling molecules, FGF-15. The FGF-15 gene is expressed in a regionally restricted pattern in the developing nervous system, suggesting that FGF-15 may play an important role in regulating cell division and pat-terning within specific regions of the embryonic brain, spinal cord and sensory organs.
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Metadata
- Authors
- McWhirter, J. R., Goulding, M., Weiner, J. A., Chun, J., & Murre, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-09-01
- Volume
- 124
- Issue
- 17
- Pages
- 3221-3232
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2187415142
- Cited by
- 231
- References
- 0
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- closed
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