Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069 · see citing works

The FGF family: biology, pathophysiology and therapy

Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945 · see citing works

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865 · see citing works

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,846 · see citing works

Stromal gene expression predicts clinical outcome in breast cancer

Finak, G., Bertos, N., Pepin, F., Sadekova, S., Souleimanova, M., Zhao, H., Chen, H., Ömeroğlu, G., Meterissian, S. H., Ömeroğlu, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1764 · Cited by 1,687 · see citing works

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 935 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.

Relf, M., LeJeune, S., Scott, P. A. E., Fox, S. B., Smith, K. A., Leek, R., Moghaddam, A., Whitehouse, R. M., Bicknell, R., & Harris, A. L. (1997) · PubMed · Cited by 833 · see citing works

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A., Kharitonenkov, A., Flier, J. S., & Maratos-Flier, E. (2010) · Diabetes · doi:10.2337/db10-0193 · Cited by 830 · see citing works

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works

Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748 · see citing works

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738 · see citing works

Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

Itoh, N., & Ornitz, D. M. (2010) · The Journal of Biochemistry · doi:10.1093/jb/mvq121 · Cited by 708 · see citing works

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704 · see citing works

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

Lin, Z., Tian, H., Lam, K. S. L., Lin, S., Hoo, R. C. L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S. R., Xu, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.005 · Cited by 691 · see citing works

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A., & Mangelsdorf, D. J. (2011) · Science · doi:10.1126/science.1198363 · Cited by 637 · see citing works

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

Shabalina, I. G., Petrovič, N., de Jong, J. M. A., Kalinovich, A., Cannon, B., & Nedergaard, J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.044 · Cited by 637 · see citing works

Adiponectin: mechanistic insights and clinical implications

Turer, A. T., & Scherer, P. E. (2012) · Diabetologia · doi:10.1007/s00125-012-2598-x · Cited by 636 · see citing works

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623 · see citing works

βKlotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617 · see citing works

FGF21 is an endocrine signal of protein restriction

Laeger, T., Henagan, T. M., Albarado, D. C., Redman, L. M., Bray, G. A., Noland, R. C., Münzberg, H., Hutson, S. M., Gettys, T. W., Schwartz, M. W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74915 · Cited by 593 · cited 2× · see citing works

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes · doi:10.2337/db14-0595 · Cited by 590 · see citing works

Fibroblast Growth Factor 19 Increases Metabolic Rate and Reverses Dietary and Leptin-Deficient Diabetes

Fu, L., John, L. M., Adams, S. H., Yu, X. X., Tomlinson, E., Renz, M. E., Williams, P. M., Soriano, R. H., Corpuz, R. T., Moffat, B., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1671 · Cited by 580 · see citing works

Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., et al. (2002) · Endocrinology · doi:10.1210/endo.143.5.8850 · Cited by 576 · see citing works

Exploring mechanisms of FGF signalling through the lens of structural biology

Goetz, R., & Mohammadi, M. (2013) · Nature reviews. Molecular cell biology · doi:10.1038/nrm3528 · Cited by 556 · see citing works

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works

Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members

Goetz, R., Beenken, A., Ibrahimi, O., Kalinina, J., Olsen, S., Eliseenkova, A. V., Xu, C.-F., Neubert, T., Zhang, F.-M., Linhardt, R., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02249-06 · Cited by 544 · see citing works

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

Holland, W., Adams, A., Brozinick, J., Bui, H., Miyauchi, Y., Kusminski, C., Bauer, S., Wade, M., Singhal, E., Cheng, C. C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.019 · Cited by 525 · see citing works

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.012 · Cited by 523 · see citing works

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.019 · Cited by 431 · see citing works

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

Inagaki, T., Lin, V. Y., Goetz, R., Mohammadi, M., Mangelsdorf, D. J., & Kliewer, S. A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.006 · Cited by 409 · see citing works

Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man

Lundåsen, T., Gälman, C., Angelin, B., & Rudling, M. J. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01731.x · Cited by 406 · see citing works

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.002 · Cited by 403 · see citing works

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377 · see citing works

A Mouse Model of Hepatocellular Carcinoma

Nicholes, K., Guillet, S., Tomlinson, E., Hillan, K., Wright, B., Frantz, G. D., Pham, T. A., Dillard-Telm, L., Tsai, S. P., Stephan, J.-P., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61177-7 · Cited by 359 · see citing works

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

Xu, J., Stanislaus, S., Chinookoswong, N., Lau, Y. Y., Hager, T., Patel, J., Ge, H., Weiszmann, J., Lu, S.-C., Graham, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00348.2009 · Cited by 340 · see citing works

FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho

Kharitonenkov, A., Dunbar, J. D., Bina, H. A., Bright, S. W., Moyers, J. S., Zhang, C., Ding, L., Micanovic, R., Mehrbod, S. F., Knierman, M. D., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21357 · Cited by 329 · see citing works

Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice

Miller, D. L., Ortega, S., Bashayan, O., Basch, R. S., & Basilico, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2260-2268.2000 · Cited by 326 · see citing works

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Liang, Q., Zhong, L., Zhang, J., Wang, Y., Bornstein, S. R., Triggle, C. R., Ding, H., Lam, K. S. L., & Xu, A. (2014) · Diabetes · doi:10.2337/db14-0541 · Cited by 299 · see citing works

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

Sarruf, D. A., Thaler, J. P., Morton, G. J., German, J. P., Fischer, J. D., Ogimoto, K., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1878 · Cited by 287 · see citing works

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.10.002 · Cited by 286 · see citing works

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

Jonker, J., Suh, J. M., Atkins, A., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.-Q., Phillips, C. T., et al. (2012) · Nature · doi:10.1038/nature10998 · Cited by 286 · see citing works

Paradoxical resistance to diet-induced obesity in UCP1-deficient mice

Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200315737 · Cited by 281 · see citing works

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

Adams, A. C., Yang, C., Coskun, T., Cheng, C. C., Gimeno, R. E., Luo, Y., & Kharitonenkov, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2012.08.007 · Cited by 266 · see citing works

Paradoxical resistance to diet-induced obesity in UCP1-deficient mice

Liu, X., Rossmeisl, M., McClaine, J. W., & Kozak, L. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15737 · Cited by 265 · see citing works

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

Suh, J. M., Jonker, J. W., Ahmadian, M., Goetz, R. M., Lackey, D. E., Osborn, O., Huang, Z., Liu, W., Yoshihara, E., van Dijk, T. H., et al. (2014) · Nature · doi:10.1038/nature13540 · Cited by 259 · see citing works

Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21

Chartoumpekis, D. V., Habeos, I. G., Ziros, P. G., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00075 · Cited by 252 · see citing works

Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho

Ito, S., Fujimori, T., Furuya, A., Satoh, J., Nabeshima, Y., & Nabeshima, Y. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23076 · Cited by 245 · see citing works

Interplay between FGF21 and insulin action in the liver regulates metabolism

Emanuelli, B., Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, M., Michael, M. D., Adams, A. C., Kharitonenkov, A., & Kahn, C. R. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67353 · Cited by 243 · see citing works

FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity

Arner, P., Pettersson, A., Mitchell, P. J., Dunbar, J. D., Kharitonenkov, A., & Rydén, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.04.038 · Cited by 234 · see citing works

A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1

McWhirter, J. R., Goulding, M., Weiner, J. A., Chun, J. J. M., & Murre, C. (1997) · Development · doi:10.1242/dev.124.17.3221 · Cited by 231 · see citing works

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A., & Mangelsdorf, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3250 · Cited by 230 · see citing works

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

Camporez, J. P., Jornayvaz, F. R., Petersen, M. C., Pesta, D. H., Guigni, B. A., Serr, J., Zhang, D., Kahn, M., Samuel, V. T., Jurczak, M. J., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1191 · Cited by 226 · see citing works

Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states

Hasek, B. E., Stewart, L. K., Henagan, T. M., Boudreau, A., Lenard, N. R., Black, C. L., Shin, J., Huypens, P., Malloy, V. L., Plaisance, E. P., et al. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00837.2009 · Cited by 218 · see citing works

FGF19 action in the brain induces insulin-independent glucose lowering

Morton, G. J., Matsen, M. E., Bracy, D. P., Meek, T. H., Hồng, N. T., Stefanovski, D., Bergman, R. N., Wasserman, D. H., & Schwartz, M. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70710 · Cited by 216 · see citing works

Functional thermogenic beige adipogenesis is inducible in human neck fat

Lee, P., Werner, C., Kebebew, E., & Celi, F. S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.82 · Cited by 205 · see citing works

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

Véniant, M. M., Sivits, G., Helmering, J., Komorowski, R., Lee, J., Fan, W., Moyer, C., & Lloyd, D. J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.019 · Cited by 204 · see citing works

Inventing new medicines: The FGF21 story

Kharitonenkov, A., & Adams, A. C. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.003 · Cited by 198 · see citing works

Improved Glycemic Control with Colesevelam Treatment in Patients with Type 2 Diabetes Is Not Directly Associated with Changes in Bile Acid Metabolism

Brufau, G., Stellaard, F., Prado, K. B., Bloks, V. W., Jonkers, E., Boverhof, R., Kuipers, F., & Murphy, E. J. (2010) · Hepatology · doi:10.1002/hep.23831 · Cited by 198 · see citing works

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

Iizuka, K., Takeda, J., & Horikawa, Y. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.053 · Cited by 187 · see citing works

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

Ryan, K. K., Kohli, R., Gutierrez-Aguilar, R., Gaitonde, S. G., Woods, S. C., & Seeley, R. J. (2013) · Endocrinology · doi:10.1210/en.2012-1891 · Cited by 185 · see citing works

FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways

Wu, A.-L., Coulter, S., Liddle, C., Wong, A., Eastham‐Anderson, J., French, D. M., Peterson, A. S., & Sonoda, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017868 · Cited by 185 · see citing works

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Hale, C., Chen, M. M., Stanislaus, S., Chinookoswong, N., Hager, T., Wang, M., Véniant, M. M., & Xu, J. (2012) · Endocrinology · doi:10.1210/en.2010-1262 · Cited by 185 · see citing works

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

Wu, A.-L., Kolumam, G., Stawicki, S., Chen, Y., Li, J., Zavala-Solorio, J., Phamluong, K., Feng, B., Li, L., Marsters, S., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002669 · Cited by 184 · see citing works

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

Zhou, M., Wang, X., Phung, V., Lindhout, D. A., Mondal, K., Hsu, J.-Y., Yang, H., Humphrey, M., Ding, X., Arora, T., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0208 · Cited by 183 · see citing works

FGF21 Requires βklotho to Act In Vivo

Adams, A. C., Cheng, C. C., Coskun, T., & Kharitonenkov, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049977 · Cited by 181 · see citing works

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

Yang, C., Jin, C., Li, X., Wang, F., McKeehan, W. L., & Luo, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033870 · Cited by 173 · see citing works

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

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A nontumorigenic variant of FGF19 treats cholestatic liver diseases

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Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

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FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

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Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression

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Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation

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Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

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Analysis of Fgf15 expression pattern in the mouse neural tube

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A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes

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Interplay between FGF21 and insulin action in the liver regulates metabolism

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A Novel Approach to Improve the Function of FGF21

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Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

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TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection

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Effect of ethanol on lipid metabolism

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FGF21 gene therapy as treatment for obesity and insulin resistance

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Bile acids and their receptors in metabolic disorders

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Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

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FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

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New developments in the biology of fibroblast growth factors

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FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

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FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

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FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

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Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure

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The transcription factor carbohydrate-response element-binding protein (ChREBP): A possible link between metabolic disease and cancer

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Recovery of Bacteroides thetaiotaomicron ameliorates hepatic steatosis in experimental alcohol-related liver disease

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The potential function and clinical application of FGF21 in metabolic diseases

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MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling

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FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue

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Alteration in Cellular Signaling and Metabolic Reprogramming during Viral Infection

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A new frontier in FGF21 biology

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FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes

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Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

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NRG1-Fc improves metabolic health via dual hepatic and central action.

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Regulation of Energy Metabolism by Receptor Tyrosine Kinase Ligands

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Disturbed gut microbiota and bile homeostasis in Giardia -infected mice contributes to metabolic dysregulation and growth impairment

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Key Roles of Brown, Subcutaneous, and Visceral Adipose Tissues in Obesity and Insulin Resistance

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Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways

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Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity

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Acute hyperenergetic, high-fat feeding increases circulating FGF21, LECT2, and fetuin-A in healthy men

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Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease

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The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease

Fiorucci, S., Biagioli, M., Baldoni, M., Ricci, P., Sepe, V., Zampella, A., & Distrutti, E. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1916465 · Cited by 31 · see citing works

Fibroblast growth factor 21 and bone homeostasis

Tang, Y., & Zhang, M. (2022) · Biomedical Journal · doi:10.1016/j.bj.2022.07.002 · Cited by 31 · see citing works

Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases

Zhao, L., Niu, J., Lin, H., Zhao, J., Liu, Y., Song, Z., Xiang, C., Wang, X., Yang, Y., Li, X., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.052 · Cited by 30 · see citing works

Vascular Endothelial Regulation of Obesity-Associated Insulin Resistance

Li, M., Qian, M., & Xu, J. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00051 · Cited by 28 · see citing works

Gall bladder: The metabolic orchestrator

Li, Q., Tian, Y., & Chen, Y. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3140 · Cited by 28 · see citing works

MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE.

Abel, E. D. (2018) · Europe PMC (PubMed Central) · Cited by 27 · see citing works

Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows

Caixeta, L. S., Giesy, S. L., Krumm, C. S., Perfield, J. W., Butterfield, A. M., Schoenberg, K. M., Beitz, D. C., & Boisclair, Y. R. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00197.2017 · Cited by 27 · see citing works

FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition

Reilly, S. M., Abu-Odeh, M., Ameka, M., DeLuca, J. H., Naber, M. C., Dadpey, B., Ebadat, N., Gomez, A. V., Peng, X., Poirier, B., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145546 · Cited by 18 · see citing works

Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. I. Effects on signaling and indices of insulin action

Krumm, C. S., Giesy, S. L., Caixeta, L. S., Perfield, J. W., Sauerwein, H., Moore, B. L., & Boisclair, Y. R. (2019) · Journal of Dairy Science · doi:10.3168/jds.2019-16695 · Cited by 18 · see citing works

Various types of fasting diet and possible benefits in nonalcoholic fatty liver: Mechanism of actions and literature update

Mirrazavi, Z. S., & Behrouz, V. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.01.005 · Cited by 20 · see citing works

Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation

Dey, S., Cui, Z., Gavrilova, O., Zhang, X., Gassmann, M., & Noguchi, C. T. (2020) · JCI Insight · doi:10.1172/jci.insight.134061 · Cited by 17 · see citing works

Genetically engineered FGF1-sericin hydrogel material treats intrauterine adhesion and restores fertility in rat

Guan, C.-Y., Wang, F., Zhang, L., Sun, X., Zhang, D., Wang, H., Xia, H., Xia, Q., & Ma, X. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac016 · Cited by 17 · see citing works

Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study

Xie, Z.-Q., Li, H., Tan, W., Yang, L., Ma, X., Li, W., Wang, Q., Shang, C., & Chen, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.787777 · Cited by 16 · see citing works

Exploring endocrine FGFs - structures, functions and biomedical applications

Phan, P. (2024) · International Journal of Biochemistry and Molecular Biology · doi:10.62347/palk2137 · Cited by 15 · see citing works

FAP finds FGF21 easy to digest

Gillum, M. P., & Potthoff, M. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160004 · Cited by 14 · see citing works

Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma

Wang, D., Zhang, J., Li, Z., Han, J., Gao, Y., Chen, M., & Li, Y. (2018) · Digestive Diseases · doi:10.1159/000494454 · Cited by 13 · see citing works

Characterization of FGF21 Sites of Production and Signaling in Mice

Sullivan, A. I., Jensen-Cody, S. O., Claflin, K. E., Vorhies, K., Flippo, K. H., & Potthoff, M. J. (2024) · Endocrinology · doi:10.1210/endocr/bqae120 · Cited by 11 · see citing works

Identification, Characterization and Functional Analysis of Fibroblast Growth Factors in Black Rockfish (Sebastes schlegelii)

Jin, C., Yan, K., Wang, M., Song, W., Kong, X., & Zhang, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043626 · Cited by 12 · see citing works

Tanycyte radial morphology and proliferation are influenced by fibroblast growth factor receptor 1 and high‐fat diet

Esteve, N. A., Rogers, D. J., Stagray, J. A., Mayeux, H., Nora, G., Huval, L., & Smith, K. M. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16473 · Cited by 11 · see citing works

Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice

Ziros, P. G., Zagoriti, Z., Lagoumintzis, G., Kyriazopoulou, V. E., Iskrenova, R. P., Habeos, E. E., Sykiotis, G. P., Chartoumpekis, D. V., & Habeos, I. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162024 · Cited by 11 · see citing works

Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs

Vonderohe, C. E., Guthrie, G. J., Stoll, B., Chacko, S. K., Dawson, H. D., & Burrin, D. G. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00274.2021 · Cited by 12 · see citing works

Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control

Kozuka, C., Efthymiou, V., Sales, V., Zhou, L., Osataphan, S. A., Yuchi, Y., CHIMENE-WEISS, J. I., Mulla, C. M., ISGANAITIS, E. M., Desmond, J., et al. (2022) · Diabetes · doi:10.2337/db21-0574 · Cited by 11 · see citing works

Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential.

Krzyścik, M., Opaliński, Ł., Szymczyk, J., & Otlewski, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.105 · Cited by 9 · see citing works

18F-FDG PET as an imaging biomarker for the response to FGFR-targeted therapy of cancer cells via FGFR-initiated mTOR/HK2 axis

Jiang, Y., Zeng, Q., Jiang, Q., Xia, P., Gao, J., Wan, H., Wang, L., Gao, Y., Zhou, X., Lin, D., et al. (2022) · Theranostics · doi:10.7150/thno.74848 · Cited by 10 · see citing works

Natural H2S ‐donors: A new pharmacological opportunity for the management of overweight and obesity

Spezzini, J., Piragine, E., Flori, L., Calderone, V., & Martelli, A. (2024) · Phytotherapy Research · doi:10.1002/ptr.8181 · Cited by 9 · see citing works

Fibroblast growth factor 19 secretion and function in perinatal development

Vonderohe, C. E., Guthrie, G. J., & Burrin, D. G. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00208.2022 · Cited by 9 · see citing works

ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells

Huang, Y., Zhang, Y., Yang, N., Qian, Z., Fang, Z., Zeng, L., Huang, Y., Li, H., Luo, M., Yan, J., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01463-y · Cited by 8 · see citing works

Central FGF19 signaling enhances energy homeostasis and adipose tissue thermogenesis through sympathetic activation in obese mice

Zangerolamo, L., Carvalho, M. U. W. B. D., Solon, C., Sidarta-Oliveira, D., Soares, G. M., Marmentini, C., Boschero, A. C., Tseng, Y., Velloso, L. A., & Barbosa, H. C. L. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2024 · Cited by 8 · see citing works

Differential effects of protein intake versus intake of a defined oligopeptide on FGF-21 in obese human subjects in vivo

Fangmann, D., Geisler, C., Schlicht, K., Hartmann, K., Köpke, J., Tiede, A., Settgast, U., Türk, K., Schulte, D. M., Altmann, K., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.06.006 · Cited by 8 · see citing works

Effects of beta-conglycinin intake on circulating FGF21 levels and brown adipose tissue activity in Japanese young men: a single intake study and a randomized controlled trial

Taniguchi, H., Shimizu, K., Wada, S., Nirengi, S., Kataoka, H., & Higashi, A. (2020) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-020-00226-w · Cited by 8 · see citing works

Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus

Mashili, F. L., Ramaiya, K. L., Lutale, J. K., Njelekela, M. A., Francis, F. T., Zierath, J. R., & Krook, A. (2018) · Journal of Obesity · doi:10.1155/2018/7461903 · Cited by 8 · see citing works

FGF1 as a New Promising Therapeutic Target in Type 2 Diabetes: Advances in Research and Clinical Trials

Bu, T.-S., Gao, X., Zhang, R.-N., & Xu, Y. (2025) · Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy · doi:10.2147/dmso.s505285 · Cited by 5 · see citing works

The role of FGF21 in the metabolic adjustments required for exercise capacity

Abe, L., & Dantzer, R. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123940 · Cited by 5 · see citing works

Higher fasting plasma FGF21 concentration is associated with lower ad libitum soda consumption in humans

Basolo, A., Hollstein, T., Shah, M. H., Walter, M. F., Krakoff, J. A., Votruba, S. B., & Piaggi, P. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab204 · Cited by 6 · see citing works

Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside

Huang, Y., Liu, B., Hu, C., & Lu, Y. (2025) · Protein & Cell · doi:10.1093/procel/pwaf027 · Cited by 4 · see citing works

The effects of fasting diets on nonalcoholic fatty liver disease

Mokhtari, Z., Hosseini, E., Hekmatdoost, A., Haskey, N., Gibson, D. L., & Askari, G. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac092 · Cited by 4 · see citing works

Increased Circulating Cortisol After Vaginal Birth Is Associated With Increased FGF19 Secretion in Neonatal Pigs

Vonderohe, C. E., Guthrie, G. J., Stoll, B., Hebib, V. M., Dawson, H. D., & Burrin, D. G. (2022) · Endocrinology · doi:10.1210/endocr/bqac188 · Cited by 4 · see citing works

Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation

Rijal, G. (2021) · Bioengineering · doi:10.3390/bioengineering8110163 · Cited by 4 · see citing works

Recent Insights into Treatment of Non-Alcoholic Steatohepatitis

Chiappini, F. (2016) · Journal of Endocrinology and Diabetes · doi:10.15226/2374-6890/3/1/00142 · Cited by 3 · see citing works

Pandora's box opens for cholestatic liver disease

Jansen, P. L. M., & Schaap, F. G. (2015) · Hepatology · doi:10.1002/hep.28364 · Cited by 3 · see citing works

Plasma FGF21 concentrations and spontaneous self-selection of protein suggest that 15% protein in the diet may not be enough for male adult rats

Gehring, J., Azzout‐Marniche, D., Chaumontet, C., Gaudichon, C., & Even, P. C. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00204.2021 · Cited by 2 · see citing works

Cord Blood as a Trophic-Growth Additive for Culture Work

Goncharov, A., Shupletsova, V., Gazatova, N. D., Melashchenko, O., Yurova, K., & Litvinova, L. S. (2024) · Cell and Tissue Biology · doi:10.1134/s1990519x24700299

Targeting the FGF1/FGFR signaling pathway enhances the antitumor effect of oxaliplatin and alleviates chemotherapy-induced peripheral neuropathy.

Xie, C., Li, Z., Cao, J., Cheng, Y.-N., Jin, Z., Ge, Y., Deng, J., Luo, Z., Zheng, C., Hou, L., et al. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.02.005

The use of FGF21 analogues in MASH and MASH cirrhosis – metabolic master regulators or liver-specific mechanisms?

Holleboom, A. G., & Schattenberg, J. M. (2026) · JHEP Reports · doi:10.1016/j.jhepr.2026.101957 · Cited by 1 · see citing works

Fibroblast Growth Factor 21: Possible Role in Growth and Metabolic Development during Early Life, Nutritional Interactions and Biological Actions

Wali, J. A., Ramos-Nieves, J. M., Binia, A., & van der Beek, E. M. (2026) · Advances in Nutrition · doi:10.1016/j.advnut.2026.100713 · Cited by 1 · see citing works

Outcome nach bariatrischer Chirurgie bei Jugendlichen verglichen mit Erwachsenen

Pfeiffer, A. F. H., & Nitschmann, S. (2020) · Der Internist · doi:10.1007/s00108-020-00751-x · Cited by 1 · see citing works

miR-383-3p and miR-6951-3p activate cell proliferation through the regulation of genes related to hypertelorism

Iwaya, C., & Iwata, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1587052 · Cited by 1 · see citing works

Influencia del factor de crecimiento fibroblástico 2 en células madre in vitro

Vargas, A. C. R., Arzuza, J. P. A., & Turner, L. F. (2020) · Actualidades Biológicas · doi:10.17533/udea.acbi.v41n111a03

Faculty Opinions recommendation of Regulation of energy metabolism by receptor tyrosine kinase ligands.

Ladbury, J. E. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737907472.793574673

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for three monthsPreprint

Lü, C., Jin, L., Bi, J., Jin, H., You, X., Peng, L., Wang, L., Fan, Z., & Wang, X. (2023) · Research Square · doi:10.21203/rs.3.rs-2441482/v1

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

Lü, C., Jin, L., Bi, J., Jin, H., You, X., Peng, L., Fan, H., Wang, H., Wang, L., Fan, Z., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1176136

Umbilical blood as a trophic-growth supplement for cultural work

Goncharov, A., Shupletsova, V., Gazatova, N. D., Melashchenko, O., Yurova, K., & Litvinova, L. S. (2024) · Tsitologiya · doi:10.31857/s0041377124020019

FGF21 Blunts Cardiac Ischemia/Reperfusion Injury by Promoting Autophagic Flux Via Stat1/Irgm1 Pathway

Tu, T., Ning, Z., He, Y., Ma, Y., Xiao, Y., Zhu, Z., Tang, L., Li, X., Yang, H., Chen, M., et al. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-025-10707-x

Evaluation of leptin, neuregulin 4, FGF21, and vitamin D levels in patients with lichen planus

Akyürek, F. T., Akyürek, F., & Demirbaş, G. U. (2025) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2025-0117

Human FGF1ΔHBS Gene Therapy as Treatment for Metabolic Dysfunction-Associated Steatohepatitis in ApoE-KO Mice

Li, Y., Hui, X., Gu, C., Lin, Q., Abdelbaset-Ismail, A., Xu, Z., Yadav, S. K., Huang, H., Xu, J. J., Watson, S. E., et al. (2026) · Cells · doi:10.3390/cells15050387

Implication de FGF9 et de FGF19 dans la fibrose pulmonaire idiopathique

Justet, A. (2020) · doi:10.70675/6e72f095z0cb6z4dd3zb204z88d1b08b9910

Marqueurs diagnostiques et pronostiques de la stéatohépatite métabolique

Coilly, A. (2019) · doi:10.70675/488abf31z3acfz4f13z88e2zd974ef8b9b7b

Conséquences de l’altération du métabolisme des macronutriments sur la prise alimentaire, le risque de carcinome hépatocellulaire et l’état nutritionnel au cours de la cirrhose

Mouillot, T. (2021) · doi:10.70675/0bb9fa70z5648z44eazab59zc2a4236991a3

Fibroblast Growth Factor Signaling in Metabolic Regulation

Nies, V. J. M., Sancar, G., Liu, W., van Zutphen, T., Struik, D., Yu, R. T., Atkins, A. R., Evans, R. M., Jonker, J. W., & Downes, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00193 · Cited by 135 · see citing works

Metabolic messengers: FGF21

Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311 · see citing works

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.10.002 · Cited by 286 · see citing works

Metabolic roles of endocrine fibroblast growth factors

Fernandes-Freitas, I., & Owen, B. M. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.014 · Cited by 45 · see citing works

Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Guan, D., Zhao, L., Chen, D., Yu, B., & Yu, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0821-0 · Cited by 36 · see citing works